ATE510917T1 - Desensibilisierte aspartokinase - Google Patents
Desensibilisierte aspartokinaseInfo
- Publication number
- ATE510917T1 ATE510917T1 AT00917314T AT00917314T ATE510917T1 AT E510917 T1 ATE510917 T1 AT E510917T1 AT 00917314 T AT00917314 T AT 00917314T AT 00917314 T AT00917314 T AT 00917314T AT E510917 T1 ATE510917 T1 AT E510917T1
- Authority
- AT
- Austria
- Prior art keywords
- amino acid
- dna
- coryneform bacterium
- aspartokinase
- lysine
- Prior art date
Links
- 108010055400 Aspartate kinase Proteins 0.000 title abstract 3
- 108010064711 Homoserine dehydrogenase Proteins 0.000 title abstract 3
- 108020004414 DNA Proteins 0.000 abstract 4
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 abstract 4
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 abstract 3
- 150000001413 amino acids Chemical group 0.000 abstract 3
- 241000186254 coryneform bacterium Species 0.000 abstract 3
- 235000019766 L-Lysine Nutrition 0.000 abstract 2
- 239000004472 Lysine Substances 0.000 abstract 2
- 108020004511 Recombinant DNA Proteins 0.000 abstract 2
- 241000186216 Corynebacterium Species 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 239000004473 Threonine Substances 0.000 abstract 1
- 229940024606 amino acid Drugs 0.000 abstract 1
- 235000001014 amino acid Nutrition 0.000 abstract 1
- 125000000539 amino acid group Chemical group 0.000 abstract 1
- 210000000349 chromosome Anatomy 0.000 abstract 1
- 230000002153 concerted effect Effects 0.000 abstract 1
- 238000010276 construction Methods 0.000 abstract 1
- 238000012258 culturing Methods 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 244000005700 microbiome Species 0.000 abstract 1
- 239000002773 nucleotide Substances 0.000 abstract 1
- 125000003729 nucleotide group Chemical group 0.000 abstract 1
- 229960002898 threonine Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1217—Phosphotransferases with a carboxyl group as acceptor (2.7.2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Saccharide Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP11043799 | 1999-04-19 | ||
| PCT/JP2000/002456 WO2000063388A1 (en) | 1999-04-19 | 2000-04-14 | Novel desensitized aspartokinase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE510917T1 true ATE510917T1 (de) | 2011-06-15 |
Family
ID=14535714
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00917314T ATE510917T1 (de) | 1999-04-19 | 2000-04-14 | Desensibilisierte aspartokinase |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6893848B1 (de) |
| EP (1) | EP1172437B1 (de) |
| JP (1) | JP4526710B2 (de) |
| KR (1) | KR100671785B1 (de) |
| CN (1) | CN100540668C (de) |
| AT (1) | ATE510917T1 (de) |
| AU (1) | AU3837400A (de) |
| HK (1) | HK1042321B (de) |
| MX (1) | MXPA01010413A (de) |
| WO (1) | WO2000063388A1 (de) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK0841395T3 (da) | 1995-06-07 | 2012-01-09 | Ajinomoto Kk | Fremgangsmåde til at fremstille L-lysin |
| JP4035855B2 (ja) | 1996-06-05 | 2008-01-23 | 味の素株式会社 | Ｌ−リジンの製造法 |
| US6927046B1 (en) | 1999-12-30 | 2005-08-09 | Archer-Daniels-Midland Company | Increased lysine production by gene amplification using coryneform bacteria |
| AR032570A1 (es) | 2001-02-08 | 2003-11-12 | Archer Daniels Midland Co | Construcciones de polinucleotidicas para aumentar la produccion de lisina |
| KR100943834B1 (ko) * | 2001-08-06 | 2010-02-24 | 에보니크 데구사 게엠베하 | Ｌ-리신을 생산하는 코리네형 세균 및 코리네형 세균을 사용하여 l-리신을 생산하는 방법 |
| US7160711B2 (en) | 2001-08-06 | 2007-01-09 | Degussa Ag | Coryneform bacteria which produce chemical compounds I |
| BR0211723A (pt) * | 2001-08-06 | 2004-09-21 | Degussa | Bactérias corineformes que produzem compostos quìmicos i |
| DE10210527A1 (de) | 2002-03-09 | 2003-09-18 | Degussa | Allele des aceA-Gens aus coryneformen Bakterien |
| DE10239073A1 (de) * | 2002-08-26 | 2004-03-11 | Basf Ag | Verfahren zur fermentativen Herstellung schwefelhaltiger Feinchemikalien |
| DE10359661A1 (de) | 2003-12-18 | 2005-07-28 | Basf Ag | Genvarianten die für Proteine aus dem Stoffwechselweg von Feinchemikalien codieren |
| DE102004011248A1 (de) * | 2004-03-09 | 2005-09-22 | Degussa Ag | Verfahren zur Herstellung von L-Aminosäuren unter Verwendung coryneformer Bakterien |
| CN101351551A (zh) * | 2005-11-29 | 2009-01-21 | 协和发酵工业株式会社 | 新型蛋白质和编码该蛋白质的dna |
| ES2382207T3 (es) | 2005-12-27 | 2012-06-06 | Kyowa Hakko Bio Co., Ltd. | Procedimiento para la producción de L-glutamina |
| US20090029425A1 (en) * | 2006-03-09 | 2009-01-29 | Basf Se | Process for the production of beta-lysine |
| BRPI0709628A2 (pt) * | 2006-03-30 | 2011-07-19 | Basf Se | processo para produção de cadaverina, e de uma poliamida, e, microrganismo recombinante |
| EP2386650B1 (de) * | 2006-04-07 | 2013-07-03 | Evonik Degussa GmbH | Verfahren zur Herstellung von L-Lysin unter Verwendung des gap Promotors |
| DE102006032634A1 (de) | 2006-07-13 | 2008-01-17 | Evonik Degussa Gmbh | Verfahren zur Herstellung von L-Aminosäuren |
| EP1881076A1 (de) * | 2006-07-17 | 2008-01-23 | Evonik Degussa GmbH | Verfahren zur Herstellung von L-Aminosäuren |
| JP5064396B2 (ja) | 2006-09-01 | 2012-10-31 | 協和発酵バイオ株式会社 | Ｌ‐グルタミンの製造法 |
| WO2009098046A1 (en) * | 2008-02-04 | 2009-08-13 | Basf Se | Method for the production of dipicolinate |
| DE102008001874A1 (de) | 2008-05-20 | 2009-11-26 | Evonik Degussa Gmbh | Verfahren zur Herstellung von L-Aminosäuren |
| WO2010005099A1 (ja) | 2008-07-09 | 2010-01-14 | 味の素株式会社 | アミノヒドロキシ安息香酸類の製造方法 |
| JP5170012B2 (ja) * | 2009-06-26 | 2013-03-27 | 東レ株式会社 | カダベリン発酵コリネ型細菌を用いたポリアミドの製造方法 |
| WO2011073278A1 (en) | 2009-12-17 | 2011-06-23 | Basf Se | Processes and recombinant microorganisms for the production of cadaverine |
| JP5719434B2 (ja) | 2010-06-15 | 2015-05-20 | パク グアン インダストリアル カンパニー リミテッドＰａｉｋ Ｋｗａｎｇ Ｉｎｄｕｓｔｒｉａｌ Ｃｏ．， Ｌｔｄ． | 微生物を用いたアスパラギン酸系アミノ酸の生産方法 |
| CN103492553B (zh) | 2011-02-22 | 2018-06-12 | 巴斯夫欧洲公司 | 用于生产尸胺的方法和重组微生物 |
