ATE510018T1 - Synthetische menschliche gene und polypeptide und deren verwendung in der behandlung von autoimmunkrankheiten - Google Patents

Synthetische menschliche gene und polypeptide und deren verwendung in der behandlung von autoimmunkrankheiten

Info

Publication number
ATE510018T1
ATE510018T1 AT00971684T AT00971684T ATE510018T1 AT E510018 T1 ATE510018 T1 AT E510018T1 AT 00971684 T AT00971684 T AT 00971684T AT 00971684 T AT00971684 T AT 00971684T AT E510018 T1 ATE510018 T1 AT E510018T1
Authority
AT
Austria
Prior art keywords
treatment
autoimmune diseases
synthetic human
autoantigen
polypeptides
Prior art date
Application number
AT00971684T
Other languages
English (en)
Inventor
Avraham Ben-Nun
De Rosbo Nicole Kerlero
Gregor Sappler
Original Assignee
Yeda Res & Dev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yeda Res & Dev filed Critical Yeda Res & Dev
Application granted granted Critical
Publication of ATE510018T1 publication Critical patent/ATE510018T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4713—Autoimmune diseases, e.g. Insulin-dependent diabetes mellitus, multiple sclerosis, rheumathoid arthritis, systemic lupus erythematosus; Autoantigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Public Health (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Rehabilitation Therapy (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Emergency Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AT00971684T 1999-10-27 2000-10-26 Synthetische menschliche gene und polypeptide und deren verwendung in der behandlung von autoimmunkrankheiten ATE510018T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IL13261199A IL132611A0 (en) 1999-10-27 1999-10-27 Synthetic genes and polypeptides and pharmaceutical compositions comprising them
PCT/IL2000/000688 WO2001031037A2 (en) 1999-10-27 2000-10-26 Synthetic human genes and polypeptides and their use in the treatment of autoimmune diseases

Publications (1)

Publication Number Publication Date
ATE510018T1 true ATE510018T1 (de) 2011-06-15

Family

ID=11073389

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00971684T ATE510018T1 (de) 1999-10-27 2000-10-26 Synthetische menschliche gene und polypeptide und deren verwendung in der behandlung von autoimmunkrankheiten

Country Status (7)

Country Link
US (2) US8088389B1 (de)
EP (1) EP1238089B1 (de)
AT (1) ATE510018T1 (de)
AU (1) AU1051001A (de)
CA (1) CA2404438A1 (de)
IL (2) IL132611A0 (de)
WO (1) WO2001031037A2 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002083860A2 (en) 2001-04-10 2002-10-24 Agensys, Inc. Nucleic acid and corresponding protein entitled 151p3d4 useful in treatment and detection of cancer
IL146016A0 (en) 2001-10-17 2002-07-25 Yeda Res & Dev Synthetic peptides and dna sequences and compositions comprising them for treatment of multiple sclerosis
CN1798569A (zh) * 2003-06-02 2006-07-05 莫西亚药物公司 用于治疗1型糖尿病的治疗性疫苗组合物
WO2006072946A2 (en) * 2005-01-04 2006-07-13 Yeda Research And Development Co. Ltd. At The Weizmann Institute Of Science Hsp60, hsp60 peptides and t cell vaccines for immunomodulation
WO2011056226A1 (en) 2009-11-05 2011-05-12 Mercia Pharma Llc Adjuvanted nanoparticulate influenza vaccine
PL217128B1 (pl) * 2010-08-02 2014-06-30 Inst Biochemii I Biofizyki Polskiej Akademii Nauk Syntetyczne geny kodujące fragmenty peptydowe naturalnych białek mielinowych przeznaczone do wywoływania efektu tolerancji pokarmowej, fragmenty DNA zawierające te geny, sposób otrzymywania tych peptydów w układzie mikrobiologicznym (bakteryjnym) oraz ich zastosowanie medyczne
US9040046B2 (en) 2011-01-31 2015-05-26 Kai Xu Sodium pump antibody agonists and methods of treating heart disease using the same
WO2013104424A1 (en) * 2012-01-13 2013-07-18 Instytut Biochemii I Biofizyki Pan Synthetic genes encoding peptide fragments of natural myelin proteins for induction of oral tolerance, dna fragment comprising these genes, means of obtaining these peptides in a microbial (bacterial) system and their medical application
WO2013107526A2 (en) * 2012-01-22 2013-07-25 Instytut Biochemii I Biofizyki Pan Synthetic genes encoding peptide fragments of natural myelin proteins for induction of oral tolerance, dna fragment comprising these genes, means of obtaining these peptides in a microbial (bacterial) system and their medical application
GB201300684D0 (en) 2013-01-15 2013-02-27 Apitope Int Nv Peptide
HK1244821A1 (zh) 2014-11-21 2018-08-17 Immusant Inc. 用於治疗和诊断1型糖尿病中使用的肽
US12458683B2 (en) 2015-03-09 2025-11-04 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Myelin oligodendrocyte glycoprotein, myelin basic protein, and proteolipid protein compositions and methods of use
US10759838B2 (en) * 2015-03-09 2020-09-01 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Myelin oligodendrocyte glycoprotein, myelin basic protein, and proteolipid protein compositions and methods of use
CN113336862B (zh) * 2021-07-05 2022-03-01 广东省科学院动物研究所 一种抗多发性硬化的重组蛋白及其制备方法和用途

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5547669A (en) * 1989-11-03 1996-08-20 Immulogic Pharma Corp Recombinant peptides comprising T cell epitopes of the cat allergen, Fel d I
IL103456A (en) * 1991-10-16 2006-06-11 Merck Patent Gmbh Isolated peptides having t-cell stimulating activity
US5683695A (en) * 1993-02-10 1997-11-04 United Biomedical, Inc. Production of recombinant proteins containing multiple antigenic determinants linked by flexible hinge domains
US5759551A (en) * 1993-04-27 1998-06-02 United Biomedical, Inc. Immunogenic LHRH peptide constructs and synthetic universal immune stimulators for vaccines
EP0751957B1 (de) 1994-03-21 2004-02-25 Rijksuniversiteit Utrecht Peptidfragmente von mikrobiellen stressproteinen und daraus hergestellte pharmazeutische zusammensetzungen für die behandlung und vorbeugung von entzündungserkrankungen
WO1996034622A1 (en) 1995-05-02 1996-11-07 Alexion Pharmaceuticals, Inc. Modified myelin protein molecules
IL118524A (en) * 1995-06-19 2004-02-19 Akzo Nobel Nv Peptides and pharmaceutical preparations containing them useful in the treatment of peptide tolerance
US5821334A (en) * 1996-01-26 1998-10-13 Vanderbilt University Insulin-dependent diabetes mellitus-specific chimeric polypeptides
TW575583B (en) 1996-04-24 2004-02-11 Akzo Nobel Nv Novel peptides suitable for use in antigen specific immunosuppressive therapy
US6274136B1 (en) 1996-05-29 2001-08-14 University Of Southern California Construction and use of genes encoding pathogenic epitopes for treatment of autoimmune disease
AUPO468597A0 (en) * 1997-01-21 1997-02-13 Montech Medical Developments Pty Ltd Expression in yeast of antigenically active, recombinant hybrid glutamic acid decarboxylase
WO1999032136A1 (en) * 1997-12-23 1999-07-01 Alexion Pharmaceuticals, Inc. Chimeric proteins for the treatment of diabetes
US6770460B1 (en) * 1998-01-29 2004-08-03 Wallac Oy Fusion protein and its use in an immunoassay for the simultaneous detection of autoantibodies related to insulin-dependent diabetes mellitus
US7030098B2 (en) 1999-03-12 2006-04-18 The Board Of Trustees Of The Leland Stanford Junior University DNA vaccination for treatment of autoimmune disease
IL146016A0 (en) 2001-10-17 2002-07-25 Yeda Res & Dev Synthetic peptides and dna sequences and compositions comprising them for treatment of multiple sclerosis

Also Published As

Publication number Publication date
WO2001031037A2 (en) 2001-05-03
EP1238089B1 (de) 2011-05-18
CA2404438A1 (en) 2001-05-03
WO2001031037A3 (en) 2002-07-11
IL149325A (en) 2009-12-24
EP1238089A2 (de) 2002-09-11
AU1051001A (en) 2001-05-08
IL132611A0 (en) 2001-03-19
US8088389B1 (en) 2012-01-03
US8501189B2 (en) 2013-08-06
US20120172297A1 (en) 2012-07-05

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