ATE515265T1 - Vitamin d und dessen analoge zur behandlung vom tumoren und anderen hyperproliferativen erkrankungen - Google Patents
Vitamin d und dessen analoge zur behandlung vom tumoren und anderen hyperproliferativen erkrankungenInfo
- Publication number
- ATE515265T1 ATE515265T1 AT99914109T AT99914109T ATE515265T1 AT E515265 T1 ATE515265 T1 AT E515265T1 AT 99914109 T AT99914109 T AT 99914109T AT 99914109 T AT99914109 T AT 99914109T AT E515265 T1 ATE515265 T1 AT E515265T1
- Authority
- AT
- Austria
- Prior art keywords
- treatment
- drug
- vitamin
- analogues
- tumors
- Prior art date
Links
- 230000003463 hyperproliferative effect Effects 0.000 title abstract 3
- 201000010099 disease Diseases 0.000 title abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 2
- 206010028980 Neoplasm Diseases 0.000 title 1
- 229940088594 vitamin Drugs 0.000 title 1
- 229930003231 vitamin Natural products 0.000 title 1
- 235000013343 vitamin Nutrition 0.000 title 1
- 239000011782 vitamin Substances 0.000 title 1
- 150000003722 vitamin derivatives Chemical class 0.000 title 1
- 239000003814 drug Substances 0.000 abstract 6
- 229940079593 drug Drugs 0.000 abstract 4
- 208000037147 Hypercalcaemia Diseases 0.000 abstract 2
- 230000000148 hypercalcaemia Effects 0.000 abstract 2
- 208000030915 hypercalcemia disease Diseases 0.000 abstract 2
- 208000017520 skin disease Diseases 0.000 abstract 2
- 229930003316 Vitamin D Natural products 0.000 abstract 1
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 abstract 1
- 230000001028 anti-proliverative effect Effects 0.000 abstract 1
- 235000020964 calcitriol Nutrition 0.000 abstract 1
- 239000011612 calcitriol Substances 0.000 abstract 1
- GMRQFYUYWCNGIN-NKMMMXOESA-N calcitriol Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](CCCC(C)(C)O)C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C GMRQFYUYWCNGIN-NKMMMXOESA-N 0.000 abstract 1
- 229960005084 calcitriol Drugs 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 235000019166 vitamin D Nutrition 0.000 abstract 1
- 239000011710 vitamin D Substances 0.000 abstract 1
- 150000003710 vitamin D derivatives Chemical class 0.000 abstract 1
- 229940046008 vitamin d Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
- A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/12—Keratolytics, e.g. wart or anti-corn preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
Landscapes
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Dermatology (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Endocrinology (AREA)
- Oncology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7969698P | 1998-03-27 | 1998-03-27 | |
| PCT/US1999/006442 WO1999049870A1 (en) | 1998-03-27 | 1999-03-25 | Vitamin d and its analogs in the treatment of tumors and other hyperproliferative disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE515265T1 true ATE515265T1 (de) | 2011-07-15 |
Family
ID=22152202
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99914109T ATE515265T1 (de) | 1998-03-27 | 1999-03-25 | Vitamin d und dessen analoge zur behandlung vom tumoren und anderen hyperproliferativen erkrankungen |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US6521608B1 (de) |
| EP (2) | EP1064000B1 (de) |
| JP (1) | JP2002509888A (de) |
| AT (1) | ATE515265T1 (de) |
| AU (1) | AU762481C (de) |
| CA (1) | CA2326117A1 (de) |
| ES (1) | ES2368824T3 (de) |
| WO (1) | WO1999049870A1 (de) |
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| US20040167106A1 (en) * | 1993-06-04 | 2004-08-26 | Rodriguez Gustavo C. | Prevention of ovarian cancer by administration of a Vitamin D compound |
| US5763429A (en) * | 1993-09-10 | 1998-06-09 | Bone Care International, Inc. | Method of treating prostatic diseases using active vitamin D analogues |
| US6242434B1 (en) * | 1997-08-08 | 2001-06-05 | Bone Care International, Inc. | 24-hydroxyvitamin D, analogs and uses thereof |
| US20020183288A1 (en) * | 1995-04-03 | 2002-12-05 | Bone Care International, Inc. | Method for treating and preventing hyperparathyroidism |
| US20040043971A1 (en) * | 1995-04-03 | 2004-03-04 | Bone Care International, Inc. | Method of treating and preventing hyperparathyroidism with active vitamin D analogs |
| US20020128240A1 (en) * | 1996-12-30 | 2002-09-12 | Bone Care International, Inc. | Treatment of hyperproliferative diseases using active vitamin D analogues |
| US6573256B2 (en) | 1996-12-30 | 2003-06-03 | Bone Care International, Inc. | Method of inhibiting angiogenesis using active vitamin D analogues |
| US6566353B2 (en) * | 1996-12-30 | 2003-05-20 | Bone Care International, Inc. | Method of treating malignancy associated hypercalcemia using active vitamin D analogues |
| US6503893B2 (en) * | 1996-12-30 | 2003-01-07 | Bone Care International, Inc. | Method of treating hyperproliferative diseases using active vitamin D analogues |
| US20030129194A1 (en) * | 1997-02-13 | 2003-07-10 | Bone Care International, Inc. | Targeted therapeutic delivery of vitamin D compounds |
| CA2279590A1 (en) * | 1997-02-13 | 1998-08-20 | Bone Care International, Inc. | Targeted therapeutic delivery of vitamin d compounds |
| US6087350A (en) | 1997-08-29 | 2000-07-11 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Use of pretreatment chemicals to enhance efficacy of cytotoxic agents |
| EP1064000B1 (de) * | 1998-03-27 | 2011-07-06 | Oregon Health & Science University | Vitamin d und dessen analoge zur behandlung vom tumoren und anderen hyperproliferativen erkrankungen |
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| MXPA04005260A (es) * | 2001-12-03 | 2005-03-23 | Novacea Inc | Composiciones farmaceuticas que comprenden compuestos activos de vitamina d. |
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| US7148211B2 (en) * | 2002-09-18 | 2006-12-12 | Genzyme Corporation | Formulation for lipophilic agents |
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| MXPA05004985A (es) * | 2002-11-06 | 2005-08-02 | Novacea Inc | Metodos de uso de compuestos de vitamina d en el tratamiento de sindromes mielodisplasticos. |
| US20050101576A1 (en) * | 2003-11-06 | 2005-05-12 | Novacea, Inc. | Methods of using vitamin D compounds in the treatment of myelodysplastic syndromes |
| AU2003295773A1 (en) * | 2002-11-21 | 2004-06-18 | Novacea, Inc. | Treatment of liver disease with active vitamin d compounds |
| US20050026877A1 (en) * | 2002-12-03 | 2005-02-03 | Novacea, Inc. | Pharmaceutical compositions comprising active vitamin D compounds |
| US20060217316A1 (en) * | 2003-04-02 | 2006-09-28 | Ragab El-Rashidy | Method for the treatment of prostate cancer |
| US20050020546A1 (en) * | 2003-06-11 | 2005-01-27 | Novacea, Inc. | Pharmaceutical compositions comprising active vitamin D compounds |
| AU2004247108A1 (en) * | 2003-06-11 | 2004-12-23 | Novacea, Inc | Treatment of immune-mediated disorders with active vitamin D compounds alone or in combination with other therapeutic agents |
| JP2007501865A (ja) * | 2003-06-11 | 2007-02-01 | ノバセア インコーポレイティッド | 放射線治療薬および放射線治療と併用した、活性ビタミンd化合物による癌の治療法 |
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| US20070142339A1 (en) * | 2004-05-10 | 2007-06-21 | Novacea, Inc. | Prevention of arterial restenosis with active vitamin d compounds |
| WO2005117542A2 (en) * | 2004-05-10 | 2005-12-15 | Novacea, Inc. | Treatment of pancreatic cancer with active vitamin d compounds in combination with other treatments |
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| JP2008538580A (ja) * | 2005-04-22 | 2008-10-30 | ノバセア インコーポレイティッド | 活性ビタミンd化合物またはその模倣体による、化学療法または放射線療法と関連する肺疾患の治療、予防、および改善 |
| GB0513984D0 (en) * | 2005-07-07 | 2005-08-17 | Teva Pharma | Dosage form |
| SI1993559T1 (sl) | 2006-02-03 | 2017-01-31 | Opko Renal, Llc | Zdravljenje nezadostnosti in pomanjkanja vitamina D s 25-hidroksivitaminon D2 in 25-hidroksivitaminom D3 |
| US8193169B2 (en) * | 2006-04-06 | 2012-06-05 | Wisconsin Alumni Research Foundation | (20R)-2α-methyl-19,26,2-trinor-vitamin D analogs |
| PT3357496T (pt) * | 2006-06-21 | 2020-05-12 | Opko Ireland Global Holdings Ltd | Terapia utilizando um agente de repleção de vitamina d e um agente de substituição hormonal de vitamina d |
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| KR20190141269A (ko) | 2007-04-25 | 2019-12-23 | 사이토크로마 인코포레이티드 | 비타민 d 화합물과 밀랍성 담체를 포함하는 경구 조절성 방출 조성물 |
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-
1999
- 1999-03-25 EP EP99914109A patent/EP1064000B1/de not_active Expired - Lifetime
- 1999-03-25 AT AT99914109T patent/ATE515265T1/de not_active IP Right Cessation
- 1999-03-25 CA CA002326117A patent/CA2326117A1/en not_active Abandoned
- 1999-03-25 EP EP10184333A patent/EP2340840B1/de not_active Expired - Lifetime
- 1999-03-25 JP JP2000540833A patent/JP2002509888A/ja not_active Ceased
- 1999-03-25 AU AU32022/99A patent/AU762481C/en not_active Ceased
- 1999-03-25 US US09/647,075 patent/US6521608B1/en not_active Expired - Lifetime
- 1999-03-25 WO PCT/US1999/006442 patent/WO1999049870A1/en not_active Ceased
- 1999-03-25 ES ES99914109T patent/ES2368824T3/es not_active Expired - Lifetime
-
2002
- 2002-11-21 US US10/302,654 patent/US20030119795A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US6521608B1 (en) | 2003-02-18 |
| EP2340840B1 (de) | 2012-08-29 |
| EP1064000B1 (de) | 2011-07-06 |
| AU3202299A (en) | 1999-10-18 |
| JP2002509888A (ja) | 2002-04-02 |
| AU762481C (en) | 2004-08-19 |
| EP1064000A1 (de) | 2001-01-03 |
| US20030119795A1 (en) | 2003-06-26 |
| EP2340840A1 (de) | 2011-07-06 |
| AU762481B2 (en) | 2003-06-26 |
| WO1999049870A1 (en) | 1999-10-07 |
| CA2326117A1 (en) | 1999-10-07 |
| EP1064000A4 (de) | 2002-01-02 |
| ES2368824T3 (es) | 2011-11-22 |
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| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |