BRPI0816426A2 - Dispositivo para investigar uma molécula, método para investigar uma molécula, substrato adequado para uso no dispositivo para investigar moléculas, método para sequenciar um ácido nucléico. - Google Patents

Dispositivo para investigar uma molécula, método para investigar uma molécula, substrato adequado para uso no dispositivo para investigar moléculas, método para sequenciar um ácido nucléico.

Info

Publication number
BRPI0816426A2
BRPI0816426A2 BRPI0816426-6A2A BRPI0816426A BRPI0816426A2 BR PI0816426 A2 BRPI0816426 A2 BR PI0816426A2 BR PI0816426 A BRPI0816426 A BR PI0816426A BR PI0816426 A2 BRPI0816426 A2 BR PI0816426A2
Authority
BR
Brazil
Prior art keywords
investigating
molecula
molecule
nucleic acid
molecules
Prior art date
Application number
BRPI0816426-6A2A
Other languages
English (en)
Inventor
Cameron Frayling
Original Assignee
Base4 Innovation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Base4 Innovation Ltd filed Critical Base4 Innovation Ltd
Publication of BRPI0816426A2 publication Critical patent/BRPI0816426A2/pt

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416Systems
    • G01N27/447Systems using electrophoresis
    • G01N27/44756Apparatus specially adapted therefor
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/645Specially adapted constructive features of fluorimeters
    • G01N21/648Specially adapted constructive features of fluorimeters using evanescent coupling or surface plasmon coupling for the excitation of fluorescence
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65Raman scattering
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65Raman scattering
    • G01N21/658Raman scattering enhancement Raman, e.g. surface plasmons
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416Systems
    • G01N27/447Systems using electrophoresis
    • G01N27/44704Details; Accessories
    • G01N27/44717Arrangements for investigating the separated zones, e.g. localising zones
    • G01N27/44721Arrangements for investigating the separated zones, e.g. localising zones by optical means
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00Nanotechnology
    • Y10S977/70Nanostructure
    • Y10S977/701Integrated with dissimilar structures on a common substrate
    • Y10S977/702Integrated with dissimilar structures on a common substrate having biological material component
    • Y10S977/704Nucleic acids, e.g. DNA or RNA
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00Nanotechnology
    • Y10S977/70Nanostructure
    • Y10S977/724Devices having flexible or movable element
    • Y10S977/733Nanodiaphragm
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00Nanotechnology
    • Y10S977/70Nanostructure
    • Y10S977/778Nanostructure within specified host or matrix material, e.g. nanocomposite films
    • Y10S977/781Possessing nonosized surface openings that extend partially into or completely through the host material

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
BRPI0816426-6A2A 2007-09-04 2008-09-04 Dispositivo para investigar uma molécula, método para investigar uma molécula, substrato adequado para uso no dispositivo para investigar moléculas, método para sequenciar um ácido nucléico. BRPI0816426A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0717150.7A GB0717150D0 (en) 2007-09-04 2007-09-04 Apparatus and method
PCT/GB2008/050783 WO2009030953A1 (en) 2007-09-04 2008-09-04 Apparatus and method

Publications (1)

Publication Number Publication Date
BRPI0816426A2 true BRPI0816426A2 (pt) 2015-03-03

Family

ID=38640188

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0816426-6A2A BRPI0816426A2 (pt) 2007-09-04 2008-09-04 Dispositivo para investigar uma molécula, método para investigar uma molécula, substrato adequado para uso no dispositivo para investigar moléculas, método para sequenciar um ácido nucléico.

Country Status (9)

