ATE502938T1 - Pyridinderivate als s1p1/edg1-rezeptormodulatoren - Google Patents

Pyridinderivate als s1p1/edg1-rezeptormodulatoren

Info

Publication number: ATE502938T1
Authority: AT; Austria
Prior art keywords: receptor modulators; pyridine derivatives; edg1 receptor; edg1; pyridine
Prior art date: 2007-08-17

Application number

AT08789611T

Other languages

English (en)

Inventor

Martin Bolli

Cyrille Lescop

Boris Mathys

Claus Mueller

Oliver Nayler

Beat Steiner

Joerg Velker

Original Assignee

Actelion Pharmaceuticals Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-08-17

Filing date

2008-08-14

Publication date

2011-04-15

2008-08-14 Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd

2011-04-15 Application granted granted Critical

2011-04-15 Publication of ATE502938T1 publication Critical patent/ATE502938T1/de

Links

102100025750 Sphingosine 1-phosphate receptor 1 Human genes 0.000 title 2
101000693265 Homo sapiens Sphingosine 1-phosphate receptor 1 Proteins 0.000 title 1
JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical class C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 title 1
101710155454 Sphingosine 1-phosphate receptor 1 Proteins 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Diabetes (AREA)
Pulmonology (AREA)
Rheumatology (AREA)
Dermatology (AREA)
Endocrinology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Hematology (AREA)
Pain & Pain Management (AREA)
Hospice & Palliative Care (AREA)
Oncology (AREA)
Obesity (AREA)
Psychiatry (AREA)
Ophthalmology & Optometry (AREA)
Emergency Medicine (AREA)
Transplantation (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Otolaryngology (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Pyridine Compounds (AREA)

AT08789611T 2007-08-17 2008-08-14 Pyridinderivate als s1p1/edg1-rezeptormodulatoren ATE502938T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IB2007053293		2007-08-17
PCT/IB2008/053269 WO2009024905A1 (en)	2007-08-17	2008-08-14	Pyridine derivatives as s1p1/edg1 receptor modulators

Publications (1)

Publication Number	Publication Date
ATE502938T1 true ATE502938T1 (de)	2011-04-15

Family

ID=40193868

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT08789611T ATE502938T1 (de)	2007-08-17	2008-08-14	Pyridinderivate als s1p1/edg1-rezeptormodulatoren

Country Status (26)

Country	Link
US (1)	US8598208B2 (de)
EP (1)	EP2195311B1 (de)
JP (1)	JP5451614B2 (de)
KR (1)	KR101541558B1 (de)
CN (1)	CN102648198B (de)
AR (1)	AR067977A1 (de)
AT (1)	ATE502938T1 (de)
AU (1)	AU2008290233B2 (de)
BR (1)	BRPI0815190A2 (de)
CA (1)	CA2695509A1 (de)
CY (1)	CY1111830T1 (de)
DE (1)	DE602008005770D1 (de)
DK (1)	DK2195311T3 (de)
ES (1)	ES2361463T3 (de)
HR (1)	HRP20110449T1 (de)
MA (1)	MA31703B1 (de)
MX (1)	MX2010001881A (de)
MY (1)	MY153975A (de)
NZ (1)	NZ583957A (de)
PL (1)	PL2195311T3 (de)
PT (1)	PT2195311E (de)
RU (1)	RU2492168C2 (de)
SI (1)	SI2195311T1 (de)
TW (1)	TWI422373B (de)
WO (1)	WO2009024905A1 (de)
ZA (1)	ZA201001873B (de)

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WO2009109872A1 (en) *	2008-03-07	2009-09-11	Actelion Pharmaceuticals Ltd	Pyridin-2-yl derivatives as immunomodulating agents
PL2278960T5 (pl)	2008-03-17	2020-06-29	Actelion Pharmaceuticals Ltd.	Schemat dawkowania dla selektywnego agonisty receptora sip1
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CA2871270A1 (en)	2012-05-02	2013-11-07	Lupin Limited	Substituted pyridine compounds as crac modulators
SMT202000298T1 (it)	2012-08-17	2020-07-08	Actelion Pharmaceuticals Ltd	Processo per la produzione di (2z,5z)-5-(3-cloro-4((r)-2,3-diidrossipropossi) benziliden)-2-(propilimmino)-3-(o-tolil)tiazolidin-4-one e intermedio usato in detto processo
NZ713080A (en)	2013-03-15	2020-06-26	Idorsia Pharmaceuticals Ltd	Pyridin-4-yl derivatives
PH12017502097B1 (en)	2015-05-20	2023-05-05	Idorsia Pharmaceuticals Ltd	Crystalline form of the compound (s)-3-{4-[5-(2-cyclopentyl-6-methoxy-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-2-ethyl-6-methyl-phenoxy}-propane-1,2-diol
US10111841B2 (en)	2015-06-19	2018-10-30	University Of South Florida	Stabilization of alcohol intoxication-induced cardiovascular instability
WO2017004610A1 (en)	2015-07-02	2017-01-05	Exelixis, Inc.	Tercyclic s1p3-sparing, s1p1 receptor agonists
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ES2934785T3 (es)	2016-03-07	2023-02-27	Global Alliance For Tb Drug Development Inc	Compuestos antibacterianos y usos de los mismos
JP2019513700A (ja)	2016-03-16	2019-05-30	バイエル・クロップサイエンス・アクチェンゲゼルシャフト	殺有害生物剤及び植物保護剤としてのｎ−（シアノベンジル）−６−（シクロプロピル−カルボニルアミノ）−４−（フェニル）−ピリジン−２−カルボキサミド誘導体及び関連する化合物
US11014940B1 (en)	2018-10-16	2021-05-25	Celgene Corporation	Thiazolidinone and oxazolidinone compounds and formulations
US11013723B1 (en)	2018-10-16	2021-05-25	Celgene Corporation	Solid forms of a thiazolidinone compound, compositions and methods of use thereof
US11014897B1 (en)	2018-10-16	2021-05-25	Celgene Corporation	Solid forms comprising a thiazolidinone compound, compositions and methods of use thereof
US11186556B1 (en)	2018-10-16	2021-11-30	Celgene Corporation	Salts of a thiazolidinone compound, solid forms, compositions and methods of use thereof
EP4211112A1 (de)	2020-09-11	2023-07-19	PI Industries Ltd.	Verfahren zur herstellung von substituierten pyridinverbindungen und deren zwischenprodukte

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GB0601744D0 (en)	2006-01-27	2006-03-08	Novartis Ag	Organic compounds
PT2069336E (pt) *	2006-09-07	2013-03-07	Actelion Pharmaceuticals Ltd	Derivados de piridin-4-ilo como agentes imunomoduladores
PL2069335T3 (pl) *	2006-09-08	2013-05-31	Actelion Pharmaceuticals Ltd	Pochodne pirydyn-3-ylu jako środki immunomodulujące
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BRPI0808789A2 (pt) *	2007-03-16	2014-08-12	Actelion Pharmaceuticals Ltd	Compostos e composição farmacêutica de derivados aminopiridina e uso destes
KR20100092473A (ko) *	2007-11-01	2010-08-20	액테리온 파마슈티칼 리미티드	신규한 피리미딘 유도체
EP2262799B1 (de) *	2008-03-06	2012-07-04	Actelion Pharmaceuticals Ltd.	Pyridinverbindungen
WO2009109907A1 (en) *	2008-03-06	2009-09-11	Actelion Pharmaceuticals Ltd	Novel pyrimidine-pyridine derivatives
CA2715317A1 (en) *	2008-03-07	2009-09-11	Actelion Pharmaceuticals Ltd	Novel aminomethyl benzene derivatives
WO2009109872A1 (en) *	2008-03-07	2009-09-11	Actelion Pharmaceuticals Ltd	Pyridin-2-yl derivatives as immunomodulating agents
EP3782991A1 (de)	2008-05-14	2021-02-24	The Scripps Research Institute	Neue modulatoren von sphingosinphophatrezeptoren
CA2767585C (en) *	2009-07-16	2017-09-26	Actelion Pharmaceuticals Ltd	Pyridin-4-yl derivatives

