ATE510013T1 - Verfahren und verwendungen von linker enthaltenden polypeptidliganden - Google Patents

Verfahren und verwendungen von linker enthaltenden polypeptidliganden

Info

Publication number
ATE510013T1
ATE510013T1 AT05759242T AT05759242T ATE510013T1 AT E510013 T1 ATE510013 T1 AT E510013T1 AT 05759242 T AT05759242 T AT 05759242T AT 05759242 T AT05759242 T AT 05759242T AT E510013 T1 ATE510013 T1 AT E510013T1
Authority
AT
Austria
Prior art keywords
binding
molecule
affinity
target
site
Prior art date
Application number
AT05759242T
Other languages
English (en)
Inventor
Feng Ni
Dmitri Tolkatchev
Zhengding Su
Original Assignee
Ca Nat Research Council
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ca Nat Research Council filed Critical Ca Nat Research Council
Application granted granted Critical
Publication of ATE510013T1 publication Critical patent/ATE510013T1/de

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/542Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/66Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid the modifying agent being a pre-targeting system involving a peptide or protein for targeting specific cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B82NANOTECHNOLOGY
    • B82YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/37Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
    • C07K14/39Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts
    • C07K14/40Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts from Candida
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00Screening for compounds of potential therapeutic value
    • G01N2500/02Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • Mycology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Nanotechnology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Medical Informatics (AREA)
  • Epidemiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
AT05759242T 2004-06-23 2005-06-20 Verfahren und verwendungen von linker enthaltenden polypeptidliganden ATE510013T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58170304P 2004-06-23 2004-06-23
PCT/CA2005/000951 WO2006000081A1 (en) 2004-06-23 2005-06-20 Polypeptide ligands containing linkers

Publications (1)

Publication Number Publication Date
ATE510013T1 true ATE510013T1 (de) 2011-06-15

Family

ID=35781537

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05759242T ATE510013T1 (de) 2004-06-23 2005-06-20 Verfahren und verwendungen von linker enthaltenden polypeptidliganden

Country Status (5)

Country Link
US (1) US8063018B2 (de)
EP (1) EP1766011B1 (de)
AT (1) ATE510013T1 (de)
CA (1) CA2571815A1 (de)
WO (1) WO2006000081A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1737889E (pt) 2004-10-19 2010-12-13 Lonza Ag Método para síntese de péptidos em fase sólida
WO2010027642A2 (en) * 2008-09-04 2010-03-11 Arizona Board Of Regents Selecting for cooperatively interacting molecules
WO2010135277A2 (en) * 2009-05-18 2010-11-25 Brown University Cyclic-glur6 analogs, methods of treatment and use
WO2011159913A2 (en) * 2010-06-16 2011-12-22 The Trustees Of Dartmouth College Magnetic particle heating system and method for occlusion of the fallopian tube
CA2833614C (en) * 2011-04-20 2021-08-03 National Research Council Of Canada Locally-active anticoagulants and anti-inflammatory agents
CA2888653A1 (en) * 2012-10-19 2014-04-24 National Research Council Of Canada Derivatives of collagen-binding hairpin peptides
US9545383B2 (en) 2014-04-01 2017-01-17 Massachusetts Institute Of Technology Blood clotting control
IL234246A0 (en) 2014-08-21 2014-11-30 Omrix Biopharmaceuticals Ltd Stabilized thrombin
KR102722610B1 (ko) 2018-02-20 2024-10-25 파보니스 다이아그노스틱 인코포레이티드. 산화 알루미늄 표면 및 계면 분자

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990006128A1 (en) * 1988-12-05 1990-06-14 Biogen, Inc. Methods and compositions for inhibiting platelet aggregation
US5443827A (en) * 1993-05-03 1995-08-22 President And Fellows Of Harvard College Fibrin-targeted inhibitors of thrombin
CA2175388A1 (en) * 1993-10-25 1995-05-04 Yasuo Konishi Bivalent thrombin inhibitors
DE4404168A1 (de) * 1994-02-10 1995-08-17 Hoechst Ag Hirudinderivate und Verfahren zu deren Herstellung
US6225100B1 (en) * 1996-07-09 2001-05-01 Dcv, Inc. Arylsulfotransferase
AU2798599A (en) * 1998-02-27 1999-09-15 Bioelastics Research Ltd. Injectable implants for tissue augmentation and restoration
AU2003201554A1 (en) * 2002-01-11 2003-07-24 National Research Council Of Canada Quantitative ranking of transient ligand binding to target biomolecules
EP1597279A1 (de) 2003-02-27 2005-11-23 National Research Council Of Canada Peptid thrombin inhibitore mit hoher blutgerinnungshemmender aktivität

Also Published As

Publication number Publication date
EP1766011A1 (de) 2007-03-28
WO2006000081A1 (en) 2006-01-05
US20090105116A1 (en) 2009-04-23
EP1766011B1 (de) 2011-05-18
EP1766011A4 (de) 2009-06-24
CA2571815A1 (en) 2006-01-05
US8063018B2 (en) 2011-11-22

Similar Documents

Publication Publication Date Title
EP1545582A4 (de) Von amyolid-beta abgeleitete diffundierbare liganden (addls), addl-ersatzstoffe, addl-bindungsmoleküle und verwendungen davon
DK1503800T3 (da) Behandling og forebyggelse af vævsskade associeret med forøget C-reaktiv-protein produktion
EP1864998A3 (de) Bindungsmoleküle
ATE510013T1 (de) Verfahren und verwendungen von linker enthaltenden polypeptidliganden
HRP20230761T1 (hr) Gdf zamke
ATE440619T1 (de) Gerinnungsfaktor-fc chimere proteine zur behandlung von hämophilie
ATE555202T1 (de) Verfahren zur lieferung von rna-interferenz und verwendungen damit
WO2006023831A3 (en) Sequential protein isolation and purification schemes by affinity chromatography
JP2004521666A5 (de)
DK3085783T3 (da) Bispecifikt antistof som substitution for funktionelle proteiner
WO2008036406A3 (en) Compositions and methods related to protein displacement therapy for myotonic distrophy
DE602006020715D1 (de) Multiplex-assays für verzweigtkettige dna
WO2004093894A8 (en) Use of b7-h3 as an immunoregulatory agent
ATE485844T1 (de) Einwegvorrichtung zur diffusion von flüchtigen substanzen
BRPI0209933B8 (pt) proteína de fusão, e, molécula de ácido nucleico
ATE480643T1 (de) Homogener nachweis von analyten
DK0915974T3 (da) Modificerede tie-2 receptor-ligander
EA200870244A1 (ru) Слитые белки rage и способы применения
WO2005017205A3 (en) Nucleic acid mapping using linear analysis
WO2004082608A3 (en) Ligands for tgf-beta binding proteins and uses thereof
DE60235467D1 (de) Emissionsarmer einkomponentige klebstoff
EP1972639A3 (de) Reagenzien zur Erkennung von Proteinphosphorylierung in Karzinom-Signalwegen
EP2083018A3 (de) Zusammensetzungen und Verfahren mit Bezug zu STOP-1
BRPI0507918A (pt) processo para a carbonilação de compostos insaturados, composição de catalisador, e, ligando de difosfina bidentado assimétrico
AU2001296830A1 (en) Ligand based solution assay for low concentration analytes

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties