ATE511850T1 - Behandlung von blasenfibrose mit antikörpern gegen alpha-v-beta-6-integrin - Google Patents

Behandlung von blasenfibrose mit antikörpern gegen alpha-v-beta-6-integrin

Info

Publication number
ATE511850T1
ATE511850T1 AT08004714T AT08004714T ATE511850T1 AT E511850 T1 ATE511850 T1 AT E511850T1 AT 08004714 T AT08004714 T AT 08004714T AT 08004714 T AT08004714 T AT 08004714T AT E511850 T1 ATE511850 T1 AT E511850T1
Authority
AT
Austria
Prior art keywords
integrin
antibodies
beta
alpha
treatment
Prior art date
Application number
AT08004714T
Other languages
English (en)
Inventor
Xiaozhu Huang
Dean Sheppard
Robert Pytela
Original Assignee
Univ California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ California filed Critical Univ California
Application granted granted Critical
Publication of ATE511850T1 publication Critical patent/ATE511850T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2839—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70546—Integrin superfamily
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Urology & Nephrology (AREA)
  • Toxicology (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT08004714T 1997-08-08 1998-08-07 Behandlung von blasenfibrose mit antikörpern gegen alpha-v-beta-6-integrin ATE511850T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US5506097P 1997-08-08 1997-08-08

Publications (1)

Publication Number Publication Date
ATE511850T1 true ATE511850T1 (de) 2011-06-15

Family

ID=21995323

Family Applications (3)

Application Number Title Priority Date Filing Date
AT08004714T ATE511850T1 (de) 1997-08-08 1998-08-07 Behandlung von blasenfibrose mit antikörpern gegen alpha-v-beta-6-integrin
AT04022921T ATE410179T1 (de) 1997-08-08 1998-08-07 Behandlung von leberfibrose mit anti-alpha v beta 6 integrin antikörpern
AT98939278T ATE286742T1 (de) 1997-08-08 1998-08-07 Behandlung von nierenfibrose durch antikörper gegen integrin alpha-v-beta 6

Family Applications After (2)

Application Number Title Priority Date Filing Date
AT04022921T ATE410179T1 (de) 1997-08-08 1998-08-07 Behandlung von leberfibrose mit anti-alpha v beta 6 integrin antikörpern
AT98939278T ATE286742T1 (de) 1997-08-08 1998-08-07 Behandlung von nierenfibrose durch antikörper gegen integrin alpha-v-beta 6

Country Status (23)

Country Link
US (5) US20020004482A1 (de)
EP (3) EP0996460B1 (de)
JP (2) JP2001513333A (de)
KR (1) KR100586202B1 (de)
CN (1) CN1267224A (de)
AT (3) ATE511850T1 (de)
AU (1) AU739283B2 (de)
BR (1) BR9814040A (de)
CA (1) CA2297736A1 (de)
CY (2) CY1110462T1 (de)
CZ (1) CZ299768B6 (de)
DE (2) DE69828614T2 (de)
DK (2) DK1930022T3 (de)
EE (1) EE04752B1 (de)
ES (3) ES2364703T3 (de)
HU (1) HU228900B1 (de)
IL (2) IL134288A0 (de)
NZ (2) NZ515955A (de)
PL (2) PL201716B1 (de)
PT (3) PT1930022E (de)
RU (1) RU2221589C2 (de)
TR (2) TR200202323T2 (de)
WO (1) WO1999007405A1 (de)

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EE04752B1 (et) * 1997-08-08 2006-12-15 The Regents Of The University Of California Monoklonaalne antikeha, seda tootev hübridoom ja antikeha kasutamine
CN1332714C (zh) * 1999-04-22 2007-08-22 比奥根艾迪克Ma公司 整联蛋白α4亚单位的拮抗剂在制备治疗纤维变性的药物组合物中的用途
DE19929410A1 (de) * 1999-06-26 2000-12-28 Merck Patent Gmbh Inhibitoren des Integrins avß6
US20030114410A1 (en) 2000-08-08 2003-06-19 Technion Research And Development Foundation Ltd. Pharmaceutical compositions and methods useful for modulating angiogenesis and inhibiting metastasis and tumor fibrosis
AUPR230500A0 (en) * 2000-12-22 2001-01-25 University Of Newcastle Research Associates Limited, The A method of modulating map kinase mediated cellular activity and agents useful in same
US7320790B2 (en) * 2001-04-30 2008-01-22 Eli Lilly And Company Humanized antibodies
CN1646160A (zh) 2002-03-13 2005-07-27 拜奥根Idec马萨诸塞公司 抗αvβ6抗体
US20040048312A1 (en) * 2002-04-12 2004-03-11 Ronghao Li Antibodies that bind to integrin alpha-v-beta-6 and methods of use thereof
ES2671522T3 (es) 2004-04-02 2018-06-06 The Regents Of The University Of California Métodos y composiciones para tratar y prevenir una enfermedad asociada con la integrina alfa V beta 5
CN102875681A (zh) 2005-07-08 2013-01-16 拜奥根Idec马萨诸塞公司 抗-αvβ6抗体及其用途
US8795668B2 (en) * 2005-12-23 2014-08-05 The Regents Of The University Of Michigan Methods for treating pulmonary fibrosis
CN101563105B (zh) 2006-07-10 2013-01-23 拜奥根Idec马萨诸塞公司 用于抑制smad4-缺陷癌症的组合物和方法
TW200815474A (en) * 2006-08-03 2008-04-01 Astrazeneca Ab Antibodies alphaVbeta6 and uses thereof
JP2010506944A (ja) * 2006-10-19 2010-03-04 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア インテグリンαＶβ６のアンタゴニストを用いる慢性喘息の処置および予防
CA2693310C (en) * 2007-08-02 2018-11-27 Arresto Biosciences, Inc. Lox and loxl2 inhibitors, antibodies and uses thereof
KR101046317B1 (ko) * 2008-07-04 2011-07-05 이종대 조력발전 방법 및 그 장치
WO2010080769A2 (en) 2009-01-06 2010-07-15 Arresto Biosciences, Inc. Chemotherapeutic methods and compositions
CA2767409C (en) 2009-07-24 2018-10-30 The Regents Of The University Of California Methods and compositions for treating and preventing disease associated with .alpha.v.beta.5 integrin
EP2467396A4 (de) 2009-08-21 2012-12-26 Gilead Biologics Inc Katalytische domänen aus lysyl-oxidase und loxl2
AU2010283997B2 (en) * 2009-08-21 2015-04-09 Gilead Biologics, Inc. Methods and compositions for treatment of pulmonary fibrotic disorders
US8680246B2 (en) * 2010-02-04 2014-03-25 Gilead Biologics, Inc. Antibodies that bind to lysyl oxidase-like 2 (LOXL2)
CN104220094A (zh) 2012-02-17 2014-12-17 西雅图基因公司 针对整联蛋白αvβ6的抗体和使用该抗体治疗癌症
US10035859B2 (en) 2013-03-15 2018-07-31 Biogen Ma Inc. Anti-alpha V beta 6 antibodies and uses thereof
WO2014143739A2 (en) 2013-03-15 2014-09-18 Biogen Idec Ma Inc. Anti-alpha v beta 6 antibodies and uses thereof
EP2784511A1 (de) 2013-03-27 2014-10-01 Universität Zürich Integrin-alpha-v-beta 6 zur Diagnose/Prognose von Kolorektalkarzinomen
JP6104312B2 (ja) * 2014-06-19 2017-03-29 日東電工株式会社 組織再生促進剤
US20190144547A1 (en) * 2015-11-23 2019-05-16 Merck Patent Gmbh Anti-alpha-v integrin antibody for the treatment of fibrosis and/or fibrotic disorders
KR20200044066A (ko) 2017-08-22 2020-04-28 바이오젠 엠에이 인코포레이티드 항-알파(v)베타(6) 항체를 함유하는 약제학적 조성물 및 투약 요법
KR20220110231A (ko) 2019-12-05 2022-08-05 씨젠 인크. 항-αvβ6 항체 및 항체-약물 접합체
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Also Published As

Publication number Publication date
DK1930022T3 (da) 2011-07-25
JP2001513333A (ja) 2001-09-04
NZ502546A (en) 2002-02-01
US7544358B2 (en) 2009-06-09
US20020004482A1 (en) 2002-01-10
ATE410179T1 (de) 2008-10-15
EE200000068A (et) 2000-10-16
EP0996460A1 (de) 2000-05-03
IL134288A0 (en) 2001-04-30
PT1504764E (pt) 2009-01-14
US7150871B2 (en) 2006-12-19
ES2235350T3 (es) 2005-07-01
BR9814040A (pt) 2000-10-03
US20040208878A1 (en) 2004-10-21
DE69840113D1 (de) 2008-11-20
RU2221589C2 (ru) 2004-01-20
CY1111792T1 (el) 2015-10-07
NZ515955A (en) 2003-04-29
AU739283B2 (en) 2001-10-11
DK1504764T3 (da) 2008-11-17
HUP0003547A3 (en) 2002-05-28
US6316601B1 (en) 2001-11-13
ATE286742T1 (de) 2005-01-15
CA2297736A1 (en) 1999-02-18
ES2311131T3 (es) 2009-02-01
EP1504764B1 (de) 2008-10-08
US20010056076A1 (en) 2001-12-27
EP0996460B1 (de) 2005-01-12
CZ2000413A3 (cs) 2000-11-15
PT1930022E (pt) 2011-08-01
PL199014B1 (pl) 2008-08-29
HUP0003547A2 (hu) 2001-02-28
HU228900B1 (en) 2013-06-28
EE04752B1 (et) 2006-12-15
ES2364703T3 (es) 2011-09-12
US20070148173A1 (en) 2007-06-28
EP1930022A1 (de) 2008-06-11
KR20010022740A (ko) 2001-03-26
PL201716B1 (pl) 2009-05-29
DE69828614T2 (de) 2006-02-09
CY1110462T1 (el) 2015-04-29
DE69828614D1 (de) 2005-02-17
JP2009001587A (ja) 2009-01-08
AU8774398A (en) 1999-03-01
PT996460E (pt) 2005-04-29
EP0996460A4 (de) 2001-03-07
EP1930022B1 (de) 2011-06-08
WO1999007405A1 (en) 1999-02-18
CN1267224A (zh) 2000-09-20
PL341029A1 (en) 2001-03-26
TR200000374T2 (tr) 2000-09-21
EP1504764A1 (de) 2005-02-09
KR100586202B1 (ko) 2006-06-07
IL134288A (en) 2008-07-08
CZ299768B6 (cs) 2008-11-19
TR200202323T2 (tr) 2002-12-23
US6692741B2 (en) 2004-02-17

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