2008
- 2008-08-14 PT PT08789611T patent/PT2195311E/pt unknown
- 2008-08-14 CA CA2695509A patent/CA2695509A1/en not_active Abandoned
- 2008-08-14 DK DK08789611.4T patent/DK2195311T3/da active
- 2008-08-14 ES ES08789611T patent/ES2361463T3/es active Active
- 2008-08-14 HR HR20110449T patent/HRP20110449T1/hr unknown
- 2008-08-14 PL PL08789611T patent/PL2195311T3/pl unknown
- 2008-08-14 BR BRPI0815190 patent/BRPI0815190A2/pt not_active IP Right Cessation
- 2008-08-14 SI SI200830269T patent/SI2195311T1/sl unknown
- 2008-08-14 CN CN200880103070.2A patent/CN102648198B/zh not_active Expired - Fee Related
- 2008-08-14 MX MX2010001881A patent/MX2010001881A/es active IP Right Grant
- 2008-08-14 WO PCT/IB2008/053269 patent/WO2009024905A1/en not_active Ceased
- 2008-08-14 AU AU2008290233A patent/AU2008290233B2/en not_active Ceased
- 2008-08-14 US US12/673,918 patent/US8598208B2/en not_active Expired - Fee Related
- 2008-08-14 DE DE602008005770T patent/DE602008005770D1/de active Active
- 2008-08-14 EP EP08789611A patent/EP2195311B1/de not_active Not-in-force
- 2008-08-14 AT AT08789611T patent/ATE502938T1/de active
- 2008-08-14 JP JP2010520670A patent/JP5451614B2/ja not_active Expired - Fee Related
- 2008-08-14 RU RU2010109542/04A patent/RU2492168C2/ru not_active IP Right Cessation
- 2008-08-14 MY MYPI2010000684A patent/MY153975A/en unknown
- 2008-08-14 NZ NZ583957A patent/NZ583957A/en not_active IP Right Cessation
- 2008-08-14 KR KR1020107005759A patent/KR101541558B1/ko not_active Expired - Fee Related
- 2008-08-15 TW TW097131346A patent/TWI422373B/zh not_active IP Right Cessation
- 2008-08-19 AR ARP080103611A patent/AR067977A1/es not_active Application Discontinuation
2010
- 2010-03-12 MA MA32693A patent/MA31703B1/fr unknown
- 2010-03-16 ZA ZA2010/01873A patent/ZA201001873B/en unknown
2011
- 2011-05-30 CY CY20111100521T patent/CY1111830T1/el unknown

Also Published As

Publication number	Publication date
EP2195311A1 (de)	2010-06-16
MX2010001881A (es)	2010-03-10
EP2195311B1 (de)	2011-03-23
US20110212998A1 (en)	2011-09-01
CY1111830T1 (el)	2015-10-07
RU2492168C2 (ru)	2013-09-10
AU2008290233A1 (en)	2009-02-26
RU2010109542A (ru)	2011-09-27
HK1144809A1 (en)	2011-03-11
PL2195311T3 (pl)	2011-08-31
AU2008290233B2 (en)	2013-10-10
DE602008005770D1 (de)	2011-05-05
HRP20110449T1 (hr)	2011-07-31
CA2695509A1 (en)	2009-02-26
JP2010536741A (ja)	2010-12-02
AR067977A1 (es)	2009-10-28
BRPI0815190A2 (pt)	2015-03-31
WO2009024905A1 (en)	2009-02-26
CN102648198A (zh)	2012-08-22
TW200918055A (en)	2009-05-01
PT2195311E (pt)	2011-05-25
KR101541558B1 (ko)	2015-08-03
MA31703B1 (fr)	2010-09-01
SI2195311T1 (sl)	2011-07-29
KR20100058561A (ko)	2010-06-03
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