ATE517101T1 - Als mmp-inhibitoren verwendete hydantoinderivate - Google Patents

Als mmp-inhibitoren verwendete hydantoinderivate

Info

Publication number: ATE517101T1
Authority: AT; Austria
Prior art keywords: derivatives used; mmp inhibitors; hydantoine; hydantoine derivatives; mmp
Prior art date: 2006-11-29

Application number

AT07824738T

Other languages

English (en)

Inventor

David Chapman

Balint Gabos

Af Rosenschold Magnus Munck

Original Assignee

Astrazeneca Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-11-29

Filing date

2007-11-28

Publication date

2011-08-15

2007-11-28 Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab

2011-08-15 Application granted granted Critical

2011-08-15 Publication of ATE517101T1 publication Critical patent/ATE517101T1/de

Links

229940124761 MMP inhibitor Drugs 0.000 title 1
WJRBRSLFGCUECM-UHFFFAOYSA-N hydantoin Chemical class O=C1CNC(=O)N1 WJRBRSLFGCUECM-UHFFFAOYSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/34—One oxygen atom

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Physical Education & Sports Medicine (AREA)
Pulmonology (AREA)
Rheumatology (AREA)
Cardiology (AREA)
Neurology (AREA)
Heart & Thoracic Surgery (AREA)
Orthopedic Medicine & Surgery (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Hospice & Palliative Care (AREA)
Urology & Nephrology (AREA)
Pain & Pain Management (AREA)
Oncology (AREA)
Endocrinology (AREA)
Immunology (AREA)
Otolaryngology (AREA)
Vascular Medicine (AREA)
Virology (AREA)
Ophthalmology & Optometry (AREA)
Reproductive Health (AREA)
Psychiatry (AREA)
Communicable Diseases (AREA)
Dermatology (AREA)
Gastroenterology & Hepatology (AREA)
Epidemiology (AREA)

AT07824738T 2006-11-29 2007-11-28 Als mmp-inhibitoren verwendete hydantoinderivate ATE517101T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US86760606P	2006-11-29	2006-11-29
PCT/GB2007/004556 WO2008065393A1 (en)	2006-11-29	2007-11-28	Hydantoin derivatives used as mmp inhibitors

Publications (1)

Publication Number	Publication Date
ATE517101T1 true ATE517101T1 (de)	2011-08-15

Family

ID=38969379

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT07824738T ATE517101T1 (de)	2006-11-29	2007-11-28	Als mmp-inhibitoren verwendete hydantoinderivate

Country Status (26)

Country	Link
US (2)	US8183251B2 (de)
EP (1)	EP2097406B1 (de)
JP (1)	JP5097212B2 (de)
KR (1)	KR20090083416A (de)
CN (1)	CN101541789B (de)
AR (1)	AR064041A1 (de)
AT (1)	ATE517101T1 (de)
AU (1)	AU2007327105B2 (de)
BR (1)	BRPI0719389A2 (de)
CA (1)	CA2670166A1 (de)
CL (1)	CL2007003423A1 (de)
CO (1)	CO6210692A2 (de)
EC (1)	ECSP099370A (de)
ES (1)	ES2368013T3 (de)
IL (1)	IL198640A0 (de)
MX (1)	MX2009005357A (de)
NO (1)	NO20092412L (de)
NZ (1)	NZ576821A (de)
PE (1)	PE20081120A1 (de)
RU (1)	RU2463301C2 (de)
SA (1)	SA07280646B1 (de)
TW (1)	TW200831488A (de)
UA (1)	UA93425C2 (de)
UY (1)	UY30748A1 (de)
WO (1)	WO2008065393A1 (de)
ZA (1)	ZA200903286B (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE0100902D0 (sv) *	2001-03-15	2001-03-15	Astrazeneca Ab	Compounds
SE0100903D0 (sv) *	2001-03-15	2001-03-15	Astrazeneca Ab	Compounds
SE0202539D0 (sv) *	2002-08-27	2002-08-27	Astrazeneca Ab	Compounds
SE0401762D0 (sv) *	2004-07-05	2004-07-05	Astrazeneca Ab	Novel compounds
US7648992B2 (en) *	2004-07-05	2010-01-19	Astrazeneca Ab	Hydantoin derivatives for the treatment of obstructive airway diseases
SE0403086D0 (sv) *	2004-12-17	2004-12-17	Astrazeneca Ab	Compounds
SE0403085D0 (sv) *	2004-12-17	2004-12-17	Astrazeneca Ab	Novel componds
EP1859356B1 (de) *	2005-03-16	2019-07-10	Sensus Metering Systems Inc.	Verfahren, system, vorrichtung und computerprogrammprodukt zur bestimmung eines physischen ortes eines sensors
TW200740769A (en) *	2006-03-16	2007-11-01	Astrazeneca Ab	Novel process
TW200831488A (en)	2006-11-29	2008-08-01	Astrazeneca Ab	Novel compounds
PT2225238E (pt)	2007-11-29	2014-12-18	Boehringer Ingelheim Int	Derivados de amidas do ácido 6,7-di-hidro-5h-imidazo[1,2- a]imidazol-3-carboxílico
US9186377B2 (en)	2011-06-03	2015-11-17	Maguire Abbey, Llc	Method, composition, and articles for improving joint lubrication
WO2013113720A1 (en)	2012-02-03	2013-08-08	Basf Se	Fungicidal pyrimidine compounds
WO2013113716A1 (en)	2012-02-03	2013-08-08	Basf Se	Fungicidal pyrimidine compounds
WO2013113788A1 (en)	2012-02-03	2013-08-08	Basf Se	Fungicidal pyrimidine compounds
EP2809659A1 (de)	2012-02-03	2014-12-10	Basf Se	Fungizide pyrimidinverbindungen
WO2013113773A1 (en)	2012-02-03	2013-08-08	Basf Se	Fungicidal pyrimidine compounds
JP2015511940A (ja)	2012-02-03	2015-04-23	ビーエーエスエフソシエタス・ヨーロピアＢａｓｆＳｅ	殺菌性ピリミジン化合物
WO2013113776A1 (en)	2012-02-03	2013-08-08	Basf Se	Fungicidal pyrimidine compounds
WO2013135672A1 (en)	2012-03-13	2013-09-19	Basf Se	Fungicidal pyrimidine compounds
AR092971A1 (es) *	2012-10-26	2015-05-06	Lilly Co Eli	Inhibidores de agrecanasa
RU2667644C2 (ru) *	2013-04-22	2018-09-21	Тотиги Инститьют Оф Клиникал Патолоджи	Противоопухолевое средство
EP2907512A1 (de)	2014-02-14	2015-08-19	Commissariat A L'energie Atomique Et Aux Energies Alternatives	Hemmer von MMP-12 als antivirale Wirkstoffe
CN111533699B (zh) *	2020-05-27	2023-12-01	龙曦宁（上海）医药科技有限公司	一种2-（三氟甲基）嘧啶-5-醇的合成方法

