ATE508795T1 - Vorrichtung und verfahren zur erkennung von dna- beschädigung - Google Patents

Vorrichtung und verfahren zur erkennung von dna- beschädigung

Info

Publication number
ATE508795T1
ATE508795T1 AT08857721T AT08857721T ATE508795T1 AT E508795 T1 ATE508795 T1 AT E508795T1 AT 08857721 T AT08857721 T AT 08857721T AT 08857721 T AT08857721 T AT 08857721T AT E508795 T1 ATE508795 T1 AT E508795T1
Authority
AT
Austria
Prior art keywords
dna damage
well
electrode pairs
detecting dna
assays
Prior art date
Application number
AT08857721T
Other languages
English (en)
Inventor
Nicholas Thomas
Michael Kenrick
Simon Stubbs
Original Assignee
Ge Healthcare Uk Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ge Healthcare Uk Ltd filed Critical Ge Healthcare Uk Ltd
Application granted granted Critical
Publication of ATE508795T1 publication Critical patent/ATE508795T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3275—Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Rigid containers without fluid transport within
    • B01L3/5085—Rigid containers without fluid transport within for multiple samples, e.g. microtitration plates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44756—Apparatus specially adapted therefor
    • G01N27/44773—Multi-stage electrophoresis, e.g. two-dimensional electrophoresis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/046—Function or devices integrated in the closure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0645—Electrodes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0829—Multi-well plates; Microtitration plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B01L2400/0421—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic electrophoretic flow

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Electrochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AT08857721T 2007-12-05 2008-12-05 Vorrichtung und verfahren zur erkennung von dna- beschädigung ATE508795T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0723725.8A GB0723725D0 (en) 2007-12-05 2007-12-05 Apparatus and method for detecting dna damage
PCT/EP2008/066895 WO2009071665A1 (en) 2007-12-05 2008-12-05 Apparatus and method for detecting dna damage

Publications (1)

Publication Number Publication Date
ATE508795T1 true ATE508795T1 (de) 2011-05-15

Family

ID=38982976

Family Applications (1)

Application Number Title Priority Date Filing Date
AT08857721T ATE508795T1 (de) 2007-12-05 2008-12-05 Vorrichtung und verfahren zur erkennung von dna- beschädigung

Country Status (9)

Country Link
US (2) US20120058467A1 (de)
EP (1) EP2234724B1 (de)
JP (1) JP5599718B2 (de)
CN (1) CN101939106B (de)
AT (1) ATE508795T1 (de)
AU (1) AU2008333180A1 (de)
CA (1) CA2707662A1 (de)
GB (1) GB0723725D0 (de)
WO (1) WO2009071665A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101788527B (zh) * 2010-03-09 2013-01-23 浙江大学 用于单细胞凝胶电泳试验的成套装置
US9128046B2 (en) * 2011-10-31 2015-09-08 Cellomics, Inc. Slide holder assembly for comet assay
EP2918667B1 (de) * 2012-12-12 2017-11-01 National University Corporation Toyohashi University of Technology Fremdstoffeinführungsvorrichtung und verfahren zur herstellung von zellen mit integrierten fremdstoffen
KR20140123243A (ko) * 2013-04-12 2014-10-22 주식회사 나노엔텍 단일세포 전기영동측정칩, 칩 홀딩유닛 및 단일세포 전기영동처리장치
DE102013212811A1 (de) * 2013-07-01 2015-01-08 Leica Microsystems Cms Gmbh Lasermikrodissektionssystem und Untersuchungsverfahren für nukleinsäurehaltige Proben
JP6573899B2 (ja) 2013-11-17 2019-09-11 クアンタム−エスアイ インコーポレイテッドＱｕａｎｔｕｍ−Ｓｉ Ｉｎｃｏｒｐｏｒａｔｅｄ 分子をプローブし、検出し、及び分析するための、外部光源を備えた集積デバイス
CN103952302B (zh) * 2014-04-15 2016-02-17 同济大学 一种用于单细胞胶电泳实验的新型基片
WO2017216270A1 (de) 2016-06-15 2017-12-21 Grabmayr Heinrich Einzelmolekülnachweis bzw. -quantifizierung durch dna-nanotechnologie
CN107576713B (zh) * 2017-07-12 2019-09-27 浙江省农业科学院 一种检测蚯蚓体腔细胞dna损伤的方法及其运用
BR112020000826A2 (pt) * 2017-07-24 2020-07-21 Quantum-Si Incorporated instrumento bio-optoeletrônico maciçamente paralelo portátil
EP3508841A1 (de) 2018-01-08 2019-07-10 4D Lifetec AG Einzelzellengelelektrophorese
US20210301245A1 (en) * 2020-03-29 2021-09-30 Agilent Technologies, Inc. Systems and methods for electronically and optically monitoring biological samples
CN112067535B (zh) * 2020-09-26 2024-12-27 宁波大学 细胞流通池、细胞检测装置及方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4473452A (en) * 1982-11-18 1984-09-25 The Trustees Of Columbia University In The City Of New York Electrophoresis using alternating transverse electric fields
US5137817A (en) * 1990-10-05 1992-08-11 Amoco Corporation Apparatus and method for electroporation
CA2258279A1 (en) * 1996-06-27 1997-12-31 Peter J. Dehlinger High-throughput screening method and apparatus
EP0947249A1 (de) * 1998-03-18 1999-10-06 Corning Incorporated Extrudierte Matrixplatte mit hoher Dichte
US7312043B2 (en) * 2000-07-10 2007-12-25 Vertex Pharmaceuticals (San Diego) Llc Ion channel assay methods
ATE342504T1 (de) * 2000-07-10 2006-11-15 Vertex Pharma San Diego Llc Ionenkanal-testverfahren
KR20020012915A (ko) * 2000-08-09 2002-02-20 유상옥,송운한 자외선에 대한 피부보호용 도화추출물-함유 조성물
US20050009004A1 (en) * 2002-05-04 2005-01-13 Jia Xu Apparatus including ion transport detecting structures and methods of use
US7704745B2 (en) * 2001-08-06 2010-04-27 Vanderbilt University Apparatus and methods for monitoring the status of a metabolically active cell
JP2003210155A (ja) * 2002-01-21 2003-07-29 Hitachi Plant Eng & Constr Co Ltd コメットアッセイ解析装置
JP3896458B2 (ja) * 2002-09-17 2007-03-22 独立行政法人放射線医学総合研究所 試料の搭載方法
JP2004108972A (ja) * 2002-09-19 2004-04-08 Hitachi Plant Eng & Constr Co Ltd 液体の有害性診断方法
US20050000811A1 (en) * 2003-05-06 2005-01-06 Janos Luka Electrophoretically enhanced methods
US7169609B2 (en) * 2004-03-31 2007-01-30 Vertex Pharmaceutcals, Inc. Multiwell plate assembly for use in high throughput assays
DE102004042729B4 (de) * 2004-09-03 2018-02-01 Robert Bosch Gmbh Bio-Chip mit einem Elektrodenarray auf einem Substrat
DE102004046364A1 (de) * 2004-09-24 2006-03-30 Intox Gmbh Verfahren zur Bestimmung von DNA- Schäden und Vielkammer-Behälter
JP4355832B2 (ja) * 2005-07-14 2009-11-04 パナソニックエコシステムズ株式会社 コメットアッセイ解析方法およびコメットアッセイ画像解析装置およびコメットアッセイ解析装置
US20070269824A1 (en) * 2006-03-02 2007-11-22 Jeffrey Albrecht Methods and systems for evaluating health risk factors by measurement of DNA damage and DNA repair

Also Published As

Publication number Publication date
EP2234724A1 (de) 2010-10-06
EP2234724B1 (de) 2011-05-11
US20120058467A1 (en) 2012-03-08
WO2009071665A1 (en) 2009-06-11
AU2008333180A1 (en) 2009-06-11
JP5599718B2 (ja) 2014-10-01
US20130177903A1 (en) 2013-07-11
CA2707662A1 (en) 2009-06-11
CN101939106A (zh) 2011-01-05
AU2008333180A8 (en) 2010-08-19
CN101939106B (zh) 2014-09-24
JP2011507492A (ja) 2011-03-10
GB0723725D0 (en) 2008-01-16

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