ATE311444T1 - Verbesserungen in bezug auf ribosom-komplexe als selektionspartikel - Google Patents

Verbesserungen in bezug auf ribosom-komplexe als selektionspartikel

Info

Publication number
ATE311444T1
ATE311444T1 AT01914058T AT01914058T ATE311444T1 AT E311444 T1 ATE311444 T1 AT E311444T1 AT 01914058 T AT01914058 T AT 01914058T AT 01914058 T AT01914058 T AT 01914058T AT E311444 T1 ATE311444 T1 AT E311444T1
Authority
AT
Austria
Prior art keywords
specific binding
selection
oxidised
optionally
ratio
Prior art date
Application number
AT01914058T
Other languages
English (en)
Inventor
Jane Osbourn
Thor Holet
Original Assignee
Cambridge Antibody Tech
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cambridge Antibody Tech filed Critical Cambridge Antibody Tech
Application granted granted Critical
Publication of ATE311444T1 publication Critical patent/ATE311444T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/44—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1041—Ribosome/Polysome display, e.g. SPERT, ARM
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Ink Jet Recording Methods And Recording Media Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT01914058T 2000-03-31 2001-03-26 Verbesserungen in bezug auf ribosom-komplexe als selektionspartikel ATE311444T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19380200P 2000-03-31 2000-03-31
PCT/GB2001/001319 WO2001075097A2 (en) 2000-03-31 2001-03-26 Improvements to ribosome display

Publications (1)

Publication Number Publication Date
ATE311444T1 true ATE311444T1 (de) 2005-12-15

Family

ID=22715061

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01914058T ATE311444T1 (de) 2000-03-31 2001-03-26 Verbesserungen in bezug auf ribosom-komplexe als selektionspartikel

Country Status (11)

Country Link
US (2) US7074557B2 (de)
EP (1) EP1268766B1 (de)
JP (1) JP2003529369A (de)
AT (1) ATE311444T1 (de)
AU (2) AU2001239444B2 (de)
CA (1) CA2402452A1 (de)
DE (1) DE60115405T2 (de)
DK (1) DK1268766T3 (de)
ES (1) ES2253358T3 (de)
GB (1) GB2365429B (de)
WO (1) WO2001075097A2 (de)

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EP0985032B2 (de) 1997-05-28 2009-06-03 Discerna Limited Ribosom-komplexe als selektionspartikel für die in vitro anzeige und evolution von proteinen
EP1664343B1 (de) * 2003-09-09 2014-05-07 Integrigen, Inc. Verfahren und zusammensetzungen zur erzeugung menschlicher keimlinien-antikörpergene
US20070111237A1 (en) * 2005-09-14 2007-05-17 Maurizio Zanetti Process for identifying antigenized antibodies using ribosome cell free expression system
US7749957B2 (en) 2006-04-06 2010-07-06 E.I. Du Pont De Nemours And Company Clay-binding peptides and methods of use
US9879252B2 (en) 2007-06-13 2018-01-30 Cornell Research Foundation, Inc. Protein discovery using intracellular ribosome display
WO2009018438A1 (en) * 2007-07-31 2009-02-05 Cornell Research Foundation, Inc. Protein discovery using intracellular ribosome display
US7829311B2 (en) 2007-07-25 2010-11-09 E.I. Du Pont De Nemours And Company Ketosteroid isomerase inclusion body tag engineered to be acid-resistant by replacing aspartates with glutamate
US7951559B2 (en) * 2007-07-25 2011-05-31 E.I. Du Pont De Nemours And Company Recombinant peptide production using a cross-linkable solubility tag
US7678883B2 (en) 2007-07-25 2010-03-16 E.I. Du Pont De Nemours And Company Solubility tags for the expression and purification of bioactive peptides
US7794963B2 (en) 2007-11-02 2010-09-14 E.I. Du Pont De Nemours And Company Use of tetracysteine tags in fluorescence-activated cell sorting analysis of prokaryotic cells producing peptides or proteins
GB0806562D0 (en) 2008-04-10 2008-05-14 Fermentas Uab Production of nucleic acid
CN102177438A (zh) 2008-07-25 2011-09-07 理查德·W·瓦格纳 蛋白筛选方法
US20100113304A1 (en) * 2008-09-26 2010-05-06 Wyeth Compatible display vector systems
WO2010036856A2 (en) * 2008-09-26 2010-04-01 Wyeth Llc Compatible display vector systems
CN102227638B (zh) * 2008-09-30 2015-05-20 Abbvie公司 Rna展示的改良方法
US20100158837A1 (en) 2008-12-18 2010-06-24 E. I. Du Pont De Nemours And Company Iron oxide-binding peptides
US8287845B2 (en) * 2008-12-18 2012-10-16 E I Du Pont De Nemours And Company Hair-binding peptides
US20100158822A1 (en) * 2008-12-18 2010-06-24 E .I. Du Pont De Nemours And Company Peptides that bind to silica-coated particles
US20100158846A1 (en) * 2008-12-18 2010-06-24 E. I. Du Pont De Nemours And Company Hair-binding peptides
US8481678B2 (en) 2009-03-30 2013-07-09 E I Du Pont De Nemours And Company Peptide-based tooth whitening reagents
JP2012522057A (ja) * 2009-03-30 2012-09-20 ジヨンソン・アンド・ジヨンソン・コンシユーマー・カンパニーズ・インコーポレーテツド 化粧用剤の送達のためのペプチドに基づく系
JP5863045B2 (ja) 2010-03-11 2016-02-16 国立研究開発法人理化学研究所 ポリペプチド配列の選択方法、並びに金属酸化物または含珪素化合物結合ペプチドおよびその利用
US9255144B2 (en) 2010-12-20 2016-02-09 Medimmune Limited Anti-IL-18 antibodies and their uses
DE102010056289A1 (de) 2010-12-24 2012-06-28 Geneart Ag Verfahren zur Herstellung von Leseraster-korrekten Fragment-Bibliotheken
JP5948673B2 (ja) 2011-03-10 2016-07-06 ジーンフロンティア株式会社 リポ多糖混入量を低減した蛋白質合成用組成物、該組成物を用いた蛋白質製造方法
WO2012161227A1 (ja) 2011-05-23 2012-11-29 独立行政法人理化学研究所 核酸構築物、核酸－蛋白質複合体、及びその利用
WO2014060444A1 (en) 2012-10-15 2014-04-24 Medimmune Limited Antibodies to amyloid beta
EP2989202B1 (de) 2013-04-25 2019-04-10 Sutro Biopharma, Inc. Die verwendung des lambda-gam proteins in der ribosomen-display-technologie
DK2989239T4 (da) * 2013-04-25 2025-04-07 Sutro Biopharma Inc Selektion af Fab-fragmenter ved anvendelse af ribosomfremvisningsteknologi
WO2014189768A1 (en) * 2013-05-19 2014-11-27 The Board Of Trustees Of The Leland Devices and methods for display of encoded peptides, polypeptides, and proteins on dna
US10059937B2 (en) 2013-09-27 2018-08-28 The Board Of Trustees Of The University Of Illinois Method and kit for generating high affinity binding agents
EP3102245B1 (de) 2014-02-05 2021-09-08 Molecular Templates, Inc. Verfahren zum abtasten, auswählen und identifizieren von cytotoxischen rekombinanten polypeptiden auf grundlage einer vorläufigen minderung der ribotoxizität
US10906982B2 (en) 2015-05-15 2021-02-02 The General Hospital Corporation Antagonistic anti-tumor necrosis factor receptor 2 antibodies
JP2019500899A (ja) 2015-11-23 2019-01-17 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア ＣＲＩＳＰＲ／Ｃａｓ９の核送達を通じた細胞ＲＮＡの追跡と操作
EP3622062A4 (de) 2017-05-10 2020-10-14 The Regents of the University of California Gerichtetes editing von zellulärer rna durch nukleare abgabe von crispr/cas9
CN112513250A (zh) * 2018-04-20 2021-03-16 加利福尼亚大学董事会 用于跟踪和操纵细胞rna的融合蛋白和融合核糖核酸
US11174479B2 (en) 2018-08-13 2021-11-16 The Board Of Trustees Of The Leland Stanford Junior University Devices and methods for display of encoded peptides, PolyPeptides, and proteins on DNA
US20210371537A1 (en) 2018-09-18 2021-12-02 Merrimack Pharmaceuticals, Inc. Anti-tnfr2 antibodies and uses thereof
CA3131953A1 (en) 2019-03-01 2020-09-10 Merrimack Pharmaceuticals, Inc. Anti-tnfr2 antibodies and uses thereof
WO2022167396A1 (en) 2021-02-02 2022-08-11 Biocopy Gmbh Method for identifying emerging pathogen mutations enabling host cell entry and immune evasion

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DK0494955T3 (da) * 1989-10-05 1998-10-26 Optein Inc Cellefri syntese og isolering af hidtil ukendte gener og polypeptider
EP0670905B1 (de) 1992-09-22 2003-07-23 Biofocus Discovery Limited Rekombinante viren, die an ihrer äusseren oberfläche ein nichtvirales polypeptid präsentieren
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WO1995011922A1 (en) * 1993-10-29 1995-05-04 Affymax Technologies N.V. In vitro peptide and antibody display libraries
US5939262A (en) 1996-07-03 1999-08-17 Ambion, Inc. Ribonuclease resistant RNA preparation and utilization
US5677124A (en) 1996-07-03 1997-10-14 Ambion, Inc. Ribonuclease resistant viral RNA standards
WO1998048008A1 (en) * 1997-04-23 1998-10-29 Plueckthun Andreas Methods for identifying nucleic acid molecules encoding (poly)peptides that interact with target molecules
EP0985032B2 (de) * 1997-05-28 2009-06-03 Discerna Limited Ribosom-komplexe als selektionspartikel für die in vitro anzeige und evolution von proteinen
CA2302147C (en) * 1997-09-03 2008-05-13 Biovation Limited Methods for protein screening
US6562622B1 (en) * 1998-05-08 2003-05-13 Diatech Pty, Ltd Continuous in vitro evolution

Also Published As

Publication number Publication date
US20020076692A1 (en) 2002-06-20
WO2001075097A2 (en) 2001-10-11
US7074557B2 (en) 2006-07-11
DK1268766T3 (da) 2006-04-10
GB0107543D0 (en) 2001-05-16
DE60115405T2 (de) 2006-08-03
EP1268766B1 (de) 2005-11-30
ES2253358T3 (es) 2006-06-01
AU2001239444B2 (en) 2004-10-07
CA2402452A1 (en) 2001-10-11
JP2003529369A (ja) 2003-10-07
US20060177862A1 (en) 2006-08-10
DE60115405D1 (de) 2006-01-05
WO2001075097A3 (en) 2002-01-03
AU3944401A (en) 2001-10-15
GB2365429A (en) 2002-02-20
GB2365429B (en) 2002-07-24
EP1268766A2 (de) 2003-01-02

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