ATE503759T1 - 7-ä2-ä4-(6-fluor-3-methyl-1,2-benzisoxazol-5-yl - 1-piperazinylüethylü-2-(1-propinyl)-7h-pyrazolo - Google Patents

7-ä2-ä4-(6-fluor-3-methyl-1,2-benzisoxazol-5-yl - 1-piperazinylüethylü-2-(1-propinyl)-7h-pyrazolo

Info

Publication number: ATE503759T1
Authority: AT; Austria
Prior art keywords: piperazinylüethylü; propinyl; benzisoxazole; pyrazolo; fluoro
Prior art date: 2005-09-23

Application number

AT06804036T

Other languages

English (en)

Inventor

Craig Boyle

Samuel Chackalamannil

Unmesh Shah

Jean Lachowicz

Original Assignee

Schering Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-09-23

Filing date

2006-09-21

Publication date

2011-04-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37487759&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE503759(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2006-09-21 Application filed by Schering Corp filed Critical Schering Corp

2011-04-15 Application granted granted Critical

2011-04-15 Publication of ATE503759T1 publication Critical patent/ATE503759T1/de

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Neurology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Psychology (AREA)
Epidemiology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Pain & Pain Management (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

AT06804036T 2005-09-23 2006-09-21 7-ä2-ä4-(6-fluor-3-methyl-1,2-benzisoxazol-5-yl - 1-piperazinylüethylü-2-(1-propinyl)-7h-pyrazolo ATE503759T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US72002705P	2005-09-23	2005-09-23
PCT/US2006/037003 WO2007038284A1 (en)	2005-09-23	2006-09-21	7-[2-[4-(6-FLUORO-3-METHYL-1,2-BENZISOXAZOL-5-YL)-1-PIPERAZINYL]ETHYL]-2-(1-PROPYNYL)-7H-PYRAZOLO-[4,3-e]-[1,2,4]-TRIAZOLO-[1,5-c]-PYRIMIDIN-5 AMINE

Publications (1)

Publication Number	Publication Date
ATE503759T1 true ATE503759T1 (de)	2011-04-15

Family

ID=37487759

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT06804036T ATE503759T1 (de)	2005-09-23	2006-09-21	7-ä2-ä4-(6-fluor-3-methyl-1,2-benzisoxazol-5-yl - 1-piperazinylüethylü-2-(1-propinyl)-7h-pyrazolo

Country Status (30)

Country	Link
US (2)	US7572802B2 (de)
EP (1)	EP1937687B1 (de)
JP (1)	JP4808779B2 (de)
KR (1)	KR101396614B1 (de)
CN (2)	CN101273045B (de)
AR (1)	AR056080A1 (de)
AT (1)	ATE503759T1 (de)
AU (1)	AU2006294633B8 (de)
BR (1)	BRPI0616264B8 (de)
CA (1)	CA2623047C (de)
CY (1)	CY1111921T1 (de)
DE (1)	DE602006021042D1 (de)
DK (1)	DK1937687T3 (de)
EC (1)	ECSP088297A (de)
ES (1)	ES2361856T3 (de)
HR (1)	HRP20110466T1 (de)
IL (1)	IL190275A (de)
MY (1)	MY146429A (de)
NO (1)	NO341760B1 (de)
NZ (1)	NZ566737A (de)
PE (1)	PE20070521A1 (de)
PL (1)	PL1937687T3 (de)
PT (1)	PT1937687E (de)
RS (1)	RS51702B (de)
RU (1)	RU2417997C2 (de)
SG (1)	SG165419A1 (de)
SI (1)	SI1937687T1 (de)
TW (1)	TWI335329B (de)
WO (1)	WO2007038284A1 (de)
ZA (1)	ZA200802550B (de)

Families Citing this family (17)

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NZ527142A (en)	2003-07-23	2006-03-31	Douglas Pharmaceuticals Ltd	A stable suspension formulation
US7691869B2 (en)	2007-03-30	2010-04-06	King Pharmaceuticals Research And Development, Inc.	Pyrrolotriazolopyrimidine derivatives, pharmaceutical compositions containing them and methods of treating conditions and diseases mediated by the adenosine A2A receptor activity
JP5765239B2 (ja)	2009-03-13	2015-08-19	アドヴィナス・セラピューティックス・リミテッド	置換縮合ピリミジン化合物
US8598343B2 (en)	2009-08-07	2013-12-03	Merck Sharp & Dohme Corp.	Process for preparing a 2-alkynyl substituted 5-amino-pyrazolo-[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine
WO2011101861A1 (en)	2010-01-29	2011-08-25	Msn Laboratories Limited	Process for preparation of dpp-iv inhibitors
CN103261202B (zh) *	2010-09-24	2016-01-20	阿迪维纳斯疗法有限公司	作为腺苷受体拮抗剂的稠合三环化合物
WO2012135083A1 (en) *	2011-03-31	2012-10-04	Merck Sharp & Dohme Corp.	METABOLITES OF 7-(2-(4-(6-FLUORO-3-METHYLBENZO[d]ISOXAZOL-5-YL)PIPERAZIN-1-YL)ETHYL)-2-(PROP-1-YNYL)-7H-PYRAZOLO[4,3-e][1,2,4]TRIAZOLO[1,5-c]PYRIMIDIN-5-AMINE AND THEIR UTILITY AS ADENOSINE A2a RECEPTOR ANTAGONISTS
WO2014101113A1 (en) *	2012-12-28	2014-07-03	Merck Sharp & Dohme Corp.	Piperazine-substituted 7-methoxy-[1,2,4]triazolo[1,5-c]quinazolin-5-amine compounds with a2a antagonist properties
WO2014101120A1 (en)	2012-12-28	2014-07-03	Merck Sharp & Dohme Corp.	Heterobicyclo-substituted-7-methoxy-[1,2,4]triazolo[1,5-c]quinazolin-5-amine compounds with a2a antagonist properties
WO2014128882A1 (ja) *	2013-02-21	2014-08-28	医療法人和楽会	不安うつ病の治療薬
WO2015027431A1 (en)	2013-08-29	2015-03-05	Merck Sharp & Dohme Corp.	2,2-difluorodioxolo a2a receptor antagonists
RU2719446C2 (ru)	2014-11-03	2020-04-17	Айомет Фарма Лтд	Фармацевтическое соединение
EP3227299B1 (de)	2014-12-04	2021-05-26	Merck Sharp & Dohme Corp.	Formulierung zur hemmung der effekte einer schwach sauren umgebung
CN106543095B (zh) *	2016-09-23	2019-03-05	江苏大学	一种基于2-羟基苯乙酮肟及其衍生物一锅制备苯并异噁唑的方法
EP3723754A4 (de)	2017-12-13	2021-05-19	Merck Sharp & Dohme Corp.	Imidazo[1,2-c]chinazolin-5-amin-verbindungen mit eigenschaften von a2a-antagonist
CN110742893B (zh) *	2018-07-23	2024-04-05	百济神州(北京)生物科技有限公司	A2a受体拮抗剂治疗癌症的方法
TW202039496A (zh)	2018-11-30	2020-11-01	美商默沙東藥廠	做為腺苷受體拮抗劑之9-經取代胺基三唑喹唑啉衍生物、醫藥組合物及其用途

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SE462170B (sv)	1987-10-27	1990-05-14	Aahlstrom Corp	Avlaegsnande av loesta och kolloidala makromolekylaera organiska aemnen ur effluenter
IT1264901B1 (it)	1993-06-29	1996-10-17	Schering Plough S P A	Analoghi eterociclici di 1,2,4-triazolo(15-c)pirimidine ad attivita' antagonista per il recettore a2 dell'adenosina
EP0666079B1 (de) *	1993-07-27	2001-11-07	Kyowa Hakko Kogyo Co., Ltd.	Arzneimittel gegen Parkinsonsche Krankheit
IT1275420B (it)	1995-06-02	1997-08-05	Schering Plough S P A	Metodo per misurare l'affinita' di legame al recettore a2a dell'adenosina di componenti di interesse farmacologico mediante l'uso del ligando triziato (3h)-sch 58261
IT1277392B1 (it)	1995-07-28	1997-11-10	Schering Plough S P A	Analoghi eterociclici di 1,2,4-triazolo(1,5-c]pirimidine ad attivita' antagonista per il recettore a2a dell'adenosina
DE19604919A1 (de) *	1996-02-01	1997-08-07	Schering Ag	Neue 2,3-Benzodiazepinderivate, deren Herstellung und Verwendung als Arzneimittel
IT1291372B1 (it)	1997-05-21	1999-01-07	Schering Plough S P A	Uso di analoghi eterociclici di 1,2,4-triazolo (1,5-c) pirimidine per la preparazione di medicamenti utili per il trattamento delle malattie
SI1283839T1 (de) *	2000-05-26	2005-08-31	Schering Corp
GB0100624D0 (en)	2001-01-10	2001-02-21	Vernalis Res Ltd	Chemical compounds VII
JP4545437B2 (ja)	2001-10-15	2010-09-15	シェーリングコーポレイション	アデノシンａ２ａ受容体アンタゴニストとしてのイミダゾ（４，３−ｅ）−１，２，４−トリアゾロ（１，５−ｃ）ピリミジン
JP2006514697A (ja)	2002-12-19	2006-05-11	シェーリング　コーポレイション	アデノシンＡ２ａレセプターアンタゴニストの使用
CL2004000847A1 (es) *	2003-04-23	2005-03-11	Schering Corp	Compuestos derivados de 2-alquinil o 2-alquenil-5amino-pirazolo-[4,3-e]-1,2,4-triazolo[1,5-]pirimidina; composicion farmaceutica, y uso en el tratamiento de enfermedades del sistema nervioso central o un accidente cerebrovascular tal como depresion,
EP1745047B1 (de)	2004-04-21	2010-03-24	Schering Corporation	Pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine als antagonisten des adenosin-a2a-rezeptors

2006
- 2006-09-20 AR ARP060104110A patent/AR056080A1/es active IP Right Grant
- 2006-09-20 PE PE2006001140A patent/PE20070521A1/es active IP Right Grant
- 2006-09-21 DK DK06804036.9T patent/DK1937687T3/da active
- 2006-09-21 PL PL06804036T patent/PL1937687T3/pl unknown
- 2006-09-21 WO PCT/US2006/037003 patent/WO2007038284A1/en not_active Ceased
- 2006-09-21 TW TW095134895A patent/TWI335329B/zh not_active IP Right Cessation
- 2006-09-21 CN CN2006800352004A patent/CN101273045B/zh not_active Expired - Fee Related
- 2006-09-21 DE DE602006021042T patent/DE602006021042D1/de active Active
- 2006-09-21 RU RU2008115239/04A patent/RU2417997C2/ru active
- 2006-09-21 MY MYPI20080750A patent/MY146429A/en unknown
- 2006-09-21 US US11/525,065 patent/US7572802B2/en active Active
- 2006-09-21 AU AU2006294633A patent/AU2006294633B8/en not_active Ceased
- 2006-09-21 EP EP06804036A patent/EP1937687B1/de active Active
- 2006-09-21 RS RS20110262A patent/RS51702B/sr unknown
- 2006-09-21 SI SI200631017T patent/SI1937687T1/sl unknown
- 2006-09-21 SG SG201006970-6A patent/SG165419A1/en unknown
- 2006-09-21 JP JP2008532422A patent/JP4808779B2/ja not_active Expired - Fee Related
- 2006-09-21 HR HR20110466T patent/HRP20110466T1/hr unknown
- 2006-09-21 BR BRPI0616264A patent/BRPI0616264B8/pt not_active IP Right Cessation
- 2006-09-21 AT AT06804036T patent/ATE503759T1/de active
- 2006-09-21 PT PT06804036T patent/PT1937687E/pt unknown
- 2006-09-21 ES ES06804036T patent/ES2361856T3/es active Active
- 2006-09-21 KR KR1020087007052A patent/KR101396614B1/ko not_active Expired - Fee Related
- 2006-09-21 NZ NZ566737A patent/NZ566737A/en not_active IP Right Cessation
- 2006-09-21 CA CA2623047A patent/CA2623047C/en not_active Expired - Fee Related
- 2006-09-21 CN CN201110394181.7A patent/CN102716131B/zh not_active Expired - Fee Related
2008
- 2008-03-18 IL IL190275A patent/IL190275A/en active IP Right Grant
- 2008-03-19 EC EC2008008297A patent/ECSP088297A/es unknown
- 2008-03-19 ZA ZA200802550A patent/ZA200802550B/xx unknown
- 2008-04-22 NO NO20081924A patent/NO341760B1/no not_active IP Right Cessation
2009
- 2009-07-06 US US12/498,013 patent/US8389532B2/en active Active
2011
- 2011-06-28 CY CY20111100618T patent/CY1111921T1/el unknown

