NO20054554L - Dyremodell for rask identifikasjon av farmasoytiske aktive forbindelser in vivo - Google Patents
Dyremodell for rask identifikasjon av farmasoytiske aktive forbindelser in vivoInfo
- Publication number
- NO20054554L NO20054554L NO20054554A NO20054554A NO20054554L NO 20054554 L NO20054554 L NO 20054554L NO 20054554 A NO20054554 A NO 20054554A NO 20054554 A NO20054554 A NO 20054554A NO 20054554 L NO20054554 L NO 20054554L
- Authority
- NO
- Norway
- Prior art keywords
- tumor
- protein
- expression
- reporter gene
- growth
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
- A61K49/0008—Screening agents using (non-human) animal models or transgenic animal models or chimeric hosts, e.g. Alzheimer disease animal model, transgenic model for heart failure
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0271—Chimeric vertebrates, e.g. comprising exogenous cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4738—Cell cycle regulated proteins, e.g. cyclin, CDC, INK-CCR
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0331—Animal model for proliferative diseases
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0393—Animal model comprising a reporter system for screening tests
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Environmental Sciences (AREA)
- Physics & Mathematics (AREA)
- Animal Behavior & Ethology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Plant Pathology (AREA)
- Rheumatology (AREA)
- Animal Husbandry (AREA)
- Biodiversity & Conservation Biology (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
I et første aspekt fremskaffer foreliggende oppfinnelse en tumorcellelinje som er stabilt transfektert med en ekspresjonsvektor inneholdende et reportergen, fortrinnsvis et fluorescent protein, operativt knyttet til en promoter som også kontrollerer ekspresjon av et protein som er assosiert med tumorregresjon, stabilisering av tumorvekst eller inhibering av metastatisk vekst, og som er særpreget ved at nevnte cellelinje er i stand til å danne en tumor når implantert eller injisert i det ikke-humane dyr. Sammenlignet med tradisjonelle in vivo-modeller er foreliggende oppfinnelse forskjellig ved at reportergenet ikke blir konstituitivt uttrykt, men kun etter eksponering til en forsøksforbindelse som resulterer i ekspresjonen av et protein eller enzym som er assosiert med tumorregresjon, stabilisering av tumorvekst eller inhibering av metastatisk vekst. Kun når en forbindelse som skal undersøkes, kommer inn i sirkulasjonen og infiltrerer tumoren, kan den generere reportersignalet, forutsatt at den fremmer ekspres3onen av et protein assosiert med tumorregresjon, og promoteren av nevnte protein er operativt knyttet til reportergenet.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/EP2003/002264 WO2004078984A1 (en) | 2003-03-05 | 2003-03-05 | Animal model for the fast identification of pharmaceutical active compounds in vivo |
| PCT/EP2004/002195 WO2004078985A1 (en) | 2003-03-05 | 2004-03-03 | Animal model for the fast identification of pharmaceutical active compounds in vivo |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO20054554D0 NO20054554D0 (no) | 2005-10-04 |
| NO20054554L true NO20054554L (no) | 2005-11-17 |
| NO334878B1 NO334878B1 (no) | 2014-06-30 |
Family
ID=32946821
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20054554A NO334878B1 (no) | 2003-03-05 | 2005-10-04 | Dyremodell for rask identifikasjon av farmasøytiske aktive forbindelser in vivo |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US7666670B2 (no) |
| EP (1) | EP1601775B1 (no) |
| JP (1) | JP4545142B2 (no) |
| CN (2) | CN1756846A (no) |
| AT (1) | ATE516359T1 (no) |
| AU (1) | AU2004217817B2 (no) |
| CA (1) | CA2516519C (no) |
| DK (1) | DK1601775T3 (no) |
| ES (1) | ES2368328T3 (no) |
| IL (1) | IL170611A (no) |
| NO (1) | NO334878B1 (no) |
| NZ (1) | NZ542577A (no) |
| WO (2) | WO2004078984A1 (no) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8592147B2 (en) | 2005-01-13 | 2013-11-26 | Senex Biotechnology | High-content screening for drugs against cancer and age-related diseases |
| FR2893525B1 (fr) * | 2005-11-23 | 2008-01-18 | Cogema | Couteau a lame retractile, utilisable notamment en milieu hostile |
| EP2176409B1 (en) * | 2007-07-11 | 2012-01-04 | Yeda Research And Development Co. Ltd. | Nucleic acid construct systems capable of diagnosing or treating a cell state |
| SI23294A (sl) * | 2010-02-25 | 2011-08-31 | Nacionalni inštitut za biologijo | Celiäśni sistem za hitro zaznavanje in doloäśanje genotoksiäśnosti |
| WO2012071559A2 (en) * | 2010-11-23 | 2012-05-31 | Presage Biosciences, Inc. | Therapeutic methods and compositions for solid delivery |
| CN114350604A (zh) * | 2021-12-30 | 2022-04-15 | 华南理工大学 | Mc38-n4/ot-i共培养系统筛选方法及其筛选的多糖组方与多糖组合物的应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU5965294A (en) * | 1993-01-08 | 1994-08-15 | Exemplar Corporation | An (in vitro)/(in vivo) method for identifying anti-neoplastic drugs |
| US5650135A (en) * | 1994-07-01 | 1997-07-22 | The Board Of Trustees Of The Leland Stanford Junior University | Non-invasive localization of a light-emitting conjugate in a mammal |
| JP2003527833A (ja) * | 1999-10-14 | 2003-09-24 | クロンテック・ラボラトリーズ・インコーポレーテッド | 花虫類に由来する発色団／蛍光体、およびそれらの使用法 |
| WO2002055742A2 (en) * | 2001-01-09 | 2002-07-18 | Novartis Ag | Rapid method for screening compounds for in vivo activity |
| US20030228627A1 (en) * | 2002-03-22 | 2003-12-11 | Emerson Beverly M. | Assay for p53 function in cells |
-
2003
- 2003-03-05 WO PCT/EP2003/002264 patent/WO2004078984A1/en not_active Ceased
-
2004
- 2004-03-03 AT AT04716577T patent/ATE516359T1/de not_active IP Right Cessation
- 2004-03-03 WO PCT/EP2004/002195 patent/WO2004078985A1/en not_active Ceased
- 2004-03-03 CN CNA2004800058454A patent/CN1756846A/zh active Pending
- 2004-03-03 EP EP04716577A patent/EP1601775B1/en not_active Expired - Lifetime
- 2004-03-03 AU AU2004217817A patent/AU2004217817B2/en not_active Expired
- 2004-03-03 CN CN2012102237690A patent/CN102766602A/zh active Pending
- 2004-03-03 JP JP2006504535A patent/JP4545142B2/ja not_active Expired - Lifetime
- 2004-03-03 ES ES04716577T patent/ES2368328T3/es not_active Expired - Lifetime
- 2004-03-03 NZ NZ542577A patent/NZ542577A/en not_active IP Right Cessation
- 2004-03-03 US US10/547,518 patent/US7666670B2/en not_active Expired - Lifetime
- 2004-03-03 DK DK04716577.4T patent/DK1601775T3/da active
- 2004-03-03 CA CA2516519A patent/CA2516519C/en not_active Expired - Lifetime
-
2005
- 2005-09-01 IL IL170611A patent/IL170611A/en active IP Right Grant
- 2005-10-04 NO NO20054554A patent/NO334878B1/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20060147377A1 (en) | 2006-07-06 |
| NO20054554D0 (no) | 2005-10-04 |
| DK1601775T3 (da) | 2011-10-31 |
| JP4545142B2 (ja) | 2010-09-15 |
| CA2516519C (en) | 2013-09-17 |
| NZ542577A (en) | 2007-12-21 |
| ATE516359T1 (de) | 2011-07-15 |
| AU2004217817B2 (en) | 2009-12-10 |
| JP2007523606A (ja) | 2007-08-23 |
| US7666670B2 (en) | 2010-02-23 |
| EP1601775A1 (en) | 2005-12-07 |
| NO334878B1 (no) | 2014-06-30 |
| WO2004078984A1 (en) | 2004-09-16 |
| CA2516519A1 (en) | 2004-09-16 |
| IL170611A (en) | 2013-10-31 |
| CN1756846A (zh) | 2006-04-05 |
| CN102766602A (zh) | 2012-11-07 |
| EP1601775B1 (en) | 2011-07-13 |
| WO2004078985A1 (en) | 2004-09-16 |
| AU2004217817A1 (en) | 2004-09-16 |
| ES2368328T3 (es) | 2011-11-16 |
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