ATE506449T1 - Direkte rt-pcr auf oligonukleotid-immobilisierten pcr-mikroplatten - Google Patents

Direkte rt-pcr auf oligonukleotid-immobilisierten pcr-mikroplatten

Info

Publication number
ATE506449T1
ATE506449T1 AT07016364T AT07016364T ATE506449T1 AT E506449 T1 ATE506449 T1 AT E506449T1 AT 07016364 T AT07016364 T AT 07016364T AT 07016364 T AT07016364 T AT 07016364T AT E506449 T1 ATE506449 T1 AT E506449T1
Authority
AT
Austria
Prior art keywords
pcr
microplates
immobilized
oligonucleotide
filter plate
Prior art date
Application number
AT07016364T
Other languages
English (en)
Inventor
Masato Mitsuhashi
Original Assignee
Hitachi Chemical Co Ltd
Hitachi Chemical Res Ct Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hitachi Chemical Co Ltd, Hitachi Chemical Res Ct Inc filed Critical Hitachi Chemical Co Ltd
Application granted granted Critical
Publication of ATE506449T1 publication Critical patent/ATE506449T1/de

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844Nucleic acid amplification reactions
    • C12Q1/686Polymerase chain reaction [PCR]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/06Lysis of microorganisms
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6834Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844Nucleic acid amplification reactions
    • C12Q1/6851Quantitative amplification

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicinal Chemistry (AREA)
  • Mycology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
AT07016364T 1997-12-22 1998-12-22 Direkte rt-pcr auf oligonukleotid-immobilisierten pcr-mikroplatten ATE506449T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6839497P 1997-12-22 1997-12-22
US7162798P 1998-01-16 1998-01-16

Publications (1)

Publication Number Publication Date
ATE506449T1 true ATE506449T1 (de) 2011-05-15

Family

ID=26748929

Family Applications (3)

Application Number Title Priority Date Filing Date
AT07016364T ATE506449T1 (de) 1997-12-22 1998-12-22 Direkte rt-pcr auf oligonukleotid-immobilisierten pcr-mikroplatten
AT98964860T ATE401415T1 (de) 1997-12-22 1998-12-22 Direkte rt-pcr auf mikrotiterplatten mit immobilisierten oligonukleotid
AT05017491T ATE397086T1 (de) 1997-12-22 1998-12-22 Reinigung von mrna auf mikroplatten

Family Applications After (2)

Application Number Title Priority Date Filing Date
AT98964860T ATE401415T1 (de) 1997-12-22 1998-12-22 Direkte rt-pcr auf mikrotiterplatten mit immobilisierten oligonukleotid
AT05017491T ATE397086T1 (de) 1997-12-22 1998-12-22 Reinigung von mrna auf mikroplatten

Country Status (5)

Country Link
EP (3) EP1600512B1 (de)
JP (3) JP4325114B2 (de)
AT (3) ATE506449T1 (de)
DE (3) DE69842238D1 (de)
WO (1) WO1999032654A1 (de)

Families Citing this family (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6844158B1 (en) 1997-12-22 2005-01-18 Hitachi Chemical Co., Ltd. Direct RT-PCR on oligonucleotide-immobilized PCR microplates
US6686151B1 (en) * 1998-02-06 2004-02-03 Digene Corporation Immunological detection of RNA:DNA hybrids on microarrays
US7399589B2 (en) 1998-02-06 2008-07-15 Digene Corporation Immunological detection of RNA:DNA hybrids on microarrays
WO2000061198A1 (en) * 1999-04-12 2000-10-19 Hitachi Chemical Co., Ltd. Method of producing probe arrays for biological materials using fine particles
US20050100943A1 (en) 2000-04-11 2005-05-12 Hideki Kambara Method of producing probe arrays for biological materials using fine particles
FR2798675B1 (fr) * 1999-09-16 2004-02-27 Centre Nat Rech Scient Procede et dispositif de fabrication d'un support porteur d'une pluralite de sequences polynucleotidiques et/ou peptidiques differentes
CA2318730C (en) * 1999-09-20 2008-01-22 Ortho-Clinical Diagnostics, Inc. A method for reverse transcribing rna isolated in dry form
US6642000B1 (en) * 1999-11-12 2003-11-04 University Of Chicago PCR amplification on microarrays of gel immobilized oligonucleotides
ITCA20000004A1 (it) * 2000-03-07 2001-09-07 Mario Raimondo Caria Metodo e sistema per la rivelazione simultanea e multipla con quantificazione della ibridizzazione di composti molecolari quali acidi nuclei
US6376191B1 (en) * 2000-03-22 2002-04-23 Mergen, Ltd. Microarray-based analysis of polynucleotide sequence variations
US7439016B1 (en) 2000-06-15 2008-10-21 Digene Corporation Detection of nucleic acids by type-specific hybrid capture method
US7601497B2 (en) 2000-06-15 2009-10-13 Qiagen Gaithersburg, Inc. Detection of nucleic acids by target-specific hybrid capture method
DE10033091A1 (de) * 2000-07-07 2002-01-31 Max Planck Gesellschaft Polymer-Chip
JP2004532382A (ja) * 2000-09-27 2004-10-21 サントル・ナショナル・ドゥ・ラ・ルシェルシュ・シアンティフィク−シーエヌアールエス 複数の異なるポリヌクレオチドおよび/またはペプチド配列を保有する支持体を製造するための方法および装置
US7285199B2 (en) 2000-10-31 2007-10-23 Hitachi Chemical Research Center, Inc. Apparatus and method for electrophoretic microspot concentration
WO2002066637A2 (en) * 2000-10-31 2002-08-29 Hitachi Chemical Research Center, Inc. Method for collecting and using nuclear mrna
GB0105790D0 (en) * 2001-03-08 2001-04-25 Expresson Biosystems Ltd Detecting binding of mRNA to an oligonnucleotide array using RNA dependent nucleic acid modifying enzymes
CN100487116C (zh) * 2001-07-09 2009-05-13 旭化成株式会社 应用非织造织物纯化和检测核酸的方法
AU2003201910A1 (en) * 2002-01-09 2003-07-30 Sysmex Corporation Nucleic acid detection method and system thereof
WO2003091407A2 (en) * 2002-04-24 2003-11-06 Hitachi Chemical Research Center, Inc. Device and method for high-throughput quantification of mrna from whole blood
US7745180B2 (en) * 2002-04-24 2010-06-29 Hitachi Chemical Co., Ltd. Device and method for high-throughput quantification of mRNA from whole blood
US7508608B2 (en) 2004-11-17 2009-03-24 Illumina, Inc. Lithographically fabricated holographic optical identification element
US7619819B2 (en) 2002-08-20 2009-11-17 Illumina, Inc. Method and apparatus for drug product tracking using encoded optical identification elements
US7441703B2 (en) 2002-08-20 2008-10-28 Illumina, Inc. Optical reader for diffraction grating-based encoded optical identification elements
US7092160B2 (en) 2002-09-12 2006-08-15 Illumina, Inc. Method of manufacturing of diffraction grating-based optical identification element
EP1540591A1 (de) 2002-09-12 2005-06-15 Cyvera Corporation Mit hilfe eines beugungsgitters kodierte mikropartikeln für multiplex-experimente
AU2003267192A1 (en) 2002-09-12 2004-04-30 Cyvera Corporation Method and apparatus for aligning elongated microbeads in order to interrogate the same
US20040067492A1 (en) * 2002-10-04 2004-04-08 Allan Peng Reverse transcription on microarrays
CA2513889A1 (en) 2003-01-29 2004-08-19 454 Corporation Double ended sequencing
CN1580283A (zh) * 2003-08-13 2005-02-16 清华大学 一种检测核酸分子的方法
DE10353887A1 (de) * 2003-11-18 2005-06-16 Febit Ag Hochparalleler DNA-Synthesizer auf Matrizenbasis
EP1548126A1 (de) * 2003-12-22 2005-06-29 Bio-Rad Pasteur Trägermaterial für Kontrollnukleinsäuren und Anwendung dieser zur Nukleinsäuredetektion.
US7433123B2 (en) 2004-02-19 2008-10-07 Illumina, Inc. Optical identification element having non-waveguide photosensitive substrate with diffraction grating therein
US20050277121A1 (en) 2004-06-11 2005-12-15 Ambion, Inc. Crude biological derivatives competent for nucleic acid detection
US7604173B2 (en) 2004-11-16 2009-10-20 Illumina, Inc. Holographically encoded elements for microarray and other tagging labeling applications, and method and apparatus for making and reading the same
EP1869615B1 (de) 2004-11-16 2010-03-03 Illumina, Inc. Verfahren und vorrichtung zum lesen von kodierten mikrokugeln
WO2006055735A2 (en) 2004-11-16 2006-05-26 Illumina, Inc Scanner having spatial light modulator
EP1846579A4 (de) * 2005-01-21 2008-12-24 New York Blood Ct Inc Verfahren zur extraktion und identifikation von nukleinsäuren
EP1875243B1 (de) * 2005-04-28 2013-04-03 Hitachi Chemical Research Center, Inc. Verfahren zur minimierung des reagenzverbrauchs bei auf mikroplatten basierenden reaktionen
FR2885140B1 (fr) * 2005-04-29 2010-12-31 Millipore Corp Procede de detection et de caracterisation de microorgarnismes sur une membrane.
JP4916689B2 (ja) * 2005-09-12 2012-04-18 住友ベークライト株式会社 Dna鎖増幅方法
US7623624B2 (en) 2005-11-22 2009-11-24 Illumina, Inc. Method and apparatus for labeling using optical identification elements characterized by X-ray diffraction
US7830575B2 (en) 2006-04-10 2010-11-09 Illumina, Inc. Optical scanner with improved scan time
US8088580B2 (en) 2006-06-07 2012-01-03 Sumitomo Bakelite Company, Ltd. RNA detection method
WO2008008878A2 (en) 2006-07-12 2008-01-17 Color Savvy Systems Limited Method for deriving consistent color measurements
EP2484781B1 (de) 2006-08-01 2017-08-23 Applied Biosystems, LLC Nachweis von Analyten und Nukleinsäuren
TWI417389B (zh) 2008-10-27 2013-12-01 Qiagen Gaithersburg Inc 於自動平台上之快速結果雜交捕捉法
AU2010242867B2 (en) 2009-05-01 2016-05-12 Qiagen Gaithersburg, Inc. A non-target amplification method for detection of RNA splice-forms in a sample
JP5729904B2 (ja) * 2009-06-02 2015-06-03 キヤノン株式会社 細胞から蛋白質、dna、rnaを調製する方法
JP5815518B2 (ja) * 2009-07-17 2015-11-17 キヤノン ユー.エス. ライフ サイエンシズ, インコーポレイテッドCanon U.S. Life Sciences, Inc. マイクロ流体装置においてdnaを単離する方法及びシステム
JP5826752B2 (ja) 2009-09-14 2015-12-02 キアジェン ゲイサーズバーグ インコーポレイテッド 細胞学用培地に固定された組織サンプルから核酸またはタンパク質を回収するための組成物および方法
ES2615728T3 (es) 2010-01-29 2017-06-08 Qiagen Gaithersburg, Inc. Métodos y composiciones para una purificación y un análisis múltiple específico de secuencia de ácidos nucleicos
CA2787781A1 (en) 2010-01-29 2011-08-04 Qiagen Gaithersburg, Inc. Method of determining and confirming the presence of an hpv in a sample
AU2011237729B2 (en) 2010-04-05 2014-04-03 Prognosys Biosciences, Inc. Spatially encoded biological assays
US20190300945A1 (en) 2010-04-05 2019-10-03 Prognosys Biosciences, Inc. Spatially Encoded Biological Assays
US10787701B2 (en) 2010-04-05 2020-09-29 Prognosys Biosciences, Inc. Spatially encoded biological assays
US9422593B2 (en) 2010-05-19 2016-08-23 Qiagen Gaithresburg, Inc Methods and compositions for sequence-specific purification and multiplex analysis of nucleic acids
CA2799205A1 (en) 2010-05-25 2011-12-01 Qiagen Gaithersburg, Inc. Fast results hybrid capture assay and associated strategically-truncated probes
AU2012220575B2 (en) 2011-02-24 2017-01-12 Qiagen Gaithersburg, Inc. Materials and methods for detection of HPV nucleic acid
GB201106254D0 (en) 2011-04-13 2011-05-25 Frisen Jonas Method and product
JP6262657B2 (ja) * 2011-10-11 2018-01-17 キアゲン ゲゼルシャフト ミット ベシュレンクテル ハフツング 試料プロセシング方法および試料プロセシングカートリッジ
US9593365B2 (en) 2012-10-17 2017-03-14 Spatial Transcriptions Ab Methods and product for optimising localised or spatial detection of gene expression in a tissue sample
JP2014176303A (ja) * 2013-03-13 2014-09-25 Seiko Epson Corp cDNAの合成方法
DK3013983T3 (da) 2013-06-25 2023-03-06 Prognosys Biosciences Inc Spatialt kodede biologiske assays ved brug af en mikrofluidisk anordning
CN120425026A (zh) 2015-04-10 2025-08-05 十程基因技术瑞典公司 生物样本的空间区别、多重核酸分析
CN106867993A (zh) * 2017-02-17 2017-06-20 唐旌生物科技(上海)有限公司 一种逆转录方法、逆转录试剂盒及其应用
US12110541B2 (en) 2020-02-03 2024-10-08 10X Genomics, Inc. Methods for preparing high-resolution spatial arrays
US12031177B1 (en) 2020-06-04 2024-07-09 10X Genomics, Inc. Methods of enhancing spatial resolution of transcripts
US20240318162A1 (en) * 2021-07-01 2024-09-26 Cubit Diagnostics, Inc. Methods and reagents for analyzing nucleic acids

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4034036C2 (de) * 1990-10-26 1994-03-03 Diagen Inst Molekularbio Vorrichtung und Verfahren zur Isolierung von Nukleinsäuren aus Zellsuspensionen
JPH04187077A (ja) * 1990-11-22 1992-07-03 Shimadzu Corp 核酸の抽出精製装置
JPH04360686A (ja) * 1991-06-04 1992-12-14 Tosoh Corp Dnaの精製方法
US5437976A (en) * 1991-08-08 1995-08-01 Arizona Board Of Regents, The University Of Arizona Multi-domain DNA ligands bound to a solid matrix for protein and nucleic acid affinity chromatography and processing of solid-phase DNA
WO1993009250A1 (en) * 1991-11-01 1993-05-13 Adelaide Children's Hospital Solid phase amplification process
CA2128891A1 (en) * 1992-01-29 1993-08-05 Cylia Keller Polynucleotide immobilized support
US5545528A (en) * 1993-04-15 1996-08-13 Hitachi Chemical Research Center Rapid screening method of gene amplification products in polypropylene plates
GB9314249D0 (en) * 1993-07-09 1993-08-18 Proofname Ltd Purification method and apparatus
GB9507238D0 (en) * 1995-04-07 1995-05-31 Isis Innovation Detecting dna sequence variations
WO1996041810A1 (en) * 1995-06-08 1996-12-27 Progen Industries Limited Method and apparatus for dna extraction
DE69719409T2 (de) * 1996-06-18 2004-01-15 Rikagaku Kenkyusho Verfahren zur Reinigung von DNS

Also Published As

Publication number Publication date
ATE397086T1 (de) 2008-06-15
DE69842238D1 (de) 2011-06-01
JP2006051042A (ja) 2006-02-23
EP1600512A1 (de) 2005-11-30
EP1865074B1 (de) 2011-04-20
DE69839572D1 (de) 2008-07-10
DE69839734D1 (de) 2008-08-28
EP1865074A2 (de) 2007-12-12
EP1600512B1 (de) 2008-05-28
JP2009189368A (ja) 2009-08-27
ATE401415T1 (de) 2008-08-15
JP4337796B2 (ja) 2009-09-30
EP1042497B1 (de) 2008-07-16
JP4983836B2 (ja) 2012-07-25
JP4325114B2 (ja) 2009-09-02
WO1999032654A1 (en) 1999-07-01
EP1042497A4 (de) 2004-09-22
EP1865074A3 (de) 2008-02-27
JP2002505080A (ja) 2002-02-19
EP1042497A1 (de) 2000-10-11

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