ATE512135T1 - Spiroindolinonderivate - Google Patents

Spiroindolinonderivate

Info

Publication number
ATE512135T1
ATE512135T1 AT07822025T AT07822025T ATE512135T1 AT E512135 T1 ATE512135 T1 AT E512135T1 AT 07822025 T AT07822025 T AT 07822025T AT 07822025 T AT07822025 T AT 07822025T AT E512135 T1 ATE512135 T1 AT E512135T1
Authority
AT
Austria
Prior art keywords
spiroindolinone derivatives
spiroindolinone
derivatives
Prior art date
Application number
AT07822025T
Other languages
English (en)
Inventor
Jin-Jun Liu
Zhuming Zhang
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38942414&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE512135(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of ATE512135T1 publication Critical patent/ATE512135T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/54—Spiro-condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT07822025T 2006-11-09 2007-10-30 Spiroindolinonderivate ATE512135T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US85803906P 2006-11-09 2006-11-09
PCT/EP2007/061671 WO2008055812A1 (en) 2006-11-09 2007-10-30 Spiroindolinone derivatives

Publications (1)

Publication Number Publication Date
ATE512135T1 true ATE512135T1 (de) 2011-06-15

Family

ID=38942414

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07822025T ATE512135T1 (de) 2006-11-09 2007-10-30 Spiroindolinonderivate

Country Status (16)

Country Link
US (1) US7638548B2 (de)
EP (1) EP2089360B1 (de)
JP (1) JP2010509260A (de)
KR (1) KR20090095563A (de)
CN (1) CN101535255A (de)
AR (1) AR063602A1 (de)
AT (1) ATE512135T1 (de)
AU (1) AU2007316740A1 (de)
CA (1) CA2668398A1 (de)
CL (1) CL2007003202A1 (de)
ES (1) ES2364784T3 (de)
IL (1) IL198319A0 (de)
MX (1) MX2009004766A (de)
PE (1) PE20081346A1 (de)
TW (1) TW200829551A (de)
WO (1) WO2008055812A1 (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8134001B2 (en) * 2007-12-14 2012-03-13 Hoffmann-La Roche Inc. Spiroindolinone derivatives
US7776875B2 (en) * 2007-12-19 2010-08-17 Hoffman-La Roche Inc. Spiroindolinone derivatives
US7723372B2 (en) * 2008-03-19 2010-05-25 Hoffman-La Roche Inc. Spiroindolinone derivatives
EP2350001A4 (de) * 2008-10-14 2011-11-16 Univ Singapore Neue benzylidene-indolinonen und ihre medische und diagnostische verwendung
US20100190814A1 (en) * 2009-01-26 2010-07-29 Li Chen Spiroindolinone derivative prodrugs
US7928233B2 (en) * 2009-02-10 2011-04-19 Hoffmann-La Roche Inc. Spiroindolinone pyridine derivatives
US8217051B2 (en) * 2009-02-17 2012-07-10 Hoffmann-La Roche Inc. Spiroindolinone derivatives
US8076482B2 (en) 2009-04-23 2011-12-13 Hoffmann-La Roche Inc. 3,3′-spiroindolinone derivatives
KR20120099462A (ko) * 2009-11-12 2012-09-10 더 리젠츠 오브 더 유니버시티 오브 미시건 스피로-옥신돌 ｍｄｍ2 길항제
US8088815B2 (en) * 2009-12-02 2012-01-03 Hoffman-La Roche Inc. Spiroindolinone pyrrolidines
US8288431B2 (en) * 2010-02-17 2012-10-16 Hoffmann-La Roche Inc. Substituted spiroindolinones
US8217044B2 (en) 2010-04-28 2012-07-10 Hoffmann-La Roche Inc. Spiroindolinone pyrrolidines
MX2013005238A (es) 2010-11-12 2013-09-02 Univ Michigan Antagonistas de mdm2 de espiro-oxindol.
DK2684880T3 (en) 2011-03-10 2018-05-22 Daiichi Sankyo Co Ltd DISPIROPYRROLIDINE DERIVATIVES
CN102180828A (zh) * 2011-03-31 2011-09-14 四川大学 手性吲哚啉酮螺五环骨架化合物及不对称合成
BR112013028983A2 (pt) 2011-05-11 2017-02-07 Sanofi Sa antagonistas mdm2 espiro-oxindol
TWI586668B (zh) 2012-09-06 2017-06-11 第一三共股份有限公司 二螺吡咯啶衍生物之結晶
US8846657B2 (en) 2012-12-20 2014-09-30 Merck Sharp & Dohme Corp. Substituted imidazopyridines as HDM2 inhibitors
CN103992334A (zh) * 2014-05-29 2014-08-20 中国人民解放军第二军医大学 吲哚酮螺四氢硫代吡喃类抗肿瘤衍生物及其制备方法
KR102595395B1 (ko) 2015-02-20 2023-10-27 다이이찌 산쿄 가부시키가이샤 암의 병용 치료법
HK1251165A1 (en) 2015-04-13 2019-01-25 Daiichi Sankyo Company, Limited Treatment method combining mdm2 inhibitor and btk inhibitor
CN113788818A (zh) 2016-04-06 2021-12-14 密执安大学评议会 Mdm2蛋白质降解剂
AU2017246453A1 (en) 2016-04-06 2018-11-08 The Regents Of The University Of Michigan Monofunctional intermediates for ligand-dependent target protein degradation
CN118436801A (zh) 2016-05-20 2024-08-06 豪夫迈·罗氏有限公司 Protac抗体缀合物及其使用方法
TW201818934A (zh) 2016-10-17 2018-06-01 日商第一三共股份有限公司 Ｍｄｍ２抑制劑與ｄｎａ甲基轉移酶抑制劑之倂用治療法
EP3863720A1 (de) 2018-10-08 2021-08-18 The Regents Of The University Of Michigan Kleinmolekülige mdm2-proteindegrader
MX2022011602A (es) 2020-03-19 2023-01-04 Kymera Therapeutics Inc Degradadores de la proteína de homólogo de ratón de minuto 2 (mdm2) y usos de los mismos.
CN113149890B (zh) * 2021-04-27 2023-01-03 华东理工大学 合成3-螺-2-吲哚酮类化合物的方法
WO2023056069A1 (en) 2021-09-30 2023-04-06 Angiex, Inc. Degrader-antibody conjugates and methods of using same
CN116354786A (zh) * 2021-12-27 2023-06-30 北京化工大学 一种碗状并苯类化合物，制备及应用
WO2024240858A1 (en) 2023-05-23 2024-11-28 Valerio Therapeutics Protac molecules directed against dna damage repair system and uses thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0947511A1 (de) 1998-03-30 1999-10-06 F. Hoffmann-La Roche Ag Phenoxy-Essigsäurederivate und Phenoxymetyl-Tetrazolderivate mit antitumoraler Wirkung
HUP9902374A3 (en) * 1999-07-15 2002-11-28 Sanofi Aventis Process for producing spiro[(4-cyclohexanone)-[3h]indol-2'[1'h]-on derivatives and intermediates
EA019566B1 (ru) * 2005-02-22 2014-04-30 Дзе Риджентс Оф Дзе Юниверсити Оф Мичиган Низкомолекулярные ингибиторы mdm2
US7553833B2 (en) * 2007-05-17 2009-06-30 Hoffmann-La Roche Inc. 3,3-spiroindolinone derivatives

Also Published As

Publication number Publication date
JP2010509260A (ja) 2010-03-25
CA2668398A1 (en) 2008-05-15
AR063602A1 (es) 2009-02-04
KR20090095563A (ko) 2009-09-09
TW200829551A (en) 2008-07-16
CN101535255A (zh) 2009-09-16
US20080114013A1 (en) 2008-05-15
CL2007003202A1 (es) 2008-03-07
AU2007316740A1 (en) 2008-05-15
IL198319A0 (en) 2010-02-17
PE20081346A1 (es) 2008-10-24
EP2089360B1 (de) 2011-06-08
US7638548B2 (en) 2009-12-29
ES2364784T3 (es) 2011-09-14
EP2089360A1 (de) 2009-08-19
MX2009004766A (es) 2009-05-21
WO2008055812A1 (en) 2008-05-15

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Legal Events

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