| DE102011118019A1 (de) | 2011-06-28 | 2013-01-03 | Evonik Degussa Gmbh | Varianten des Promotors des für die Glyzerinaldehyd-3-phosphat-Dehydrogenase kodierenden gap-Gens |
| JP6183358B2 (ja) | 2012-05-29 | 2017-08-23 | 味の素株式会社 | ３−アセチルアミノ−４−ヒドロキシ安息香酸の製造方法 |
| DE102014208199A1 (de) | 2014-04-30 | 2015-11-05 | Evonik Degussa Gmbh | Verfahren zur Produktion von L-Aminosäuren unter Verwendung eines alkaliphilen Bakteriums |
| EP2940143B1 (de) | 2014-04-30 | 2020-02-05 | Evonik Operations GmbH | Verfahren zur Produktion von L-Aminosäuren unter Verwendung eines alkaliphilen Bakteriums |
| EP2940144A1 (de) | 2014-04-30 | 2015-11-04 | Evonik Degussa GmbH | Verfahren zur Produktion von L-Lysin unter Verwendung eines alkaliphilen Bakteriums |
| EP2940039A1 (de) | 2014-04-30 | 2015-11-04 | Evonik Degussa GmbH | Verfahren zur Produktion von L-Aminosäuren in Corynebakterien unter Verwendung eines Glycin spaltenden Systems |
| EP3456833A1 (de) | 2017-09-18 | 2019-03-20 | Evonik Degussa GmbH | Methode zur fermentativen production von l-aminosäuren |
| EP3467099A1 (de) | 2017-10-05 | 2019-04-10 | Evonik Degussa GmbH | Verfahren zur fermentativen herstellung von l-aminosäuren |
| EP3498853A1 (de) | 2017-12-14 | 2019-06-19 | Evonik Degussa GmbH | Verfahren zur fermentativen herstellung von l-lysin |
| EP3594355A1 (de) | 2018-07-12 | 2020-01-15 | Evonik Operations GmbH | Verfahren zur fermentativen herstellung von l-lysin |
| EP3599282B1 (de) | 2018-07-24 | 2021-03-17 | Evonik Operations GmbH | Verfahren zur fermentativen herstellung von l-lysin |
| RU2019128538A (ru) | 2018-09-26 | 2021-03-11 | Эвоник Оперейшенс ГмбХ | Способ ферментативного получения l-лизина |
| EP3660158A1 (de) | 2018-11-29 | 2020-06-03 | Evonik Operations GmbH | Verfahren zur fermentativen herstellung von l-lysin |
| EP3670525A1 (de) | 2018-12-18 | 2020-06-24 | Evonik Operations GmbH | Verfahren zur fermentativen herstellung von l-lysin unter verwendung von c.-glutamicum-stämmen mit einem mutierten kup-transporter |
| US10829746B2 (en) | 2019-01-23 | 2020-11-10 | Evonik Operations Gmbh | Method for the fermentative production of L-lysine |
| WO2021048353A1 (en) | 2019-09-11 | 2021-03-18 | Evonik Operations Gmbh | Coryneform bacteria with a heterologous threonine transporter and their use in the production of l-threonine |
| US12258600B2 (en) | 2021-09-20 | 2025-03-25 | Evonik Operations Gmbh | Method for the fermentative production of L-lysine using C. glutamicum strains expressing modified gluconate repressor proteins GntR1 and GntR2 |
| CN119212692A (zh) | 2022-05-18 | 2024-12-27 | 赢创运营有限公司 | 比苏卡林、去铁胺及其类似物的单体的生物技术生产 |
| CN119212691A (zh) | 2022-05-18 | 2024-12-27 | 赢创运营有限公司 | 比苏卡林、去铁胺及其类似物的生物技术生产 |
| US20250340893A1 (en) | 2022-05-18 | 2025-11-06 | Evonik Operations Gmbh | Biotechnological production of desferrioxamines and analogs thereof |
| EP4497818A1 (de) | 2023-07-25 | 2025-01-29 | Evonik Operations GmbH | Verfahren zur fermentativen herstellung von l-lysin unter verwendung von c. glutamicum-stämmen zur expression von heterologen nikotinamid-nukleotid-transhydrogenase pntab |
