ATE511846T1 - Derivate von teildesulfatierten glycosaminoglycanen als inhibitoren von heparanase, mit antiangiogener wirkung und ohne antikoagulatorische wirkung - Google Patents

Derivate von teildesulfatierten glycosaminoglycanen als inhibitoren von heparanase, mit antiangiogener wirkung und ohne antikoagulatorische wirkung

Info

Publication number: ATE511846T1
Authority: AT; Austria
Prior art keywords: effect; heparanase; inhibitors; derivatives; anticoagulative
Prior art date: 2001-09-12

Application number

AT01972468T

Other languages

English (en)

Inventor

B Casu

G Torri

A Naggi

Giuseppe Giannini

Claudio Pisano

Sergio Penco

Original Assignee

Sigma Tau Res Switzerland Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-09-12

Filing date

2001-09-12

Publication date

2011-06-15

2001-09-12 Application filed by Sigma Tau Res Switzerland Sa filed Critical Sigma Tau Res Switzerland Sa

2011-06-15 Application granted granted Critical

2011-06-15 Publication of ATE511846T1 publication Critical patent/ATE511846T1/de

Links

230000001772 anti-angiogenic effect Effects 0.000 title abstract 2
229920002683 Glycosaminoglycan Polymers 0.000 title 1
102100024025 Heparanase Human genes 0.000 title 1
230000002429 anti-coagulating effect Effects 0.000 title 1
108010037536 heparanase Proteins 0.000 title 1
239000003112 inhibitor Substances 0.000 title 1
HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical class OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 abstract 1
239000002628 heparin derivative Substances 0.000 abstract 1
230000014508 negative regulation of coagulation Effects 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/727—Heparin; Heparan
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
- C08B37/0078—Degradation products

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Molecular Biology (AREA)
Diabetes (AREA)
Immunology (AREA)
Biochemistry (AREA)
Polymers & Plastics (AREA)
Materials Engineering (AREA)
Dermatology (AREA)
Cardiology (AREA)
Epidemiology (AREA)
Hematology (AREA)
Obesity (AREA)
Pulmonology (AREA)
Rheumatology (AREA)
Heart & Thoracic Surgery (AREA)
Pain & Pain Management (AREA)
Transplantation (AREA)
Ophthalmology & Optometry (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Oncology (AREA)
Urology & Nephrology (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Neurosurgery (AREA)
Orthopedic Medicine & Surgery (AREA)

AT01972468T 2001-09-12 2001-09-12 Derivate von teildesulfatierten glycosaminoglycanen als inhibitoren von heparanase, mit antiangiogener wirkung und ohne antikoagulatorische wirkung ATE511846T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
PCT/IT2001/000472 WO2003022291A1 (en)	2001-09-12	2001-09-12	Derivatives of partially desulphated glycosaminoglycans as heparanase inhibitors, endowed with antiangiogenic activity and devoid of anticoagulating effect

Publications (1)

Publication Number	Publication Date
ATE511846T1 true ATE511846T1 (de)	2011-06-15

Family

ID=11133723

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT01972468T ATE511846T1 (de)	2001-09-12	2001-09-12	Derivate von teildesulfatierten glycosaminoglycanen als inhibitoren von heparanase, mit antiangiogener wirkung und ohne antikoagulatorische wirkung

Country Status (19)

Country	Link
US (1)	US20050137167A1 (de)
EP (2)	EP1427427B1 (de)
JP (1)	JP2005506326A (de)
KR (1)	KR100855331B1 (de)
CN (1)	CN1547477B (de)
AT (1)	ATE511846T1 (de)
AU (1)	AU2001292231B2 (de)
BR (1)	BR0117124A (de)
CA (1)	CA2457719C (de)
CY (2)	CY1112551T1 (de)
CZ (1)	CZ307433B6 (de)
DK (1)	DK1427427T3 (de)
ES (2)	ES2367778T3 (de)
HU (1)	HU230385B1 (de)
MX (1)	MXPA04002217A (de)
PT (2)	PT1427427E (de)
SI (1)	SI1427427T1 (de)
SK (1)	SK288335B6 (de)
WO (1)	WO2003022291A1 (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20060293275A1 (en) *	2004-03-29	2006-12-28	Toshikazu Nakamura	Hgf production accelerator containing heparin-like oligosaccharide
JP5404406B2 (ja) *	2006-10-20	2014-01-29	ジオーストラリアンナショナルユニバーシティ	細胞外マトリクスの分解の阻害
WO2009007224A1 (en) *	2007-07-10	2009-01-15	Sigma-Tau Industrie Farmaceutiche Riunite S.P.A.	Low molecular weight heparin derivatives having neuroprotective activity
EP2205642B1 (de)	2007-11-02	2016-01-27	Momenta Pharmaceuticals, Inc.	Nicht gerinnungshemmende polysaccharidzusammensetzungen
US8592393B2 (en)	2007-11-02	2013-11-26	Momenta Pharmaceuticals, Inc.	Polysaccharide compositions and methods of use for the treatment and prevention of disorders associated with progenitor cell mobilization
US8569262B2 (en)	2007-11-02	2013-10-29	Momenta Pharmaceuticals, Inc.	Polysaccharide compositions and methods of use for the treatment and prevention of disorders associated with progenitor cell mobilization
FI20085308A0 (fi) *	2008-04-11	2008-04-11	Polysackaridforskning I Uppsal	Heparanaasittomia ihmiskuntaan kuulumattomia nisäkkäitä
FR2949115B1 (fr) *	2009-08-14	2012-11-02	Sanofi Aventis	OLIGOSACCHARIDES N-SULFATES ACTIVATEURS DES RECEPTEURS DES FGFs, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
WO2011109877A1 (en) *	2010-03-12	2011-09-15	The Australian National University	Heparan sulfate replacement therapy
BR112012026542A2 (pt)	2010-04-16	2016-07-12	Momenta Pharmaceuticals Inc	abordagem seletiva de tecido
AU2011268470B2 (en)	2010-06-17	2017-02-02	Momenta Pharmaceuticals, Inc.	Methods and compositions for promoting hair growth
FR2970969B1 (fr) *	2011-01-27	2013-10-18	Sanofi Aventis	Oligosaccharides 3-o-alkyles activateurs des recepteurs des fgfs, leur preparation et leur application en therapeutique
KR101522604B1 (ko) *	2013-03-21	2015-05-26	대한민국	곤충 글라이코자미노글라이칸 유래 헤파린 단편 및 이의 제조 방법
SG11201509430WA (en) *	2013-05-16	2015-12-30	Agency Science Tech & Res	Heparan sulphates
US10016449B2 (en)	2013-05-28	2018-07-10	Momenta Pharmaceuticals, Inc.	Pharmaceutical compositions
ITLO20130005A1 (it) *	2013-10-31	2015-05-01	He E Biochimiche G Ronzonr S R	Derivati di glucosamminoglicani n-desolfatati e loro uso come farmaci
ITLO20130006A1 (it) *	2013-11-06	2015-05-07	He E Biochimiche G Ronzoni S R	Derivati carbossilati di glucosamminoglicani e loro uso come farmaci
US10576101B2 (en)	2015-03-06	2020-03-03	Leadiant Biosciences Sa	Roneparstat combined therapy of multiple myeloma
US11787783B2 (en)	2016-12-13	2023-10-17	Beta Therapeutics Pty Ltd	Heparanase inhibitors and use thereof
MX2019006863A (es)	2016-12-13	2019-09-13	Beta Therapeutics Pty Ltd	Inhibidores de heparanasa y uso de los mismos.
CN108424474B (zh) *	2017-02-15	2023-07-25	清华大学	去抗凝肝素衍生物及其用于炎症性肠病的治疗
US11186603B2 (en) *	2017-03-23	2021-11-30	Victoria Link Limited	Heparan sulfate glycomimetic compounds and their pharmaceutical and cosmeceutical uses
EP3388439A1 (de)	2017-04-11	2018-10-17	Leadiant Biosciences SA	Biotinkonjugiertes n-acetylglycolgeteiltes heparin
US11225531B2 (en) *	2018-02-02	2022-01-18	Shenzhen Hepalink Pharmaceutical Group Co., Ltd.	Glycosaminoglycan derivative and preparation method therefor and use thereof
EP3705126A1 (de)	2019-03-05	2020-09-09	Leadiant Biosciences S.p.A.	Roneparstat zur behandlung von amyloidose
CN114901702B (zh) *	2019-12-27	2024-01-09	深圳市海普瑞药业集团股份有限公司	一种糖胺聚糖衍生物及其应用
WO2022003112A1 (en) *	2020-07-02	2022-01-06	Institut Francais De Recherche Pour L'exploitation De La Mer (Ifremer)	Marine bacterial exopolysaccharide derivatives and uses thereof in the treatment of mucopolysaccharidoses

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS62265998A (ja) *	1986-03-10	1987-11-18	ボ−ド　オブ　リ−ジエンツ　ザ　ユニヴア−シテイ　オブ　テキサス　システム	ヘパラン硫酸エンドグリコシダーゼアッセイ
US5262403A (en) *	1986-03-10	1993-11-16	Board Of Regents, The University Of Texas System	Glycosaminoglycan derivatives and their use as inhibitors of tumor invasiveness of metastatic profusion-II
IE61758B1 (en)	1986-05-23	1994-11-30	Daiichi Seiyaku Co	Use of a sulfated polysaccharide
IL79255A0 (en) *	1986-06-26	1986-09-30	Hadassah Med Org	Composition for metastasis prevention
IL79254A0 (en)	1986-06-26	1986-09-30	Hadassah Med Org	Compositions for preventing graft rejection
WO1988001280A1 (en) *	1986-08-21	1988-02-25	Board Of Regents, The University Of Texas System	Glycosaminoglycan derivatives and their use as inhibitors of tumor invasiveness or metastatic profusion
IL85145A (en)	1987-01-23	1994-08-26	Univ Australian	Anti-metastatic pharmacological or veterinary preparations containing modified herpin with reduced anticoagulant activity
FR2614026B1 (fr) *	1987-04-16	1992-04-17	Sanofi Sa	Heparines de bas poids moleculaire, a structure reguliere, leur preparation et leurs applications biologiques
PT93847A (pt)	1989-04-24	1990-11-20	Harvard College	Processo para a preparacao de oligossacaridos de baixo peso molecular derivados de heparina ou de sulfato de heparano despolimerizados e de composicoes farmaceuticas que os contem
US5474765A (en)	1992-03-23	1995-12-12	Ut Sw Medical Ctr At Dallas	Preparation and use of steroid-polyanionic polymer-based conjugates targeted to vascular endothelial cells
ZA936925B (en)	1992-09-25	1995-03-20	Lilly Co Eli	Modified platelet factor-4.
US5696100A (en) *	1992-12-22	1997-12-09	Glycomed Incorporated	Method for controlling O-desulfation of heparin and compositions produced thereby
US5296471A (en)	1992-12-22	1994-03-22	Glycomed Incorporated	Method for controlling o-desulfation of heparin and compositions produced thereby
US5399667A (en)	1993-03-05	1995-03-21	Washington University	Thrombospondin receptor binding peptides
IT1264101B1 (it)	1993-03-29	1996-09-10	Alfa Wassermann Spa	Processo per la sintesi di glicosaminoglicani semisintetici a struttura eparinica od eparanica modificati nella posizione 2
IT1264709B1 (it) *	1993-07-12	1996-10-04	Italfarmaco Spa	Derivati eparinici ad attivita' antimetastatica
WO1995005182A1 (en)	1993-08-13	1995-02-23	Glycomed Incorporated	Bridged oligosaccharides and sulfated derivatives thereof
CA2171465A1 (en)	1993-10-07	1995-04-13	Peter Fugedi	Highly sulfated maltooligosaccharides with heparin-like properties
US5739115A (en)	1993-10-07	1998-04-14	Glycomed Incorporated	Sulfated maltooligosaccharides with heparin-like properties
AU2435795A (en)	1994-05-06	1995-11-29	Glycomed Incorporated	O-desulfated heparin derivatives, methods of making and uses thereof
AUPN261895A0 (en)	1995-04-28	1995-05-18	Australian National University, The	Preparation and use of sulfated oligosaccharides
JP4051099B2 (ja) *	1997-01-31	2008-02-20	生化学工業株式会社	低分子化ヘパリン、その製造法及び医薬組成物
DE19955803A1 (de)	1999-11-19	2001-05-23	Knoll Ag	Verwendung von Heparanase-Inhibitoren zur Behandlung von Hersinsuffizienz
IT1316986B1 (it)	2000-01-25	2003-05-26	Sigma Tau Ind Farmaceuti	Derivati glicosamminoglicani parzialmente desolfatati nonanticoagulanti ad attivita' antiangiogenica.
AU3078800A (en) *	2000-01-25	2001-08-07	Nippon Eisei Center Co., Ltd.	Earthquake-proofing reinforcing metal fitting

2001
- 2001-09-12 US US10/489,359 patent/US20050137167A1/en not_active Abandoned
- 2001-09-12 JP JP2003526419A patent/JP2005506326A/ja active Pending
- 2001-09-12 DK DK01972468.1T patent/DK1427427T3/da active
- 2001-09-12 HU HU0401693A patent/HU230385B1/hu not_active IP Right Cessation
- 2001-09-12 SK SK160-2004A patent/SK288335B6/sk not_active IP Right Cessation
- 2001-09-12 CA CA2457719A patent/CA2457719C/en not_active Expired - Fee Related
- 2001-09-12 CN CN018236324A patent/CN1547477B/zh not_active Expired - Fee Related
- 2001-09-12 PT PT01972468T patent/PT1427427E/pt unknown
- 2001-09-12 BR BR0117124-0A patent/BR0117124A/pt active Search and Examination
- 2001-09-12 AU AU2001292231A patent/AU2001292231B2/en not_active Ceased
- 2001-09-12 EP EP01972468A patent/EP1427427B1/de not_active Expired - Lifetime
- 2001-09-12 CZ CZ2004-255A patent/CZ307433B6/cs not_active IP Right Cessation
- 2001-09-12 ES ES01972468T patent/ES2367778T3/es not_active Expired - Lifetime
- 2001-09-12 WO PCT/IT2001/000472 patent/WO2003022291A1/en not_active Ceased
- 2001-09-12 ES ES10183832T patent/ES2431362T3/es not_active Expired - Lifetime
- 2001-09-12 AT AT01972468T patent/ATE511846T1/de active
- 2001-09-12 EP EP10183832.4A patent/EP2343077B1/de not_active Expired - Lifetime
- 2001-09-12 KR KR1020047003203A patent/KR100855331B1/ko not_active Expired - Fee Related
- 2001-09-12 PT PT101838324T patent/PT2343077E/pt unknown
- 2001-09-12 SI SI200130998T patent/SI1427427T1/sl unknown
- 2001-09-12 MX MXPA04002217A patent/MXPA04002217A/es active IP Right Grant
2011
- 2011-08-29 CY CY20111100823T patent/CY1112551T1/el unknown
2013
- 2013-08-09 CY CY20131100685T patent/CY1114544T1/el unknown

Also Published As

Publication number	Publication date
CA2457719A1 (en)	2003-03-20
US20050137167A1 (en)	2005-06-23
CY1114544T1 (el)	2016-10-05
EP1427427B1 (de)	2011-06-08
HUP0401693A3 (en)	2009-06-29
PT2343077E (pt)	2013-08-29
BR0117124A (pt)	2004-09-28
DK1427427T3 (da)	2011-09-19
MXPA04002217A (es)	2004-07-08
AU2001292231B2 (en)	2008-06-05
HUP0401693A2 (hu)	2004-12-28
HU230385B1 (hu)	2016-03-29
ES2431362T3 (es)	2013-11-26
EP2343077B1 (de)	2013-07-17
CZ307433B6 (cs)	2018-08-22
SK288335B6 (sk)	2016-02-02
PT1427427E (pt)	2011-09-13
ES2367778T3 (es)	2011-11-08
CZ2004255A3 (cs)	2004-11-10
CY1112551T1 (el)	2016-02-10
CN1547477A (zh)	2004-11-17
KR100855331B1 (ko)	2008-09-04
SI1427427T1 (sl)	2011-10-28
JP2005506326A (ja)	2005-03-03
WO2003022291A1 (en)	2003-03-20
KR20040048404A (ko)	2004-06-09
EP2343077A1 (de)	2011-07-13
CN1547477B (zh)	2010-12-22
HK1069537A1 (en)	2005-05-27
CA2457719C (en)	2012-01-03
EP1427427A1 (de)	2004-06-16
SK1602004A3 (en)	2004-08-03

Legal Events

Date

Code

Title

Description

2012-03-15

UEP

Publication of translation of european patent specification

Ref document number: 1427427

Country of ref document: EP

Publication	Publication Date	Title
DK1427427T3 (da)	2011-09-19	Derivater af delvist desulfaterede glucosaminoglykaner som heparanasehæmmere med antiangiogen virkning og uden antikoaguleringsvirkning
ATE348115T1 (de)	2007-01-15	Teildesulfatierte glykosaminoglykanderivate mit antiangiogenischer aktivität und ohne antikoagulierender wirkung
DE69933020D1 (de)	2006-10-12	Nitroxyl derivate mit glycidyl oder alkylcarbonyl gruppen als initiatoren für radikal polymerisationen
ATE376835T1 (de)	2007-11-15	Verwendung von fucanen in der behandlung von adhäsion, arthritis und psoriasis
ATE344799T1 (de)	2006-11-15	Piperidinderivate als antibakterielle mittel
IS7337A (is)	2004-06-28	Nikótínamíð afleiður nytsamlegar sem P38 hindrar
ATE438637T1 (de)	2009-08-15	Thiophenderivate als antivirale mittel gegen flavivirus-infektion
ATE374026T1 (de)	2007-10-15	Rho-kinase-inhibitoren für die vorbeugung oder behandlung von interstitieller pneumonie und pulmonaler fibrose
DE60027769D1 (de)	2006-06-08	Pyrrolidin-derivate als inhibitoren von cyclischer amp-phosphodiesterase
NO20051082L (no)	2005-04-29	Antimikrobielle kinoloner, deres sammensetninger og anvendelser
ATE355278T1 (de)	2006-03-15	Isochinolinon derivate als parp inhibitoren
DE60215494D1 (de)	2006-11-30	Bicyclische, stickstoffhaltige heterocyclische derivate zur verwendung als antibakterielle mittel
BR9610385A (pt)	1999-07-06	Novas 4-(oxalcoxifenil)-3-óxi-piperidinas para tratamento de insuficiência cardiáca e renal
ATE348826T1 (de)	2007-01-15	Aminopiperidin chinoline und ihre azaisosteren analoga mit antibakterieller wirkung
ATE414514T1 (de)	2008-12-15	Kombinationen, ein antidiarrhoikum und epothilon oder ein epothilonderivat enthaltend
EA200300836A1 (ru)	2004-02-26	Производные фталазинон-пиперидина в качестве ингибиторов pde4
DE60206171D1 (de)	2005-10-20	Kaliumkanal-modulierende imidazolderivate
NO20043952L (no)	2004-10-22	Benzofuran- og benzotiofenderivater som er nyttige ved behandling av hyperproliferative forstyrrelser
CY1106409T1 (el)	2011-10-12	Παραγωγα κινολινης
ATE308325T1 (de)	2005-11-15	Triaryl-oxy-aryloxy-pyrimidine-2,4,6-trion derivate als metalloproteinase inhibitoren
ATE549024T1 (de)	2012-03-15	Chinazolin-kaliumkanalhemmer
EA200400464A1 (ru)	2005-02-24	Способы и композиции новых триазиновых соединений
EA200601176A1 (ru)	2006-10-27	3-цианохинолиновые производные с антипролиферативной активностью
ATE476419T1 (de)	2010-08-15	Isochinolinon-kaliumkanalinhibitoren
BR0316763A (pt)	2005-10-25	Compostos de sais sulfÈnicos eficazes em fotoiniciadores catiÈnicos multifuncionais, composição e processo