ATE533759T1 - Imidazolinon- und hydantoinderivate als neue inhibitoren von histondeacetylase - Google Patents
Imidazolinon- und hydantoinderivate als neue inhibitoren von histondeacetylaseInfo
- Publication number
- ATE533759T1 ATE533759T1 AT06763797T AT06763797T ATE533759T1 AT E533759 T1 ATE533759 T1 AT E533759T1 AT 06763797 T AT06763797 T AT 06763797T AT 06763797 T AT06763797 T AT 06763797T AT E533759 T1 ATE533759 T1 AT E533759T1
- Authority
- AT
- Austria
- Prior art keywords
- histone deacetylase
- imidazolinone
- new inhibitors
- hydantoine
- derivatives
- Prior art date
Links
- 102000003964 Histone deacetylase Human genes 0.000 title abstract 2
- 108090000353 Histone deacetylase Proteins 0.000 title abstract 2
- CAAMSDWKXXPUJR-UHFFFAOYSA-N 3,5-dihydro-4H-imidazol-4-one Chemical compound O=C1CNC=N1 CAAMSDWKXXPUJR-UHFFFAOYSA-N 0.000 title 1
- WJRBRSLFGCUECM-UHFFFAOYSA-N hydantoin Chemical class O=C1CNC(=O)N1 WJRBRSLFGCUECM-UHFFFAOYSA-N 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000002255 enzymatic effect Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05105592 | 2005-06-23 | ||
| PCT/EP2006/063351 WO2006136553A1 (en) | 2005-06-23 | 2006-06-20 | Imidazolinone and hydantoine derivatives as novel inhibitors of histone deacetylase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE533759T1 true ATE533759T1 (de) | 2011-12-15 |
Family
ID=35115704
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06763797T ATE533759T1 (de) | 2005-06-23 | 2006-06-20 | Imidazolinon- und hydantoinderivate als neue inhibitoren von histondeacetylase |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20100160321A1 (de) |
| EP (1) | EP1899325B1 (de) |
| JP (1) | JP5047168B2 (de) |
| AT (1) | ATE533759T1 (de) |
| AU (1) | AU2006260961B2 (de) |
| CA (1) | CA2608929C (de) |
| DK (1) | DK1899325T3 (de) |
| ES (1) | ES2377446T3 (de) |
| WO (1) | WO2006136553A1 (de) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA007270B1 (ru) * | 2002-03-13 | 2006-08-25 | Янссен Фармацевтика Н.В. | Пиперазинил-, пиперидинил- и морфолинилпроизводные как новые ингибиторы гистондеацетилазы |
| AU2003218737B2 (en) | 2002-03-13 | 2008-04-10 | Janssen Pharmaceutica N.V. | Inhibitors of histone deacetylase |
| ES2306880T3 (es) | 2002-03-13 | 2008-11-16 | Janssen Pharmaceutica Nv | Derivados de sulfonilamino como inhibidores novedosos de la histona desacetilasa. |
| CA2476067C (en) | 2002-03-13 | 2011-09-20 | Janssen Pharmaceutica N.V. | Carbonylamino-derivatives as novel inhibitors of histone deacetylase |
| PL1781639T3 (pl) * | 2004-07-28 | 2012-07-31 | Janssen Pharmaceutica Nv | Podstawione pochodne indolilo-alkiloaminowe jako nowe inhibitory deacetylazy histonowej |
| UA86066C2 (ru) * | 2004-07-28 | 2009-03-25 | Янссен Фармацевтика Н.В. | Производные замещенного пропенилпиперазина как ингибиторы гистондеацетилазы |
| AU2006248938B2 (en) | 2005-05-18 | 2011-09-29 | Janssen Pharmaceutica N.V. | Substituted aminopropenyl piperidine or morpholine derivatives as novel inhibitors of histone deacetylase |
| EP1943232B1 (de) * | 2005-10-27 | 2011-05-18 | Janssen Pharmaceutica NV | Quadratsäurederivate als Inhibitoren von Histondeacetylase |
| US8022617B2 (en) | 2005-11-30 | 2011-09-20 | Mitsubishi Chemical Corporation | Organic compound, charge-transporting material, composition for charge-transporting material and organic electroluminescent device |
| JP5250967B2 (ja) * | 2005-11-30 | 2013-07-31 | 三菱化学株式会社 | 有機化合物、電荷輸送材料、電荷輸送材料用組成物および有機電界発光素子 |
| JP5247470B2 (ja) * | 2006-01-19 | 2013-07-24 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | ヒストンデアセチラーゼのインヒビターとしてのピリジン及びピリミジン誘導体 |
| CA2635015C (en) * | 2006-01-19 | 2014-06-03 | Janssen Pharmaceutica N.V. | Substituted indolyl-alkyl-amino-derivatives as inhibitors of histone deacetylase |
| DE602007001190D1 (de) * | 2006-01-19 | 2009-07-09 | Janssen Pharmaceutica Nv | Aminophenylderivate als neue inhibitoren von histondeacetylase |
| DK1979328T3 (da) * | 2006-01-19 | 2013-03-25 | Janssen Pharmaceutica Nv | Pyridin- og pyrimidinderivater i deres egenskab af histondeacetylasehæmmere |
| US8101616B2 (en) | 2006-01-19 | 2012-01-24 | Janssen Pharmaceutica N.V. | Pyridine and pyrimidine derivatives as inhibitors of histone deacetylase |
| GB0619753D0 (en) * | 2006-10-06 | 2006-11-15 | Chroma Therapeutics Ltd | Enzyme inhibitors |
| WO2009050201A2 (en) | 2007-10-16 | 2009-04-23 | Novartis Ag | 4-phenyl-5-oxo-imidazole derivatives, pharmaceutical compositions and uses therof |
| WO2009050200A1 (en) * | 2007-10-16 | 2009-04-23 | Novartis Ag | Imidazolidine-2,4-dione (hydantoin) derivatives useful as npy y2 receptor modulators |
| WO2012149093A1 (en) * | 2011-04-26 | 2012-11-01 | THE UNITED STATES OF AMERICA, as represented by THE SECRETARY OF ARMY | 2-guanidino-4-oxo-imidazoline derivatives as antimalarial agents, synthesis and methods of use thereof |
| KR101842645B1 (ko) * | 2012-04-12 | 2018-03-29 | 한국화학연구원 | 신규한 히드라진온이 치환된 피리미딘 유도체 및 그의 용도 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003066889A2 (en) * | 2002-02-07 | 2003-08-14 | Axys Pharmaceuticals, Inc. | Assay for acytyltransferase or deacetylase activity |
| AU2003218737B2 (en) * | 2002-03-13 | 2008-04-10 | Janssen Pharmaceutica N.V. | Inhibitors of histone deacetylase |
| GB0209715D0 (en) * | 2002-04-27 | 2002-06-05 | Astrazeneca Ab | Chemical compounds |
-
2006
- 2006-06-20 WO PCT/EP2006/063351 patent/WO2006136553A1/en not_active Ceased
- 2006-06-20 US US11/917,999 patent/US20100160321A1/en not_active Abandoned
- 2006-06-20 EP EP06763797A patent/EP1899325B1/de active Active
- 2006-06-20 AU AU2006260961A patent/AU2006260961B2/en not_active Ceased
- 2006-06-20 CA CA2608929A patent/CA2608929C/en active Active
- 2006-06-20 ES ES06763797T patent/ES2377446T3/es active Active
- 2006-06-20 JP JP2008517483A patent/JP5047168B2/ja active Active
- 2006-06-20 AT AT06763797T patent/ATE533759T1/de active
- 2006-06-20 DK DK06763797.5T patent/DK1899325T3/da active
Also Published As
| Publication number | Publication date |
|---|---|
| US20100160321A1 (en) | 2010-06-24 |
| CA2608929C (en) | 2014-01-28 |
| CA2608929A1 (en) | 2006-12-28 |
| AU2006260961A1 (en) | 2006-12-28 |
| EP1899325A1 (de) | 2008-03-19 |
| JP2008546737A (ja) | 2008-12-25 |
| WO2006136553A1 (en) | 2006-12-28 |
| JP5047168B2 (ja) | 2012-10-10 |
| EP1899325B1 (de) | 2011-11-16 |
| DK1899325T3 (da) | 2012-03-05 |
| ES2377446T3 (es) | 2012-03-27 |
| AU2006260961B2 (en) | 2011-08-11 |
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