ATE513049T1 - Ortsgerichtete transformation unter verwendung von amplifikationsvektoren - Google Patents
Ortsgerichtete transformation unter verwendung von amplifikationsvektorenInfo
- Publication number
- ATE513049T1 ATE513049T1 AT02730049T AT02730049T ATE513049T1 AT E513049 T1 ATE513049 T1 AT E513049T1 AT 02730049 T AT02730049 T AT 02730049T AT 02730049 T AT02730049 T AT 02730049T AT E513049 T1 ATE513049 T1 AT E513049T1
- Authority
- AT
- Austria
- Prior art keywords
- dna
- vector
- site
- plant
- amplification
- Prior art date
Links
- 239000013598 vector Substances 0.000 title abstract 5
- 230000003321 amplification Effects 0.000 title abstract 3
- 238000003199 nucleic acid amplification method Methods 0.000 title abstract 3
- 230000009466 transformation Effects 0.000 title 1
- 108020004414 DNA Proteins 0.000 abstract 2
- 108091093105 Nuclear DNA Proteins 0.000 abstract 2
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 2
- 230000006801 homologous recombination Effects 0.000 abstract 2
- 238000002744 homologous recombination Methods 0.000 abstract 2
- 230000010076 replication Effects 0.000 abstract 2
- 230000009087 cell motility Effects 0.000 abstract 1
- 230000010354 integration Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000002243 precursor Substances 0.000 abstract 1
- 230000006798 recombination Effects 0.000 abstract 1
- 238000005215 recombination Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8201—Methods for introducing genetic material into plant cells, e.g. DNA, RNA, stable or transient incorporation, tissue culture methods adapted for transformation
- C12N15/8213—Targeted insertion of genes into the plant genome by homologous recombination
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8201—Methods for introducing genetic material into plant cells, e.g. DNA, RNA, stable or transient incorporation, tissue culture methods adapted for transformation
- C12N15/8202—Methods for introducing genetic material into plant cells, e.g. DNA, RNA, stable or transient incorporation, tissue culture methods adapted for transformation by biological means, e.g. cell mediated or natural vector
- C12N15/8203—Virus mediated transformation
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10114209A DE10114209A1 (de) | 2001-03-23 | 2001-03-23 | Ortsgerichtete Transformation durch Verwendung von Amplifikationsvektoren |
| PCT/EP2002/003266 WO2002077246A2 (en) | 2001-03-23 | 2002-03-22 | Site-targeted transformation using amplification vectors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE513049T1 true ATE513049T1 (de) | 2011-07-15 |
Family
ID=7678670
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02730049T ATE513049T1 (de) | 2001-03-23 | 2002-03-22 | Ortsgerichtete transformation unter verwendung von amplifikationsvektoren |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US8058506B2 (de) |
| EP (1) | EP1392833B1 (de) |
| JP (1) | JP2004524039A (de) |
| AT (1) | ATE513049T1 (de) |
| AU (1) | AU2002302460B2 (de) |
| CA (1) | CA2442254A1 (de) |
| DE (1) | DE10114209A1 (de) |
| MX (1) | MXPA03008640A (de) |
| WO (1) | WO2002077246A2 (de) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10049587A1 (de) * | 2000-10-06 | 2002-05-02 | Icon Genetics Ag | Vektorsystem für Pflanzen |
| DE10061150A1 (de) | 2000-12-08 | 2002-06-13 | Icon Genetics Ag | Verfahren und Vektoren zur Erzeugung von transgenen Pflanzen |
| DE10102389A1 (de) | 2001-01-19 | 2002-08-01 | Icon Genetics Ag | Verfahren und Vektoren zur Plastidentransformation höherer Pflanzen |
| DE10114209A1 (de) | 2001-03-23 | 2002-12-05 | Icon Genetics Ag | Ortsgerichtete Transformation durch Verwendung von Amplifikationsvektoren |
| DE10115507A1 (de) | 2001-03-29 | 2002-10-10 | Icon Genetics Ag | Verfahren zur Kodierung von Information in Nukleinsäuren eines genetisch veränderten Organismus |
| DE10121283B4 (de) | 2001-04-30 | 2011-08-11 | Icon Genetics GmbH, 80333 | Verfahren und Vektoren zur Amplifikation oder Expression von gewünschten Nucleinsäuresequenzen in Pflanzen |
| DE10132780A1 (de) | 2001-07-06 | 2003-01-16 | Icon Genetics Ag | Plastidäre Genexpression über autonom replizierende Vektoren |
| DE10143237A1 (de) | 2001-09-04 | 2003-03-20 | Icon Genetics Ag | Herstellung künstlicher interner ribosomaler Eingangsstellenelemente (Ires-Elemente) |
| DE10143238A1 (de) | 2001-09-04 | 2003-03-20 | Icon Genetics Ag | Identifizierung eukaryotischer interner Ribosomen-Eingangsstellen (IRES)-Elemente |
| DE10143205A1 (de) * | 2001-09-04 | 2003-03-20 | Icon Genetics Ag | Verfahren zur Proteinproduktion in Pflanzen |
| US7164056B2 (en) * | 2002-05-03 | 2007-01-16 | Pioneer Hi-Bred International, Inc. | Gene targeting using replicating DNA molecules |
| US9856484B2 (en) * | 2003-01-31 | 2018-01-02 | Bayer Cropscience N.V. | Plant transformation with in vivo assembly of a trait |
| DE10303937A1 (de) * | 2003-01-31 | 2004-08-12 | Icon Genetics Ag | Pflanzentransformation mit Assemblierung einer gewünschten Sequenz in Vivo |
| WO2004108935A1 (ja) * | 2003-06-03 | 2004-12-16 | Nippon Paper Industries Co., Ltd. | 新規ベクター |
| DE10325814A1 (de) * | 2003-06-06 | 2004-12-23 | Icon Genetics Ag | Sichere Erzeugung eines gewünschten Produkts in hybriden Samen |
| PT2025756E (pt) * | 2003-11-18 | 2011-09-28 | Bayer Bioscience Nv | Inserção direccionada de adn em plantas |
| EP1616959A1 (de) | 2004-07-07 | 2006-01-18 | Icon Genetics AG | Biologisch sichere transiente Proteinexpression in Pflanzen |
| KR20080039885A (ko) | 2005-06-28 | 2008-05-07 | 벤트리아 바이오사이언스 | 식물 세포로부터 생산된 세포 배양 배지의 성분 |
| WO2007125146A1 (es) * | 2006-04-28 | 2007-11-08 | Universitat Autonoma De Barcelona | Método de producción de vectores adenovirus para terapia génica y secuencias de adn útiles para ello |
| US20080317086A1 (en) * | 2007-06-22 | 2008-12-25 | Santos Ishmael F | Self-calibrating digital thermal sensors |
| GB2467167B (en) * | 2009-01-26 | 2013-09-11 | Algentech Sas | Gene targeting in plants |
| WO2013050318A1 (en) | 2011-10-07 | 2013-04-11 | Basf Plant Science Company Gmbh | Method of producing plants having increased resistance to pathogens |
| WO2013050593A1 (en) | 2011-10-07 | 2013-04-11 | Basf Plant Science Company Gmbh | Method of producing plants having increased resistance to pathogens |
| WO2013050611A1 (en) | 2011-10-07 | 2013-04-11 | Basf Plant Science Company Gmbh | Method of producing plants having increased resistance to pathogens |
| WO2013053711A1 (en) | 2011-10-10 | 2013-04-18 | Basf Plant Science Company Gmbh | Method of producing plants having increased resistance to pathogens |
| WO2013053686A1 (en) | 2011-10-10 | 2013-04-18 | Basf Plant Science Company Gmbh | Method of producing plants having increased resistance to pathogens |
| EP2612918A1 (de) | 2012-01-06 | 2013-07-10 | BASF Plant Science Company GmbH | In planta-Rekombination |
| US20150225734A1 (en) | 2012-06-19 | 2015-08-13 | Regents Of The University Of Minnesota | Gene targeting in plants using dna viruses |
| DE102013212488B4 (de) * | 2013-06-27 | 2016-01-07 | MTU Aero Engines AG | Verstellleitschaufelanordnung |
| EP3260542A1 (de) * | 2016-06-20 | 2017-12-27 | Algentech | Proteinproduktion in pflanzenzellen |
Family Cites Families (71)
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| EP0229174A1 (de) | 1985-07-16 | 1987-07-22 | The Salk Institute For Biological Studies | Genetische modifikation von pflanzen mittels retroviren |
| US6147278A (en) * | 1985-10-25 | 2000-11-14 | Monsanto Company | Plant vectors |
| EP0265556A1 (de) | 1986-10-31 | 1988-05-04 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Stabile binäre Agrobakterium-Vektoren und ihre Verwendung |
| GB8626878D0 (en) | 1986-11-11 | 1986-12-10 | Ici Plc | Dna |
| US5922602A (en) | 1988-02-26 | 1999-07-13 | Biosource Technologies, Inc. | Cytoplasmic inhibition of gene expression |
| US6174700B1 (en) * | 1988-07-08 | 2001-01-16 | University Of British Columbia | Purification of a polypeptide compound having a polysaccharide binding domain by affinity phase separation |
| FR2649518B1 (fr) * | 1989-07-07 | 1991-10-18 | Bioprobe Systems Sa | Procede et dispositif de marquage crypte de haute securite pour la protection d'objets de valeur |
| US5501967A (en) * | 1989-07-26 | 1996-03-26 | Mogen International, N.V./Rijksuniversiteit Te Leiden | Process for the site-directed integration of DNA into the genome of plants |
| NL8901931A (nl) | 1989-07-26 | 1991-02-18 | Mogen International N V En Rij | Werkwijze voor het plaatsgericht introduceren van vreemd dna in het genoom van planten. |
| US5464764A (en) * | 1989-08-22 | 1995-11-07 | University Of Utah Research Foundation | Positive-negative selection methods and vectors |
| US5877402A (en) * | 1990-05-01 | 1999-03-02 | Rutgers, The State University Of New Jersey | DNA constructs and methods for stably transforming plastids of multicellular plants and expressing recombinant proteins therein |
| WO1992015694A1 (en) * | 1991-03-08 | 1992-09-17 | The Salk Institute For Biological Studies | Flp-mediated gene modification in mammalian cells, and compositions and cells useful therefor |
| US5474925A (en) * | 1991-12-19 | 1995-12-12 | Agracetus, Inc. | Immobilized proteins in cotton fiber |
| US5635381A (en) * | 1992-02-26 | 1997-06-03 | Mogen International Nv | Agrobacterium bacteria capable of site-specific recombination |
| ES2176208T3 (es) * | 1992-10-05 | 2002-12-01 | Univ North Carolina State | Metodo para incrementar la expresion y para reducir la variabilidad de expresion de genes foraneos en celulas vegetales. |
| US6239328B1 (en) * | 1992-10-05 | 2001-05-29 | North Carolina State University | Method for reducing expression variability of transgenes in plant cells |
| AU694102B2 (en) | 1992-12-30 | 1998-07-16 | Kentucky Bioprocessing, Llc | Viral amplification of recombinant messenger RNA in transgenic plants |
| US5527695A (en) * | 1993-01-29 | 1996-06-18 | Purdue Research Foundation | Controlled modification of eukaryotic genomes |
| US5496934A (en) * | 1993-04-14 | 1996-03-05 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Nucleic acids encoding a cellulose binding domain |
| US5576198A (en) * | 1993-12-14 | 1996-11-19 | Calgene, Inc. | Controlled expression of transgenic constructs in plant plastids |
| US5723765A (en) * | 1994-08-01 | 1998-03-03 | Delta And Pine Land Co. | Control of plant gene expression |
| EP0795029A1 (de) | 1994-12-08 | 1997-09-17 | Pabio | Chemische markierung von gegenständen |
| AR006928A1 (es) | 1996-05-01 | 1999-09-29 | Pioneer Hi Bred Int | Una molecula de adn aislada que codifica una proteina fluorescente verde como marcador rastreable para la transformacion de plantas, un metodo para laproduccion de plantas transgenicas, un vector de expresion, una planta transgenica y celulas de dichas plantas. |
| US6037525A (en) * | 1996-08-01 | 2000-03-14 | North Carolina State University | Method for reducing expression variability of transgenes in plant cells |
| CA2264489A1 (en) | 1996-09-09 | 1998-03-12 | Loyola University Of Chicago | Plant retroviral polynucleotides and methods for use thereof |
| US5939541A (en) | 1997-03-28 | 1999-08-17 | University Of South Carolina | Method for enhancing expression of a foreign or endogenous gene product in plants |
| FI972293A7 (fi) | 1997-05-30 | 1998-12-01 | Timo Korpela | Useamman kuin yhden geenin yhteisekspressiomenetelmät |
| US6077992A (en) * | 1997-10-24 | 2000-06-20 | E. I. Du Pont De Nemours And Company | Binary viral expression system in plants |
| CA2309719A1 (en) | 1997-11-18 | 1999-05-27 | Pioneer Hi-Bred International, Inc. | Targeted manipulation of genes in plants |
| PT1034262E (pt) * | 1997-11-18 | 2005-10-31 | Pioneer Hi Bred Int | Composicoes e metodos para a modificacao genetica de plantas |
| US5929301A (en) * | 1997-11-18 | 1999-07-27 | Pioneer Hi-Bred International | Nucleic acid sequence encoding FLP recombinase |
| AU745960C (en) | 1997-11-18 | 2003-09-18 | Pioneer Hi-Bred International, Inc. | A novel method for the integration of foreign DNA into eukaryoticgenomes |
| NZ504510A (en) | 1997-11-18 | 2002-10-25 | Pioneer Hi Bred Int | Methods and compositions for increasing efficiency of excision of a viral replicon from T-DNA that is transferred to a plant by agroinfection |
| US6303848B1 (en) * | 1998-01-16 | 2001-10-16 | Large Scale Biology Corporation | Method for conferring herbicide, pest, or disease resistance in plant hosts |
| EP1045899A2 (de) | 1998-01-16 | 2000-10-25 | Biosource Technologies, Inc. | Methode zur bestimmung der funktion von nukleinsäurensequenzen und davon kodierten proteine durch transfektion in einem gast |
| EP1115870A2 (de) | 1998-09-23 | 2001-07-18 | E.I. Du Pont De Nemours And Company | Binäres virales expressionssystem in pflanzen |
| GB9821303D0 (en) | 1998-10-01 | 1998-11-25 | Novartis Ag | Organic compounds |
| US6392121B1 (en) * | 1998-10-07 | 2002-05-21 | Boyce Thompson Institute For Plant Research | Gemini virus vectors for gene expression in plants |
| WO2000068391A1 (en) | 1998-10-23 | 2000-11-16 | University Of British Columbia | Expression of a mannan binding domain to alter plant morphology |
| EP1144665A1 (de) | 1998-11-25 | 2001-10-17 | Calgene LLC | Verfahren zur transformation von plastiden |
| US6770800B2 (en) * | 1999-03-12 | 2004-08-03 | Pioneer Hi-Bred International, Inc. | Methods of using viral replicase polynucleotides and polypeptides |
| EP1045037A1 (de) | 1999-04-12 | 2000-10-18 | Discovery Biotech., Inc. | System zu Identifizierung von Planzenzellen |
| AU4703300A (en) | 1999-05-06 | 2000-11-21 | Mount Sinai School Of Medicine Of The City University Of New York, The | Dna-based steganography |
| WO2000070019A2 (en) * | 1999-05-17 | 2000-11-23 | Icon Genetics, Inc. | Process of rapid variety-independent plant transformation |
| US6331416B1 (en) | 1999-06-10 | 2001-12-18 | Cbd Technologies Ltd. | Process of expressing and isolating recombinant proteins and recombinant protein products from plants, plant derived tissues or cultured plant cells |
| JP2003503033A (ja) | 1999-06-24 | 2003-01-28 | メタボリックス,インコーポレイテッド | 植物多重遺伝子発現構築物 |
| US6746870B1 (en) * | 1999-07-23 | 2004-06-08 | The Regents Of The University Of California | DNA recombination in eukaryotic cells by the bacteriophage PHIC31 recombination system |
| CA2378787A1 (en) | 1999-08-05 | 2001-02-15 | Icon Genetics, Inc. | Method of making plant artificial chromosomes |
| US6686515B1 (en) * | 1999-11-23 | 2004-02-03 | Maxygen, Inc. | Homologous recombination in plants |
| US7126041B1 (en) * | 1999-12-10 | 2006-10-24 | North Carolina State Unversity | High efficiency gene targeting in plants |
| AU2001242360A1 (en) | 2000-02-10 | 2001-08-20 | Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw | Plant internal ribosome entry segment |
| EP1276884A2 (de) * | 2000-04-20 | 2003-01-22 | Btg International Limited | Transgene pflanzen |
| WO2001081605A2 (en) * | 2000-04-26 | 2001-11-01 | Monsanto Technology Llc | Method for the transformation of plant cell plastids |
| GB0019745D0 (en) | 2000-08-10 | 2000-09-27 | Univ Surrey | Gene expression element |
| DE10049587A1 (de) * | 2000-10-06 | 2002-05-02 | Icon Genetics Ag | Vektorsystem für Pflanzen |
| DE10061150A1 (de) | 2000-12-08 | 2002-06-13 | Icon Genetics Ag | Verfahren und Vektoren zur Erzeugung von transgenen Pflanzen |
| DE10101276A1 (de) * | 2001-01-12 | 2002-07-18 | Icon Genetics Ag | Verfahren und Vektoren zur Transformation von Plastiden |
| DE10102389A1 (de) * | 2001-01-19 | 2002-08-01 | Icon Genetics Ag | Verfahren und Vektoren zur Plastidentransformation höherer Pflanzen |
| DE10109354A1 (de) | 2001-02-27 | 2002-09-05 | Icon Genetics Ag | Rekombinante virale Schaltersysteme |
| DE10114209A1 (de) | 2001-03-23 | 2002-12-05 | Icon Genetics Ag | Ortsgerichtete Transformation durch Verwendung von Amplifikationsvektoren |
| DE10115507A1 (de) | 2001-03-29 | 2002-10-10 | Icon Genetics Ag | Verfahren zur Kodierung von Information in Nukleinsäuren eines genetisch veränderten Organismus |
| DE10121283B4 (de) | 2001-04-30 | 2011-08-11 | Icon Genetics GmbH, 80333 | Verfahren und Vektoren zur Amplifikation oder Expression von gewünschten Nucleinsäuresequenzen in Pflanzen |
| DE10129010A1 (de) | 2001-06-13 | 2002-12-19 | Icon Genetics Ag | Verfahren und Vektoren zur Erzeugung von transgenen Pflanzen |
| DE10131680A1 (de) * | 2001-06-29 | 2003-01-23 | Voith Paper Patent Gmbh | Auftragsvorrichtung |
| DE10131690A1 (de) | 2001-06-29 | 2003-01-16 | Icon Genetics Ag | Verfahren zum kontrollierten Umordnen von Chromosomenfragmenten für die Pflanzenzucht |
| DE10132780A1 (de) | 2001-07-06 | 2003-01-16 | Icon Genetics Ag | Plastidäre Genexpression über autonom replizierende Vektoren |
| DE10143205A1 (de) * | 2001-09-04 | 2003-03-20 | Icon Genetics Ag | Verfahren zur Proteinproduktion in Pflanzen |
| DE10143237A1 (de) * | 2001-09-04 | 2003-03-20 | Icon Genetics Ag | Herstellung künstlicher interner ribosomaler Eingangsstellenelemente (Ires-Elemente) |
| DE10143238A1 (de) * | 2001-09-04 | 2003-03-20 | Icon Genetics Ag | Identifizierung eukaryotischer interner Ribosomen-Eingangsstellen (IRES)-Elemente |
| US20040016015A1 (en) * | 2002-07-17 | 2004-01-22 | Nguyen Thanh-Tuyen T. | High efficiency germline transformation system |
| US20040016014A1 (en) * | 2002-07-17 | 2004-01-22 | Nguyen Thanh-Tuyen T. | High efficiency germline transformation system |
-
2001
- 2001-03-23 DE DE10114209A patent/DE10114209A1/de not_active Withdrawn
-
2002
- 2002-03-22 CA CA002442254A patent/CA2442254A1/en not_active Abandoned
- 2002-03-22 AU AU2002302460A patent/AU2002302460B2/en not_active Ceased
- 2002-03-22 US US10/473,508 patent/US8058506B2/en not_active Expired - Lifetime
- 2002-03-22 JP JP2002576688A patent/JP2004524039A/ja not_active Ceased
- 2002-03-22 EP EP02730049A patent/EP1392833B1/de not_active Expired - Lifetime
- 2002-03-22 AT AT02730049T patent/ATE513049T1/de active
- 2002-03-22 WO PCT/EP2002/003266 patent/WO2002077246A2/en not_active Ceased
- 2002-03-22 MX MXPA03008640A patent/MXPA03008640A/es active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| US8058506B2 (en) | 2011-11-15 |
| CA2442254A1 (en) | 2002-10-03 |
| WO2002077246A3 (en) | 2003-11-20 |
| JP2004524039A (ja) | 2004-08-12 |
| EP1392833B1 (de) | 2011-06-15 |
| AU2002302460B2 (en) | 2007-08-30 |
| WO2002077246A2 (en) | 2002-10-03 |
| DE10114209A1 (de) | 2002-12-05 |
| EP1392833A2 (de) | 2004-03-03 |
| US20050066384A1 (en) | 2005-03-24 |
| MXPA03008640A (es) | 2005-03-07 |
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Legal Events
| Date | Code | Title | Description |
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