ATE513820T1 - Neue benzamidinderivate, verfahren zu deren herstellung und pharmazeutische zusammensetzung, die diese enthält - Google Patents
Neue benzamidinderivate, verfahren zu deren herstellung und pharmazeutische zusammensetzung, die diese enthältInfo
- Publication number
- ATE513820T1 ATE513820T1 AT07708686T AT07708686T ATE513820T1 AT E513820 T1 ATE513820 T1 AT E513820T1 AT 07708686 T AT07708686 T AT 07708686T AT 07708686 T AT07708686 T AT 07708686T AT E513820 T1 ATE513820 T1 AT E513820T1
- Authority
- AT
- Austria
- Prior art keywords
- pharmaceutical composition
- production
- composition containing
- containing same
- benzamidine derivatives
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- PXXJHWLDUBFPOL-UHFFFAOYSA-N benzamidine Chemical class NC(=N)C1=CC=CC=C1 PXXJHWLDUBFPOL-UHFFFAOYSA-N 0.000 title 1
- 150000003937 benzamidines Chemical class 0.000 abstract 2
- 208000001132 Osteoporosis Diseases 0.000 abstract 1
- 210000000988 bone and bone Anatomy 0.000 abstract 1
- 230000004069 differentiation Effects 0.000 abstract 1
- 210000002997 osteoclast Anatomy 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/28—Radicals substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR20060009459 | 2006-01-31 | ||
| PCT/KR2007/000533 WO2007089101A1 (en) | 2006-01-31 | 2007-01-31 | Novel benzamidine derivatives, process for the preparation thereof and pharmaceutical composition comprising the same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE513820T1 true ATE513820T1 (de) | 2011-07-15 |
Family
ID=38327631
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT07708686T ATE513820T1 (de) | 2006-01-31 | 2007-01-31 | Neue benzamidinderivate, verfahren zu deren herstellung und pharmazeutische zusammensetzung, die diese enthält |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US7943646B2 (de) |
| EP (1) | EP1979334B1 (de) |
| JP (1) | JP5102781B2 (de) |
| KR (1) | KR100875596B1 (de) |
| CN (1) | CN101379049B (de) |
| AT (1) | ATE513820T1 (de) |
| CA (1) | CA2637336A1 (de) |
| ES (1) | ES2369634T3 (de) |
| MX (1) | MX2008009939A (de) |
| WO (1) | WO2007089101A1 (de) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20060017929A (ko) * | 2004-08-04 | 2006-02-28 | 동화약품공업주식회사 | 티아졸 유도체가 치환된 신규한 벤즈아미딘 유도체, 그의제조방법 및 이를 유효성분으로 하는 약학 조성물 |
| CN101379049B (zh) | 2006-01-31 | 2012-01-04 | 同和药品株式会社 | 新型的苄脒衍生物，它的制备方法，和包含该衍生物的药物组合物 |
| CA2694639A1 (en) * | 2007-07-27 | 2009-02-05 | Dong Wha Pharmaceutical Co., Ltd. | Benzamidine derivatives, process for the preparation thereof and pharmaceutical composition for preventing or treating osteoporosis comprising the same |
| US7655925B2 (en) * | 2007-08-31 | 2010-02-02 | Cymer, Inc. | Gas management system for a laser-produced-plasma EUV light source |
| KR20100014090A (ko) * | 2008-08-01 | 2010-02-10 | 동화약품주식회사 | 벤즈아미딘 유도체 또는 이의 염, 및 비스포스포네이트를 포함하는 골다공증의 예방 또는 치료용 약학 조성물 |
| CA2751041A1 (en) * | 2009-01-30 | 2010-08-05 | Eiji Ochiai | Prophylactic agent or therapeutic agent for disease resulting from abnormal bone metabolism |
| CN102993109A (zh) * | 2012-12-03 | 2013-03-27 | 浙江工业大学 | 一种脒化合物的制备方法 |
| WO2020051424A1 (en) | 2018-09-07 | 2020-03-12 | Pic Therapeutics | Eif4e inhibitors and uses thereof |
| TW202146393A (zh) | 2020-03-03 | 2021-12-16 | 美商皮克醫療公司 | Eif4e抑制劑及其用途 |
| CA3229560A1 (en) | 2021-08-25 | 2023-03-02 | Christopher L. Vandeusen | Eif4e inhibitors and uses thereof |
| US12157732B2 (en) | 2021-08-25 | 2024-12-03 | PIC Therapeutics, Inc. | eIF4E inhibitors and uses thereof |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SK174699A3 (en) * | 1997-06-19 | 2000-08-14 | Du Pont Pharm Co | Inhibitors of factor xa with a neutral p1 specificity group |
| DE19755268A1 (de) | 1997-12-12 | 1999-06-17 | Merck Patent Gmbh | Benzamidinderivate |
| EP1375482A4 (de) * | 2001-04-05 | 2005-01-19 | Sankyo Co | Benzamidinderivate |
| KR100454767B1 (ko) * | 2001-07-19 | 2004-11-03 | 동화약품공업주식회사 | 4-[(4-티아졸릴)페녹시]알콕시-벤즈아미딘 유도체의골다공증 예방 및 치료제로서의 용도 |
| US7351727B2 (en) * | 2003-09-02 | 2008-04-01 | Bristol-Myers Squibb Company | Inhibitors of 15-lipoxygenase |
| KR100639041B1 (ko) | 2004-07-05 | 2006-10-27 | 동화약품공업주식회사 | 골절 치료용 약제학적 조성물 |
| KR20060017929A (ko) | 2004-08-04 | 2006-02-28 | 동화약품공업주식회사 | 티아졸 유도체가 치환된 신규한 벤즈아미딘 유도체, 그의제조방법 및 이를 유효성분으로 하는 약학 조성물 |
| CN101379049B (zh) | 2006-01-31 | 2012-01-04 | 同和药品株式会社 | 新型的苄脒衍生物，它的制备方法，和包含该衍生物的药物组合物 |
-
2007
- 2007-01-31 CN CN2007800040825A patent/CN101379049B/zh not_active Expired - Fee Related
- 2007-01-31 WO PCT/KR2007/000533 patent/WO2007089101A1/en not_active Ceased
- 2007-01-31 AT AT07708686T patent/ATE513820T1/de not_active IP Right Cessation
- 2007-01-31 ES ES07708686T patent/ES2369634T3/es active Active
- 2007-01-31 US US12/162,701 patent/US7943646B2/en not_active Expired - Fee Related
- 2007-01-31 JP JP2008553157A patent/JP5102781B2/ja not_active Expired - Fee Related
- 2007-01-31 CA CA002637336A patent/CA2637336A1/en not_active Abandoned
- 2007-01-31 KR KR1020070009859A patent/KR100875596B1/ko not_active Expired - Fee Related
- 2007-01-31 EP EP07708686A patent/EP1979334B1/de not_active Not-in-force
- 2007-01-31 MX MX2008009939A patent/MX2008009939A/es active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| EP1979334A4 (de) | 2010-09-08 |
| KR20070079043A (ko) | 2007-08-03 |
| WO2007089101A1 (en) | 2007-08-09 |
| US7943646B2 (en) | 2011-05-17 |
| EP1979334B1 (de) | 2011-06-22 |
| CA2637336A1 (en) | 2007-08-09 |
| KR100875596B1 (ko) | 2008-12-23 |
| JP2009525321A (ja) | 2009-07-09 |
| CN101379049A (zh) | 2009-03-04 |
| JP5102781B2 (ja) | 2012-12-19 |
| ES2369634T3 (es) | 2011-12-02 |
| MX2008009939A (es) | 2008-11-18 |
| US20090054642A1 (en) | 2009-02-26 |
| CN101379049B (zh) | 2012-01-04 |
| EP1979334A1 (de) | 2008-10-15 |
| HK1126194A1 (en) | 2009-08-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |