ATE277889T1 - Aminobenzophenone als inhibitoren von il-1beta und tnf-alpha - Google Patents

Aminobenzophenone als inhibitoren von il-1beta und tnf-alpha

Info

Publication number: ATE277889T1
Authority: AT; Austria
Prior art keywords: phenyl; alkyl; hydrogen; alkoxycarbonyl; alkylthio
Prior art date: 1999-07-16

Application number

AT00943702T

Other languages

English (en)

Inventor

Erik Rytter Ottosen

Original Assignee

Leo Pharma As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-07-16

Filing date

2000-07-11

Publication date

2004-10-15

2000-07-11 Application filed by Leo Pharma As filed Critical Leo Pharma As

2004-10-15 Application granted granted Critical

2004-10-15 Publication of ATE277889T1 publication Critical patent/ATE277889T1/de

Links

239000003112 inhibitor Substances 0.000 title 1
229910052739 hydrogen Inorganic materials 0.000 abstract 4
239000001257 hydrogen Substances 0.000 abstract 4
-1 hydroxy, mercapto Chemical group 0.000 abstract 4
150000001875 compounds Chemical class 0.000 abstract 3
125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 2
125000004455 (C1-C3) alkylthio group Chemical group 0.000 abstract 2
125000006274 (C1-C3)alkoxy group Chemical group 0.000 abstract 2
125000004890 (C1-C6) alkylamino group Chemical group 0.000 abstract 2
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 2
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
229910052736 halogen Inorganic materials 0.000 abstract 2
150000002431 hydrogen Chemical group 0.000 abstract 2
229910052760 oxygen Inorganic materials 0.000 abstract 2
239000001301 oxygen Substances 0.000 abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
150000002367 halogens Chemical group 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
MVALDVBMYCYENV-UHFFFAOYSA-N n-[2-[3-chloro-4-(2-methylbenzoyl)anilino]phenyl]-2,2,2-trifluoroacetamide Chemical compound CC1=CC=CC=C1C(=O)C(C(=C1)Cl)=CC=C1NC1=CC=CC=C1NC(=O)C(F)(F)F MVALDVBMYCYENV-UHFFFAOYSA-N 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000012453 solvate Substances 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1
238000002560 therapeutic procedure Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
- C07C233/42—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
- C07C233/43—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of a saturated carbon skeleton
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
- C07C225/22—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Physical Education & Sports Medicine (AREA)
Rheumatology (AREA)
Immunology (AREA)
Orthopedic Medicine & Surgery (AREA)
Pulmonology (AREA)
Pain & Pain Management (AREA)
Dermatology (AREA)
Communicable Diseases (AREA)
Virology (AREA)
Oncology (AREA)
AIDS & HIV (AREA)
Cardiology (AREA)
Vascular Medicine (AREA)
Heart & Thoracic Surgery (AREA)
Urology & Nephrology (AREA)
Tropical Medicine & Parasitology (AREA)
Molecular Biology (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT00943702T 1999-07-16 2000-07-11 Aminobenzophenone als inhibitoren von il-1beta und tnf-alpha ATE277889T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US14416999P	1999-07-16	1999-07-16
PCT/DK2000/000388 WO2001005745A1 (en)	1999-07-16	2000-07-11	AMINOBENZOPHENONES AS INHIBITORS OF IL-1β AND TNF-$g(a)

Publications (1)

Publication Number	Publication Date
ATE277889T1 true ATE277889T1 (de)	2004-10-15

Family

ID=22507398

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT00943702T ATE277889T1 (de)	1999-07-16	2000-07-11	Aminobenzophenone als inhibitoren von il-1beta und tnf-alpha

Country Status (18)

Country	Link
US (1)	US6555710B1 (de)
EP (1)	EP1202957B1 (de)
JP (1)	JP2003505360A (de)
KR (1)	KR20020013960A (de)
CN (1)	CN1174956C (de)
AT (1)	ATE277889T1 (de)
AU (1)	AU768816B2 (de)
CA (1)	CA2379319A1 (de)
CZ (1)	CZ2002158A3 (de)
DE (1)	DE60014393T2 (de)
DK (1)	DK1202957T3 (de)
ES (1)	ES2228557T3 (de)
HK (1)	HK1048465B (de)
HU (1)	HUP0201909A3 (de)
PL (1)	PL353639A1 (de)
PT (1)	PT1202957E (de)
RU (1)	RU2238933C2 (de)
WO (1)	WO2001005745A1 (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
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US5763429A (en) *	1993-09-10	1998-06-09	Bone Care International, Inc.	Method of treating prostatic diseases using active vitamin D analogues
US6242434B1 (en) *	1997-08-08	2001-06-05	Bone Care International, Inc.	24-hydroxyvitamin D, analogs and uses thereof
US20020128240A1 (en) *	1996-12-30	2002-09-12	Bone Care International, Inc.	Treatment of hyperproliferative diseases using active vitamin D analogues
US6566353B2 (en) *	1996-12-30	2003-05-20	Bone Care International, Inc.	Method of treating malignancy associated hypercalcemia using active vitamin D analogues
US6087350A (en) *	1997-08-29	2000-07-11	University Of Pittsburgh Of The Commonwealth System Of Higher Education	Use of pretreatment chemicals to enhance efficacy of cytotoxic agents
WO1999049870A1 (en) *	1998-03-27	1999-10-07	Oregon Health Sciences University	Vitamin d and its analogs in the treatment of tumors and other hyperproliferative disorders
AU6008101A (en)	2000-05-22	2001-12-03	Leo Pharm Prod Ltd	Benzophenones as inhibitors of il-1beta and tnf-alpha
IL153378A0 (en) *	2000-07-18	2003-07-06	Bone Care Internat Inc	STABILIZED 1alpha-HYDROXY VITAMIN D
CA2458611C (en)	2001-08-28	2012-05-29	Leo Pharma A/S	Aminobenzophenones as interleukin 1-beta and tumour necrosis factor-alpha inhibitors
MXPA04005260A (es) *	2001-12-03	2005-03-23	Novacea Inc	Composiciones farmaceuticas que comprenden compuestos activos de vitamina d.
US20030225089A1 (en) *	2002-04-10	2003-12-04	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Pharmaceutical compositions based on anticholinergics and p38 kinase inhibitors
WO2004004725A2 (en)	2002-07-09	2004-01-15	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Pharmaceutical compositions of anticholinergics and p38 kinase inhibitors in the treatment of respiratory diseases
US20050026877A1 (en) *	2002-12-03	2005-02-03	Novacea, Inc.	Pharmaceutical compositions comprising active vitamin D compounds
US20050020546A1 (en) *	2003-06-11	2005-01-27	Novacea, Inc.	Pharmaceutical compositions comprising active vitamin D compounds
US20060189586A1 (en) *	2003-06-11	2006-08-24	Cleland Jeffrey L	Pharmaceutical compositions comprising active vitamin D compounds
US7977387B2 (en)	2003-07-24	2011-07-12	Leo Pharma A/S	Aminobenzophenone compounds
US7094775B2 (en) *	2004-06-30	2006-08-22	Bone Care International, Llc	Method of treating breast cancer using a combination of vitamin D analogues and other agents
US20060003950A1 (en) *	2004-06-30	2006-01-05	Bone Care International, Inc.	Method of treating prostatic diseases using a combination of vitamin D analogues and other agents
US20060035893A1 (en)	2004-08-07	2006-02-16	Boehringer Ingelheim International Gmbh	Pharmaceutical compositions for treatment of respiratory and gastrointestinal disorders
CN101115728B (zh)	2004-12-13	2012-12-19	利奥制药有限公司	三唑取代的氨基二苯甲酮化合物
PE20060777A1 (es)	2004-12-24	2006-10-06	Boehringer Ingelheim Int	Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas
EP1992344A1 (de)	2007-05-18	2008-11-19	Institut Curie	P38 Alpha als therapeutisches Target für Erkrankungen, die mit einer FGFR3- Mutation assoziiert sind
DK2266557T3 (da)	2008-04-22	2013-09-23	Toyama Chemical Co Ltd	Kombination af benzophenonderivat eller salt deraf og immunosuppressivt stof, samt farmaceutisk sammensætning omfattede disse komponenter
EP2206534A1 (de)	2008-10-09	2010-07-14	c-a-i-r biosciences GmbH	Dibenzocycloheptanonderivate und pharmazeutische Mittel, welche diese Verbindungen enthalten
CA2851668C (en)	2011-10-12	2016-08-16	Novartis Ag	Method for making uv-absorbing ophthalmic lenses by coating
HUE031702T2 (en)	2012-12-17	2017-07-28	Novartis Ag	A method for producing improved UV absorbing ophthalmic lenses

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1535401A (en) *	1977-07-28	1978-12-13	Holliday & Co Ltd L	Nitrodiphenylamine carboxylic acid disperse dyes
GB9701453D0 (en) *	1997-01-24	1997-03-12	Leo Pharm Prod Ltd	Aminobenzophenones

2000
- 2000-07-11 PT PT00943702T patent/PT1202957E/pt unknown
- 2000-07-11 HK HK03100589.4A patent/HK1048465B/zh not_active IP Right Cessation
- 2000-07-11 PL PL00353639A patent/PL353639A1/xx not_active Application Discontinuation
- 2000-07-11 CA CA002379319A patent/CA2379319A1/en not_active Abandoned
- 2000-07-11 US US10/031,071 patent/US6555710B1/en not_active Expired - Fee Related
- 2000-07-11 DE DE60014393T patent/DE60014393T2/de not_active Expired - Fee Related
- 2000-07-11 CN CNB008115036A patent/CN1174956C/zh not_active Expired - Fee Related
- 2000-07-11 EP EP00943702A patent/EP1202957B1/de not_active Expired - Lifetime
- 2000-07-11 HU HU0201909A patent/HUP0201909A3/hu unknown
- 2000-07-11 AT AT00943702T patent/ATE277889T1/de not_active IP Right Cessation
- 2000-07-11 KR KR1020027000614A patent/KR20020013960A/ko not_active Ceased
- 2000-07-11 ES ES00943702T patent/ES2228557T3/es not_active Expired - Lifetime
- 2000-07-11 WO PCT/DK2000/000388 patent/WO2001005745A1/en not_active Ceased
- 2000-07-11 RU RU2002103867A patent/RU2238933C2/ru not_active IP Right Cessation
- 2000-07-11 AU AU58071/00A patent/AU768816B2/en not_active Ceased
- 2000-07-11 CZ CZ2002158A patent/CZ2002158A3/cs unknown
- 2000-07-11 DK DK00943702T patent/DK1202957T3/da active
- 2000-07-11 JP JP2001511406A patent/JP2003505360A/ja active Pending

Also Published As

Publication number	Publication date
WO2001005745A1 (en)	2001-01-25
DE60014393D1 (de)	2004-11-04
PL353639A1 (en)	2003-12-01
ES2228557T3 (es)	2005-04-16
KR20020013960A (ko)	2002-02-21
JP2003505360A (ja)	2003-02-12
RU2238933C2 (ru)	2004-10-27
DE60014393T2 (de)	2006-02-16
CZ2002158A3 (cs)	2002-08-14
PT1202957E (pt)	2005-01-31
DK1202957T3 (da)	2005-01-31
US6555710B1 (en)	2003-04-29
AU768816B2 (en)	2004-01-08
AU5807100A (en)	2001-02-05
EP1202957A1 (de)	2002-05-08
HUP0201909A3 (en)	2002-11-28
HK1048465A1 (en)	2003-04-04
EP1202957B1 (de)	2004-09-29
HK1048465B (zh)	2005-04-08
CA2379319A1 (en)	2001-01-25
CN1174956C (zh)	2004-11-10
CN1368953A (zh)	2002-09-11
HUP0201909A2 (en)	2002-10-28

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2005-06-15

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Publication	Publication Date	Title
DE60014393D1 (de)	2004-11-04	Aminobenzophenone als inhibitoren von il-1beta und tnf-alpha
ATE362912T1 (de)	2007-06-15	Aminobenzophenone als inhibitoren von il-1beta und tnf-alpha
DE60022328D1 (de)	2005-10-06	Amid-derivate
CA2545427A1 (en)	2005-07-21	Selective kinase inhibitors
ATE277897T1 (de)	2004-10-15	Aminobenzophenone als inhibitoren von il-1beta und tnf-alpha
NO173500C (no)	1993-12-22	Analogifremgangsmaate for fremstilling av terapeutisk aktive benzokon-densete N-holdige heterocykliske derivater
ATE277891T1 (de)	2004-10-15	Aminobenzophenone als inhibitoren von il-1beta und tnf-alpha
ATE278663T1 (de)	2004-10-15	Aminobenzophenone als inhibitoren von il-1beta und tnf-alpha
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DE602004025302D1 (de)	2010-03-11	Aryloxy- und Arylthioxyacetophenon-Verbindungen zur Behandlung von Krebs
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ATE251117T1 (de)	2003-10-15	Neue aminobenzophenone
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DE69910083D1 (de)	2003-09-04	Katecholhydrazon-derivate, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen die diese enthalten
EA200200379A2 (ru)	2002-10-31	Новые соединения пиримидин-4-она, способ их получения и содержащие их фармацевтические композиции
PE20001520A1 (es)	2001-01-08	Composiciones farmaceuticas que comprenden derivados sustituidos de indazol como inhibidores de pde tipo iv y la produccion de tnf
TW200726463A (en)	2007-07-16	Therapeutic agents