ATE507242T1 - Wirtszellenspezifische bindungsmoleküle, die dazu in der lage sind, viren zu neutralisieren, und anwendungen davon - Google Patents
Wirtszellenspezifische bindungsmoleküle, die dazu in der lage sind, viren zu neutralisieren, und anwendungen davonInfo
- Publication number
- ATE507242T1 ATE507242T1 AT06755161T AT06755161T ATE507242T1 AT E507242 T1 ATE507242 T1 AT E507242T1 AT 06755161 T AT06755161 T AT 06755161T AT 06755161 T AT06755161 T AT 06755161T AT E507242 T1 ATE507242 T1 AT E507242T1
- Authority
- AT
- Austria
- Prior art keywords
- binding molecules
- host cell
- applications
- specific binding
- human binding
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—RNA viruses
- C07K16/116—Togaviridae (F); Matonaviridae (F); Flaviviridae (F)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EPPCT/EP05/52160 | 2005-05-12 | ||
| EPPCT/EP05/52648 | 2005-06-08 | ||
| EPPCT/EP05/52946 | 2005-06-23 | ||
| EPPCT/EP05/54002 | 2005-08-15 | ||
| PCT/EP2006/062250 WO2006120230A2 (en) | 2005-05-12 | 2006-05-11 | Host cell specific binding molecules capable of neutralizing viruses and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE507242T1 true ATE507242T1 (de) | 2011-05-15 |
Family
ID=37396920
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06755161T ATE507242T1 (de) | 2005-05-12 | 2006-05-11 | Wirtszellenspezifische bindungsmoleküle, die dazu in der lage sind, viren zu neutralisieren, und anwendungen davon |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US8052974B2 (de) |
| EP (1) | EP1879921B1 (de) |
| AT (1) | ATE507242T1 (de) |
| AU (1) | AU2006245734C1 (de) |
| CA (1) | CA2608058C (de) |
| IL (1) | IL187321A (de) |
| WO (1) | WO2006120230A2 (de) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| USRE47770E1 (en) | 2002-07-18 | 2019-12-17 | Merus N.V. | Recombinant production of mixtures of antibodies |
| DK2314629T4 (da) | 2002-07-18 | 2023-02-06 | Merus Nv | Rekombinant produktion af blandinger af antistoffer |
| WO2004106375A1 (en) | 2003-05-30 | 2004-12-09 | Merus Biopharmaceuticals B.V. I.O. | Fab library for the preparation of anti vegf and anti rabies virus fabs |
| US20100069614A1 (en) | 2008-06-27 | 2010-03-18 | Merus B.V. | Antibody producing non-human mammals |
| EP2314620B1 (de) | 2004-05-27 | 2013-06-05 | Crucell Holland B.V. | Verfahren zur Identifikation von Bindungsmoleküle, die zur Neutralisierung des Tollwutvirus fähig sind |
| WO2006120230A2 (en) | 2005-05-12 | 2006-11-16 | Crucell Holland B.V. | Host cell specific binding molecules capable of neutralizing viruses and uses thereof |
| EP2450377A1 (de) | 2006-09-07 | 2012-05-09 | Crucell Holland B.V. | Zur Neutralisierung des Influenzavirus H5N1 fähige humane Bindungsmoleküle sowie deren Verwendungen |
| EP2582727B8 (de) | 2010-06-16 | 2017-04-19 | University of Pittsburgh- Of the Commonwealth System of Higher Education | Antikörper zu endoplasmin und deren verwendung |
| CA2791109C (en) | 2011-09-26 | 2021-02-16 | Merus B.V. | Generation of binding molecules |
| US9248181B2 (en) | 2012-04-20 | 2016-02-02 | Merus B.V. | Methods and means for the production of Ig-like molecules |
| KR101815265B1 (ko) * | 2013-06-20 | 2018-01-04 | 한올바이오파마주식회사 | FcRn 특이적 인간 항체 및 이를 포함하는 자가면역 질환 치료용 조성물 |
| CN106211773B (zh) | 2014-02-11 | 2021-09-03 | 威特拉公司 | 用于登革病毒的抗体分子及其应用 |
| WO2016138312A2 (en) * | 2015-02-25 | 2016-09-01 | Vanderbilt University | Antibody-mediated neutralization of marburg virus |
