ATE510917T1 - Desensibilisierte aspartokinase - Google Patents

Desensibilisierte aspartokinase

Info

Publication number
ATE510917T1
ATE510917T1 AT00917314T AT00917314T ATE510917T1 AT E510917 T1 ATE510917 T1 AT E510917T1 AT 00917314 T AT00917314 T AT 00917314T AT 00917314 T AT00917314 T AT 00917314T AT E510917 T1 ATE510917 T1 AT E510917T1
Authority
AT
Austria
Prior art keywords
amino acid
dna
coryneform bacterium
aspartokinase
lysine
Prior art date
Application number
AT00917314T
Other languages
English (en)
Inventor
Haruhiko Yokoi
Junko Ohnishi
Keiko Ochiai
Yoshiyuki Yonetani
Akio Ozaki
Original Assignee
Kyowa Hakko Bio Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Bio Co Ltd filed Critical Kyowa Hakko Bio Co Ltd
Application granted granted Critical
Publication of ATE510917T1 publication Critical patent/ATE510917T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1217—Phosphotransferases with a carboxyl group as acceptor (2.7.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Saccharide Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
AT00917314T 1999-04-19 2000-04-14 Desensibilisierte aspartokinase ATE510917T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP11043799 1999-04-19
PCT/JP2000/002456 WO2000063388A1 (en) 1999-04-19 2000-04-14 Novel desensitized aspartokinase

Publications (1)

Publication Number Publication Date
ATE510917T1 true ATE510917T1 (de) 2011-06-15

Family

ID=14535714

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00917314T ATE510917T1 (de) 1999-04-19 2000-04-14 Desensibilisierte aspartokinase

Country Status (10)

Country Link
US (1) US6893848B1 (de)
EP (1) EP1172437B1 (de)
JP (1) JP4526710B2 (de)
KR (1) KR100671785B1 (de)
CN (1) CN100540668C (de)
AT (1) ATE510917T1 (de)
AU (1) AU3837400A (de)
HK (1) HK1042321B (de)
MX (1) MXPA01010413A (de)
WO (1) WO2000063388A1 (de)

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DE10359661A1 (de) 2003-12-18 2005-07-28 Basf Ag Genvarianten die für Proteine aus dem Stoffwechselweg von Feinchemikalien codieren
DE102004011248A1 (de) * 2004-03-09 2005-09-22 Degussa Ag Verfahren zur Herstellung von L-Aminosäuren unter Verwendung coryneformer Bakterien
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US8067211B2 (en) 2005-12-27 2011-11-29 Kyowa Hakko Bio Co., Ltd. Method for production of L-glutamine
CN101400799A (zh) * 2006-03-09 2009-04-01 巴斯夫欧洲公司 生产β-赖氨酸的方法
CN102732578B (zh) * 2006-03-30 2016-02-17 巴斯夫欧洲公司 生产尸胺的方法
EP2386650B1 (de) * 2006-04-07 2013-07-03 Evonik Degussa GmbH Verfahren zur Herstellung von L-Lysin unter Verwendung des gap Promotors
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US9169502B2 (en) 2010-06-15 2015-10-27 Paik Kwang Industrial Co., Ltd. Method of producing L-lysine using a Corynebacterium glutamicum microorganism
US9745608B2 (en) 2011-02-22 2017-08-29 Basf Se Processes and recombinant microorganisms for the production of cadaverine
DE102011118019A1 (de) 2011-06-28 2013-01-03 Evonik Degussa Gmbh Varianten des Promotors des für die Glyzerinaldehyd-3-phosphat-Dehydrogenase kodierenden gap-Gens
WO2013179711A1 (ja) 2012-05-29 2013-12-05 味の素株式会社 ３－アセチルアミノ－４－ヒドロキシ安息香酸の製造方法
EP2940144A1 (de) 2014-04-30 2015-11-04 Evonik Degussa GmbH Verfahren zur Produktion von L-Lysin unter Verwendung eines alkaliphilen Bakteriums
EP2940039A1 (de) 2014-04-30 2015-11-04 Evonik Degussa GmbH Verfahren zur Produktion von L-Aminosäuren in Corynebakterien unter Verwendung eines Glycin spaltenden Systems
DE102014208199A1 (de) 2014-04-30 2015-11-05 Evonik Degussa Gmbh Verfahren zur Produktion von L-Aminosäuren unter Verwendung eines alkaliphilen Bakteriums
PL2940143T3 (pl) 2014-04-30 2020-06-29 Evonik Operations Gmbh Sposób wytwarzania L-aminokwasów z użyciem bakterii bazofilowych
EP3456833A1 (de) 2017-09-18 2019-03-20 Evonik Degussa GmbH Methode zur fermentativen production von l-aminosäuren
EP3467099A1 (de) * 2017-10-05 2019-04-10 Evonik Degussa GmbH Verfahren zur fermentativen herstellung von l-aminosäuren
EP3498853A1 (de) 2017-12-14 2019-06-19 Evonik Degussa GmbH Verfahren zur fermentativen herstellung von l-lysin
EP3594355A1 (de) 2018-07-12 2020-01-15 Evonik Operations GmbH Verfahren zur fermentativen herstellung von l-lysin
EP3599282B1 (de) 2018-07-24 2021-03-17 Evonik Operations GmbH Verfahren zur fermentativen herstellung von l-lysin
RU2019128538A (ru) 2018-09-26 2021-03-11 Эвоник Оперейшенс ГмбХ Способ ферментативного получения l-лизина
EP3660158A1 (de) 2018-11-29 2020-06-03 Evonik Operations GmbH Verfahren zur fermentativen herstellung von l-lysin
EP3670525A1 (de) 2018-12-18 2020-06-24 Evonik Operations GmbH Verfahren zur fermentativen herstellung von l-lysin unter verwendung von c.-glutamicum-stämmen mit einem mutierten kup-transporter
US10829746B2 (en) 2019-01-23 2020-11-10 Evonik Operations Gmbh Method for the fermentative production of L-lysine
WO2021048353A1 (en) 2019-09-11 2021-03-18 Evonik Operations Gmbh Coryneform bacteria with a heterologous threonine transporter and their use in the production of l-threonine
WO2023041425A1 (en) 2021-09-20 2023-03-23 Evonik Operations Gmbh Method for the fermentative production of l-lysine using c. glutamicum strains expressing modified gluconate repressor proteins gntr1 and gntr2
EP4526436A1 (de) 2022-05-18 2025-03-26 Evonik Operations GmbH Biotechnologische herstellung von desferrioxaminen und deren analogen
EP4525843A1 (de) 2022-05-18 2025-03-26 Evonik Operations GmbH Biotechnologische herstellung von monomeren von bisucaberinen, desferrioxaminen und analoga davon
EP4525842A1 (de) 2022-05-18 2025-03-26 Evonik Operations GmbH Biotechnologische herstellung von bisucaberinen, desferrioxaminen und deren analogen
EP4497818A1 (de) 2023-07-25 2025-01-29 Evonik Operations GmbH Verfahren zur fermentativen herstellung von l-lysin unter verwendung von c. glutamicum-stämmen zur expression von heterologen nikotinamid-nukleotid-transhydrogenase pntab
CN117327677B (zh) * 2023-09-26 2024-09-20 江南大学 天冬氨酸激酶突变体及其应用
EP4613854A1 (de) 2024-03-05 2025-09-10 Evonik Operations GmbH Verfahren zur fermentativen herstellung von l-lysin unter verwendung von c. glutamicum-stämmen die eine heterologe nicotinamid-nukleotid-transhydrogenase pntab exprimieren und eine erhöhte aktivität einer myo-inositol-permease aufweisen

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Also Published As

Publication number Publication date
EP1172437A1 (de) 2002-01-16
EP1172437B1 (de) 2011-05-25
JP4526710B2 (ja) 2010-08-18
CN100540668C (zh) 2009-09-16
KR20020006539A (ko) 2002-01-19
HK1042321A1 (en) 2002-08-09
AU3837400A (en) 2000-11-02
KR100671785B1 (ko) 2007-01-19
CN1355849A (zh) 2002-06-26
HK1042321B (en) 2012-02-24
MXPA01010413A (es) 2002-11-29
EP1172437A4 (de) 2002-08-14
WO2000063388A1 (en) 2000-10-26
US6893848B1 (en) 2005-05-17

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