ATE460473T1 - Immortalisierte entezelllinien zur viruserzeugung - Google Patents
Immortalisierte entezelllinien zur viruserzeugungInfo
- Publication number
- ATE460473T1 ATE460473T1 AT08101999T AT08101999T ATE460473T1 AT E460473 T1 ATE460473 T1 AT E460473T1 AT 08101999 T AT08101999 T AT 08101999T AT 08101999 T AT08101999 T AT 08101999T AT E460473 T1 ATE460473 T1 AT E460473T1
- Authority
- AT
- Austria
- Prior art keywords
- cell lines
- immortalized
- virus generation
- ent cell
- ent
- Prior art date
Links
- 241000700605 Viruses Species 0.000 title abstract 3
- 229960000074 biopharmaceutical Drugs 0.000 abstract 2
- 238000002255 vaccination Methods 0.000 abstract 2
- 241000271566 Aves Species 0.000 abstract 1
- 108050002653 Retinoblastoma protein Proteins 0.000 abstract 1
- 230000001413 cellular effect Effects 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 230000003612 virological effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0091—Purification or manufacturing processes for gene therapy compositions
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0603—Embryonic cells ; Embryoid bodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10211—Aviadenovirus, e.g. fowl adenovirus A
- C12N2710/10222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10211—Aviadenovirus, e.g. fowl adenovirus A
- C12N2710/10251—Methods of production or purification of viral material
- C12N2710/10252—Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10351—Methods of production or purification of viral material
- C12N2710/10352—Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
- C12N2710/24122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- Cell Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Reproductive Health (AREA)
- Gynecology & Obstetrics (AREA)
- Manufacturing & Machinery (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Developmental Biology & Embryology (AREA)
- Mycology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03025158A EP1528101A1 (de) | 2003-11-03 | 2003-11-03 | Immortalisierte Vogel-Zelllinien für die Produktion von Viren |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE460473T1 true ATE460473T1 (de) | 2010-03-15 |
Family
ID=34400514
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT08101999T ATE460473T1 (de) | 2003-11-03 | 2004-11-03 | Immortalisierte entezelllinien zur viruserzeugung |
| AT04798154T ATE398672T1 (de) | 2003-11-03 | 2004-11-03 | Immortalisierte vogelzellinien zur virusproduktion |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04798154T ATE398672T1 (de) | 2003-11-03 | 2004-11-03 | Immortalisierte vogelzellinien zur virusproduktion |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US8940534B2 (de) |
| EP (4) | EP1528101A1 (de) |
| JP (1) | JP4658953B2 (de) |
| KR (1) | KR101027755B1 (de) |
| CN (1) | CN1934243B (de) |
| AT (2) | ATE460473T1 (de) |
| AU (1) | AU2004285089B2 (de) |
| BR (1) | BRPI0415622B8 (de) |
| CA (1) | CA2544462C (de) |
| CY (1) | CY1110272T1 (de) |
| DE (2) | DE602004014526D1 (de) |
| DK (2) | DK1939281T4 (de) |
| ES (1) | ES2309578T3 (de) |
| PL (1) | PL1685243T3 (de) |
| PT (1) | PT1685243E (de) |
| RU (1) | RU2359999C2 (de) |
| SI (1) | SI1685243T1 (de) |
| WO (1) | WO2005042728A2 (de) |
Families Citing this family (137)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1646715T3 (da) * | 2003-07-22 | 2010-08-16 | Vivalis | Fremstilling af poxvirum med adhærente eller ikke-adhærente fuglecellelinjer |
| ATE489965T1 (de) | 2004-09-09 | 2010-12-15 | Novartis Vaccines & Diagnostic | Verminderung von potentiellen iatrogenen risiken in verbindung mit influenza impfstoffen |
| ES2525518T3 (es) | 2005-11-01 | 2014-12-26 | Novartis Vaccines And Diagnostics Gmbh | Vacunas virales derivadas de células con niveles reducidos de ADN celular residual |
| CN102755645A (zh) | 2005-11-04 | 2012-10-31 | 诺华疫苗和诊断有限公司 | 佐剂配制的包含细胞因子诱导剂的流感疫苗 |
| JP2009514844A (ja) | 2005-11-04 | 2009-04-09 | ノバルティス ヴァクシンズ アンド ダイアグノスティクス エスアールエル | スプリットインフルエンザワクチン用のアジュバントとしての遊離水相界面活性剤を含むエマルション |
| NZ568211A (en) | 2005-11-04 | 2011-11-25 | Novartis Vaccines & Diagnostic | Influenza vaccines including combinations of particulate adjuvants and immunopotentiators |
| CA2628152C (en) | 2005-11-04 | 2016-02-02 | Novartis Vaccines And Diagnostics S.R.L. | Adjuvanted vaccines with non-virion antigens prepared from influenza viruses grown in cell culture |
| NZ594482A (en) | 2005-11-04 | 2012-11-30 | Novartis Vaccines & Diagnostic | Influenza vaccines with reduced amount of oil-in-water emulsion as adjuvant |
| EP1783210A1 (de) * | 2005-11-08 | 2007-05-09 | ProBioGen AG | Proteinfaktoren zur Erhöhung der Produktivität, neue Zelllinien und deren Verwendungen |
| PL2478916T3 (pl) | 2006-01-27 | 2020-11-16 | Seqirus UK Limited | Szczepionki przeciw grypie zawierające hemaglutyninę i białka macierzy |
| CN101448523A (zh) | 2006-03-24 | 2009-06-03 | 诺华疫苗和诊断有限两合公司 | 无需冷藏储存流感疫苗 |
| GB0614460D0 (en) | 2006-07-20 | 2006-08-30 | Novartis Ag | Vaccines |
| EP4585610A3 (de) | 2006-09-11 | 2025-09-24 | Seqirus UK Limited | Herstellung von influenzavirus-impfstoffen ohne verwendung von eiern |
| PT2121011E (pt) | 2006-12-06 | 2014-07-31 | Novartis Ag | Vacinas compreendendo um antigénio a partir de quatro estirpes do vírus da gripe |
| EP1985305A1 (de) * | 2007-04-24 | 2008-10-29 | Vivalis | Aus Entenembryonen gewonnene Stammzellkulturen zur Herstellung von Impfstoffen gegen Viren |
| KR20100045437A (ko) | 2007-06-27 | 2010-05-03 | 노파르티스 아게 | 첨가물이 적은 인플루엔자 백신 |
| US8357531B2 (en) | 2007-07-03 | 2013-01-22 | Transgene S.A. | Immortalized avian cell lines |
| JP5421250B2 (ja) | 2007-07-03 | 2014-02-19 | トランスジーン ソシエテ アノニム | トリ不死化細胞株 |
| GB0810305D0 (en) | 2008-06-05 | 2008-07-09 | Novartis Ag | Influenza vaccination |
| AU2008339631B2 (en) | 2007-12-24 | 2014-07-24 | Novartis Ag | Assays for adsorbed influenza vaccines |
| JP5653223B2 (ja) * | 2008-02-25 | 2015-01-14 | バクスター・インターナショナル・インコーポレイテッドBaxter International Incorp0Rated | 連続細胞系の生成方法 |
| EP2098590A1 (de) | 2008-03-04 | 2009-09-09 | ProBioGen AG | Zelllinie des Rosettenflughundes als Hostzelle für pathogene Verstärkung |
| US8679839B2 (en) * | 2008-03-04 | 2014-03-25 | Probiogen Ag | Cell line from rousettus as host cell for pathogen amplification |
| JP5518041B2 (ja) | 2008-03-18 | 2014-06-11 | ノバルティス アーゲー | インフルエンザウイルスワクチン抗原の調製における改良 |
| US20110229969A1 (en) * | 2008-06-25 | 2011-09-22 | Volker Sandig | Cell Line for Propagation of Highly Attenuated AlphaViruses |
| EP2199385A1 (de) | 2008-12-16 | 2010-06-23 | ProBioGen AG | Spezifische und persistente Aktivierung der Hitzeschockreaktion in Zelllinien mittels eines viralen Faktors |
| WO2010079081A1 (en) | 2009-01-07 | 2010-07-15 | Glaxosmithkline Biologicals S.A. | Methods for recovering a virus or a viral antigen produced by cell culture |
| US20110293660A1 (en) | 2009-02-06 | 2011-12-01 | Bruno Rene Andre | Novel method |
| EA201171032A1 (ru) | 2009-02-10 | 2012-02-28 | Новартис Аг | Схемы лечения с помощью вакцины против гриппа, связанного с пандемическими штаммами |
| CA2752041A1 (en) | 2009-02-10 | 2010-08-19 | Novartis Ag | Influenza vaccines with increased amounts of h3 antigen |
| EP3173097A3 (de) | 2009-02-10 | 2017-07-12 | Seqirus UK Limited | Influenzaimpfstoffe mit reduzierten anteilen an squalen |
| USH2283H1 (en) | 2009-04-27 | 2013-09-03 | Novartis Ag | Vaccines for protecting against influenza |
| CA2768186A1 (en) | 2009-07-15 | 2011-01-20 | Novartis Ag | Rsv f protein compositions and methods for making same |
| US20120237536A1 (en) | 2009-09-10 | 2012-09-20 | Novartis | Combination vaccines against respiratory tract diseases |
| JP5688373B2 (ja) * | 2009-09-30 | 2015-03-25 | 国立大学法人帯広畜産大学 | α−ガラクトースエピトープを発現するトランスジェニック鳥類、ウイルス及びワクチン |
| EP2531592A1 (de) | 2010-02-04 | 2012-12-12 | Vivalis | Fed-batch-verfahren mit konzentriertem zellkulturmedium zur effizienten produktion von biologischen wirkstoffen bei eb66-zellen |
| US9494571B2 (en) | 2010-03-08 | 2016-11-15 | Novartis Ag | Methods of testing for intracellular pathogens |
| US9744228B2 (en) | 2010-04-07 | 2017-08-29 | Norvartis Ag | Method for generating a parvovirus B19 virus-like particle |
| US20130203151A1 (en) | 2010-04-26 | 2013-08-08 | Scott Balsitis | Production of alphavirus replicon particles in packaging cells |
| CA2797059A1 (en) | 2010-05-03 | 2011-11-10 | Glaxosmithkline Biologicals S.A. | Novel method |
| US9426989B2 (en) | 2010-05-06 | 2016-08-30 | Novartis Ag | Organic peroxide compounds for microorganism inactivation |
| CN103025350A (zh) | 2010-05-21 | 2013-04-03 | 诺华有限公司 | 流感病毒的重配方法 |
| CA2801151A1 (en) | 2010-06-01 | 2011-12-08 | Novartis Ag | Concentration of vaccine antigens with lyophilization |
| WO2011151723A2 (en) | 2010-06-01 | 2011-12-08 | Novartis Ag | Concentration of vaccine antigens without lyophilization |
| AU2011276328C1 (en) | 2010-07-06 | 2016-01-21 | Novartis Ag | Norovirus derived immunogenic compositions and methods |
| WO2012023044A1 (en) | 2010-08-20 | 2012-02-23 | Novartis Ag | Soluble needle arrays for delivery of influenza vaccines |
| WO2012051211A2 (en) | 2010-10-11 | 2012-04-19 | Novartis Ag | Antigen delivery platforms |
| AU2011325439B2 (en) | 2010-11-02 | 2015-07-23 | Helmholtz-Zentrum Fur Infektionsforschung Gmbh | Methods and vectors for cell immortalisation |
| WO2012095514A1 (en) | 2011-01-14 | 2012-07-19 | Vivalis | Recombinant protein production system |
| WO2012103361A1 (en) | 2011-01-26 | 2012-08-02 | Novartis Ag | Rsv immunization regimen |
| CA2835644C (en) | 2011-05-13 | 2021-06-15 | Novartis Ag | Pre-fusion rsv f antigens |
| EP2724157B1 (de) | 2011-06-27 | 2017-03-08 | Valneva | Screening-verfahren für zellen |
| EP2729165B1 (de) | 2011-07-06 | 2017-11-08 | GlaxoSmithKline Biologicals SA | Immunogene kombinationszusammensetzungen und ihre verwendung |
| CA2841047A1 (en) | 2011-07-06 | 2013-01-10 | Novartis Ag | Immunogenic compositions and uses thereof |
| RU2014118727A (ru) | 2011-10-11 | 2015-11-20 | Новартис Аг | Рекомбинантные самореплицирующиеся полицистронные молекулы рнк |
| US20140348863A1 (en) | 2011-10-12 | 2014-11-27 | Alessia Bianchi | Cmv antigens and uses thereof |
| GB201216121D0 (en) | 2012-09-10 | 2012-10-24 | Novartis Ag | Sample quantification by disc centrifugation |
| EP2768528A1 (de) | 2011-10-20 | 2014-08-27 | Novartis AG | Adjuvierte influenza-b-viren-impfstoffe für kinder |
| EP2660316A1 (de) | 2012-05-02 | 2013-11-06 | Helmholtz-Zentrum für Infektionsforschung GmbH | Vogelzelllinie und deren Verwendung bei der Herstellung eines Proteins |
| US20150140068A1 (en) | 2012-07-06 | 2015-05-21 | Novartis Ag | Immunogenic compositions and uses thereof |
| GB201218195D0 (en) | 2012-10-10 | 2012-11-21 | Istituto Zooprofilattico Sperimentale Delle Venezie | Composition |
| EP2922570A1 (de) | 2012-11-20 | 2015-09-30 | GlaxoSmithKline Biologicals SA | Präfusionierte rsv-f-trimere |
| CN103060376A (zh) * | 2012-12-11 | 2013-04-24 | 上海实验动物研究中心 | 一种禽腺病毒转移载体及其制备方法 |
| CN109045294A (zh) | 2013-01-10 | 2018-12-21 | 思齐乐 | 流感病毒免疫原性组合物及其应用 |
| US20140255447A1 (en) * | 2013-03-05 | 2014-09-11 | Biomune Company | Production of avian embryo cells |
| JP6851827B2 (ja) | 2013-08-30 | 2021-03-31 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | 細胞培養中でのウイルスの大規模製造 |
| CN104726409B (zh) * | 2013-12-19 | 2017-12-29 | 普莱柯生物工程股份有限公司 | 一种永生化的鸭胚肝细胞系的制备方法和应用 |
| WO2015153708A1 (en) * | 2014-04-02 | 2015-10-08 | Synageva Biopharma Corp. | Producing therapeutic proteins |
| EP2974739A1 (de) | 2014-07-15 | 2016-01-20 | Novartis AG | RSVF-Trimerisierungsdomänen |
| RU2696312C2 (ru) | 2014-07-16 | 2019-08-01 | Трансген Са | Онколитический вирус для экспрессии модуляторов иммунологических контрольных точек |
| US10428316B2 (en) | 2014-12-04 | 2019-10-01 | Intervet Inc. | Immortalised chicken embryo fibroblasts |
| EP3031822A1 (de) | 2014-12-08 | 2016-06-15 | Novartis AG | Cytomegalovirus-Antigene |
| BE1023903B1 (fr) | 2014-12-16 | 2017-09-08 | Glaxosmithkline Biologicals Sa | Nouveau procédé |
| US11147887B2 (en) | 2014-12-17 | 2021-10-19 | Fundación Para La Investigación Mèdica Aplicada | Nucleic acid constructs and gene therapy vectors for use in the treatment of Wilson disease |
| US11118238B2 (en) | 2014-12-17 | 2021-09-14 | Fundación Para La Investigación Mèdica Aplicada | Nucleic acid constructs and gene therapy vectors for use in the treatment of Wilson's disease and other conditions |
| EP3047856A1 (de) | 2015-01-23 | 2016-07-27 | Novartis AG | Cmv-antigene und ihre verwendungen |
| EP4523756A3 (de) | 2015-02-13 | 2025-05-28 | Transgene | Immunotherapeutischer impfstoff und antikörperkombinationstherapie |
| WO2016131945A1 (en) | 2015-02-20 | 2016-08-25 | Transgene Sa | Combination product with autophagy modulator |
| US11013795B2 (en) | 2015-06-26 | 2021-05-25 | Seqirus UK Limited | Antigenically matched influenza vaccines |
| KR102790570B1 (ko) | 2015-07-07 | 2025-04-04 | 세퀴러스 유케이 리미티드 | 인플루엔자 효능 검정 |
| CA3023022A1 (en) | 2016-05-04 | 2017-11-09 | Transgene Sa | Combination therapy with cpg tlr9 ligand |
| EP3481191A2 (de) * | 2016-07-11 | 2019-05-15 | Yissum Research and Development Company of the Hebrew University of Jerusalem Ltd. | Systeme und verfahren zur züchtung von zellen in vitro |
| WO2018069316A2 (en) | 2016-10-10 | 2018-04-19 | Transgene Sa | Immunotherapeutic product and mdsc modulator combination therapy |
| WO2018091680A1 (en) | 2016-11-18 | 2018-05-24 | Transgene Sa | Cowpox-based oncolytic vectors |
| CN107012122A (zh) * | 2016-12-12 | 2017-08-04 | 江苏省农业科学院 | 一种永生化鸡胚胎肝细胞系及其制备方法和用途 |
| CN110168092A (zh) | 2016-12-28 | 2019-08-23 | 特朗斯吉有限公司 | 溶瘤病毒和治疗分子 |
| KR20260047644A (ko) | 2017-03-30 | 2026-04-08 | 더 유니버서티 어브 퀸슬랜드 | 키메라 분자 및 그의 용도 |
| WO2018234506A2 (en) | 2017-06-21 | 2018-12-27 | Transgene Sa | PERSONALIZED VACCINE |
| WO2019020543A1 (en) | 2017-07-28 | 2019-01-31 | Transgene Sa | ONCOLYTIC VIRUSES EXPRESSING AGENTS TARGETING METABOLIC IMMUNE MODULATORS |
| EP3687561A4 (de) | 2017-09-01 | 2021-06-09 | The Australian National University | Immunregulatorische moleküle und deren verwendung |
| EP3703723A4 (de) | 2017-10-31 | 2021-12-15 | KaliVir Immunotherapeutics, Inc. | Onkolytischer plattformvektor zur systemischen abgabe |
| WO2019092002A1 (en) | 2017-11-07 | 2019-05-16 | Valneva Se | Pharmaceutical compositions for treatment or prevention of viral infections |
| EP3717505A4 (de) | 2017-12-01 | 2021-12-01 | Encoded Therapeutics, Inc. | Gentechnisch veränderte dna-bindende proteine |
| WO2019219649A1 (en) | 2018-05-14 | 2019-11-21 | Vivet Therapeutics | Gene therapy vectors comprising s/mar sequences |
| WO2020011754A1 (en) | 2018-07-09 | 2020-01-16 | Transgene | Chimeric vaccinia viruses |
| EP3820884B1 (de) | 2018-07-13 | 2025-09-03 | Valneva SE | Verfahren zur wiederherstellung und erzeugung eines virus in vogelzellen |
| EP3617230A1 (de) | 2018-09-03 | 2020-03-04 | BioInvent International AB | Neuartige antikörper und nukleotidsequenzen und verwendungen davon |
| CN110396496B (zh) * | 2018-09-30 | 2023-06-20 | 湖北省农业科学院畜牧兽医研究所 | 一种鸭小肠上皮细胞的培养方法及应用 |
| US20210292791A1 (en) | 2018-10-12 | 2021-09-23 | Vivet Therapeutics | Codon-optimized transgene for the treatment of progressive familiar intrahepatic cholestasis type 3 (pfic3) |
| CN109321516A (zh) * | 2018-11-07 | 2019-02-12 | 贵州大学 | 一种鸭原代肝细胞分离及培养方法 |
| AU2019375450A1 (en) | 2018-11-07 | 2021-06-17 | Vivet Therapeutics | Codon-optimized ABCB11 transgene for the treatment of progressive familial intrahepatic cholestasis type 2 (PFIC2) |
| EP3880809A4 (de) | 2018-11-16 | 2023-01-11 | Encoded Therapeutics, Inc. | Zusammensetzungen und verfahren zur behandlung von morbus wilson |
| SG11202104869SA (en) | 2018-11-23 | 2021-06-29 | Valneva Se | Food products comprising avian stem cells |
| US12478571B2 (en) | 2018-12-17 | 2025-11-25 | Pontis Biologics, Inc. | Enzyme based compositions and methods for removing dental calculi |
| US20220056481A1 (en) | 2018-12-28 | 2022-02-24 | Transgene | M2-defective poxvirus |
| EP3686276A1 (de) * | 2019-01-28 | 2020-07-29 | Freie Universität Berlin | Produktion von viren in kontinuierlich wachsenden epithelialen zelllinien aus hühnerdarm |
| PL3976798T3 (pl) | 2019-05-29 | 2026-04-07 | Encoded Therapeutics, Inc. | Kompozycje i sposoby selektywnej regulacji genów |
| JP7852185B2 (ja) | 2019-07-02 | 2026-04-28 | フンダシオン・パラ・ラ・インベスティガシオン・メディカ・アプリカダ | cPLA2e誘導剤及びその使用 |
| US20220273789A1 (en) | 2019-07-21 | 2022-09-01 | Glaxosmithkline Biologicals Sa | Therapeutic viral vaccine |
| WO2021014385A1 (en) | 2019-07-24 | 2021-01-28 | Glaxosmithkline Biologicals Sa | Modified human cytomegalovirus proteins |
| EP4061930A1 (de) | 2019-11-18 | 2022-09-28 | Seqirus Pty Ltd | Verfahren zur herstellung von reassortierenden influenza-viren |
| JP2021136899A (ja) * | 2020-03-04 | 2021-09-16 | 花王株式会社 | ウイルス増殖方法及びウイルス増殖促進剤の探索方法 |
| WO2021209897A1 (en) | 2020-04-13 | 2021-10-21 | Janssen Biotech, Inc. | Psma and steap1 vaccines and their uses |
| CN116322740A (zh) | 2020-07-13 | 2023-06-23 | 特兰斯吉恩股份有限公司 | 免疫抑制的治疗 |
| CN116390773A (zh) | 2020-08-06 | 2023-07-04 | 应用医学研究基金会 | 用于通过基因疗法治疗诸如阿尔茨海默病的Tau蛋白病的病毒颗粒 |
| US20230265456A1 (en) | 2020-08-10 | 2023-08-24 | Fundacion Para La Investigacion Medica Aplicada | Gene therapy vector expressing cyp27a1 for the treatment of cerebrotendinous xanthomatosis |
| IL301255A (en) | 2020-10-09 | 2023-05-01 | UCB Biopharma SRL | Nucleic acid structures, viral vectors and viral particles |
| TW202227621A (zh) | 2020-11-19 | 2022-07-16 | 美商凱立凡爾免疫治療股份有限公司 | 重塑腫瘤微環境的溶瘤免疫療法 |
| WO2022136616A1 (en) | 2020-12-23 | 2022-06-30 | Vivet Therapeutics | Minimal bile acid inducible promoters for gene therapy |
| WO2022148736A1 (en) | 2021-01-05 | 2022-07-14 | Transgene | Vectorization of muc1 t cell engager |
| AU2022206415A1 (en) | 2021-01-10 | 2023-08-17 | Supermeat The Essence Of Meat Ltd. | Pluripotent stem cell aggregates and microtissues obtained therefrom for the cultured meat industry |
| EP4032547A1 (de) | 2021-01-20 | 2022-07-27 | GlaxoSmithKline Biologicals S.A. | Hsv1 fce abgeleitete fragemente zur hsv therapie |
| BR112023022681A2 (pt) | 2021-04-30 | 2024-01-23 | Kalivir Immunotherapeutics Inc | Vírus oncolíticos para expressão modificada de mhc |
| WO2023025899A2 (en) | 2021-08-26 | 2023-03-02 | Transgene | Delivery system for targeting genes of the interferon pathway |
| TW202321458A (zh) | 2021-09-22 | 2023-06-01 | 瑞典商生物創新國際公司 | 新穎抗體組合及其用途 |
| EP4419650A1 (de) | 2021-10-18 | 2024-08-28 | Supermeat the Essence of Meat Ltd. | Verfahren zur herstellung eines nahrungsmittelbestandteils und dadurch hergestellte zusammensetzungen |
| EP4423286A1 (de) | 2021-10-28 | 2024-09-04 | UCB Biopharma SRL | Nukleinsäurekonstrukte, virale vektoren und virale partikel |
| CN114350601B (zh) * | 2021-12-21 | 2022-12-27 | 广东省华晟生物技术有限公司 | 樱桃谷鸭成纤维细胞系及其构建方法与应用 |
| WO2023144665A1 (en) | 2022-01-28 | 2023-08-03 | Glaxosmithkline Biologicals Sa | Modified human cytomegalovirus proteins |
| CN114908053A (zh) * | 2022-04-24 | 2022-08-16 | 上海交通大学 | 孔雀成纤维永生化细胞系的制备方法及其在病毒扩增中的应用 |
| WO2023213763A1 (en) | 2022-05-02 | 2023-11-09 | Transgene | Poxvirus encoding a binding agent comprising an anti- pd-l1 sdab |
| WO2023213764A1 (en) | 2022-05-02 | 2023-11-09 | Transgene | Fusion polypeptide comprising an anti-pd-l1 sdab and a member of the tnfsf |
| AU2023300419A1 (en) | 2022-07-01 | 2025-01-02 | Transgene | Fusion protein comprising a surfactant-protein-d and a member of the tnfsf |
| US20260049291A1 (en) | 2022-08-18 | 2026-02-19 | Transgene | Chimeric poxviruses |
| CN116496992B (zh) * | 2023-04-24 | 2023-12-01 | 江苏省家禽科学研究所 | 一种鸡胚成肌永生化细胞及其构建方法和应用 |
| WO2025120141A1 (en) * | 2023-12-08 | 2025-06-12 | Bavarian Nordic A/S | Downregulation of yield-reducing transgenes expressed by poxvirus |
| WO2026041811A1 (en) | 2024-08-23 | 2026-02-26 | Transgene | Recombinant poxvirus and method for regulating the expression of toxic conditional gene products of said recombinant poxvirus in a producing cell |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL160406A0 (en) | 1995-06-15 | 2004-07-25 | Crucell Holland Bv | A cell harbouring nucleic acid encoding adenoritus e1a and e1b gene products |
| KR970010968A (ko) | 1995-08-24 | 1997-03-27 | 윤원영 | 오리 배 세포를 이용한 에리스로포이틴의 발현 시스템 |
| US5989805A (en) | 1995-10-27 | 1999-11-23 | Board Of Trustees Operating Michigan State University | Immortal avian cell line to grow avian and animal viruses to produce vaccines |
| FR2749022B1 (fr) * | 1996-05-23 | 2001-06-01 | Rhone Merieux | Cellules aviaires immortelles |
| US5830723A (en) | 1996-08-13 | 1998-11-03 | Regents Of The University Of Minnesota | Method for immortalizing chicken cells |
| US5672485A (en) | 1996-08-13 | 1997-09-30 | Regents Of The University Of Minnesota | Immortalized cell lines for virus growth |
| FR2767335B1 (fr) | 1997-08-14 | 2001-09-28 | Ct Nat D Etudes Veterinaires E | Adenovirus aviaire celo recombinant comme vecteur vaccinant |
| DE19955558C2 (de) * | 1999-11-18 | 2003-03-20 | Stefan Kochanek | Permanente Amniozyten-Zelllinie, ihre Herstellung und Verwendung zur Herstellung von Gentransfervektoren |
| US7192759B1 (en) * | 1999-11-26 | 2007-03-20 | Crucell Holland B.V. | Production of vaccines |
| CN1139655C (zh) * | 2001-08-23 | 2004-02-25 | 北京大学人民医院 | 一种人卵巢癌永生化细胞株及其建立方法 |
| WO2004015118A1 (en) | 2002-08-07 | 2004-02-19 | Bavarian Nordic A/S | Vaccinia virus host range genes to increase the titer of avipoxviruses |
| ES2305514T5 (es) | 2002-09-05 | 2019-06-14 | Bavarian Nordic As | Método para la amplificación de un poxvirus en condiciones exentas de suero |
| DK1646715T3 (da) | 2003-07-22 | 2010-08-16 | Vivalis | Fremstilling af poxvirum med adhærente eller ikke-adhærente fuglecellelinjer |
-
2003
- 2003-11-03 EP EP03025158A patent/EP1528101A1/de not_active Withdrawn
-
2004
- 2004-11-03 WO PCT/EP2004/052789 patent/WO2005042728A2/en not_active Ceased
- 2004-11-03 EP EP10002423A patent/EP2192173A1/de not_active Withdrawn
- 2004-11-03 DK DK08101999.4T patent/DK1939281T4/da active
- 2004-11-03 BR BRPI0415622A patent/BRPI0415622B8/pt not_active IP Right Cessation
- 2004-11-03 AT AT08101999T patent/ATE460473T1/de active
- 2004-11-03 KR KR1020067010635A patent/KR101027755B1/ko not_active Expired - Fee Related
- 2004-11-03 DE DE602004014526T patent/DE602004014526D1/de not_active Expired - Lifetime
- 2004-11-03 RU RU2006119447/13A patent/RU2359999C2/ru active
- 2004-11-03 PL PL04798154T patent/PL1685243T3/pl unknown
- 2004-11-03 EP EP08101999.4A patent/EP1939281B2/de not_active Expired - Lifetime
- 2004-11-03 AU AU2004285089A patent/AU2004285089B2/en not_active Expired
- 2004-11-03 DK DK04798154T patent/DK1685243T3/da active
- 2004-11-03 JP JP2006537316A patent/JP4658953B2/ja not_active Expired - Lifetime
- 2004-11-03 AT AT04798154T patent/ATE398672T1/de active
- 2004-11-03 US US10/578,043 patent/US8940534B2/en active Active
- 2004-11-03 EP EP04798154A patent/EP1685243B1/de not_active Expired - Lifetime
- 2004-11-03 CA CA2544462A patent/CA2544462C/en not_active Expired - Lifetime
- 2004-11-03 PT PT04798154T patent/PT1685243E/pt unknown
- 2004-11-03 ES ES04798154T patent/ES2309578T3/es not_active Expired - Lifetime
- 2004-11-03 SI SI200430843T patent/SI1685243T1/sl unknown
- 2004-11-03 DE DE602004025996T patent/DE602004025996D1/de not_active Expired - Lifetime
- 2004-11-03 CN CN2004800397218A patent/CN1934243B/zh not_active Expired - Lifetime
-
2008
- 2008-09-18 CY CY20081101019T patent/CY1110272T1/el unknown
-
2012
- 2012-07-26 US US13/558,567 patent/US20120288916A1/en not_active Abandoned
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE460473T1 (de) | Immortalisierte entezelllinien zur viruserzeugung | |
| ATE466932T1 (de) | Vermehrung von viren in zellkultur | |
| ATE547511T1 (de) | Nichttumorbildende mdck-zellinie zur vermehrung von viren | |
| WO2007048089A3 (en) | Multi-plasmid system for the production of influenza virus | |
| WO2019139645A3 (en) | High efficiency base editors comprising gam | |
| EA200801756A1 (ru) | Противогриппозные вакцины, содержащие гемагглютинин и белки матрикса | |
| EA201200217A1 (ru) | Рнк с комбинацией из немодифицированных и модифицированных нуклеотидов для экспрессии белков | |
| BR112013007862A2 (pt) | ácidos nucleicos manipulados e métodos de uso dos mesmos. | |
| BRPI0809842A8 (pt) | processo para a obtenção de linhagens de células aviárias diploides contínuas, processo de replicação de um vírus em uma linhagem de células aviárias diploides contínuas e processo de produção de peptídeos e proteínas recombinantes | |
| CL2008002092A1 (es) | Conjugado que contiene dos o mas peptidos antifusogenicos y un anticuerpo anti-cd-4; metodo de produccion; composicion farmaceutica que lo comprende; polipeptidos antifusogenicos y uso del conjugado para tratar infecciones viricas. | |
| EA201001045A1 (ru) | Модифицированный вирус гриппа | |
| ATE469972T1 (de) | Multiplasmid-system zur erzeugung des grippevirus | |
| CY1110525T1 (el) | Βελτιστοποιημενη εκφραση της hpv 45 li σε ζυμη | |
| CL2008003794A1 (es) | Virus de la estomatitis vesicular geneticamente modificado (vsv) que comprende por lo menos una mutacion de aminoacido en una region de alguna de las proteinas m, g y l del virus; metodo para producirlo; composicion inmunogenica que lo comprende; metodo para adaptar un virus en un cultivo celular. | |
| BRPI0612268A2 (pt) | Ácido nucleico isolado, vetor de expressço, mÉtodos para produzir um rna genâmico da influenza, para produzir um vÍrus da influenza recombinante, para gerar um vÍrus de rna segmentado de filamento negativo recombinante nas cÉlulas caninas cultivadas e para gerar partÍculas virais da influenza infecciosa em cÉlulas caninas cultivadas, cÉlula, e, vÍrus | |
| EA201390856A1 (ru) | Инактивация вирусов с применением улучшенного способа растворитель-детергент | |
| AU2007240448A8 (en) | Methods and compositions for expressing negative-sense viral RNA in canine cells | |
| BRPI0509497A (pt) | seqüência de polipeptìdeos na modulação do efeito imunosupressor de proteìnas virais | |
| ATE507242T1 (de) | Wirtszellenspezifische bindungsmoleküle, die dazu in der lage sind, viren zu neutralisieren, und anwendungen davon | |
| EA200801174A1 (ru) | Антитела-миметики glp-2, полипептиды, композиции, способы и применения | |
| BRPI0508928A (pt) | fator de permissividade celular para vìrus e usos do mesmo | |
| EP1989316A4 (de) | Verfahren zur herstellung von rekombinantem virus, dna-konstrukte, rekombinantes virus und impfstoffzusammensetzungen | |
| WO2005115448A8 (en) | Multi plasmid system for the production of influenza virus | |
| ATE408013T1 (de) | Infektiöses cdna klon des gb-virus b und dessen verwendungen | |
| AR024122A1 (es) | Metodo para la estabilizacion intensificada de proteinas y produccion de lineas celulares que sirven para la produccion de dichas proteinas estabilizadas |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1939281 Country of ref document: EP |