ATE513209T1 - Grenzflächen-patch-clamp-verfahren und -gerät - Google Patents

Grenzflächen-patch-clamp-verfahren und -gerät

Info

Publication number
ATE513209T1
ATE513209T1 AT99958379T AT99958379T ATE513209T1 AT E513209 T1 ATE513209 T1 AT E513209T1 AT 99958379 T AT99958379 T AT 99958379T AT 99958379 T AT99958379 T AT 99958379T AT E513209 T1 ATE513209 T1 AT E513209T1
Authority
AT
Austria
Prior art keywords
cell
interface
patch clamp
liquid
provides
Prior art date
Application number
AT99958379T
Other languages
English (en)
Inventor
Nicholas Byrne
David Owen
Original Assignee
Xention Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9826742.0A external-priority patent/GB9826742D0/en
Priority claimed from GBGB9905998.2A external-priority patent/GB9905998D0/en
Priority claimed from GBGB9906053.5A external-priority patent/GB9906053D0/en
Application filed by Xention Ltd filed Critical Xention Ltd
Application granted granted Critical
Publication of ATE513209T1 publication Critical patent/ATE513209T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/48707—Physical analysis of biological material of liquid biological material by electrical means
    • G01N33/48728—Investigating individual cells, e.g. by patch clamp, voltage clamp
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/46—Means for regulation, monitoring, measurement or control, e.g. flow regulation of cellular or enzymatic activity or functionality, e.g. cell viability

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • General Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Urology & Nephrology (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Sustainable Development (AREA)
  • General Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Input Circuits Of Receivers And Coupling Of Receivers And Audio Equipment (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Advance Control (AREA)
  • Stored Programmes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Road Signs Or Road Markings (AREA)
  • Discharging, Photosensitive Material Shape In Electrophotography (AREA)
  • Measurement Of Current Or Voltage (AREA)
AT99958379T 1998-12-05 1999-12-06 Grenzflächen-patch-clamp-verfahren und -gerät ATE513209T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB9826742.0A GB9826742D0 (en) 1998-12-05 1998-12-05 Interface patch clamping
GBGB9905998.2A GB9905998D0 (en) 1999-03-17 1999-03-17 Interface patch clamping
GBGB9906053.5A GB9906053D0 (en) 1999-03-17 1999-03-17 Interface patch clamping
PCT/GB1999/004073 WO2000034776A1 (en) 1998-12-05 1999-12-06 Interface patch clamping

Publications (1)

Publication Number Publication Date
ATE513209T1 true ATE513209T1 (de) 2011-07-15

Family

ID=27269575

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99958379T ATE513209T1 (de) 1998-12-05 1999-12-06 Grenzflächen-patch-clamp-verfahren und -gerät

Country Status (13)

Country Link
US (1) US7384733B1 (de)
EP (1) EP1141704B1 (de)
JP (1) JP4335460B2 (de)
KR (1) KR100736059B1 (de)
AT (1) ATE513209T1 (de)
AU (1) AU775985B2 (de)
CA (1) CA2352877A1 (de)
HU (1) HUP0104675A3 (de)
IL (2) IL143213A0 (de)
MX (1) MXPA01005582A (de)
NO (1) NO20012766L (de)
PL (1) PL348035A1 (de)
WO (1) WO2000034776A1 (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020144905A1 (en) 1997-12-17 2002-10-10 Christian Schmidt Sample positioning and analysis system
US7244349B2 (en) 1997-12-17 2007-07-17 Molecular Devices Corporation Multiaperture sample positioning and analysis system
GB9812783D0 (en) 1998-06-12 1998-08-12 Cenes Ltd High throuoghput screen
AU775985B2 (en) 1998-12-05 2004-08-19 Xention Limited Interface patch clamping
GB0006748D0 (en) * 2000-03-21 2000-05-10 Cenes Ltd Improved interface patch clamping
GB0013584D0 (en) * 2000-06-06 2000-07-26 Cenes Ltd Automated flow patch-clamp system
DE10032568A1 (de) 2000-07-05 2002-01-24 Nmi Univ Tuebingen Vorrichtung und Verfahren zum elektrischen Kontaktieren von in einer Flüssigkeit in Suspension befindlichen biologischen Zellen
US7067046B2 (en) 2000-08-04 2006-06-27 Essen Instruments, Inc. System for rapid chemical activation in high-throughput electrophysiological measurements
US6815197B2 (en) * 2001-02-16 2004-11-09 Multi Channel System Mcs Gmbh Apparatus for conducting electrophysiological measurements on cells
GB0107231D0 (en) 2001-03-22 2001-05-16 Imp College Innovations Ltd Patch clamp
DE10130218A1 (de) * 2001-06-22 2003-01-09 Infineon Technologies Ag Vorrichtung für ein Patch-Clamping von Vesikeln und Verfahren zu deren Herstellung
EP1451339A4 (de) * 2001-11-30 2005-01-05 Bristol Myers Squibb Co Flüssige schnittstellen-konfigurationen zur automatischen aufzeichnung mit patch-clamp
EP1530505A4 (de) 2001-11-30 2007-09-12 Bristol Myers Squibb Co Pipettenkonfigurationen und arrays dafür zur messung zellularer elektrischer eigenschaften
DE10202887B4 (de) * 2002-01-25 2004-05-06 Advalytix Ag Zellanalyseverfahren
ES2208082B1 (es) * 2002-05-29 2005-09-16 Jose Luis Bardasano Rubio Dispositivo para la medida del potencial de la accion transmembrana en preparaciones celulares bajo la accion de campos electromagneticos de frecuencia e intensidad variables.
JP4552423B2 (ja) * 2003-11-21 2010-09-29 パナソニック株式会社 細胞外電位測定デバイスおよびこれを用いた細胞外電位の測定方法
US8202439B2 (en) 2002-06-05 2012-06-19 Panasonic Corporation Diaphragm and device for measuring cellular potential using the same, manufacturing method of the diaphragm
WO2004036202A1 (en) 2002-10-16 2004-04-29 Cellectricon Ab Nanoelectrodes and nanotips for recording transmembrane currents in a plurality of cells
FR2866958B1 (fr) 2004-02-26 2006-08-04 Commissariat Energie Atomique Procede et dispositif de controle du positionnement d'un element biologique sur un support
KR100749908B1 (ko) * 2005-07-28 2007-08-21 한국과학기술연구원 패치 클램프 시스템 및 이를 이용한 세포 밀봉 방법
US20120019270A1 (en) * 2010-07-21 2012-01-26 Amodei Dario G Microfabricated pipette and method of manufacture
EP2710109B1 (de) * 2011-05-19 2017-10-25 NMI Naturwissenschaftliches und Medizinisches Institut an der Universität Tübingen Verfahren und verwendung einer vorrichtung zur automatisierten positionsbestimmung eines mikrosystems zur manipulation eines sphärischen mikro-objekts
CN102866247A (zh) * 2012-09-26 2013-01-09 东南大学 一种全自动膜片钳电生理纪录系统及记录方法
ES2909506T3 (es) * 2015-04-08 2022-05-06 Becton Dickinson Co Dispositivo para recoger el crecimiento microbiano de una superficie semi-sólida
CN108387400A (zh) * 2018-05-28 2018-08-10 南京信息工程大学 一种沉积物孔隙水原位高分辨率采样器
CN109374875A (zh) * 2018-11-20 2019-02-22 中国科学院生物物理研究所 低噪恒温重力灌流膜片钳装置
CN112014429B (zh) * 2019-05-30 2024-01-30 华东理工大学 一种基于超微电渗流调控的细胞膜振动检测方法

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4897426A (en) 1986-03-06 1990-01-30 New York University Method for blocking calcium channels
DE3852036T2 (de) 1987-07-27 1995-03-09 Commonwealth Scientific And Industrial Research Organization, Campbell Rezeptormembranen.
US5225374A (en) 1988-05-13 1993-07-06 The United States Of America As Represented By The Secretary Of The Navy Method of fabricating a receptor-based sensor
WO1990002327A1 (en) 1988-08-18 1990-03-08 AUSTRALIAN MEMBRANE AND BIOTECHNOLOGY RESEARCH INSTITUTE LTD., Commonwealth Scientific and Industrial Research Organization Improvements in sensitivity and selectivity of ion channel membrane biosensors
US5643796A (en) 1994-10-14 1997-07-01 University Of Washington System for sensing droplet formation time delay in a flow cytometer
EP0788600B1 (de) 1994-10-28 2002-04-10 Sophion Bioscience A/S Patch-clamp-vorrichtung und -technik mit hohem durchfluss und niedrigen flüssigkeitsvolumenanforderungen
KR19990008052A (ko) 1995-04-25 1999-01-25 마이클 피 노바 기억 장치를 갖는 원격적으로 프로그램 가능한 매트릭스 및 이의 용도
US5874668A (en) * 1995-10-24 1999-02-23 Arch Development Corporation Atomic force microscope for biological specimens
WO1997020203A1 (de) 1995-11-28 1997-06-05 Thomas Schalkhammer Neuartige membranen und membran-dna/rna-sensoren
AU1360297A (en) 1996-01-11 1997-08-01 Australian Membrane And Biotechnology Research Institute Ion channel sensor typing
JPH09211010A (ja) 1996-02-06 1997-08-15 Bunshi Bio Photonics Kenkyusho:Kk 電気生理特性測定装置
DE19712309A1 (de) * 1996-11-16 1998-05-20 Nmi Univ Tuebingen Mikroelementenanordnung, Verfahren zum Kontaktieren von in einer flüssigen Umgebung befindlichen Zellen und Verfahren zum Herstellen einer Mikroelementenanordnung
WO1998022819A1 (de) * 1996-11-16 1998-05-28 Nmi Naturwissenschaftliches Und Medizinisches Institut An Der Universität Tübingen In Reutlingen Stiftung Bürgerlichen Rechts Mikroelementenanordnung, verfahren zum kontaktieren von in einer flüssigen umgebung befindlichen zellen und verfahren zum herstellen einer mikroelementenanordnung
US6228326B1 (en) 1996-11-29 2001-05-08 The Board Of Trustees Of The Leland Stanford Junior University Arrays of independently-addressable supported fluid bilayer membranes
EP0980523B1 (de) 1997-05-01 2006-12-27 Sophion Bioscience A/S Vorrichtung zur automatischen elektrodenpositionierung
US5981268A (en) 1997-05-30 1999-11-09 Board Of Trustees, Leland Stanford, Jr. University Hybrid biosensors
SE9702112D0 (sv) 1997-06-04 1997-06-04 Holdingbolaget Vid Goeteborgs Method and apparatus for detection of a receptor antagonist
DE19744649C2 (de) 1997-10-09 2003-03-27 Fraunhofer Ges Forschung Verfahren zur Messung bioelektrischer Signale von Zellen nach der Patch-Clamp-Methode sowie Verwendung einer Vorrichtung hierzu
DE19841337C1 (de) * 1998-05-27 1999-09-23 Micronas Intermetall Gmbh Verfahren und Vorrichtung zur intrazellulären Manipulation einer biologischen Zelle
GB9812783D0 (en) 1998-06-12 1998-08-12 Cenes Ltd High throuoghput screen
AU775985B2 (en) 1998-12-05 2004-08-19 Xention Limited Interface patch clamping
GB0006748D0 (en) 2000-03-21 2000-05-10 Cenes Ltd Improved interface patch clamping
GB0013584D0 (en) 2000-06-06 2000-07-26 Cenes Ltd Automated flow patch-clamp system

Also Published As

Publication number Publication date
AU1575400A (en) 2000-06-26
HUP0104675A3 (en) 2005-10-28
WO2000034776A1 (en) 2000-06-15
EP1141704A1 (de) 2001-10-10
MXPA01005582A (es) 2002-07-02
JP2002532684A (ja) 2002-10-02
KR100736059B1 (ko) 2007-07-06
AU775985B2 (en) 2004-08-19
JP4335460B2 (ja) 2009-09-30
NO20012766L (no) 2001-08-06
KR20010090865A (ko) 2001-10-19
US7384733B1 (en) 2008-06-10
EP1141704B1 (de) 2011-06-15
IL143213A (en) 2010-11-30
CA2352877A1 (en) 2000-06-15
NO20012766D0 (no) 2001-06-05
HUP0104675A2 (hu) 2002-04-29
IL143213A0 (en) 2002-04-21
PL348035A1 (en) 2002-05-06

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