ATE507844T1 - Verfahren zur herstellung eines homogenen doxorubicin-transferrin kojugates - Google Patents

Verfahren zur herstellung eines homogenen doxorubicin-transferrin kojugates

Info

Publication number
ATE507844T1
ATE507844T1 AT02736574T AT02736574T ATE507844T1 AT E507844 T1 ATE507844 T1 AT E507844T1 AT 02736574 T AT02736574 T AT 02736574T AT 02736574 T AT02736574 T AT 02736574T AT E507844 T1 ATE507844 T1 AT E507844T1
Authority
AT
Austria
Prior art keywords
molecules
drug
homogeneous
conjugate
cojugate
Prior art date
Application number
AT02736574T
Other languages
English (en)
Inventor
Ward Page Faulk
Original Assignee
Faulk Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Faulk Pharmaceuticals Inc filed Critical Faulk Pharmaceuticals Inc
Application granted granted Critical
Publication of ATE507844T1 publication Critical patent/ATE507844T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/644—Transferrin, e.g. a lactoferrin or ovotransferrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
AT02736574T 2001-05-15 2002-05-15 Verfahren zur herstellung eines homogenen doxorubicin-transferrin kojugates ATE507844T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US29068401P 2001-05-15 2001-05-15
US32953501P 2001-10-17 2001-10-17
PCT/US2002/011891 WO2002091991A2 (en) 2001-05-15 2002-05-15 Substantially homogeneous bio-affecting material having a pre-determined ratio of bioaffecting component to cell targeting component, the method for making such a material and the method of its use

Publications (1)

Publication Number Publication Date
ATE507844T1 true ATE507844T1 (de) 2011-05-15

Family

ID=26966358

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02736574T ATE507844T1 (de) 2001-05-15 2002-05-15 Verfahren zur herstellung eines homogenen doxorubicin-transferrin kojugates

Country Status (9)

Country Link
US (2) US20040167061A1 (de)
EP (1) EP1414299B1 (de)
JP (1) JP2005514322A (de)
CN (1) CN1307200C (de)
AT (1) ATE507844T1 (de)
CA (1) CA2447391C (de)
DE (1) DE60239938D1 (de)
PL (1) PL373511A1 (de)
WO (1) WO2002091991A2 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004532245A (ja) 2001-05-15 2004-10-21 ページ ダブル フォーク 癌を治療するための生体影響性化合物の標的送達
ATE333288T1 (de) 2001-05-15 2006-08-15 Faulk Pharmaceuticals Inc Gezielte freisetzung von arzneimitteln zur behandlung von virusinfektionen
CA2447395A1 (en) * 2001-05-16 2002-11-21 Faulk Pharmaceuticals, Inc. Targeted delivery of drugs for the treatment of parasitic infections
WO2003032899A2 (en) * 2001-10-17 2003-04-24 Faulk Pharmaceuticals, Inc Methods and materials for targeting and affecting selected cells
EP2531173B1 (de) * 2010-02-03 2018-09-26 Oncbiomune, L.L.C. Taxan- und taxoidproteinzusammensetzungen
JP5378469B2 (ja) * 2011-08-11 2013-12-25 学校法人 日本歯科大学 医療用薬剤
KR20140048404A (ko) * 2012-10-11 2014-04-24 포항공과대학교 산학협력단 저밀도 지단백질 유사 나노입자 및 이를 포함하는 간 표적 진단 및 치료용 조성물
EP4637829A1 (de) * 2022-12-20 2025-10-29 Cellis Sp. z o.o. ([Ltd.] Isoliertes gezieltes abgabesystem zur behandlung von ovarialkarzinom

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US28686A (en) * 1860-06-12 Improvement in steam-radiators
GB2116979B (en) * 1982-02-25 1985-05-15 Ward Page Faulk Conjugates of proteins with anti-tumour agents
JPH0720886B2 (ja) * 1983-08-10 1995-03-08 ペ−ジ フオ−ク，ウオ−ド タンパク質と抗腫瘍剤との複合体
GB8519457D0 (en) * 1985-08-02 1985-09-11 Faulk Ward Page Tumour imaging agents
US5264373A (en) * 1987-02-17 1993-11-23 Abbott Laboratories Fluorescence polarization immunoassay for tetrahydrocannabinoids
US5208323A (en) * 1989-08-10 1993-05-04 Universite Laval Coupling of an anti-tumor to an antibody using glutaraldehyde preactivated anti-tumor agent
US5393737A (en) * 1992-08-20 1995-02-28 Health Research, Inc. Cytotoxic drug conjugates for treatment of neoplastic diseases
CA2168647A1 (en) * 1993-08-02 1995-02-09 Barbara A. Sosnowski Monogenous preparations of cytotoxic conjugates
ATE225799T1 (de) * 1994-04-08 2002-10-15 Receptagen Corp Rezeptor modulierendes mitteln und entsprechendes verfahren
DE19636889A1 (de) * 1996-09-11 1998-03-12 Felix Dr Kratz Antineoplastisch wirkende Transferrin- und Albuminkonjugate zytostatischer Verbindungen aus der Gruppe der Anthrazykline, Alkylantien, Antimetabolite und Cisplatin-Analoga und diese enthaltende Arzneimittel
US6020316A (en) * 1997-09-25 2000-02-01 Lanks; Karl W. Glutaraldehyde modified chemotherapeutic agents and methods of use thereof
JP2002095476A (ja) * 2000-09-20 2002-04-02 Eisai Co Ltd トランスフェリン受容体を介した遺伝子導入法
WO2002076448A1 (en) * 2001-03-23 2002-10-03 Napro Biotherapeutics, Inc. Molecular conjugates for use in treatment of cancer
JP2004532245A (ja) * 2001-05-15 2004-10-21 ページ ダブル フォーク 癌を治療するための生体影響性化合物の標的送達
CA2447395A1 (en) * 2001-05-16 2002-11-21 Faulk Pharmaceuticals, Inc. Targeted delivery of drugs for the treatment of parasitic infections
WO2003032899A2 (en) * 2001-10-17 2003-04-24 Faulk Pharmaceuticals, Inc Methods and materials for targeting and affecting selected cells

Also Published As

Publication number Publication date
HK1067492A1 (en) 2005-04-15
EP1414299B1 (de) 2011-05-04
CA2447391C (en) 2012-08-28
WO2002091991A2 (en) 2002-11-21
EP1414299A2 (de) 2004-05-06
US20040167061A1 (en) 2004-08-26
CA2447391A1 (en) 2002-11-21
DE60239938D1 (de) 2011-06-16
WO2002091991A3 (en) 2004-02-19
EP1414299A4 (de) 2005-06-22
PL373511A1 (en) 2005-09-05
CN1529551A (zh) 2004-09-15
JP2005514322A (ja) 2005-05-19
CN1307200C (zh) 2007-03-28
US20090068104A1 (en) 2009-03-12

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