NO20085417L - Krystallinske former av 11beta-(4-acetylfenyl)-20,20,21,21,21-pentafluor-17-hydroksy-19-nor-17alfa-pregna-4,9-dien-3-on - Google Patents

Krystallinske former av 11beta-(4-acetylfenyl)-20,20,21,21,21-pentafluor-17-hydroksy-19-nor-17alfa-pregna-4,9-dien-3-on

Info

Publication number
NO20085417L
NO20085417L NO20085417A NO20085417A NO20085417L NO 20085417 L NO20085417 L NO 20085417L NO 20085417 A NO20085417 A NO 20085417A NO 20085417 A NO20085417 A NO 20085417A NO 20085417 L NO20085417 L NO 20085417L
Authority
NO
Norway
Prior art keywords
pregna
pentafluoro
dien
hydroxy
acetylphenyl
Prior art date
Application number
NO20085417A
Other languages
English (en)
Inventor
Gabriele Winter
Wolfgang Beckmann
Edda Kramer
Thomas Ginko
Evelin Amoulong
Arwed Cleve
Original Assignee
Bayer Schering Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Schering Pharma Ag filed Critical Bayer Schering Pharma Ag
Publication of NO20085417L publication Critical patent/NO20085417L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0081—Substituted in position 17 alfa and 17 beta
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/567—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/36—Antigestagens

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Foreliggende oppfinnelse gjelder krystallinske former av lip- (4- acetylfenyl)-20,20,21,21,21-penta- fluor-17-hydroksy-19-nor-17a- pregna-4,9-dien-3-on. Nærmere be- stemt gj elder oppfinnelsen to krystallinske ansolvat/anhydrat- former av denne forbindelsen, de polymorfe formene I og II. Fore- liggende oppfinnelse gjelder imid- lertid også krystallinske solvater, f.eks. metanol- og etanolsolvater av lip-(4-acetylfenyl) - 20,20,21,21,21-pentafluor-17-hydroksy-19-nor-17a-pregna-4, 9-dien-3-on som forløpere for fremstilling av de to polymorfe formene I og II. Fremgangsmåter beskrives for fremstilling av den polymorfe form I ved hjelp av fortrengnings-krystallisering eller ved hj elp av ekstraksjon. Valget av det siste løsemidlet før dannelsen av ansol-vatet kan utføres basert på f or-skjellene i de enkelte solvaters rensningsforhold for lip-(4-acetyl-fenyl)-20,20,21,21,21-pentafluor-17-hydroksy-19-nor-17a-pregna-4,9-dien-3-on. Den polymorfe form I ifølge oppfinnelsen er spesielt egnet for fremstilling av legemidler .
NO20085417A 2006-06-02 2008-12-30 Krystallinske former av 11beta-(4-acetylfenyl)-20,20,21,21,21-pentafluor-17-hydroksy-19-nor-17alfa-pregna-4,9-dien-3-on NO20085417L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US81012706P 2006-06-02 2006-06-02
EP06090095A EP1862468A1 (de) 2006-06-02 2006-06-02 Kristallines 11beta-(4-Acetylphenyl)-20,20,21,21,21-pentafluor-17-hydroxy-19-nor-17alpha-pregna-4,9-dien-3-on
PCT/EP2007/004805 WO2007140917A2 (de) 2006-06-02 2007-05-31 KRISTALLINE FORMEN VON 11 ß-(4-ACETYLPHENYL)-20, 20, 21,21, 21-PENTAFLUOR-17- HYDROXY-19-NOR-17α-PREGNA-4,9-DIEN-3-ON

Publications (1)

Publication Number Publication Date
NO20085417L true NO20085417L (no) 2008-12-30

Family

ID=37562153

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20085417A NO20085417L (no) 2006-06-02 2008-12-30 Krystallinske former av 11beta-(4-acetylfenyl)-20,20,21,21,21-pentafluor-17-hydroksy-19-nor-17alfa-pregna-4,9-dien-3-on

