ATE510833T1 - Verfahren zur herstellung von hochreinem almotriptan - Google Patents

Verfahren zur herstellung von hochreinem almotriptan

Info

Publication number: ATE510833T1
Authority: AT; Austria
Prior art keywords: almotriptan; pyrrolidinylsulfonylmethyl; formula; salt; high purity
Prior art date: 2007-06-13

Application number

AT08773241T

Other languages

English (en)

Inventor

Ludek Ridvan

Petr Hruby

Jan Stach

Stanislav Radl

Michal Voslar

Hana Brusova

Lucie Krumbholcova

Monika Zatopkova

Original Assignee

Zentiva Ks

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-06-13

Filing date

2008-06-13

Publication date

2011-06-15

2008-06-13 Application filed by Zentiva Ks filed Critical Zentiva Ks

2011-06-15 Application granted granted Critical

2011-06-15 Publication of ATE510833T1 publication Critical patent/ATE510833T1/de

Links

WKEMJKQOLOHJLZ-UHFFFAOYSA-N Almogran Chemical compound C1=C2C(CCN(C)C)=CNC2=CC=C1CS(=O)(=O)N1CCCC1 WKEMJKQOLOHJLZ-UHFFFAOYSA-N 0.000 title abstract 7
229960002133 almotriptan Drugs 0.000 title abstract 6
238000004519 manufacturing process Methods 0.000 title 1
238000006243 chemical reaction Methods 0.000 abstract 3
150000003839 salts Chemical class 0.000 abstract 3
150000007522 mineralic acids Chemical class 0.000 abstract 2
150000007524 organic acids Chemical class 0.000 abstract 2
238000000746 purification Methods 0.000 abstract 2
XLDLLAFWGVDYHM-UHFFFAOYSA-N 2-[5-(pyrrolidin-1-ylsulfonylmethyl)-1h-indol-3-yl]ethanamine Chemical compound C1=C2C(CCN)=CNC2=CC=C1CS(=O)(=O)N1CCCC1 XLDLLAFWGVDYHM-UHFFFAOYSA-N 0.000 abstract 1
URINEQNRIFSXKT-UHFFFAOYSA-N [4-(pyrrolidin-1-ylsulfonylmethyl)phenyl]hydrazine Chemical compound C1=CC(NN)=CC=C1CS(=O)(=O)N1CCCC1 URINEQNRIFSXKT-UHFFFAOYSA-N 0.000 abstract 1
238000002425 crystallisation Methods 0.000 abstract 1
230000008025 crystallization Effects 0.000 abstract 1
238000002955 isolation Methods 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000003960 organic solvent Substances 0.000 abstract 1
238000002360 preparation method Methods 0.000 abstract 1
239000000126 substance Substances 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Manufacture And Refinement Of Metals (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Plural Heterocyclic Compounds (AREA)

AT08773241T 2007-06-13 2008-06-13 Verfahren zur herstellung von hochreinem almotriptan ATE510833T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
CZ20070408A CZ302424B6 (cs)	2007-06-13	2007-06-13	Zpusob prípravy almotriptanu o vysoké cistote
PCT/CZ2008/000067 WO2008151584A1 (en)	2007-06-13	2008-06-13	Method for the preparation of high purity almotriptan

Publications (1)

Publication Number	Publication Date
ATE510833T1 true ATE510833T1 (de)	2011-06-15

Family

ID=39816937

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT08773241T ATE510833T1 (de)	2007-06-13	2008-06-13	Verfahren zur herstellung von hochreinem almotriptan

Country Status (6)

Country	Link
EP (1)	EP2158197B1 (de)
AT (1)	ATE510833T1 (de)
CZ (1)	CZ302424B6 (de)
EA (1)	EA016759B1 (de)
PL (1)	PL2158197T3 (de)
WO (1)	WO2008151584A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2010113183A2 (en) *	2009-04-03	2010-10-07	Msn Laboratories Limited	Process for the preparation of 1-[[[3-[2-(dimethylamino)ethyl]-1h-indol-5-yl]methyl]sulfonyl] pyrrolidine and its pharmaceutically acceptable salts
CN102775391B (zh) *	2011-05-12	2015-05-20	上海医药工业研究院	制备抗偏头痛药物阿莫曲坦的方法
CN102775392B (zh) *	2011-05-12	2015-11-18	上海医药工业研究院	N-保护-3，5-二取代吲哚衍生物及其制备方法和应用
CN103724252A (zh) *	2012-10-12	2014-04-16	苏州四同医药科技有限公司	一种阿莫曲坦的制备方法
CN106478484B (zh) *	2016-08-31	2017-11-10	重庆华森制药股份有限公司	一种制备阿莫曲坦关键中间体的方法
GB201907871D0 (en)	2019-06-03	2019-07-17	Small Pharma Ltd	Therapeutic compositions
NZ788543A (en) *	2019-11-07	2022-10-28	Small Pharma Ltd	Dimethyltryptamine derivatives and their use in psychedelic-assisted psychotherapy
US11773062B2 (en)	2021-03-22	2023-10-03	Small Pharma Ltd	Deuterated compounds
US12521370B2 (en)	2020-12-01	2026-01-13	Cybin Uk Ltd	Inhalable formulations
US11660289B2 (en)	2020-12-01	2023-05-30	Small Pharma Ltd.	Deuterated or partially deuterated N,N-dimethyltryptamine compounds
US11697638B2 (en)	2021-09-08	2023-07-11	Small Pharma Ltd	5-methoxy-N,N-dimethyltryptamine crystalline forms

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9216009D0 (en) *	1992-07-28	1992-09-09	Almirall Lab	New indol derivatives
WO2006129190A1 (en) *	2005-06-03	2006-12-07	Glenmark Pharmaceuticals Limited	Process for the preparation of almotriptan
WO2007013098A1 (en) *	2005-07-25	2007-02-01	Matrix Laboratories Limited	A process for the preparation of almotriptan
US7619220B2 (en) *	2005-11-30	2009-11-17	Jeol Ltd.	Method of measuring aberrations and correcting aberrations using Ronchigram and electron microscope

2007
- 2007-06-13 CZ CZ20070408A patent/CZ302424B6/cs not_active IP Right Cessation
2008
- 2008-06-13 PL PL08773241T patent/PL2158197T3/pl unknown
- 2008-06-13 AT AT08773241T patent/ATE510833T1/de not_active IP Right Cessation
- 2008-06-13 EP EP08773241A patent/EP2158197B1/de not_active Not-in-force
- 2008-06-13 WO PCT/CZ2008/000067 patent/WO2008151584A1/en not_active Ceased
- 2008-06-13 EA EA200901626A patent/EA016759B1/ru not_active IP Right Cessation

Also Published As

Publication number	Publication date
EP2158197B1 (de)	2011-05-25
EA200901626A1 (ru)	2010-06-30
EA016759B1 (ru)	2012-07-30
EP2158197A1 (de)	2010-03-03
CZ302424B6 (cs)	2011-05-11
CZ2007408A3 (cs)	2008-12-29
WO2008151584A1 (en)	2008-12-18
PL2158197T3 (pl)	2011-10-31

Similar Documents

Publication	Publication Date	Title
ATE510833T1 (de)	2011-06-15	Verfahren zur herstellung von hochreinem almotriptan
PE20080362A1 (es)	2008-04-25	Derivados de ciclohexilpirazol-lactama como inhibidores de 11-beta-hidroxiesteroide deshidrogenasa 1
DK2057126T3 (da)	2011-02-28	Fremgangsmåde til fremstilling af 3-dihalomethyl-pyrazol-4-carboxylsyrederivater
EA200901175A1 (ru)	2010-04-30	Способ получения 2,6-дихлор-4-(трифторметил)фенилгидразина, используя смеси дихлор-фтор-трифторметилбензолов
NO20085417L (no)	2008-12-30	Krystallinske former av 11beta-(4-acetylfenyl)-20,20,21,21,21-pentafluor-17-hydroksy-19-nor-17alfa-pregna-4,9-dien-3-on
EA200701470A1 (ru)	2008-02-28	Способы получения производных 4-(фенокси-5-метилпиримидин-4-илокси)пиперидин-1-карбоновой кислоты и родственных соединений
DE502006002659D1 (de)	2009-03-05	Verfahren zur herstellung von 5-(4-ä4-(5-cyano-3-indolyl)-butylü-1-piperazinyl)-benzofuran-2-carboxamid
UA107336C2 (ru)	2014-12-25	Синтез и солевые формы (r)-5-((e)-2-пирролидин-3-илвинил) пиримидина
WO2009142771A3 (en)	2010-01-14	Salts of (r)-5-(2-phenylsulphonylethenyl)-3-(n- methylpyrrolidin-2-ylmethyl)-1h-indole, 5-bromo-3-[(r)-1- methyl-pyrrolidin-2- ylmethyl]-1h-indole and of eletriptan
DE602005016223D1 (de)	2009-10-08	Neues verfahren zur synthese substituierter alpha-aminoindanderivate
WO2006114676A8 (en)	2007-11-22	A process for the preparation of rupatadine
JP2013500945A5 (de)	2015-12-17
CN102633741A (zh)	2012-08-15	噻唑类化合物在淡水藻杀藻方面的应用
EA200870405A1 (ru)	2009-04-28	Способ получения гетероциклических производных
ES2534506T3 (es)	2015-04-23	Uso de inhibidores de porfobilinógeno deaminasa en el tratamiento de la porfiria eritropoyética congénita
MX2011011547A (es)	2011-11-29	Procedimiento para la preparacion de oxindoles y anilinas orto-sustituidas y su uso como productos intermedios para sintesis.
NZ599218A (en)	2014-02-28	Process for the manufacture of organic compounds
DE602006004403D1 (de)	2009-02-05	Verfahren zur Herstellung von Carvedilol
WO2009072139A8 (en)	2009-10-22	Process for producing 2-[1-methyl-5-(4-methylbenzoyl)- pyrrol-2- yl]acetic acid or salt thereof
WO2006096709A3 (en)	2006-12-21	Process for preparing amorphous salts
WO2010049952A3 (en)	2010-11-18	A novel process for the preparation of eletriptan
ZA200804858B (en)	2010-10-27	Sulfoximine derivatives as p38 map kinase inhibitors
CL2012001528A1 (es)	2012-11-30	Proceso para preparar la forma cristalina a de ilaprazol a partir de una sal inorganica de ilaprazol y posterior neutralizacion de la sal con un acido en un solvente de reaccion; y proceso para preparar la forma cristalina b de ilaprazol en la forma cristalina a de ilaprazol.
EA200701433A1 (ru)	2008-02-28	Получение ирбесартана
Alford et al.	2011	A convenient Fischer indole synthesis of 2, 3′-biindoles

Legal Events

Date	Code	Title	Description
2011-11-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties