ATE503762T1 - Verbessertes verfahren zur isolierung von arjunasäure aus der rinde des baums terminalia arjuna und die verwendung dieser verbindung bei der behandlung von krebs - Google Patents

Verbessertes verfahren zur isolierung von arjunasäure aus der rinde des baums terminalia arjuna und die verwendung dieser verbindung bei der behandlung von krebs

Info

Publication number: ATE503762T1
Authority: AT; Austria
Prior art keywords: bark; isolation; cancer; treatment; compound
Prior art date: 2005-11-25

Application number

AT05850949T

Other languages

English (en)

Inventor

Suman Preet Singh Khanuja

Madan Mohan Gupta

Santosh Kumar Srivastava

Tiruppadiripuliyur Ranganathan Kumar

Digvijay Singh

Subash Chandra Verma

Ankur Garg

Merajuddin Khan

Ram Kishor Verma

Raghavendra Kumar Mishra

Subhash Chandra Singh

Original Assignee

Council Scient Ind Res

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-11-25

Filing date

2005-12-27

Publication date

2011-04-15

2005-12-27 Application filed by Council Scient Ind Res filed Critical Council Scient Ind Res

2011-04-15 Application granted granted Critical

2011-04-15 Publication of ATE503762T1 publication Critical patent/ATE503762T1/de

Links

XJMYUPJDAFKICJ-YZTGESMESA-N (1s,4ar,6ar,6as,6br,8ar,10r,11r,12ar,14bs)-1,10,11-trihydroxy-2,2,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid Chemical compound C1[C@@H](O)[C@H](O)C(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C(O)=O)CCC(C)(C)[C@@H](O)[C@H]5C4=CC[C@@H]3[C@]21C XJMYUPJDAFKICJ-YZTGESMESA-N 0.000 title abstract 4
235000000538 Terminalia arjuna Nutrition 0.000 title abstract 3
244000071109 Terminalia arjuna Species 0.000 title abstract 3
XJMYUPJDAFKICJ-UHFFFAOYSA-N arjunic acid Natural products C1C(O)C(O)C(C)(C)C2CCC3(C)C4(C)CCC5(C(O)=O)CCC(C)(C)C(O)C5C4=CCC3C21C XJMYUPJDAFKICJ-UHFFFAOYSA-N 0.000 title abstract 3
238000002955 isolation Methods 0.000 title abstract 3
238000000034 method Methods 0.000 title abstract 3
206010028980 Neoplasm Diseases 0.000 title abstract 2
201000011510 cancer Diseases 0.000 title abstract 2
150000001875 compounds Chemical class 0.000 title abstract 2
ZENZJGDPWWLORF-UHFFFAOYSA-N (Z)-9-Octadecenal Natural products CCCCCCCCC=CCCCCCCCC=O ZENZJGDPWWLORF-UHFFFAOYSA-N 0.000 abstract 1
239000002246 antineoplastic agent Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
- C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines Containing Plant Substances (AREA)

AT05850949T 2005-11-25 2005-12-27 Verbessertes verfahren zur isolierung von arjunasäure aus der rinde des baums terminalia arjuna und die verwendung dieser verbindung bei der behandlung von krebs ATE503762T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IN3160DE2005		2005-11-25
PCT/IN2005/000437 WO2007060684A1 (en)	2005-11-25	2005-12-27	An improved process for the isolation of arjunic acid from the bark of the tree terminalia arjuna and the use of this compound in the treatment of cancer

Publications (1)

Publication Number	Publication Date
ATE503762T1 true ATE503762T1 (de)	2011-04-15

Family

ID=36785223

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT05850949T ATE503762T1 (de)	2005-11-25	2005-12-27	Verbessertes verfahren zur isolierung von arjunasäure aus der rinde des baums terminalia arjuna und die verwendung dieser verbindung bei der behandlung von krebs

Country Status (5)

Country	Link
US (1)	US7435433B2 (de)
EP (1)	EP1951739B1 (de)
AT (1)	ATE503762T1 (de)
DE (1)	DE602005027267D1 (de)
WO (1)	WO2007060684A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP2116253A1 (de) *	2008-05-07	2009-11-11	Phytrix JV, LLC	Neuartiger Phyllanthus-Extrakt
CA3066772C (en) *	2017-06-21	2023-08-01	Sami Labs Limited	Process for the preparation of standardized composition of arjunoglucoside from the bark of terminalia arjuna
CN110294673B (zh) *	2019-07-25	2022-02-11	山东省分析测试中心	咖啡酰奎宁酸丁酯类同分异构体及其制备方法和应用
CN113797255A (zh) *	2021-09-07	2021-12-17	广州医科大学附属中医医院	荔枝核皂苷在制备治疗脂肪肝药物中的应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1493926A (en) *	1974-01-29	1977-11-30	Inverni Della Beffa Spa	Pentacyclic triterpenes obtainable from terminalia sericea and their derivatives
US4147777A (en) *	1974-01-29	1979-04-03	Inverni Della Beffa S.P.A.	Sericosides and method of use

2005
- 2005-12-27 AT AT05850949T patent/ATE503762T1/de not_active IP Right Cessation
- 2005-12-27 DE DE602005027267T patent/DE602005027267D1/de not_active Expired - Lifetime
- 2005-12-27 WO PCT/IN2005/000437 patent/WO2007060684A1/en not_active Ceased
- 2005-12-27 EP EP05850949A patent/EP1951739B1/de not_active Expired - Lifetime
2006
- 2006-03-31 US US11/395,734 patent/US7435433B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
US20070122506A1 (en)	2007-05-31
WO2007060684A1 (en)	2007-05-31
DE602005027267D1 (de)	2011-05-12
EP1951739A1 (de)	2008-08-06
US7435433B2 (en)	2008-10-14
EP1951739B1 (de)	2011-03-30

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Legal Events

Date	Code	Title	Description
2011-09-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties