ATE516026T1 - Bicyclisches carbamoylpyridonderivat mit hiv- integrase-hemmender wirkung - Google Patents

Bicyclisches carbamoylpyridonderivat mit hiv- integrase-hemmender wirkung

Info

Publication number: ATE516026T1
Authority: AT; Austria
Prior art keywords: optionally substituted; hiv integrase; bicyclic; hydrogen; group
Prior art date: 2005-02-21

Application number

AT06714066T

Other languages

English (en)

Inventor

Hiroshi Yoshida

Takashi Kawasuji

Yoshiyuki Taoda

Original Assignee

Shionogi & Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-02-21

Filing date

2006-02-20

Publication date

2011-07-15

2006-02-20 Application filed by Shionogi & Co filed Critical Shionogi & Co

2011-07-15 Application granted granted Critical

2011-07-15 Publication of ATE516026T1 publication Critical patent/ATE516026T1/de

Links

108010002459 HIV Integrase Proteins 0.000 title abstract 2
230000002401 inhibitory effect Effects 0.000 title abstract 2
OHEKQGOBJIKKIF-AWEZNQCLSA-N (12as)-n-[(4-fluorophenyl)methyl]-7-hydroxy-6,8-dioxo-3,4,12,12a-tetrahydro-2h-pyrido[5,6]pyrazino[2,6-b][1,3]oxazine-9-carboxamide Chemical class C([C@@H]1OCCCN1C(=O)C1=C(C2=O)O)N1C=C2C(=O)NCC1=CC=C(F)C=C1 OHEKQGOBJIKKIF-AWEZNQCLSA-N 0.000 title 1
125000005842 heteroatom Chemical group 0.000 abstract 3
229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
125000004450 alkenylene group Chemical group 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 2
125000002947 alkylene group Chemical group 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
150000002431 hydrogen Chemical class 0.000 abstract 2
229910052760 oxygen Inorganic materials 0.000 abstract 2
229910052717 sulfur Inorganic materials 0.000 abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
239000002259 anti human immunodeficiency virus agent Substances 0.000 abstract 1
229940124411 anti-hiv antiviral agent Drugs 0.000 abstract 1
230000000840 anti-viral effect Effects 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1
125000000547 substituted alkyl group Chemical group 0.000 abstract 1
125000003107 substituted aryl group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Immunology (AREA)
Virology (AREA)
Molecular Biology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Biochemistry (AREA)
AIDS & HIV (AREA)
Tropical Medicine & Parasitology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AT06714066T 2005-02-21 2006-02-20 Bicyclisches carbamoylpyridonderivat mit hiv- integrase-hemmender wirkung ATE516026T1 (de)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
JP2005043310		2005-02-21
JP2005131161		2005-04-28
JP2005312076		2005-10-27
PCT/JP2006/302925 WO2006088173A1 (ja)	2005-02-21	2006-02-20	Ｈｉｖインテグラーゼ阻害活性を有する２環性カルバモイルピリドン誘導体

Publications (1)

Publication Number	Publication Date
ATE516026T1 true ATE516026T1 (de)	2011-07-15

Family

ID=36916569

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT06714066T ATE516026T1 (de)	2005-02-21	2006-02-20	Bicyclisches carbamoylpyridonderivat mit hiv- integrase-hemmender wirkung

Country Status (5)

Country	Link
US (1)	US7858788B2 (de)
EP (1)	EP1852434B1 (de)
JP (1)	JP5317257B2 (de)
AT (1)	ATE516026T1 (de)
WO (1)	WO2006088173A1 (de)

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2006
- 2006-02-20 WO PCT/JP2006/302925 patent/WO2006088173A1/ja not_active Ceased
- 2006-02-20 EP EP06714066A patent/EP1852434B1/de not_active Expired - Lifetime
- 2006-02-20 AT AT06714066T patent/ATE516026T1/de not_active IP Right Cessation
- 2006-02-20 JP JP2007503763A patent/JP5317257B2/ja not_active Expired - Fee Related
- 2006-02-20 US US11/884,686 patent/US7858788B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
JP5317257B2 (ja)	2013-10-16
US7858788B2 (en)	2010-12-28
EP1852434A4 (de)	2010-01-13
US20080161271A1 (en)	2008-07-03
EP1852434A1 (de)	2007-11-07
EP1852434B1 (de)	2011-07-13
JPWO2006088173A1 (ja)	2008-07-03
WO2006088173A1 (ja)	2006-08-24

Legal Events

Date	Code	Title	Description
2012-01-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

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