| CN117327677B (zh) * | 2023-09-26 | 2024-09-20 | 江南大学 | 天冬氨酸激酶突变体及其应用 |
| EP4613854A1 (de) | 2024-03-05 | 2025-09-10 | Evonik Operations GmbH | Verfahren zur fermentativen herstellung von l-lysin unter verwendung von c. glutamicum-stämmen die eine heterologe nicotinamid-nukleotid-transhydrogenase pntab exprimieren und eine erhöhte aktivität einer myo-inositol-permease aufweisen |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5610036B1 (de) | 1969-07-23 | 1981-03-05 | ||
| JPS5828292A (ja) | 1981-08-10 | 1983-02-19 | Kyowa Hakko Kogyo Co Ltd | 発酵法によるｌ−リジンの製造法 |
| JPS5886094A (ja) | 1981-11-13 | 1983-05-23 | Kyowa Hakko Kogyo Co Ltd | 発酵法によるｌ−リジンノ製造法 |
| US5236831A (en) | 1981-12-29 | 1993-08-17 | Kiowa Hakko Kogyo Co., Ltd. | Amino acid synthesis in corynebacteria using E. coli genes |
| JPS5988094A (ja) | 1982-11-10 | 1984-05-21 | Kyowa Hakko Kogyo Co Ltd | 発酵法によるｌ−リジンの製造法 |
| JPH0673318B2 (ja) | 1986-09-02 | 1994-09-14 | 理化学研究所 | マイクロ波導入装置 |
| JPH0755155B2 (ja) | 1986-09-10 | 1995-06-14 | 協和醗酵工業株式会社 | アミノ酸の製造法 |
| US5096502A (en) | 1990-12-03 | 1992-03-17 | The Babcock & Wilcox Company | Advanced water lance control system based on peak furnace wall emissivity |
| JPH0511959A (ja) | 1991-07-04 | 1993-01-22 | Matsushita Electric Ind Co Ltd | マルチウインドウ制御装置 |
| JP3473042B2 (ja) | 1992-04-28 | 2003-12-02 | 味の素株式会社 | 変異型アスパルトキナーゼ遺伝子 |
| JPH06261766A (ja) * | 1993-03-16 | 1994-09-20 | Mitsubishi Petrochem Co Ltd | フィードバックインヒビションの解除されたアスパルトキナーゼをコードする遺伝子ｄｎａ及びその利用 |
| JP2580960B2 (ja) | 1993-08-09 | 1997-02-12 | タイガー魔法瓶株式会社 | 電子レンジの湯沸し制御システム |
-
2000
- 2000-04-14 HK HK02104011.5A patent/HK1042321B/en unknown
- 2000-04-14 US US09/958,606 patent/US6893848B1/en not_active Expired - Lifetime
- 2000-04-14 JP JP2000612467A patent/JP4526710B2/ja not_active Expired - Lifetime
- 2000-04-14 MX MXPA01010413A patent/MXPA01010413A/es active IP Right Grant
- 2000-04-14 CN CNB008088357A patent/CN100540668C/zh not_active Expired - Lifetime
- 2000-04-14 EP EP00917314A patent/EP1172437B1/de not_active Expired - Lifetime
- 2000-04-14 AU AU38374/00A patent/AU3837400A/en not_active Abandoned
- 2000-04-14 KR KR1020017013302A patent/KR100671785B1/ko not_active Expired - Lifetime
- 2000-04-14 AT AT00917314T patent/ATE510917T1/de not_active IP Right Cessation
- 2000-04-14 WO PCT/JP2000/002456 patent/WO2000063388A1/ja not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| US6893848B1 (en) | 2005-05-17 |
| EP1172437B1 (de) | 2011-05-25 |
| KR20020006539A (ko) | 2002-01-19 |
| AU3837400A (en) | 2000-11-02 |
| CN1355849A (zh) | 2002-06-26 |
| EP1172437A4 (de) | 2002-08-14 |
| CN100540668C (zh) | 2009-09-16 |
| EP1172437A1 (de) | 2002-01-16 |
| HK1042321B (en) | 2012-02-24 |
| HK1042321A1 (en) | 2002-08-09 |
| WO2000063388A1 (en) | 2000-10-26 |
| KR100671785B1 (ko) | 2007-01-19 |
| JP4526710B2 (ja) | 2010-08-18 |
| MXPA01010413A (es) | 2002-11-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |