ATE509920T1 - Quadratsäurederivate als inhibitoren von histondeacetylase - Google Patents

Quadratsäurederivate als inhibitoren von histondeacetylase

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Publication number
ATE509920T1
ATE509920T1 AT06807466T AT06807466T ATE509920T1 AT E509920 T1 ATE509920 T1 AT E509920T1 AT 06807466 T AT06807466 T AT 06807466T AT 06807466 T AT06807466 T AT 06807466T AT E509920 T1 ATE509920 T1 AT E509920T1
Authority
AT
Austria
Prior art keywords
histone deacetylase
inhibitors
acid derivatives
square acid
square
Prior art date
Application number
AT06807466T
Other languages
English (en)
Inventor
Emelen Kristof Van
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Application granted granted Critical
Publication of ATE509920T1 publication Critical patent/ATE509920T1/de

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Psychiatry (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • AIDS & HIV (AREA)
  • Emergency Medicine (AREA)
  • Communicable Diseases (AREA)
AT06807466T 2005-10-27 2006-10-23 Quadratsäurederivate als inhibitoren von histondeacetylase ATE509920T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05110080 2005-10-27
PCT/EP2006/067656 WO2007048767A1 (en) 2005-10-27 2006-10-23 Squaric acid derivatives as inhibitors of histone deacetylase

Publications (1)

Publication Number Publication Date
ATE509920T1 true ATE509920T1 (de) 2011-06-15

Family

ID=36192996

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06807466T ATE509920T1 (de) 2005-10-27 2006-10-23 Quadratsäurederivate als inhibitoren von histondeacetylase

Country Status (9)

Country Link
US (1) US7884105B2 (de)
EP (1) EP1943232B1 (de)
JP (1) JP5070214B2 (de)
AT (1) ATE509920T1 (de)
AU (1) AU2006307918B2 (de)
CA (1) CA2623360C (de)
DK (1) DK1943232T3 (de)
ES (1) ES2366132T3 (de)
WO (1) WO2007048767A1 (de)

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ES2553178T3 (es) 2005-05-18 2015-12-04 Janssen Pharmaceutica N.V. Derivados sustituidos de aminopropenil piperidina o morfolina como nuevos inhibidores de histona deacetilasa
JP5047168B2 (ja) 2005-06-23 2012-10-10 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ヒストン・デアセチラーゼの新インヒビターとしてのイミダゾリノン及びヒダントイン誘導体
EP1981875B1 (de) 2006-01-19 2014-04-16 Janssen Pharmaceutica N.V. Substituierte indolyl-amino-alkyl-derivate als histon-deacetylase-inhibitoren
WO2007082876A1 (en) 2006-01-19 2007-07-26 Janssen Pharmaceutica N.V. Pyridine and pyrimidine derivatives as inhibitors of histone deacetylase
CA2631876C (en) 2006-01-19 2014-05-27 Janssen Pharmaceutica N.V. Aminophenyl derivatives as inhibitors of histone deacetylase
US7888360B2 (en) 2006-01-19 2011-02-15 Janssen Pharmaceutica N.V. Pyridine and pyrimidine derivatives as inhibitors of histone deacetylase
WO2007082874A1 (en) 2006-01-19 2007-07-26 Janssen Pharmaceutica N.V. Pyridine and pyrimidine derivatives as inhibitors of histone deacetylase
DK1981871T3 (da) 2006-01-19 2012-02-13 Janssen Pharmaceutica Nv Heterocyclylalkylderivater som hidtil ukendte inhibitorer af histondeacetylase

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CA2623360A1 (en) 2007-05-03
US20080255140A1 (en) 2008-10-16
EP1943232A1 (de) 2008-07-16
EP1943232B1 (de) 2011-05-18
CA2623360C (en) 2014-04-22
DK1943232T3 (da) 2011-08-29
WO2007048767A1 (en) 2007-05-03
JP5070214B2 (ja) 2012-11-07
US7884105B2 (en) 2011-02-08
AU2006307918A1 (en) 2007-05-03
ES2366132T3 (es) 2011-10-17

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