Country Status (15)

Country Link
US (1) US7910573B2 (no)
EP (2) EP1862468A1 (no)
JP (1) JP2009538855A (no)
KR (1) KR20090016008A (no)
AR (1) AR061151A1 (no)
AU (1) AU2007256432A1 (no)
BR (1) BRPI0713093A2 (no)
CA (1) CA2654126A1 (no)
EA (1) EA200802385A1 (no)
EC (1) ECSP088934A (no)
MX (1) MX2008015348A (no)
NO (1) NO20085417L (no)
TN (1) TNSN08499A1 (no)
UY (1) UY30384A1 (no)
WO (1) WO2007140917A2 (no)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102006054535A1 (de) * 2006-11-15 2008-05-21 Bayer Schering Pharma Aktiengesellschaft Progesteronrezeptorantagonisten
US8486926B2 (en) * 2006-11-17 2013-07-16 Harbor Therapeutics, Inc. Steroid tetrol solid state forms
DE102009034366A1 (de) 2009-07-20 2011-01-27 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-methylenoxyalkylenaryl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten
DE102009034362A1 (de) 2009-07-20 2011-01-27 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-aryl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten
DE102009034368A1 (de) 2009-07-20 2011-01-27 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-acyloxyalkylenphenyl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten
DE102009034367A1 (de) 2009-07-20 2011-01-27 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-benzyliden-Derivate, Verfahren zu deren Herstellung und deren Verwendung zur Behandlung von Krankheiten
DE102009034525A1 (de) 2009-07-21 2011-01-27 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-aryl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten
DE102009034526A1 (de) 2009-07-21 2011-02-10 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-ethinylphenyl-Derivate, Verfahren zu deren Herstellung und deren Verwendung zur Behandlung von Krankheiten
DE102010007719A1 (de) 2010-02-10 2011-08-11 Bayer Schering Pharma Aktiengesellschaft, 13353 Progesteronrezeptorantagonisten
DE102010007722A1 (de) 2010-02-10 2011-08-11 Bayer Schering Pharma Aktiengesellschaft, 13353 Progesteronrezeptorantagonisten
US9290293B2 (en) 2013-01-03 2016-03-22 Samuel A. Tilton Storage systems and related methods
WO2019080811A1 (zh) * 2017-10-26 2019-05-02 苏州科睿思制药有限公司 一种选择性孕酮受体调节剂的晶型及其制备方法

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FR2620707B1 (fr) * 1987-09-18 1989-12-08 Roussel Uclaf Nouveaux steroides comportant un cycle spirannique a 3, 4 ou 6 chainons en position 17, leur procede et des intermediaires de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant
US4954490A (en) * 1988-06-23 1990-09-04 Research Triangle Institute 11 β-substituted progesterone analogs
FR2644789B1 (fr) * 1989-03-22 1995-02-03 Roussel Uclaf Nouveaux steroides 19-nor, 3-ceto comportant une chaine en 17 aminosubstituee, leur procede de preparation et les intermediaires de ce procede, leur application comme medicaments et les compositions pharmaceutiques les contenant
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Also Published As

Publication number Publication date
AU2007256432A1 (en) 2007-12-13
JP2009538855A (ja) 2009-11-12
WO2007140917A2 (de) 2007-12-13
UY30384A1 (es) 2008-03-31
AR061151A1 (es) 2008-08-06
US7910573B2 (en) 2011-03-22
BRPI0713093A2 (pt) 2012-10-16
CA2654126A1 (en) 2007-12-13
KR20090016008A (ko) 2009-02-12
WO2007140917A3 (de) 2008-04-10
EA200802385A1 (ru) 2009-06-30
TNSN08499A1 (en) 2010-04-14
EP1862468A1 (de) 2007-12-05
MX2008015348A (es) 2008-12-17
US20080085875A1 (en) 2008-04-10
EP2024383A2 (de) 2009-02-18
ECSP088934A (es) 2009-01-30

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