ATE504586T1 - Pyrazoloä3,4-büpyridinverbindungen und ihre verwendung als pde4-inhibitoren - Google Patents

Pyrazoloä3,4-büpyridinverbindungen und ihre verwendung als pde4-inhibitoren

Info

Publication number: ATE504586T1
Authority: AT; Austria
Prior art keywords: pyrazoloa3; bupyridine; compounds; salt; pde4 inhibitors
Prior art date: 2006-08-01

Application number

AT07766400T

Other languages

English (en)

Inventor

David George Allen

Nicola Mary Aston

Rodger Phillip Barnett

Reshma Manesh Chudasama

Caroline Jane Day

Christopher David Edlin

Leanda Jane Kindon

Naimisha Trivedi

Original Assignee

Glaxo Group Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-08-01

Filing date

2007-07-31

Publication date

2011-04-15

2006-08-01 Priority claimed from GB0615286A external-priority patent/GB0615286D0/en

2007-04-05 Priority claimed from GB0706790A external-priority patent/GB0706790D0/en

2007-07-30 Priority claimed from GB0714815A external-priority patent/GB0714815D0/en

2007-07-31 Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd

2011-04-15 Application granted granted Critical

2011-04-15 Publication of ATE504586T1 publication Critical patent/ATE504586T1/de

Links

150000001875 compounds Chemical class 0.000 title abstract 2
229940123932 Phosphodiesterase 4 inhibitor Drugs 0.000 title 1
239000002587 phosphodiesterase IV inhibitor Substances 0.000 title 1
150000003839 salts Chemical class 0.000 abstract 2
208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 abstract 1
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical class Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 1
102000004861 Phosphoric Diester Hydrolases Human genes 0.000 abstract 1
108090001050 Phosphoric Diester Hydrolases Proteins 0.000 abstract 1
206010039085 Rhinitis allergic Diseases 0.000 abstract 1
208000026935 allergic disease Diseases 0.000 abstract 1
230000000172 allergic effect Effects 0.000 abstract 1
201000010105 allergic rhinitis Diseases 0.000 abstract 1
208000006673 asthma Diseases 0.000 abstract 1
208000027866 inflammatory disease Diseases 0.000 abstract 1
230000002757 inflammatory effect Effects 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1
DEPWAGNOLISJQB-UHFFFAOYSA-N n-[[1,6-diethyl-4-(oxan-4-ylamino)pyrazolo[3,4-b]pyridin-5-yl]methyl]-4-[8-[2-hydroxyethyl(methyl)amino]octanoylamino]benzamide Chemical compound C=1C=C(NC(=O)CCCCCCCN(C)CCO)C=CC=1C(=O)NCC=1C(CC)=NC=2N(CC)N=CC=2C=1NC1CCOCC1 DEPWAGNOLISJQB-UHFFFAOYSA-N 0.000 abstract 1
208000037916 non-allergic rhinitis Diseases 0.000 abstract 1
238000011321 prophylaxis Methods 0.000 abstract 1
206010039083 rhinitis Diseases 0.000 abstract 1
238000011282 treatment Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pulmonology (AREA)
Immunology (AREA)
Rheumatology (AREA)
Physical Education & Sports Medicine (AREA)
Dermatology (AREA)
Ophthalmology & Optometry (AREA)
Pain & Pain Management (AREA)
Oncology (AREA)
Cardiology (AREA)
Communicable Diseases (AREA)
Heart & Thoracic Surgery (AREA)
Urology & Nephrology (AREA)
Otolaryngology (AREA)
Orthopedic Medicine & Surgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AT07766400T 2006-08-01 2007-07-31 Pyrazoloä3,4-büpyridinverbindungen und ihre verwendung als pde4-inhibitoren ATE504586T1 (de)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
GB0615286A GB0615286D0 (en)	2006-08-01	2006-08-01	Compounds
GB0706790A GB0706790D0 (en)	2007-04-05	2007-04-05	Compounds
GB0714815A GB0714815D0 (en)	2007-07-30	2007-07-30	Pyrazolo[3,4-b]pyridine compounds, and their use as PDE4 inhibitors
PCT/GB2007/002908 WO2008015416A1 (en)	2006-08-01	2007-07-31	Pyrazolo[3,4-b]pyridine compounds, and their use as pde4 inhibitors

Publications (1)

Publication Number	Publication Date
ATE504586T1 true ATE504586T1 (de)	2011-04-15

Family

ID=38996907

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT07766400T ATE504586T1 (de)	2006-08-01	2007-07-31	Pyrazoloä3,4-büpyridinverbindungen und ihre verwendung als pde4-inhibitoren

Country Status (17)

Country	Link
US (3)	US20090325952A1 (de)
EP (1)	EP2046787B1 (de)
JP (1)	JP2009545579A (de)
AT (1)	ATE504586T1 (de)
AU (1)	AU2007280214A1 (de)
CA (1)	CA2659539A1 (de)
CL (1)	CL2007002349A1 (de)
CY (1)	CY1111625T1 (de)
DE (1)	DE602007013762D1 (de)
DK (1)	DK2046787T3 (de)
HR (1)	HRP20110434T1 (de)
NZ (1)	NZ574533A (de)
PL (1)	PL2046787T3 (de)
PT (1)	PT2046787E (de)
SI (1)	SI2046787T1 (de)
TW (1)	TW200840818A (de)
WO (2)	WO2008015416A1 (de)

Families Citing this family (9)

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US20090325952A1 (en) *	2006-08-01	2009-12-31	Glaxo Group Limited	Pyrazolo[3,4-b]pyridine compounds, and their use as pde4 inhibitors
KR20120006059A (ko) *	2009-04-17	2012-01-17	메르츠 파마 게엠베하 운트 코. 카가아	1-아미노-1,3,3,5,5-펜타메틸사이클로헥산 메실레이트의 합성
US8367829B2 (en)	2010-05-10	2013-02-05	Gilead Sciences, Inc.	Bi-functional pyrazolopyridine compounds
US9597312B2 (en) *	2010-08-19	2017-03-21	Cognitive Research Enterprises, Inc.	Treatment of cognitive disorders associated with abnormal dendritic spines using PKC activators
EP2628730B1 (de) *	2012-02-16	2017-12-06	Noxell Corporation	Mehrstufige eintopfsynthese von salzen des 5-amino-4-nitroso-1-alkyl-1h-pyrazols
US9011934B2 (en)	2013-06-14	2015-04-21	SatisPharma, LLC	Multi-purpose anti-itch treatment
US9452178B1 (en)	2014-10-22	2016-09-27	SatisPharma, LLC	Acne formulations, treatments, and pressure sensitive patches for delivery of acne formulations
DE102015000626A1 (de) *	2015-01-22	2016-07-28	Kibion Gmbh	Verfahren zum Nachweis von Helicobacter Pylori
CN111732543A (zh) *	2020-08-14	2020-10-02	浙江鼎龙科技有限公司	一种4,5-二氨基-1-（2-羟乙基）吡唑硫酸盐的制备方法

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GB0220730D0 (en)	2002-09-06	2002-10-16	Glaxo Group Ltd	Medicinal compounds
GB0230045D0 (en)	2002-12-23	2003-01-29	Glaxo Group Ltd	Compounds
PL375993A1 (en)	2002-09-16	2005-12-12	Glaxo Group Limited	Pyrazolo[3,4-b]pyridine compounds, and their use as phosphodiesterase inhibitors
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US20090325952A1 (en) *	2006-08-01	2009-12-31	Glaxo Group Limited	Pyrazolo[3,4-b]pyridine compounds, and their use as pde4 inhibitors

2007
- 2007-07-31 US US12/375,685 patent/US20090325952A1/en not_active Abandoned
- 2007-07-31 JP JP2009522327A patent/JP2009545579A/ja active Pending
- 2007-07-31 SI SI200730620T patent/SI2046787T1/sl unknown
- 2007-07-31 US US11/831,325 patent/US8003663B2/en not_active Expired - Fee Related
- 2007-07-31 AT AT07766400T patent/ATE504586T1/de active
- 2007-07-31 DE DE602007013762T patent/DE602007013762D1/de active Active
- 2007-07-31 AU AU2007280214A patent/AU2007280214A1/en not_active Abandoned
- 2007-07-31 WO PCT/GB2007/002908 patent/WO2008015416A1/en not_active Ceased
- 2007-07-31 PL PL07766400T patent/PL2046787T3/pl unknown
- 2007-07-31 NZ NZ574533A patent/NZ574533A/en not_active IP Right Cessation
- 2007-07-31 HR HR20110434T patent/HRP20110434T1/hr unknown
- 2007-07-31 DK DK07766400.1T patent/DK2046787T3/da active
- 2007-07-31 CA CA002659539A patent/CA2659539A1/en not_active Abandoned
- 2007-07-31 EP EP07766400A patent/EP2046787B1/de not_active Not-in-force
- 2007-07-31 PT PT07766400T patent/PT2046787E/pt unknown
- 2007-08-01 WO PCT/GB2007/002935 patent/WO2008015437A1/en not_active Ceased
- 2007-08-01 US US12/375,695 patent/US20090318494A1/en not_active Abandoned
- 2007-08-13 CL CL200702349A patent/CL2007002349A1/es unknown
- 2007-08-22 TW TW096131112A patent/TW200840818A/zh unknown
2011
- 2011-06-28 CY CY20111100623T patent/CY1111625T1/el unknown

Also Published As

Publication number	Publication date
NZ574533A (en)	2011-05-27
AU2007280214A1 (en)	2008-02-07
US8003663B2 (en)	2011-08-23
HK1127603A1 (en)	2009-10-02
US20090325952A1 (en)	2009-12-31
WO2008015416A1 (en)	2008-02-07
EP2046787A1 (de)	2009-04-15
TW200840818A (en)	2008-10-16
PL2046787T3 (pl)	2011-10-31
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