ATE516359T1 - Nagetiermodell zur schnellen identifizierung pharmazeutischer wirkstoffe in vivo - Google Patents

Nagetiermodell zur schnellen identifizierung pharmazeutischer wirkstoffe in vivo

Info

Publication number
ATE516359T1
ATE516359T1 AT04716577T AT04716577T ATE516359T1 AT E516359 T1 ATE516359 T1 AT E516359T1 AT 04716577 T AT04716577 T AT 04716577T AT 04716577 T AT04716577 T AT 04716577T AT E516359 T1 ATE516359 T1 AT E516359T1
Authority
AT
Austria
Prior art keywords
tumor
protein
expression
reporter gene
growth
Prior art date
Application number
AT04716577T
Other languages
English (en)
Inventor
Ann Belion
Janine Arts
Ann Marion
Annemie Valckx
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Application granted granted Critical
Publication of ATE516359T1 publication Critical patent/ATE516359T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
    • A61K49/0008—Screening agents using (non-human) animal models or transgenic animal models or chimeric hosts, e.g. Alzheimer disease animal model, transgenic model for heart failure
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0271—Chimeric vertebrates, e.g. comprising exogenous cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4738—Cell cycle regulated proteins, e.g. cyclin, CDC, INK-CCR
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0331—Animal model for proliferative diseases
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0393—Animal model comprising a reporter system for screening tests

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Environmental Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plant Pathology (AREA)
  • Rheumatology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AT04716577T 2003-03-05 2004-03-03 Nagetiermodell zur schnellen identifizierung pharmazeutischer wirkstoffe in vivo ATE516359T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/EP2003/002264 WO2004078984A1 (en) 2003-03-05 2003-03-05 Animal model for the fast identification of pharmaceutical active compounds in vivo
PCT/EP2004/002195 WO2004078985A1 (en) 2003-03-05 2004-03-03 Animal model for the fast identification of pharmaceutical active compounds in vivo

Publications (1)

Publication Number Publication Date
ATE516359T1 true ATE516359T1 (de) 2011-07-15

Family

ID=32946821

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04716577T ATE516359T1 (de) 2003-03-05 2004-03-03 Nagetiermodell zur schnellen identifizierung pharmazeutischer wirkstoffe in vivo

Country Status (13)

Country Link
US (1) US7666670B2 (de)
EP (1) EP1601775B1 (de)
JP (1) JP4545142B2 (de)
CN (2) CN1756846A (de)
AT (1) ATE516359T1 (de)
AU (1) AU2004217817B2 (de)
CA (1) CA2516519C (de)
DK (1) DK1601775T3 (de)
ES (1) ES2368328T3 (de)
IL (1) IL170611A (de)
NO (1) NO334878B1 (de)
NZ (1) NZ542577A (de)
WO (2) WO2004078984A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8592147B2 (en) 2005-01-13 2013-11-26 Senex Biotechnology High-content screening for drugs against cancer and age-related diseases
FR2893525B1 (fr) * 2005-11-23 2008-01-18 Cogema Couteau a lame retractile, utilisable notamment en milieu hostile
EP2176409B1 (de) * 2007-07-11 2012-01-04 Yeda Research And Development Co. Ltd. Nukleinsäurekonstruktsysteme mit fähigkeit zur diagnose oder behandlung eines zellzustands
SI23294A (sl) * 2010-02-25 2011-08-31 Nacionalni inštitut za biologijo Celiäśni sistem za hitro zaznavanje in doloäśanje genotoksiäśnosti
WO2012071559A2 (en) * 2010-11-23 2012-05-31 Presage Biosciences, Inc. Therapeutic methods and compositions for solid delivery
CN114350604A (zh) * 2021-12-30 2022-04-15 华南理工大学 Mc38-n4/ot-i共培养系统筛选方法及其筛选的多糖组方与多糖组合物的应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU5965294A (en) * 1993-01-08 1994-08-15 Exemplar Corporation An (in vitro)/(in vivo) method for identifying anti-neoplastic drugs
US5650135A (en) * 1994-07-01 1997-07-22 The Board Of Trustees Of The Leland Stanford Junior University Non-invasive localization of a light-emitting conjugate in a mammal
JP2003527833A (ja) * 1999-10-14 2003-09-24 クロンテック・ラボラトリーズ・インコーポレーテッド 花虫類に由来する発色団／蛍光体、およびそれらの使用法
WO2002055742A2 (en) * 2001-01-09 2002-07-18 Novartis Ag Rapid method for screening compounds for in vivo activity
US20030228627A1 (en) * 2002-03-22 2003-12-11 Emerson Beverly M. Assay for p53 function in cells

Also Published As

Publication number Publication date
US20060147377A1 (en) 2006-07-06
NO20054554D0 (no) 2005-10-04
DK1601775T3 (da) 2011-10-31
JP4545142B2 (ja) 2010-09-15
CA2516519C (en) 2013-09-17
NZ542577A (en) 2007-12-21
AU2004217817B2 (en) 2009-12-10
JP2007523606A (ja) 2007-08-23
US7666670B2 (en) 2010-02-23
EP1601775A1 (de) 2005-12-07
NO334878B1 (no) 2014-06-30
WO2004078984A1 (en) 2004-09-16
CA2516519A1 (en) 2004-09-16
NO20054554L (no) 2005-11-17
IL170611A (en) 2013-10-31
CN1756846A (zh) 2006-04-05
CN102766602A (zh) 2012-11-07
EP1601775B1 (de) 2011-07-13
WO2004078985A1 (en) 2004-09-16
AU2004217817A1 (en) 2004-09-16
ES2368328T3 (es) 2011-11-16

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