Country Link
US (3) US8865455B2 (pt)
EP (1) EP2188618B1 (pt)
JP (2) JP2010538290A (pt)
CN (2) CN101842692B (pt)
BR (1) BRPI0816426A2 (pt)
CA (1) CA2698876A1 (pt)
ES (1) ES2617089T3 (pt)
GB (1) GB0717150D0 (pt)
WO (1) WO2009030953A1 (pt)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3543357A1 (en) 2007-05-08 2019-09-25 Trustees of Boston University Chemical functionalization of solid-state nanopores and nanopore arrays and applications thereof
GB0717150D0 (en) * 2007-09-04 2007-10-17 Univ Warwick Apparatus and method
EP2196796A1 (en) * 2008-12-09 2010-06-16 Imec Single molecule optical spectroscopy in solid-state nanopores in a transmission-based approach
EP2483680A4 (en) 2009-09-30 2014-01-01 Quantapore Inc ULTRASOUND SEQUENCING OF BIOLOGICAL POLYMERS WITH THE HELP OF A MARKED NANOPORE
US8748091B2 (en) * 2009-12-18 2014-06-10 The Board Of Trustees Of The University Of Illinois Characterizing stretched polynucleotides in a synthetic nanopassage
AU2011218847B2 (en) * 2010-02-23 2015-03-12 Christopher Gordon Atwood Methods for the detection of biologically relevant molecules and their interaction characteristics
US10010272B2 (en) 2010-05-27 2018-07-03 Profusa, Inc. Tissue-integrating electronic apparatus
EP2402738A3 (en) * 2010-07-02 2012-01-11 Imec Spectroscopy using nanopore cavities
EP2623960B1 (en) * 2010-09-29 2020-11-11 Hitachi High-Tech Corporation Biopolymer optical analysis device and method
JP5827999B2 (ja) * 2010-10-06 2015-12-02 プロフューザ,インコーポレイティド 組織集積センサー
US9274053B2 (en) * 2011-05-18 2016-03-01 Uvic Industry Partnerships Inc. Flow through metallic nanohole arrays
EP2717038A4 (en) * 2011-06-03 2015-04-08 Hitachi High Tech Corp METHOD AND DEVICE FOR THE OPTICAL ANALYSIS OF BIOPOLYMERS
GB2493397A (en) 2011-08-05 2013-02-06 Base4 Innovation Ltd Pulse counter for single photon events
US9007576B2 (en) 2011-08-12 2015-04-14 Savannah River Nuclear Solutions, Llc Surface enhanced Raman scattering spectroscopic waveguide
US11053535B2 (en) 2011-09-12 2021-07-06 The University Of North Carolina At Chapel Hill Devices with a fluid transport nanochannel intersected by a fluid sensing nanochannel and related methods
WO2013074546A1 (en) * 2011-11-14 2013-05-23 The Regents Of The University Of California Two- chamber dual-pore device
GB2497784A (en) 2011-12-20 2013-06-26 Base4 Innovation Ltd Identification of polymers using nanopore devices
EP3591408A1 (en) * 2012-02-10 2020-01-08 The University of North Carolina at Chapel Hill Devices with fluidic nanofunnels, associated methods, fabrication and analysis systems
GB201212135D0 (en) * 2012-07-09 2012-08-22 Base4 Innovation Ltd Improved sequencing apparatus
EP2906928A4 (en) 2012-10-15 2016-11-09 Nanocellect Biomedical Inc SYSTEMS, DEVICES AND METHOD FOR SORTING PARTICLES
US9651539B2 (en) 2012-10-28 2017-05-16 Quantapore, Inc. Reducing background fluorescence in MEMS materials by low energy ion beam treatment
GB201301178D0 (en) * 2013-01-23 2013-03-06 Dynamic Biosensors Gmbh Method for sequencing a template nucleic acid immobilized on a substrate
US10261065B2 (en) 2013-02-28 2019-04-16 The University Of North Carolina At Chapel Hill Nanofluidic devices with integrated components for the controlled capture, trapping, and transport of macromolecules and related methods of analysis
US9970898B2 (en) 2013-03-13 2018-05-15 The University Of North Carolina At Chapel Hill Nanofluidic devices for the rapid mapping of whole genomes and related systems and methods of analysis
CN113274007B (zh) 2013-03-14 2024-10-18 普罗菲尤萨股份有限公司 用于校正光学信号的方法和装置
CN105143858A (zh) * 2013-03-14 2015-12-09 惠普发展公司,有限责任合伙企业 用来检测物质的器件和产生这样的器件的方法
GB201306447D0 (en) * 2013-04-09 2013-05-22 Base4 Innovation Ltd Plasmonic detector
GB201306446D0 (en) * 2013-04-09 2013-05-22 Base4 Innovation Ltd Nanopore plasmonic detector
ES2994071T3 (en) 2013-05-24 2025-01-16 Illumina Cambridge Ltd Pyrophosphorolytic sequencing using nanopores
EP3004385B1 (en) 2013-05-24 2018-11-28 Quantapore Inc. Nanopore-based nucleic acid analysis with mixed fret detection
JP2014235043A (ja) * 2013-05-31 2014-12-15 キヤノン株式会社 検査器具、検査システム、および検査方法
WO2014197786A2 (en) 2013-06-06 2014-12-11 Kintz Gregory J Apparatus and methods for detecting optical signals from implanted sensors
US10184930B2 (en) 2013-11-26 2019-01-22 Stc.Unm Innovative nanopore sequencing technology
US10612084B2 (en) * 2014-04-08 2020-04-07 International Business Machines Corporation Reduction of entropic barrier of polyelectrolyte molecules in a nanopore device with agarose gel
EP2995934A1 (en) 2014-09-15 2016-03-16 Base4 Innovation Ltd Improved nanopore plasmonic analyser
EP2995933A1 (en) 2014-09-15 2016-03-16 Base4 Innovation Ltd Improved nanopore plasmonic analyser
ES2789000T3 (es) 2014-10-10 2020-10-23 Quantapore Inc Análisis de polinucleótidos basado en nanoporos con marcadores fluorescentes que se inactivan mutuamente
CA2964790C (en) 2014-10-24 2023-02-21 Quantapore, Inc. Efficient optical analysis of polymers using arrays of nanostructures
KR20170106487A (ko) * 2015-02-02 2017-09-20 투 포어 가이즈, 인코포레이티드 시료 배경으로부터의 표적 폴리뉴클레오티드의 나노포어 검출
US10471428B2 (en) 2015-05-11 2019-11-12 The University Of North Carolina At Chapel Hill Fluidic devices with nanoscale manifolds for molecular transport, related systems and methods of analysis
JP6559187B2 (ja) * 2016-07-01 2019-08-14 ツィンファ ユニバーシティ 単一分子検出用のキャリア及び単一分子検出装置
CN107561053B (zh) * 2016-07-01 2020-04-28 清华大学 一种单分子检测方法
US10823721B2 (en) 2016-07-05 2020-11-03 Quantapore, Inc. Optically based nanopore sequencing
US11331018B2 (en) 2016-12-22 2022-05-17 Profusa, Inc. System and single-channel biosensor for and method of determining analyte value
JP7272967B2 (ja) 2017-06-20 2023-05-12 イラミーナ インコーポレーテッド ナノポアシーケンサー
EP3441143B1 (en) * 2017-08-08 2022-04-13 Roche Diagnostics GmbH Laboratory instrument base plate
JP7237388B2 (ja) * 2019-12-03 2023-03-13 国立研究開発法人科学技術振興機構 ナノポア構造体、ナノポア構造体を含む塩基配列解析装置
WO2022165276A1 (en) 2021-01-29 2022-08-04 Armonica Technologies, Inc. Enhancement structures for surface-enhanced raman scattering
CN117255945A (zh) 2021-03-31 2023-12-19 伊鲁米纳公司 纳米孔传感器装置
US20230055537A1 (en) * 2021-08-18 2023-02-23 University Of South Florida Multi-modal nanopore sensors for nucleic acid sequencing
US20250014684A1 (en) * 2021-11-19 2025-01-09 National University Corporation Hokkaido University Method for generating spectral data pertaining to microparticle sample, method for analyzing microparticles, method for distinguishing microparticles, method for assessing whether cancer-cell-derived exosomes are present, substrate for measuring spectrum of microparticles, device for measuring spectrum of microparticles, and apparatus for measuring spectrum of microparticles

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63273651A (ja) * 1987-04-30 1988-11-10 Toa Nenryo Kogyo Kk 超高分子量ポリエチレン微多孔膜の製造方法
CN1038499A (zh) * 1988-06-05 1990-01-03 青州水泵厂 往复运动轴杆密封装置
US6267872B1 (en) 1998-11-06 2001-07-31 The Regents Of The University Of California Miniature support for thin films containing single channels or nanopores and methods for using same
US6818907B2 (en) * 2000-10-17 2004-11-16 The President And Fellows Of Harvard College Surface plasmon enhanced illumination system
AU2002307218A1 (en) 2001-03-24 2002-10-08 Aviva Biosciences Corporation Biochips including ion transport detecting structures and methods of use
WO2003006948A2 (en) * 2001-07-10 2003-01-23 Wisconsin Alumni Research Foundation Surface plasmon resonance imaging of micro-arrays
US6982165B2 (en) 2001-09-24 2006-01-03 Intel Corporation Nucleic acid sequencing by raman monitoring of molecular deconstruction
US6972173B2 (en) 2002-03-14 2005-12-06 Intel Corporation Methods to increase nucleotide signals by raman scattering
US7238477B2 (en) 2001-09-24 2007-07-03 Intel Corporation Methods to increase nucleotide signals by Raman scattering
DE10157070B4 (de) * 2001-11-16 2005-11-17 Technische Universität Dresden Anordnung zur Messung von durch Ionenkanäle fließenden Ionenströmen, sowie Verfahren zur Herstellung dieser und Messverfahren
US7744816B2 (en) * 2002-05-01 2010-06-29 Intel Corporation Methods and device for biomolecule characterization
US20050019784A1 (en) * 2002-05-20 2005-01-27 Xing Su Method and apparatus for nucleic acid sequencing and identification
US6970239B2 (en) * 2002-06-12 2005-11-29 Intel Corporation Metal coated nanocrystalline silicon as an active surface enhanced Raman spectroscopy (SERS) substrate
AU2003296014B2 (en) * 2002-11-26 2010-06-03 University Of Maryland Biotechnology Institute High-sensitivity assays for pathogen detection using metal-enhanced fluorescence
JP4173375B2 (ja) * 2003-01-09 2008-10-29 三菱レイヨン株式会社 電気泳動装置及びそれを用いた生体関連物質の検出方法
US7151598B2 (en) * 2003-04-04 2006-12-19 Vladimir Poponin Method and apparatus for enhanced nano-spectroscopic scanning
US7248771B2 (en) * 2003-06-16 2007-07-24 Brigham Young University Integrated sensor with electrical and optical single molecule sensitivity
US20050023156A1 (en) * 2003-07-30 2005-02-03 Ramsey J. Michael Nanostructured material transport devices and their fabrication by application of molecular coatings to nanoscale channels
FR2863053B1 (fr) * 2003-11-28 2007-04-06 Univ Claude Bernard Lyon Nouvelles sondes hybrides a luminescence exaltee
DE10361927B4 (de) * 2003-12-19 2006-12-14 Technische Universität Dresden Ionenkanal-Sensorarray
US20050148064A1 (en) * 2003-12-29 2005-07-07 Intel Corporation Microfluid molecular-flow fractionator and bioreactor with integrated active/passive diffusion barrier
US20080037022A1 (en) 2004-02-13 2008-02-14 Takeo Nishikawa Surface Plasmon Resonance Sensor
JP4579593B2 (ja) * 2004-03-05 2010-11-10 キヤノン株式会社 標的物質認識素子、検出方法及び装置
WO2005095927A1 (ja) 2004-03-31 2005-10-13 Omron Corporation 局在プラズモン共鳴センサ及び検査装置
WO2006137891A2 (en) 2004-09-29 2006-12-28 University Of Florida Research Foundation, Inc. Membrane with nanochannels for detection of molecules
US7289203B2 (en) 2004-09-30 2007-10-30 Chromaplex, Inc. Method and system for spectral analysis of biological materials using stimulated cars
US20060148104A1 (en) 2004-10-29 2006-07-06 Massachusetts Institute Of Technology Detection of ion channel or receptor activity
US7476787B2 (en) 2005-02-23 2009-01-13 Stc.Unm Addressable field enhancement microscopy
CN101278186A (zh) * 2005-10-03 2008-10-01 皇家飞利浦电子股份有限公司 提高灵敏度的生物传感器
TWI296044B (en) 2005-11-03 2008-04-21 Ind Tech Res Inst Coupled waveguide-surface plasmon resonance biosensor
CN101360986A (zh) 2005-12-16 2009-02-04 印第安纳大学研究及科技有限公司 亚微米表面等离子体激元谐振传感器系统
US7659977B2 (en) 2006-04-21 2010-02-09 Intel Corporation Apparatus and method for imaging with surface enhanced coherent anti-stokes raman scattering (SECARS)
CN100999764A (zh) * 2006-12-14 2007-07-18 上海交通大学 光学镊控制单链核酸穿孔速度的方法
JP5397577B2 (ja) 2007-03-05 2014-01-22 オムロン株式会社 表面プラズモン共鳴センサ及び当該センサ用チップ
US20080239307A1 (en) 2007-03-30 2008-10-02 The Regents Of The University Of California Sequencing single molecules using surface-enhanced Raman scattering
GB0717150D0 (en) * 2007-09-04 2007-10-17 Univ Warwick Apparatus and method

Also Published As

Publication number Publication date
GB0717150D0 (en) 2007-10-17
JP2014145771A (ja) 2014-08-14
US8440403B2 (en) 2013-05-14
CA2698876A1 (en) 2009-03-12
CN101842692A (zh) 2010-09-22
US20150001085A1 (en) 2015-01-01
CN101842692B (zh) 2012-09-12
JP5827360B2 (ja) 2015-12-02
US20110036994A1 (en) 2011-02-17
EP2188618A1 (en) 2010-05-26
ES2617089T3 (es) 2017-06-15
US8865455B2 (en) 2014-10-21
EP2188618B1 (en) 2016-10-26
JP2010538290A (ja) 2010-12-09
CN103087904A (zh) 2013-05-08
WO2009030953A1 (en) 2009-03-12
US20120237940A1 (en) 2012-09-20

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