ATE508207T1 - Nachweis und qualitätskontrolle von regulator-t- zellen mittels dna-methylierungsanalyse des foxp3-gens - Google Patents

Nachweis und qualitätskontrolle von regulator-t- zellen mittels dna-methylierungsanalyse des foxp3-gens

Info

Publication number
ATE508207T1
ATE508207T1 AT07004186T AT07004186T ATE508207T1 AT E508207 T1 ATE508207 T1 AT E508207T1 AT 07004186 T AT07004186 T AT 07004186T AT 07004186 T AT07004186 T AT 07004186T AT E508207 T1 ATE508207 T1 AT E508207T1
Authority
AT
Austria
Prior art keywords
cells
detection
regulator
methylation analysis
gene
Prior art date
Application number
AT07004186T
Other languages
English (en)
Inventor
Jochen Huehn
Stefan Floess
Alf Hamann
Sven Olek
Udo Baron
Original Assignee
Charite Universitaetsmedizin
Epiontis Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Charite Universitaetsmedizin, Epiontis Gmbh filed Critical Charite Universitaetsmedizin
Application granted granted Critical
Publication of ATE508207T1 publication Critical patent/ATE508207T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Oncology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Hospice & Palliative Care (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AT07004186T 2006-02-28 2007-02-28 Nachweis und qualitätskontrolle von regulator-t- zellen mittels dna-methylierungsanalyse des foxp3-gens ATE508207T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US77763106P 2006-02-28 2006-02-28

Publications (1)

Publication Number Publication Date
ATE508207T1 true ATE508207T1 (de) 2011-05-15

Family

ID=38039185

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07004186T ATE508207T1 (de) 2006-02-28 2007-02-28 Nachweis und qualitätskontrolle von regulator-t- zellen mittels dna-methylierungsanalyse des foxp3-gens

Country Status (8)

Country Link
US (2) US10876163B2 (de)
EP (2) EP1826279B1 (de)
AT (1) ATE508207T1 (de)
DE (1) DE602007014278D1 (de)
DK (1) DK1826279T3 (de)
ES (1) ES2367012T3 (de)
PL (1) PL1826279T3 (de)
SI (1) SI1826279T1 (de)

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EP2311984A1 (de) * 2004-12-02 2011-04-20 Epigenomics AG Verfahren und Nukleinsäuren zur Analyse von mit der Prognose von Störungen der Proliferation von Prostatazellen assoziierter Genexpression
DK1826279T3 (da) 2006-02-28 2011-09-05 Charite Universitaetsmedizin Detektering og kvalitetskontrol af regulatoriske t-celler vha. DNA-metyleringsanalyse af FoxP3--genet
US20090317810A1 (en) * 2006-04-17 2009-12-24 Epigenomics Ag Methods and nucleic acids for the detection of colorectal cell proliferative disorders
US20090203011A1 (en) * 2007-01-19 2009-08-13 Epigenomics Ag Methods and nucleic acids for analyses of cell proliferative disorders
US20090246771A1 (en) * 2007-11-02 2009-10-01 University Of Southern California Compositions and methods comprising biomarkers of sperm quality, semen quality and fertility
CA2708163A1 (en) * 2007-12-11 2009-06-18 Epigenomics Ag Methods and nucleic acids for analyses of cell proliferative disorders
CN102066557A (zh) * 2008-04-11 2011-05-18 南加州大学 加速离体产生调节性t细胞的方法和组合物
EP2141245A1 (de) * 2008-07-03 2010-01-06 Ivana Türbachova DNS-Methylationsanalyse regulatorischer T-Zellen durch DNS-Methylationsanalyse der TSDR-Region des foxP3-Gens
ES2606703T3 (es) * 2008-07-15 2017-03-27 Epigenomics Ag Método para predecir el pronóstico de una terapia de cáncer de mama con base en el análisis de metilación del gen
US9115386B2 (en) 2008-09-26 2015-08-25 Children's Medical Center Corporation Selective oxidation of 5-methylcytosine by TET-family proteins
US20100124747A1 (en) * 2008-11-03 2010-05-20 University Of Southern California Compositions and methods for diagnosis or prognosis of testicular cancer
US20170233807A1 (en) * 2008-12-16 2017-08-17 Epiontis Gmbh Epigenetic Markers for the Identification of Blood Sub-cells of Type 1
DK2199411T3 (en) 2008-12-16 2015-08-03 Epiontis Gmbh Epigenetic markers for the identification of CD3-positive T lymphocytes
EP2248913B1 (de) 2009-04-28 2016-10-05 Epiontis GmbH GNLY als epigenetischer Marker zur Identifikation von CD56-exprimierenden natürlichen Killerzellen
WO2011084333A1 (en) * 2009-12-16 2011-07-14 Hitachi Chemical Co., Ltd. Method for characterizing host immune function by ex vivo induction of offensive and defensive immune markers
WO2012045888A1 (en) 2010-10-08 2012-04-12 Epiontis Gmbh Method for determining cancer patient survival based on analyzing tumor-infiltrating overall t-lymphocytes
US20140178348A1 (en) 2011-05-25 2014-06-26 The Regents Of The University Of California Methods using DNA methylation for identifying a cell or a mixture of cells for prognosis and diagnosis of diseases, and for cell remediation therapies
CA2869295A1 (en) * 2011-05-25 2012-11-29 Brown University Methods using dna methylation for identifying a cell or a mixture of cells for prognosis and diagnosis of diseases, and for cell remediation therapies
US9926599B2 (en) 2012-03-12 2018-03-27 Epiontis Gmbh Epigenetic marker for the identification of CD3CD4 positive T lymphocytes
GB201221133D0 (en) 2012-11-23 2013-01-09 Epiontis Gmbh Epigenetic method for the identification of subpopulations of CD8 and T lympocytes, in particular CD8 alpha and beta T lymphocytes
WO2015006811A2 (en) * 2013-07-19 2015-01-22 The Walter And Eliza Hall Institute Of Medical Research Diagnostic methods
JP6709541B2 (ja) * 2014-10-17 2020-06-17 国立大学法人東北大学 大腸癌に対する薬物療法の感受性を予測する方法
PL3029150T3 (pl) * 2014-12-05 2019-03-29 Epiontis Gmbh Epigenetyczny sposób identyfikacji folikularnych pomocniczych limfocytów T (TFH)
DE112016003948T5 (de) 2015-08-31 2018-05-09 City Of Sapporo Molekulare verfahren zum beurteilen einer urothelialen erkrankung
GB201516971D0 (en) * 2015-09-25 2015-11-11 Epiontis Gmbh MVD as epigenetic marker for the identification of immune cells, in particular CD56+ NK cells
GB201516972D0 (en) * 2015-09-25 2015-11-11 Epiontis Gmbh LRP5 as epigenetic marker for the identification of immune cells, in particular B-cells
GB201516975D0 (en) * 2015-09-25 2015-11-11 Epiontis Gmbh PARK2 as epigenetic marker for the identification of immune cells, in particular monocytes
US20170253927A1 (en) * 2016-03-01 2017-09-07 Washington State University Heritable epigenetic modifications as markers of chemotherapy exposure
CN107301330A (zh) * 2017-06-02 2017-10-27 西安电子科技大学 一种利用全基因组数据挖掘甲基化模式的方法
CN107236805A (zh) * 2017-06-22 2017-10-10 深圳市龙岗区疾病预防控制中心（深圳市龙岗区卫生检验中心） 基于亚硫酸氢盐测序法的foxp3基因甲基化检测方法
WO2020007951A1 (en) * 2018-07-05 2020-01-09 Epiontis Gmbh Epigenetic method to detect and distinguish ipex and ipex-like syndromes, in particular in newborns
US20230257823A1 (en) * 2020-07-15 2023-08-17 Rutgers, The State University Of New Jersey Biomarkers for identifying patients at high risk of progressing from barrett's esophagus to esophageal adenocarcinoma
EP4277999A4 (de) * 2021-01-14 2024-12-18 Loma Linda University Verfahren zur beurteilung von oralem plattenepithelkarzinom im frühstadium
DE102023112426A1 (de) * 2023-05-11 2024-11-14 Miltenyi Biotec B.V. & Co. KG Verfahren zur Optimierung von T-Zell - Produkten

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001077375A2 (en) 2000-04-06 2001-10-18 Epigenomics Ag Diagnosis of diseases associated with gene regulation
WO2002024056A2 (en) 2000-09-20 2002-03-28 Case Western Reserve University METHODS AND COMPOSITIONS FOR DETECTING CANCERS ASSOCIATED WITH METHYLATION OF hMLH1PROMOTER DNA
US7662549B1 (en) * 2000-10-27 2010-02-16 The University Of Southern California Methylation altered DNA sequences as markers associated with human cancer
JP2002171973A (ja) 2000-12-07 2002-06-18 Univ Tokyo Ｄｎａメチル化パターンによる細胞の同定法
EP1967525B1 (de) * 2001-05-08 2012-11-14 Darwin Molecular Corporation Verfahren zur Regulierung der Immunfunktion in Primaten unter Verwendung des foxp3-Proteins
US20040072197A1 (en) * 2001-11-08 2004-04-15 Jones Peter A. Assay for the detection and quantitation of hemimethylation
WO2004050706A2 (en) 2002-12-03 2004-06-17 Medical Research Council Regulatory t-cells
US20060024676A1 (en) * 2003-04-14 2006-02-02 Karen Uhlmann Method of detecting epigenetic biomarkers by quantitative methyISNP analysis
GB0402051D0 (en) * 2004-01-29 2004-03-03 Metcalfe Su Fate determination in immunity
US7279281B2 (en) 2004-06-01 2007-10-09 The Regents Of The University Of Michigan Methods and kits for diagnosing or monitoring autoimmune and chronic inflammatory diseases
DK1826279T3 (da) 2006-02-28 2011-09-05 Charite Universitaetsmedizin Detektering og kvalitetskontrol af regulatoriske t-celler vha. DNA-metyleringsanalyse af FoxP3--genet

Also Published As

Publication number Publication date
EP1826278A1 (de) 2007-08-29
EP1826279B1 (de) 2011-05-04
US20070269823A1 (en) 2007-11-22
SI1826279T1 (sl) 2011-10-28
ES2367012T3 (es) 2011-10-27
DK1826279T3 (da) 2011-09-05
EP1826279A1 (de) 2007-08-29
DE602007014278D1 (de) 2011-06-16
US20070243161A1 (en) 2007-10-18
US10876163B2 (en) 2020-12-29
PL1826279T3 (pl) 2011-11-30

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