ATE516821T1 - Zweiphotonensonde zur echtzeit-beobachtung intrazellulärer freier zinkionen, verfahren zur herstellung der sonde und verfahren zur echtzeit- beobachtung der intrazellulären freien zinkionen unter verwendung der sonde - Google Patents

Zweiphotonensonde zur echtzeit-beobachtung intrazellulärer freier zinkionen, verfahren zur herstellung der sonde und verfahren zur echtzeit- beobachtung der intrazellulären freien zinkionen unter verwendung der sonde

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Publication number
ATE516821T1
ATE516821T1 AT09159851T AT09159851T ATE516821T1 AT E516821 T1 ATE516821 T1 AT E516821T1 AT 09159851 T AT09159851 T AT 09159851T AT 09159851 T AT09159851 T AT 09159851T AT E516821 T1 ATE516821 T1 AT E516821T1
Authority
AT
Austria
Prior art keywords
probe
real
zinc ions
intracellular free
free zinc
Prior art date
Application number
AT09159851T
Other languages
English (en)
Inventor
Bong-Rae Cho
Original Assignee
Univ Ind & Acad Collaboration
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Ind & Acad Collaboration filed Critical Univ Ind & Acad Collaboration
Application granted granted Critical
Publication of ATE516821T1 publication Critical patent/ATE516821T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B57/00—Other synthetic dyes of known constitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/533—Production of labelled immunochemicals with fluorescent label

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pyridine Compounds (AREA)
AT09159851T 2008-05-13 2009-05-11 Zweiphotonensonde zur echtzeit-beobachtung intrazellulärer freier zinkionen, verfahren zur herstellung der sonde und verfahren zur echtzeit- beobachtung der intrazellulären freien zinkionen unter verwendung der sonde ATE516821T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1020080044176A KR100954585B1 (ko) 2008-05-13 2008-05-13 세포질 내 자유 아연 이온의 실시간 모니터링용 이광자염료, 그 제조방법 및 이를 이용한 세포질 내 자유 아연이온의 실시간 모니터링 방법

Publications (1)

Publication Number Publication Date
ATE516821T1 true ATE516821T1 (de) 2011-08-15

Family

ID=41017107

Family Applications (1)

Application Number Title Priority Date Filing Date
AT09159851T ATE516821T1 (de) 2008-05-13 2009-05-11 Zweiphotonensonde zur echtzeit-beobachtung intrazellulärer freier zinkionen, verfahren zur herstellung der sonde und verfahren zur echtzeit- beobachtung der intrazellulären freien zinkionen unter verwendung der sonde

Country Status (5)

Country Link
US (1) US8129137B2 (de)
EP (1) EP2119456B1 (de)
JP (1) JP4901908B2 (de)
KR (1) KR100954585B1 (de)
AT (1) ATE516821T1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101233679B1 (ko) * 2010-08-05 2013-02-15 아주대학교산학협력단 서로 다른 형광색의 이광자 형광 프로브를 이용하여 나트륨/칼슘 활성을 동시에 이미지화하는 방법 및 이광자 형광 프로브의 제조방법
KR101190722B1 (ko) 2011-01-21 2012-10-12 아주대학교산학협력단 이광자 형광 프로브를 이용한 미토콘드리아 내 아연 활성의 영상화 방법 및 이의 제조방법
KR101395457B1 (ko) 2012-05-17 2014-05-15 포항공과대학교 산학협력단 새로운 이광자 흡수 형광체 및 이를 이용한 기질 감지 방법
CN102735662B (zh) * 2012-07-19 2014-06-18 贵州大学 一种锌离子的荧光发射光谱分析法
KR101493935B1 (ko) 2012-10-17 2015-02-16 아주대학교산학협력단 아밀로이드 베타 플라크에 특이적인 이광자 형광 프로브, 이의 제조방법, 및 이를 이용한 생체 내 아밀로이드 베타 플라크의 영상화 방법
CN104693221A (zh) * 2015-03-25 2015-06-10 徐伟鹏 检测稀土金属Eu离子的化合物及其制备方法和应用
CN107860732B (zh) * 2017-04-19 2019-05-24 南京晓庄学院 一种多信号探针的用途

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2001235997B2 (en) * 2000-02-28 2005-06-09 Daiichi Pure Chemicals Co., Ltd. Fluorescent probes for the quantitation of zinc
US20040235902A1 (en) * 2001-06-14 2004-11-25 Tetsuo Nagano Fluorescent probes for zinc
JP2004359677A (ja) * 2003-05-13 2004-12-24 Asahi Kasei Corp 複核錯体
AU2007297573A1 (en) * 2006-06-12 2008-03-27 Viamet Pharmaceuticals, Inc. Metallo-hydrolase inhibitors using metal binding moieties in combination with targeting moieties
KR100776830B1 (ko) 2006-06-29 2007-11-28 고려대학교 산학협력단 리피드 래프트의 실시간 영상용 이광자 염료
KR100805262B1 (ko) 2007-06-28 2008-02-20 고려대학교 산학협력단 리피드 래프트의 실시간 영상용 이광자 염료

Also Published As

Publication number Publication date
EP2119456A1 (de) 2009-11-18
JP4901908B2 (ja) 2012-03-21
US8129137B2 (en) 2012-03-06
KR20090118412A (ko) 2009-11-18
JP2009280811A (ja) 2009-12-03
KR100954585B1 (ko) 2010-04-26
US20090286275A1 (en) 2009-11-19
EP2119456B1 (de) 2011-07-20

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