ATE513209T1 - Grenzflächen-patch-clamp-verfahren und -gerät - Google Patents

Grenzflächen-patch-clamp-verfahren und -gerät

Info

Publication number
ATE513209T1
ATE513209T1 AT99958379T AT99958379T ATE513209T1 AT E513209 T1 ATE513209 T1 AT E513209T1 AT 99958379 T AT99958379 T AT 99958379T AT 99958379 T AT99958379 T AT 99958379T AT E513209 T1 ATE513209 T1 AT E513209T1
Authority
AT
Austria
Prior art keywords
cell
interface
patch clamp
liquid
provides
Prior art date
Application number
AT99958379T
Other languages
English (en)
Inventor
Nicholas Byrne
David Owen
Original Assignee
Xention Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9826742.0A external-priority patent/GB9826742D0/en
Priority claimed from GBGB9905998.2A external-priority patent/GB9905998D0/en
Priority claimed from GBGB9906053.5A external-priority patent/GB9906053D0/en
Application filed by Xention Ltd filed Critical Xention Ltd
Application granted granted Critical
Publication of ATE513209T1 publication Critical patent/ATE513209T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/48707—Physical analysis of biological material of liquid biological material by electrical means
    • G01N33/48728—Investigating individual cells, e.g. by patch clamp, voltage clamp
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/46—Means for regulation, monitoring, measurement or control, e.g. flow regulation of cellular or enzymatic activity or functionality, e.g. cell viability

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Pathology (AREA)
  • Urology & Nephrology (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Food Science & Technology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Sustainable Development (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Stored Programmes (AREA)
  • Advance Control (AREA)
  • Input Circuits Of Receivers And Coupling Of Receivers And Audio Equipment (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Measurement Of Current Or Voltage (AREA)
  • Medicinal Preparation (AREA)
  • Road Signs Or Road Markings (AREA)
  • Discharging, Photosensitive Material Shape In Electrophotography (AREA)
AT99958379T 1998-12-05 1999-12-06 Grenzflächen-patch-clamp-verfahren und -gerät ATE513209T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB9826742.0A GB9826742D0 (en) 1998-12-05 1998-12-05 Interface patch clamping
GBGB9905998.2A GB9905998D0 (en) 1999-03-17 1999-03-17 Interface patch clamping
GBGB9906053.5A GB9906053D0 (en) 1999-03-17 1999-03-17 Interface patch clamping
PCT/GB1999/004073 WO2000034776A1 (en) 1998-12-05 1999-12-06 Interface patch clamping

Publications (1)

Publication Number Publication Date
ATE513209T1 true ATE513209T1 (de) 2011-07-15

Family

ID=27269575

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99958379T ATE513209T1 (de) 1998-12-05 1999-12-06 Grenzflächen-patch-clamp-verfahren und -gerät

Country Status (13)