Also Published As

Publication number	Publication date
PL1937687T3 (pl)	2011-09-30
EP1937687B1 (de)	2011-03-30
CA2623047A1 (en)	2007-04-05
ES2361856T3 (es)	2011-06-22
AU2006294633A1 (en)	2007-04-05
RU2008115239A (ru)	2009-10-27
EP1937687A1 (de)	2008-07-02
US20090270432A1 (en)	2009-10-29
US20070072867A1 (en)	2007-03-29
DK1937687T3 (da)	2011-07-18
BRPI0616264B8 (pt)	2021-05-25
NO20081924L (no)	2008-05-22
DE602006021042D1 (de)	2011-05-12
ZA200802550B (en)	2009-06-24
TWI335329B (en)	2011-01-01
KR20080047423A (ko)	2008-05-28
WO2007038284A1 (en)	2007-04-05
KR101396614B1 (ko)	2014-05-16
JP4808779B2 (ja)	2011-11-02
ECSP088297A (es)	2008-04-28
NZ566737A (en)	2011-09-30
PT1937687E (pt)	2011-06-01
US8389532B2 (en)	2013-03-05
AU2006294633A8 (en)	2012-03-29
TW200730531A (en)	2007-08-16
IL190275A (en)	2014-06-30
IL190275A0 (en)	2009-09-22
MY146429A (en)	2012-08-15
AR056080A1 (es)	2007-09-19
CA2623047C (en)	2013-04-23
JP2009509959A (ja)	2009-03-12
CN101273045B (zh)	2012-02-01
CN102716131B (zh)	2014-04-23
PE20070521A1 (es)	2007-07-13
US7572802B2 (en)	2009-08-11
AU2006294633B2 (en)	2012-03-01
NO341760B1 (no)	2018-01-15
AU2006294633B8 (en)	2012-03-29
CY1111921T1 (el)	2015-11-04
BRPI0616264A2 (pt)	2011-06-14
HK1119681A1 (en)	2009-03-13
BRPI0616264B1 (pt)	2020-12-22
RU2417997C2 (ru)	2011-05-10
HRP20110466T1 (hr)	2011-08-31
CN101273045A (zh)	2008-09-24
SI1937687T1 (sl)	2011-07-29
CN102716131A (zh)	2012-10-10
SG165419A1 (en)	2010-10-28
RS51702B (sr)	2011-10-31

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2011-12-15

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ITMI20050051A1 (it)	2006-07-19	Fotodiodio organico di poli-9,9-diottil-fluorene
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DE502006002564D1 (de)	2009-02-26	Ndungen
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ES1059785Y (es)	2005-09-16	Caja-asiento.
ES1059992Y (es)	2005-10-16	Marco-estuche.
ES1060970Y (es)	2006-03-16	Llavero-monedero.
NO20052882D0 (no)	2005-06-14	Bolgekraftverk.
NO20051198D0 (no)	2005-03-07	Nokkelsystem.