ATE511503T1 - Aryl- und heteroarylharnstoff-chk1-inhibitoren zur verwendung als radiosensibilisatoren und chemosensibilisatoren - Google Patents

Aryl- und heteroarylharnstoff-chk1-inhibitoren zur verwendung als radiosensibilisatoren und chemosensibilisatoren

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Publication number
ATE511503T1
ATE511503T1 AT02728396T AT02728396T ATE511503T1 AT E511503 T1 ATE511503 T1 AT E511503T1 AT 02728396 T AT02728396 T AT 02728396T AT 02728396 T AT02728396 T AT 02728396T AT E511503 T1 ATE511503 T1 AT E511503T1
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Austria
Prior art keywords
aryl
chemosensitizers
radiosensitizers
chk1 inhibitors
heteroaryl
Prior art date
Application number
AT02728396T
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English (en)
Inventor
Kathleen Keegan
Edward Kesicki
John Gaudino
Adam Wade Cook
Scott Cowen
Laurence Burgess
Original Assignee
Icos Corp
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Publication date
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Publication of ATE511503T1 publication Critical patent/ATE511503T1/de

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    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
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    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
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AT02728396T 2001-03-02 2002-03-01 Aryl- und heteroarylharnstoff-chk1-inhibitoren zur verwendung als radiosensibilisatoren und chemosensibilisatoren ATE511503T1 (de)

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EA014954B1 (ru) 2011-04-29
CY1111590T1 (el) 2015-10-07
PL364564A1 (en) 2004-12-13
SI1379510T1 (sl) 2011-10-28
PL212707B1 (pl) 2012-11-30
RS52077B (sr) 2012-06-30
CA2439709A1 (en) 2002-09-12
EP1379510A1 (de) 2004-01-14
CN100374425C (zh) 2008-03-12
PT1379510E (pt) 2011-07-15
DK1379510T3 (da) 2011-08-29
US7608618B2 (en) 2009-10-27
CA2439709C (en) 2011-05-03
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UA76977C2 (en) 2006-10-16
CN1507436A (zh) 2004-06-23
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NO20033858L (no) 2003-10-10
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KR20080046228A (ko) 2008-05-26
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