Country Link
US (1) US7384733B1 (de)
EP (1) EP1141704B1 (de)
JP (1) JP4335460B2 (de)
KR (1) KR100736059B1 (de)
AT (1) ATE513209T1 (de)
AU (1) AU775985B2 (de)
CA (1) CA2352877A1 (de)
HU (1) HUP0104675A3 (de)
IL (2) IL143213A0 (de)
MX (1) MXPA01005582A (de)
NO (1) NO20012766L (de)
PL (1) PL348035A1 (de)
WO (1) WO2000034776A1 (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020144905A1 (en) 1997-12-17 2002-10-10 Christian Schmidt Sample positioning and analysis system
US7244349B2 (en) 1997-12-17 2007-07-17 Molecular Devices Corporation Multiaperture sample positioning and analysis system
GB9812783D0 (en) 1998-06-12 1998-08-12 Cenes Ltd High throuoghput screen
IL143213A0 (en) 1998-12-05 2002-04-21 Cenes Ltd Interface patch clamping
GB0006748D0 (en) * 2000-03-21 2000-05-10 Cenes Ltd Improved interface patch clamping
GB0013584D0 (en) * 2000-06-06 2000-07-26 Cenes Ltd Automated flow patch-clamp system
DE10032568A1 (de) * 2000-07-05 2002-01-24 Nmi Univ Tuebingen Vorrichtung und Verfahren zum elektrischen Kontaktieren von in einer Flüssigkeit in Suspension befindlichen biologischen Zellen
US7067046B2 (en) 2000-08-04 2006-06-27 Essen Instruments, Inc. System for rapid chemical activation in high-throughput electrophysiological measurements
US6815197B2 (en) * 2001-02-16 2004-11-09 Multi Channel System Mcs Gmbh Apparatus for conducting electrophysiological measurements on cells
GB0107231D0 (en) 2001-03-22 2001-05-16 Imp College Innovations Ltd Patch clamp
DE10130218A1 (de) * 2001-06-22 2003-01-09 Infineon Technologies Ag Vorrichtung für ein Patch-Clamping von Vesikeln und Verfahren zu deren Herstellung
JP2005511039A (ja) * 2001-11-30 2005-04-28 ブリストル−マイヤーズ　スクイブ　カンパニー 自動パッチクランプ記録用液体界面形態
JP2005528081A (ja) 2001-11-30 2005-09-22 ブリストル−マイヤーズ　スクイブ　カンパニー 細胞電気特性計測用のピペット形態及びそのアレイ
DE10202887B4 (de) * 2002-01-25 2004-05-06 Advalytix Ag Zellanalyseverfahren
ES2208082B1 (es) * 2002-05-29 2005-09-16 Jose Luis Bardasano Rubio Dispositivo para la medida del potencial de la accion transmembrana en preparaciones celulares bajo la accion de campos electromagneticos de frecuencia e intensidad variables.
JP4552423B2 (ja) * 2003-11-21 2010-09-29 パナソニック株式会社 細胞外電位測定デバイスおよびこれを用いた細胞外電位の測定方法
US8202439B2 (en) 2002-06-05 2012-06-19 Panasonic Corporation Diaphragm and device for measuring cellular potential using the same, manufacturing method of the diaphragm
AU2003278461A1 (en) 2002-10-16 2004-05-04 Cellectricon Ab Nanoelectrodes and nanotips for recording transmembrane currents in a plurality of cells
FR2866958B1 (fr) * 2004-02-26 2006-08-04 Commissariat Energie Atomique Procede et dispositif de controle du positionnement d'un element biologique sur un support
KR100749908B1 (ko) * 2005-07-28 2007-08-21 한국과학기술연구원 패치 클램프 시스템 및 이를 이용한 세포 밀봉 방법
US20120019270A1 (en) * 2010-07-21 2012-01-26 Amodei Dario G Microfabricated pipette and method of manufacture
EP2710109B1 (de) * 2011-05-19 2017-10-25 NMI Naturwissenschaftliches und Medizinisches Institut an der Universität Tübingen Verfahren und verwendung einer vorrichtung zur automatisierten positionsbestimmung eines mikrosystems zur manipulation eines sphärischen mikro-objekts
CN102866247A (zh) * 2012-09-26 2013-01-09 东南大学 一种全自动膜片钳电生理纪录系统及记录方法
EP4027127B1 (de) * 2015-04-08 2024-07-31 Becton, Dickinson and Company Verfahren zur entnahme von mikrobiellem wachstum von einer halbfesten oberfläche
CN108387400A (zh) * 2018-05-28 2018-08-10 南京信息工程大学 一种沉积物孔隙水原位高分辨率采样器
CN109374875A (zh) * 2018-11-20 2019-02-22 中国科学院生物物理研究所 低噪恒温重力灌流膜片钳装置
CN112014429B (zh) * 2019-05-30 2024-01-30 华东理工大学 一种基于超微电渗流调控的细胞膜振动检测方法

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4897426A (en) 1986-03-06 1990-01-30 New York University Method for blocking calcium channels
JP2682859B2 (ja) 1987-07-27 1997-11-26 コモンウェルス サイエンティフィック アンド インダストリアル リサーチ オーガニゼーション レセプター膜
US5225374A (en) 1988-05-13 1993-07-06 The United States Of America As Represented By The Secretary Of The Navy Method of fabricating a receptor-based sensor
DE68926118T2 (de) 1988-08-18 1996-08-22 Australian Membrane And Biotechnology Research Institute Ltd. Commonwealth Scientific And Industrial Research Organization, North Ryde, Neusuedwales Verbesserungen an der empfindlichkeit und der selektivität von ionenkanalmembranbiosensoren
US5643796A (en) 1994-10-14 1997-07-01 University Of Washington System for sensing droplet formation time delay in a flow cytometer
ES2171542T3 (es) 1994-10-28 2002-09-16 Sophion Bioscience As Aparato y tecnica de patch-clamp que tienen alta produccion y que requieren un pequeño volumen de fluido.
CN1181720A (zh) 1995-04-25 1998-05-13 伊萝莉公司 可远程编程的存储器材料及其应用
US5874668A (en) * 1995-10-24 1999-02-23 Arch Development Corporation Atomic force microscope for biological specimens
WO1997020203A1 (de) 1995-11-28 1997-06-05 Thomas Schalkhammer Neuartige membranen und membran-dna/rna-sensoren
AU1360297A (en) 1996-01-11 1997-08-01 Australian Membrane And Biotechnology Research Institute Ion channel sensor typing
JPH09211010A (ja) 1996-02-06 1997-08-15 Bunshi Bio Photonics Kenkyusho:Kk 電気生理特性測定装置
DE19712309A1 (de) * 1996-11-16 1998-05-20 Nmi Univ Tuebingen Mikroelementenanordnung, Verfahren zum Kontaktieren von in einer flüssigen Umgebung befindlichen Zellen und Verfahren zum Herstellen einer Mikroelementenanordnung
EP0938674B1 (de) * 1996-11-16 2005-06-01 NMI Naturwissenschaftliches und Medizinisches Institut an der Universität Tübingen in Reutlingen Stiftung Bürgerlichen Rechts Mikroelementenanordnung, verfahren zum kontaktieren von in einer flüssigen umgebung befindlichen zellen und verfahren zum herstellen einer mikroelementenanordnung
DE69735601T2 (de) 1996-11-29 2007-10-18 The Board Of Trustees Of The Leland Stanford Junior University, Stanford Anordnungen von unabhängig voneinander ansteuerbaren, gestützten flüssigbilayer-membranen und ihre anwendungsverfahren
IL131823A0 (en) 1997-05-01 2001-03-19 Neurosearch As An automatic electrode positioning apparatus
US5981268A (en) 1997-05-30 1999-11-09 Board Of Trustees, Leland Stanford, Jr. University Hybrid biosensors
SE9702112D0 (sv) * 1997-06-04 1997-06-04 Holdingbolaget Vid Goeteborgs Method and apparatus for detection of a receptor antagonist
DE19744649C2 (de) * 1997-10-09 2003-03-27 Fraunhofer Ges Forschung Verfahren zur Messung bioelektrischer Signale von Zellen nach der Patch-Clamp-Methode sowie Verwendung einer Vorrichtung hierzu
DE19841337C1 (de) 1998-05-27 1999-09-23 Micronas Intermetall Gmbh Verfahren und Vorrichtung zur intrazellulären Manipulation einer biologischen Zelle
GB9812783D0 (en) 1998-06-12 1998-08-12 Cenes Ltd High throuoghput screen
IL143213A0 (en) 1998-12-05 2002-04-21 Cenes Ltd Interface patch clamping
GB0006748D0 (en) 2000-03-21 2000-05-10 Cenes Ltd Improved interface patch clamping
GB0013584D0 (en) 2000-06-06 2000-07-26 Cenes Ltd Automated flow patch-clamp system

Also Published As

Publication number Publication date
EP1141704A1 (de) 2001-10-10
KR20010090865A (ko) 2001-10-19
NO20012766L (no) 2001-08-06
CA2352877A1 (en) 2000-06-15
IL143213A (en) 2010-11-30
JP4335460B2 (ja) 2009-09-30
JP2002532684A (ja) 2002-10-02
PL348035A1 (en) 2002-05-06
IL143213A0 (en) 2002-04-21
EP1141704B1 (de) 2011-06-15
AU1575400A (en) 2000-06-26
MXPA01005582A (es) 2002-07-02
AU775985B2 (en) 2004-08-19
NO20012766D0 (no) 2001-06-05
US7384733B1 (en) 2008-06-10
HUP0104675A2 (hu) 2002-04-29
WO2000034776A1 (en) 2000-06-15
HUP0104675A3 (en) 2005-10-28
KR100736059B1 (ko) 2007-07-06

Similar Documents

Publication Publication Date Title
IL143213A (en) Interface patch clamping
DE50110063D1 (de) Vorrichtung und verfahren zum elektrischen kontaktieren von in einer flüssigkeit in suspension befindlichen biologischen zellen
US5989400A (en) Device and method for applying power to gel electrophoresis modules
DE69905389D1 (de) Bipolare platten für brennstoffzellen und diese platten enthaltende brennstoffzelle
Hu et al. Cell cycle-dependent protein fingerprint from a single cancer cell: image cytometry coupled with single-cell capillary sieving electrophoresis
AR031803A1 (es) Analisis electroquimico de coagulacion y dispositivo
ATE252730T1 (de) Zelle für elektrochemilumineszenz mit potentialfreien reaktionselektroden
ATE480636T1 (de) Elektrochemische testvorrichtung und damit verbundene verfahren
DK505489A (da) Apparat og fremgangsmaade til indikering af tilboejelighed til dannelse af nyresten og til dehydrering, isaer hos mennesker
Li et al. Spatial control of cellular measurements with the laser micropipet
DE69835516D1 (de) Elektrophoretische analyse von molekülen mit immobilisierten sonden
IL140174A0 (en) Device for organic cell culture and for studying their electrophysiological activity and membrane used in said device
WO2003061037A3 (en) Electrochemical cells comprising laminar flow induced dynamic conducting interfaces, electronic devices and methods using such cells
EP2584044A3 (de) Vorrichtung und Verfahren zur Erkennung elektrochemischer Analyte
WO2004025252A3 (en) Automated system for high-throughput electrophoretic separations
DK1218736T3 (da) Indretning til måling på celler i flydende omgivelser
ATE19437T1 (de) System zum elektrochemischen nachweis.
DE60126006D1 (de) Sonde, Zelle und Verfahren zur Messung der Konzentration und der Zusammensetzung von Biomasse
DK1368488T3 (da) Sensorindretning, indretning og fremgangsmåde til aomperometrisk og/eller potentiometrisk, farmakologisk testning af aktive steder og/eller aktive stoffer
JP4586179B2 (ja) 二次元電気泳動法用試料注入器具及びそれを含む二次元電気泳動用装置並びに該装置を用いた二次元電気泳動法
DE60303863D1 (de) Elektrodenmembrananordnung für Brennstoffzelle und Betriebsverfahren dieser Anordnung enthaltende Brennstoffzelle
DE50213167D1 (de) Elektrophoresevorrichtung und ihre verwendung
Wang et al. Determination of glutathione in single human hepatocarcinoma cells by capillary electrophoresis with electrochemical detection
Bao et al. Electrochemical detector for microchip electrophoresis of poly (dimethylsiloxane) with a three-dimensional adjustor
Kraiya et al. Investigation of potential inversion in the reduction of 9, 10-dinitroanthracene and 3, 6-dinitrodurene

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties