ATE509026T1 - Phenylalanin- derivate - Google Patents

Phenylalanin- derivate

Info

Publication number: ATE509026T1
Authority: AT; Austria
Prior art keywords: phenyl ring; present; carboxyl; phosphonohaloalkyl; phosphonoalkyl
Prior art date: 1999-03-23

Application number

AT00918474T

Other languages

English (en)

Inventor

Terrence R Burke

Yang Gao

Dajun Yang

Original Assignee

Us Gov Health & Human Serv

Univ Georgetown

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-03-23

Filing date

2000-03-23

Publication date

2011-05-15

2000-03-23 Application filed by Us Gov Health & Human Serv, Univ Georgetown filed Critical Us Gov Health & Human Serv

2011-05-15 Application granted granted Critical

2011-05-15 Publication of ATE509026T1 publication Critical patent/ATE509026T1/de

Links

150000002993 phenylalanine derivatives Chemical class 0.000 title abstract 3
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 3
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
239000002243 precursor Substances 0.000 abstract 3
150000001412 amines Chemical class 0.000 abstract 2
125000001691 aryl alkyl amino group Chemical group 0.000 abstract 2
125000001424 substituent group Chemical group 0.000 abstract 2
102000007982 Phosphoproteins Human genes 0.000 abstract 1
108010089430 Phosphoproteins Proteins 0.000 abstract 1
102000014400 SH2 domains Human genes 0.000 abstract 1
108050003452 SH2 domains Proteins 0.000 abstract 1
125000003282 alkyl amino group Chemical group 0.000 abstract 1
125000004448 alkyl carbonyl group Chemical group 0.000 abstract 1
150000001413 amino acids Chemical class 0.000 abstract 1
125000004181 carboxyalkyl group Chemical group 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
-1 e.g. Chemical group 0.000 abstract 1
125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 1
QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
125000003431 oxalo group Chemical group 0.000 abstract 1
230000000144 pharmacologic effect Effects 0.000 abstract 1
125000000405 phenylalanyl group Chemical group 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0819—Tripeptides with the first amino acid being acidic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
- C07D265/32—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings with oxygen atoms directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Diabetes (AREA)
Immunology (AREA)
Hematology (AREA)
Obesity (AREA)
Heart & Thoracic Surgery (AREA)
Rheumatology (AREA)
Transplantation (AREA)
Emergency Medicine (AREA)
Cardiology (AREA)
Endocrinology (AREA)
Pain & Pain Management (AREA)
Oncology (AREA)
Child & Adolescent Psychology (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Peptides Or Proteins (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

AT00918474T 1999-03-23 2000-03-23 Phenylalanin- derivate ATE509026T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US12604799P	1999-03-23	1999-03-23
PCT/US2000/008231 WO2000056760A1 (en)	1999-03-23	2000-03-23	Phenylalanine derivatives

Publications (1)

Publication Number	Publication Date
ATE509026T1 true ATE509026T1 (de)	2011-05-15

Family

ID=22422719

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT00918474T ATE509026T1 (de)	1999-03-23	2000-03-23	Phenylalanin- derivate

Country Status (7)

Country	Link
US (1)	US7825216B2 (de)
EP (1)	EP1163262B1 (de)
JP (1)	JP4604161B2 (de)
AT (1)	ATE509026T1 (de)
AU (1)	AU770920C (de)
CA (2)	CA2368733C (de)
WO (1)	WO2000056760A1 (de)

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US7871981B2 (en) *	1999-10-22	2011-01-18	The United States Of America As Represented By The Department Of Health And Human Services	Inhibition of cell motility, angiogenesis, and metastasis
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CN115192564B (zh) *	2022-05-23	2023-11-17	四川大学华西医院	一种苯丙氨酸衍生物、药物组合物及其在肿瘤治疗中的应用
CN117603075B (zh) *	2024-01-18	2024-04-12	深圳创元生物医药科技有限公司	一种碳13标记的3-羧酸苯丙氨酸的制备方法

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2000
- 2000-03-23 AT AT00918474T patent/ATE509026T1/de not_active IP Right Cessation
- 2000-03-23 JP JP2000606620A patent/JP4604161B2/ja not_active Expired - Fee Related
- 2000-03-23 AU AU39276/00A patent/AU770920C/en not_active Ceased
- 2000-03-23 EP EP00918474A patent/EP1163262B1/de not_active Expired - Lifetime
- 2000-03-23 WO PCT/US2000/008231 patent/WO2000056760A1/en not_active Ceased
- 2000-03-23 CA CA2368733A patent/CA2368733C/en not_active Expired - Fee Related
- 2000-03-23 CA CA2855415A patent/CA2855415A1/en not_active Abandoned
2007
- 2007-05-16 US US11/749,499 patent/US7825216B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP1163262B1 (de)	2011-05-11
AU770920C (en)	2004-10-07
CA2368733C (en)	2014-10-07
EP1163262A1 (de)	2001-12-19
WO2000056760A1 (en)	2000-09-28
JP4604161B2 (ja)	2010-12-22
US20070219194A1 (en)	2007-09-20
AU3927600A (en)	2000-10-09
CA2368733A1 (en)	2000-09-28
AU770920B2 (en)	2004-03-11
JP2002544119A (ja)	2002-12-24
US7825216B2 (en)	2010-11-02
CA2855415A1 (en)	2000-09-28

Legal Events

Date	Code	Title	Description
2011-11-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
PT1315694E (pt)	2005-07-29	Inibidores da adesao celular mediada por alfa 4
CA2345297A1 (en)	2000-04-06	Synthetic analogs of ecteinascidin-743
ATE509026T1 (de)	2011-05-15	Phenylalanin- derivate
CA2437983A1 (en)	2002-08-29	Transporters comprising spaced arginine moieties
DE69615808D1 (de)	2001-11-15	Camphothecinderivate
AU7115191A (en)	1991-08-22	Biphenylylaliphathylamino compounds, their use as antihypertensives, pharmaceutical compositions and processes for their manufacture
BR9912943A (pt)	2001-05-08	Peptìdeos inibidores de hepatite c
KR930016389A (ko)	1993-08-26	No 신타제 및 시클로옥시게나제의 이중 억제제, 이들의 제조방법 및 이들을 함유하는 치료 조성물
NZ336629A (en)	2002-11-26	Heteroaryl-hexanoic acid amide derivatives, their preparation and their use as selective inhibitors of mip-1-alpha binding to its ccr1 receptor
CY1114024T1 (el)	2016-07-27	Ενωσεις που αναστελλουν τη φλεγμονη
DK0583485T3 (da)	1997-10-06	Ethanolaminderivater med sympathomimetiske og anti-pollakisuria-virkninger
ATE230740T1 (de)	2003-01-15	Piperidinylpyrimidine derivate
CO5261493A1 (es)	2003-03-31	Procedimiento y compuestos para la inhibicion de la mrp1
UA49005C2 (uk)	2002-09-16	Похідні камптотецину (варіанти), спосіб їх одержання (варіанти) та фармацевтична композиція на їх основі
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