| CN107847591B (zh) * | 2015-04-17 | 2023-07-28 | Igm生物科学股份有限公司 | 多价人免疫缺陷病毒抗原结合分子及其应用 |
| TW201702272A (zh) | 2015-05-22 | 2017-01-16 | 美國紀念斯隆 凱特琳癌症中心 | Prame肽專一性類t細胞受體抗體 |
| WO2017165736A1 (en) | 2016-03-25 | 2017-09-28 | Visterra, Inc. | Formulation of antibody molecules to dengue virus |
| IL272696B2 (en) | 2017-08-21 | 2025-01-01 | Adagene Inc | Dynamic human heavy chain antibody libraries |
| NZ761785A (en) | 2017-08-21 | 2025-11-28 | Adagene Inc | Dynamic human antibody light chain libraries |
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| US4529700A (en) | 1982-08-20 | 1985-07-16 | University Of Miami | Hybridoma cells secreting a monoclonal antibody specific for 5-bromo and 5-iodoeoxyuridine and reagents for measuring cellular proliferation |
| NZ207394A (en) | 1983-03-08 | 1987-03-06 | Commw Serum Lab Commission | Detecting or determining sequence of amino acids |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US6184024B1 (en) | 1988-07-14 | 2001-02-06 | The United States Of America As Represented By The Department Of Health And Human Services | Chimeric and/or growth-restricted flaviviruses |
| US5514375A (en) | 1990-08-15 | 1996-05-07 | Virogenetics Corporation | Flavivirus recombinant poxvirus vaccine |
| MY109299A (en) | 1990-08-15 | 1996-12-31 | Virogenetics Corp | Recombinant pox virus encoding flaviviral structural proteins |
| US5494671A (en) | 1990-08-27 | 1996-02-27 | The United States Of America As Represented By The Department Of Health And Human Services | C-terminally truncated dengue and Japanese encephalitis virus envelope proteins |
| EP1018556B1 (de) | 1991-09-19 | 2005-11-23 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by the Secretary of the Department of HEALTH AND HUMAN SERVICES | Chimäre und/oder wachstumsgehemmte Flaviviren |
| NL9101953A (nl) | 1991-11-21 | 1993-06-16 | Seed Capital Investments | Testinrichting omvattende een plaat met een veelvoud van putjes met een bijbehorende doseerinrichting, alsmede een kit die deze inrichtingen omvat en toepassing van de inrichtingen. |
| US5624949A (en) | 1993-12-07 | 1997-04-29 | Eli Lilly And Company | Protein kinase C inhibitors |
| HU224199B1 (hu) | 1994-07-08 | 2005-06-28 | Baxter Aktiengesellschaft | Flavivírus-fertőzések elleni immunizálásra alkalmas, csupasz nukleinsavat tartalmazó vakcina |
| US6265150B1 (en) | 1995-06-07 | 2001-07-24 | Becton Dickinson & Company | Phage antibodies |
| US6455509B1 (en) | 1996-06-04 | 2002-09-24 | The United States Of America As Represented By The Secretary Of The Navy | Dengue nucleic acid vaccines that induce neutralizing antibodies |
| EP0947581A4 (de) | 1996-08-08 | 2004-07-28 | Mitsubishi Pharma Corp | Kulturmedium und seine verwendung. |
| DK0934526T3 (da) | 1996-10-08 | 2003-05-05 | Bisys B V U | Fremgangsmåder og midler til udvælgelse af peptider og proteiner, der har specifik affinitet til et mål |
| EP0977587B1 (de) | 1997-02-28 | 2005-06-15 | Acambis Inc. | Chimäre impfstoffe gegen flaviviren |
| ATE316796T1 (de) | 1997-11-20 | 2006-02-15 | Us Army Medical Res And Materi | Dna impfstoffe gegen zecken-flavivieren |
| IL139844A0 (en) | 1998-06-04 | 2002-02-10 | Us Gov Health & Human Serv | Nucleic acid vaccines for prevention of flavivirus infection |
| JP2002523408A (ja) | 1998-08-25 | 2002-07-30 | イェール ユニバーシティ | ヘリオキサンチンおよびその類似体によるb型肝炎ウイルスおよびフラビウイルスの阻害および治療 |
| US6416763B1 (en) | 1998-08-28 | 2002-07-09 | Hawaii Biotechnology Group, Inc. | Recombinant nonstructural protein subunit vaccine against flaviviral infection |
| AU774045B2 (en) | 1998-09-02 | 2004-06-17 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Dengue viruses that are replication defective in mosquitos for use as vaccines |
| US6685948B1 (en) | 1998-09-02 | 2004-02-03 | The United States Of America As Represented By The Department Of Health And Human Services | Replication-defective dengue viruses that are replication-defective in mosquitoes for use as vaccines |
| HK1048138B (zh) | 1999-04-15 | 2009-06-12 | 荷兰克鲁塞尔公司 | 用编码腺病毒e1蛋白的序列在人体细胞中生产重组蛋白 |
| US6432411B1 (en) | 1999-07-13 | 2002-08-13 | Hawaii Biotechnology Group | Recombinant envelope vaccine against flavivirus infection |
| US7425437B2 (en) | 1999-11-26 | 2008-09-16 | Crucell Holland B.V. | Vaccines against West Nile Virus |
| EP1103610A1 (de) | 1999-11-26 | 2001-05-30 | Introgene B.V. | Impfstoffherstellung von immortalisierten Säugetierzellinien |
| AU1813901A (en) | 1999-12-01 | 2001-06-12 | Oravax, Inc | Chimeric flavivirus vaccines |
| ATE526411T1 (de) | 2000-02-16 | 2011-10-15 | Us Gov Health & Human Serv | Avirulente, immunogene flavivirus-chimäre |
| KR20030005197A (ko) | 2000-02-18 | 2003-01-17 | 샤이어 바이오켐 인코포레이티드 | 뉴클레오시드유도체를 이용한 플라비바이러스 감염의 치료또는 예방 방법 |
| KR100919593B1 (ko) | 2000-06-29 | 2009-09-29 | 아보트 러보러터리즈 | 이중 특이성 항체 및 이의 제조 방법 및 이를 포함하는 조성물 |
| AU2001288357A1 (en) | 2000-08-23 | 2002-03-04 | The New York Hospital Medical Center Of Queens | Methods of preventing or treating west nile virus and other infections |
| WO2002072036A2 (en) | 2001-03-12 | 2002-09-19 | Yale University | Compositions and methods comprising west nile virus polypeptides |
| ES2257560T3 (es) | 2001-06-15 | 2006-08-01 | Crucell Holland B.V. | Fagos quimericos. |
| HU228690B1 (en) | 2001-07-27 | 2013-05-28 | Wyeth Corp | West nile vaccine |
| US20040009178A1 (en) | 2002-02-11 | 2004-01-15 | Bowdish Katherine S. | Immunotherapeutics for biodefense |
| US20040258699A1 (en) | 2002-02-11 | 2004-12-23 | Bowdish Katherine S. | Immunotherapeutics for biodefense |
| EP2287288B1 (de) | 2002-07-09 | 2012-11-07 | Baxter International Inc. | Tierproteinfreies Zellkulturmedium |
| US6875433B2 (en) | 2002-08-23 | 2005-04-05 | The United States Of America As Represented By The Secretary Of The Army | Monoclonal antibodies and complementarity-determining regions binding to Ebola glycoprotein |
| EP1601947A2 (de) | 2002-10-31 | 2005-12-07 | Health Research, Incorporated | Diagnostischer test für west-nil-virus |
| DE60330795D1 (de) | 2002-11-08 | 2010-02-11 | Crucell Holland Bv | Impfstoff gegen west nile virus |
| US20100069614A1 (en) | 2008-06-27 | 2010-03-18 | Merus B.V. | Antibody producing non-human mammals |
| US20070025992A1 (en) | 2003-07-18 | 2007-02-01 | Mochida Pharmaceutical Co., Ltd | Monoclonal antibody against platelet membrane glycoprotein VI |
| SG128680A1 (en) | 2003-07-22 | 2007-01-30 | Crucell Holland Bv | Binding molecules against sars-coronavirus and uses thereof |
| WO2005063819A2 (en) | 2003-12-23 | 2005-07-14 | Crucell Holland B.V. | Human binding molecule against cd1a |
| US7074555B2 (en) | 2004-04-28 | 2006-07-11 | Idexx Laboratories, Inc. | Detection of West Nile Virus |
| WO2005111623A1 (en) | 2004-05-17 | 2005-11-24 | Crucell Holland B.V. | Methods for diagnosis of acute myeloid leukemia |
| EP2314620B1 (de) | 2004-05-27 | 2013-06-05 | Crucell Holland B.V. | Verfahren zur Identifikation von Bindungsmoleküle, die zur Neutralisierung des Tollwutvirus fähig sind |
| US20090130123A1 (en) | 2004-06-15 | 2009-05-21 | Erol Fikrig | Antibodies to west nile virus polypeptides |
| US7527973B2 (en) | 2004-06-21 | 2009-05-05 | Washington University | Antibodies against West Nile Virus and therapeutic and prophylactic uses thereof |
| US7572456B2 (en) | 2004-09-13 | 2009-08-11 | Macrogenics, Inc. | Humanized antibodies against West Nile Virus and therapeutic and prophylactic uses thereof |
| JP4852046B2 (ja) | 2004-10-12 | 2012-01-11 | クルセル ホランド ベー ヴェー | 癌の治療及び検出に用いる結合分子 |
| US7498419B2 (en) | 2004-10-14 | 2009-03-03 | Washington University | Crystals and structure of domain III of West Nile Virus envelope protein in association with a Fab fragment of a neutralizing antibody |
| US8106170B2 (en) | 2004-11-11 | 2012-01-31 | Crucell Holland B.V. | Compositions against SARS-coronavirus and uses thereof |
| WO2006056006A1 (en) | 2004-11-23 | 2006-06-01 | The University Of Queensland | Equine west nile virus immunotherapy |
| CA2591665C (en) | 2004-12-20 | 2015-05-05 | Crucell Holland B.V. | Binding molecules capable of neutralizing west nile virus and uses thereof |
| WO2006120230A2 (en) | 2005-05-12 | 2006-11-16 | Crucell Holland B.V. | Host cell specific binding molecules capable of neutralizing viruses and uses thereof |
| WO2006136601A1 (en) | 2005-06-23 | 2006-12-28 | Crucell Holland B.V. | Optimization of west nile virus antibodies |
| CA2622603C (en) | 2005-09-15 | 2014-06-17 | Crucell Holland B.V. | Method for preparing immunoglobulin libraries |
| MX2008014978A (es) | 2006-06-06 | 2008-12-09 | Crucell Holland Bv | Moleculas de union humanas que tienen actividad exterminadora contra enterococos y staphylococcus aureus y usos de las mismas. |
| CA2881717C (en) | 2006-06-06 | 2018-06-12 | Cecilia Anna Wilhelmina Geuijen | Human binding molecules having killing activity against staphylococci and uses thereof |
| EP2450377A1 (de) | 2006-09-07 | 2012-05-09 | Crucell Holland B.V. | Zur Neutralisierung des Influenzavirus H5N1 fähige humane Bindungsmoleküle sowie deren Verwendungen |
-
2006
- 2006-05-11 WO PCT/EP2006/062250 patent/WO2006120230A2/en not_active Ceased
- 2006-05-11 EP EP06755161A patent/EP1879921B1/de not_active Not-in-force
- 2006-05-11 CA CA2608058A patent/CA2608058C/en not_active Expired - Fee Related
- 2006-05-11 US US11/919,265 patent/US8052974B2/en not_active Expired - Fee Related
- 2006-05-11 AT AT06755161T patent/ATE507242T1/de not_active IP Right Cessation
- 2006-05-11 AU AU2006245734A patent/AU2006245734C1/en not_active Ceased
-
2007
- 2007-11-12 IL IL187321A patent/IL187321A/en active IP Right Grant
-
2011
- 2011-08-25 US US13/199,348 patent/US8911738B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US8911738B2 (en) | 2014-12-16 |
| WO2006120230A3 (en) | 2007-06-21 |
| CA2608058A1 (en) | 2006-11-16 |
| US20100303801A1 (en) | 2010-12-02 |
| US20120076794A1 (en) | 2012-03-29 |
| AU2006245734A1 (en) | 2006-11-16 |
| EP1879921A2 (de) | 2008-01-23 |
| AU2006245734C1 (en) | 2012-05-24 |
| US8052974B2 (en) | 2011-11-08 |
| IL187321A (en) | 2013-06-27 |
| WO2006120230A2 (en) | 2006-11-16 |
| IL187321A0 (en) | 2008-04-13 |
| AU2006245734B2 (en) | 2011-12-01 |
| EP1879921B1 (de) | 2011-04-27 |
| CA2608058C (en) | 2013-09-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |