ATE508207T1 - Nachweis und qualitätskontrolle von regulator-t- zellen mittels dna-methylierungsanalyse des foxp3-gens - Google Patents
Nachweis und qualitätskontrolle von regulator-t- zellen mittels dna-methylierungsanalyse des foxp3-gensInfo
- Publication number
- ATE508207T1 ATE508207T1 AT07004186T AT07004186T ATE508207T1 AT E508207 T1 ATE508207 T1 AT E508207T1 AT 07004186 T AT07004186 T AT 07004186T AT 07004186 T AT07004186 T AT 07004186T AT E508207 T1 ATE508207 T1 AT E508207T1
- Authority
- AT
- Austria
- Prior art keywords
- cells
- detection
- regulator
- methylation analysis
- gene
- Prior art date
Links
- 230000007067 DNA methylation Effects 0.000 title abstract 2
- 238000001514 detection method Methods 0.000 title abstract 2
- 238000003908 quality control method Methods 0.000 title abstract 2
- 101000861452 Homo sapiens Forkhead box protein P3 Proteins 0.000 title 1
- 210000001744 T-lymphocyte Anatomy 0.000 title 1
- 238000000034 method Methods 0.000 abstract 3
- 108090000623 proteins and genes Proteins 0.000 abstract 3
- 210000003289 regulatory T cell Anatomy 0.000 abstract 3
- 101001057504 Homo sapiens Interferon-stimulated gene 20 kDa protein Proteins 0.000 abstract 1
- 101001055144 Homo sapiens Interleukin-2 receptor subunit alpha Proteins 0.000 abstract 1
- 102100026878 Interleukin-2 receptor subunit alpha Human genes 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 102000040945 Transcription factor Human genes 0.000 abstract 1
- 108091023040 Transcription factor Proteins 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 230000011987 methylation Effects 0.000 abstract 1
- 238000007069 methylation reaction Methods 0.000 abstract 1
- 238000000275 quality assurance Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/118—Prognosis of disease development
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/154—Methylation markers
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pathology (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Oncology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Hospice & Palliative Care (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US77763106P | 2006-02-28 | 2006-02-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE508207T1 true ATE508207T1 (de) | 2011-05-15 |
Family
ID=38039185
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT07004186T ATE508207T1 (de) | 2006-02-28 | 2007-02-28 | Nachweis und qualitätskontrolle von regulator-t- zellen mittels dna-methylierungsanalyse des foxp3-gens |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US20070243161A1 (de) |
| EP (2) | EP1826278A1 (de) |
| AT (1) | ATE508207T1 (de) |
| DE (1) | DE602007014278D1 (de) |
| DK (1) | DK1826279T3 (de) |
| ES (1) | ES2367012T3 (de) |
| PL (1) | PL1826279T3 (de) |
| SI (1) | SI1826279T1 (de) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2534139T3 (es) * | 2004-12-02 | 2015-04-17 | Epigenomics Ag | Métodos y ácidos nucleicos para el análisis de la expresión génica asociada con el pronóstico de trastornos proliferativos de células de próstata |
| ATE508207T1 (de) * | 2006-02-28 | 2011-05-15 | Charite Universitaetsmedizin | Nachweis und qualitätskontrolle von regulator-t- zellen mittels dna-methylierungsanalyse des foxp3-gens |
| US20090317810A1 (en) * | 2006-04-17 | 2009-12-24 | Epigenomics Ag | Methods and nucleic acids for the detection of colorectal cell proliferative disorders |
| US20090203011A1 (en) * | 2007-01-19 | 2009-08-13 | Epigenomics Ag | Methods and nucleic acids for analyses of cell proliferative disorders |
| WO2009059327A2 (en) * | 2007-11-02 | 2009-05-07 | University Of Southern California (Usc) | Compositions and methods comprising biomarkers of sperm quality, semen quality and fertility |
| US20110003292A1 (en) * | 2007-12-11 | 2011-01-06 | Dimo Dietrich | Methods and nucleic acids for analyses of cell proliferative disorders |
| EP2281031A2 (de) * | 2008-04-11 | 2011-02-09 | University Of Southern California | Verfahren und zusammensetzungen zur beschleunigung der erzeugung regulatorischer t-zellen ex vivo |
| EP2141245A1 (de) * | 2008-07-03 | 2010-01-06 | Ivana Türbachova | DNS-Methylationsanalyse regulatorischer T-Zellen durch DNS-Methylationsanalyse der TSDR-Region des foxP3-Gens |
| WO2010007083A2 (en) * | 2008-07-15 | 2010-01-21 | Epigenomics Ag | Methods and nucleic acids for analyses of cell proliferative disorders |
| WO2010037001A2 (en) | 2008-09-26 | 2010-04-01 | Immune Disease Institute, Inc. | Selective oxidation of 5-methylcytosine by tet-family proteins |
| US20100124747A1 (en) * | 2008-11-03 | 2010-05-20 | University Of Southern California | Compositions and methods for diagnosis or prognosis of testicular cancer |
| US20170233807A1 (en) * | 2008-12-16 | 2017-08-17 | Epiontis Gmbh | Epigenetic Markers for the Identification of Blood Sub-cells of Type 1 |
| DK2199411T3 (en) | 2008-12-16 | 2015-08-03 | Epiontis Gmbh | Epigenetic markers for the identification of CD3-positive T lymphocytes |
| EP2248913B1 (de) | 2009-04-28 | 2016-10-05 | Epiontis GmbH | GNLY als epigenetischer Marker zur Identifikation von CD56-exprimierenden natürlichen Killerzellen |
| WO2011084333A1 (en) * | 2009-12-16 | 2011-07-14 | Hitachi Chemical Co., Ltd. | Method for characterizing host immune function by ex vivo induction of offensive and defensive immune markers |
| EP2625288B1 (de) | 2010-10-08 | 2016-05-25 | Epiontis GmbH | Verfahren zur bestimmung des überlebens eines krebspatienten auf basis der analyse der tumorinfiltration insgesamt |
| WO2012162660A2 (en) * | 2011-05-25 | 2012-11-29 | Brown University | Methods using dna methylation for identifying a cell or a mixture of cells for prognosis and diagnosis of diseases, and for cell remediation therapies |
| US20140178348A1 (en) | 2011-05-25 | 2014-06-26 | The Regents Of The University Of California | Methods using DNA methylation for identifying a cell or a mixture of cells for prognosis and diagnosis of diseases, and for cell remediation therapies |
| WO2013135454A1 (en) * | 2012-03-12 | 2013-09-19 | Epiontis Gmbh | Epigenetic marker for the identification of cd3cd4 positive t lymphocytes |
| GB201221133D0 (en) | 2012-11-23 | 2013-01-09 | Epiontis Gmbh | Epigenetic method for the identification of subpopulations of CD8 and T lympocytes, in particular CD8 alpha and beta T lymphocytes |
| WO2015006811A2 (en) * | 2013-07-19 | 2015-01-22 | The Walter And Eliza Hall Institute Of Medical Research | Diagnostic methods |
| JP6709541B2 (ja) * | 2014-10-17 | 2020-06-17 | 国立大学法人東北大学 | 大腸癌に対する薬物療法の感受性を予測する方法 |
| DK3029150T3 (en) * | 2014-12-05 | 2018-12-10 | Epiontis Gmbh | Epigenetic method for the identification of follicular T helper cells (TFH cells) |
| JP6624704B2 (ja) | 2015-08-31 | 2019-12-25 | 日立化成株式会社 | 尿路上皮疾患の評価のための分子法 |
| GB201516972D0 (en) * | 2015-09-25 | 2015-11-11 | Epiontis Gmbh | LRP5 as epigenetic marker for the identification of immune cells, in particular B-cells |
| GB201516975D0 (en) * | 2015-09-25 | 2015-11-11 | Epiontis Gmbh | PARK2 as epigenetic marker for the identification of immune cells, in particular monocytes |
| GB201516971D0 (en) * | 2015-09-25 | 2015-11-11 | Epiontis Gmbh | MVD as epigenetic marker for the identification of immune cells, in particular CD56+ NK cells |
| US20170253927A1 (en) * | 2016-03-01 | 2017-09-07 | Washington State University | Heritable epigenetic modifications as markers of chemotherapy exposure |
| CN107301330A (zh) * | 2017-06-02 | 2017-10-27 | 西安电子科技大学 | 一种利用全基因组数据挖掘甲基化模式的方法 |
| CN107236805A (zh) * | 2017-06-22 | 2017-10-10 | 深圳市龙岗区疾病预防控制中心（深圳市龙岗区卫生检验中心） | 基于亚硫酸氢盐测序法的foxp3基因甲基化检测方法 |
| WO2020007951A1 (en) * | 2018-07-05 | 2020-01-09 | Epiontis Gmbh | Epigenetic method to detect and distinguish ipex and ipex-like syndromes, in particular in newborns |
| WO2022015860A1 (en) * | 2020-07-15 | 2022-01-20 | Rutgers, The State University Of New Jersey | Biomarkers for identifying patients at high risk of progressing from barrett's esophagus to esophageal adenocarcinoma |
| CA3204918A1 (en) * | 2021-01-14 | 2022-07-21 | Chi T. VIET | Methods for evaluation of early stage oral squamous cell carcinoma |
| DE102023112426A1 (de) * | 2023-05-11 | 2024-11-14 | Miltenyi Biotec B.V. & Co. KG | Verfahren zur Optimierung von T-Zell - Produkten |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1370685A2 (de) * | 2000-04-06 | 2003-12-17 | Epigenomics AG | Diagnose von dns-reparatur assozierten krankheiten |
| US6858388B2 (en) * | 2000-09-20 | 2005-02-22 | Case Western Reserve University | Methods and compositions for detecting cancers associated with methylation of hMLH1 promoter DNA |
| US7662549B1 (en) * | 2000-10-27 | 2010-02-16 | The University Of Southern California | Methylation altered DNA sequences as markers associated with human cancer |
| JP2002171973A (ja) | 2000-12-07 | 2002-06-18 | Univ Tokyo | Ｄｎａメチル化パターンによる細胞の同定法 |
| US7507542B2 (en) | 2001-05-08 | 2009-03-24 | Ucb Sa | Method for regulating immune function using the FOXP3 protein |
| US20040072197A1 (en) * | 2001-11-08 | 2004-04-15 | Jones Peter A. | Assay for the detection and quantitation of hemimethylation |
| WO2004050706A2 (en) | 2002-12-03 | 2004-06-17 | Medical Research Council | Regulatory t-cells |
| US20060024676A1 (en) * | 2003-04-14 | 2006-02-02 | Karen Uhlmann | Method of detecting epigenetic biomarkers by quantitative methyISNP analysis |
| GB0402051D0 (en) * | 2004-01-29 | 2004-03-03 | Metcalfe Su | Fate determination in immunity |
| US7279281B2 (en) | 2004-06-01 | 2007-10-09 | The Regents Of The University Of Michigan | Methods and kits for diagnosing or monitoring autoimmune and chronic inflammatory diseases |
| ATE508207T1 (de) * | 2006-02-28 | 2011-05-15 | Charite Universitaetsmedizin | Nachweis und qualitätskontrolle von regulator-t- zellen mittels dna-methylierungsanalyse des foxp3-gens |
-
2007
- 2007-02-28 AT AT07004186T patent/ATE508207T1/de active
- 2007-02-28 DK DK07004186.8T patent/DK1826279T3/da active
- 2007-02-28 EP EP07004137A patent/EP1826278A1/de not_active Ceased
- 2007-02-28 EP EP07004186A patent/EP1826279B1/de active Active
- 2007-02-28 PL PL07004186T patent/PL1826279T3/pl unknown
- 2007-02-28 US US11/713,579 patent/US20070243161A1/en active Pending
- 2007-02-28 DE DE602007014278T patent/DE602007014278D1/de active Active
- 2007-02-28 ES ES07004186T patent/ES2367012T3/es active Active
- 2007-02-28 US US11/713,240 patent/US10876163B2/en active Active
- 2007-02-28 SI SI200730679T patent/SI1826279T1/sl unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE602007014278D1 (de) | 2011-06-16 |
| PL1826279T3 (pl) | 2011-11-30 |
| EP1826278A1 (de) | 2007-08-29 |
| US20070269823A1 (en) | 2007-11-22 |
| US20070243161A1 (en) | 2007-10-18 |
| DK1826279T3 (da) | 2011-09-05 |
| ES2367012T3 (es) | 2011-10-27 |
| SI1826279T1 (sl) | 2011-10-28 |
| EP1826279B1 (de) | 2011-05-04 |
| US10876163B2 (en) | 2020-12-29 |
| EP1826279A1 (de) | 2007-08-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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