Family Cites Families (72)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2327890A (en) *	1940-04-17	1943-08-24	Parke Davis & Co	Substituted phenoxyalkyl ethers
US2745875A (en) *	1953-06-30	1956-05-15	Hoechst Ag	Preparation of nu-acylamino-phenylpropane diols
US3452040A (en) *	1966-01-05	1969-06-24	American Home Prod	5,5-disubstituted hydantoins
US3529019A (en) *	1968-04-23	1970-09-15	Colgate Palmolive Co	Alkylaryloxy alanines
US3849574A (en) *	1971-05-24	1974-11-19	Colgate Palmolive Co	Alpha-substituted-beta-arylthioalkyl amino-acids,for increasing heart rate
US4315031A (en) *	1977-09-01	1982-02-09	Science Union Et Cie	Thiosubstituted amino acids
GB1601310A (en) *	1978-05-23	1981-10-28	Lilly Industries Ltd	Aryl hydantoins
JPS6172762A (ja)	1984-09-17	1986-04-14	Kanegafuchi Chem Ind Co Ltd	光学活性ヒダントイン類の製造法
JPS61212292A (ja) *	1985-03-19	1986-09-20	Mitsui Toatsu Chem Inc	Ｄ−α−アミノ酸の製造方法
CA1325222C (en)	1985-08-23	1993-12-14	Lederle (Japan), Ltd.	Process for producing 4-biphenylylacetic acid
GB8618559D0 (en)	1986-07-30	1986-09-10	Genetics Int Inc	Rhodococcus bacterium
US4983771A (en) *	1989-09-18	1991-01-08	Hexcel Corporation	Method for resolution of D,L-alpha-phenethylamine with D(-)mandelic acid
NL9000386A (nl)	1990-02-16	1991-09-16	Stamicarbon	Werkwijze voor de bereiding van optisch aktief aminozuuramide.
DK161690D0 (da)	1990-07-05	1990-07-05	Novo Nordisk As	Fremgangsmaade til fremstilling af enantiomere forbindelser
IL99957A0 (en)	1990-11-13	1992-08-18	Merck & Co Inc	Piperidinylcamphorsulfonyl oxytocin antagonists and pharmaceutical compositions containing them
PH31245A (en) *	1991-10-30	1998-06-18	Janssen Pharmaceutica Nv	1,3-Dihydro-2H-imidazoÄ4,5-BÜ-quinolin-2-one derivatives.
US5308853A (en) *	1991-12-20	1994-05-03	Warner-Lambert Company	Substituted-5-methylidene hydantoins with AT1 receptor antagonist properties
US5246943A (en) *	1992-05-19	1993-09-21	Warner-Lambert Company	Substituted 1,2,3,4-tetahydroisoquinolines with angiotensin II receptor antagonist properties
NL9201230A (nl)	1992-07-09	1994-02-01	Dsm Nv	Werkwijze voor de bereiding van optisch aktief methionineamide.
EP0640594A1 (de)	1993-08-23	1995-03-01	Fujirebio Inc.	Hydantoinderivat als Metalloproteaseinhibitor
WO1995014025A1 (en)	1993-11-16	1995-05-26	Merck & Co., Inc.	Piperidinylcamphorsulfonyl oxytocin antagonists
DE69534213T2 (de)	1994-10-25	2006-01-12	Astrazeneca Ab	Therapeutisch wirksame Heterocyclen
ZA96211B (en)	1995-01-12	1996-07-26	Teva Pharma	Compositions containing and methods of using 1- aminoindan and derivatives thereof and process for preparing optically active 1-aminoindan derivatives
US5863949A (en)	1995-03-08	1999-01-26	Pfizer Inc	Arylsulfonylamino hydroxamic acid derivatives
US6166041A (en) *	1995-10-11	2000-12-26	Euro-Celtique, S.A.	2-heteroaryl and 2-heterocyclic benzoxazoles as PDE IV inhibitors for the treatment of asthma
CA2229438C (en) *	1995-11-22	2006-01-17	Chiroscience Limited	Mercaptoalkylpeptidyl compounds having an imidazole substituent and their use as inhibitors of matrix metalloproteinases (mmp) and/or tumour necrosis factor (tnf)
GB9616643D0 (en) *	1996-08-08	1996-09-25	Chiroscience Ltd	Compounds
US5919790A (en) *	1996-10-11	1999-07-06	Warner-Lambert Company	Hydroxamate inhibitors of interleukin-1β converting enzyme
JP2001503400A (ja) *	1996-10-22	2001-03-13	ファルマシア・アンド・アップジョン・カンパニー	マトリックス・メタロプロテイナーゼ阻害剤としてのα―アミノスルホニルヒドロキサム酸類
WO1998050359A1 (en)	1997-05-06	1998-11-12	Novo Nordisk A/S	Novel heterocyclic compounds
PT877019E (pt) *	1997-05-09	2002-05-31	Hoechst Ag	Acidos diaminocarboxilicos substituidos
TR199903287T2 (xx)	1997-07-31	2000-09-21	Abbott Laboratories	Matriks metaloproteinazlar�n�n ters hidroksamat inhibit�rleri.
TW514634B (en)	1997-10-14	2002-12-21	Lilly Co Eli	Process to make chiral compounds
EP1053226A1 (de) *	1998-02-04	2000-11-22	Novartis AG	Sulfonylaminoderivate, die metalloproteinasen hemmen
US6329418B1 (en) *	1998-04-14	2001-12-11	The Procter & Gamble Company	Substituted pyrrolidine hydroxamate metalloprotease inhibitors
WO1999058528A1 (en) *	1998-05-14	1999-11-18	Bristol-Myers Squibb Pharma Company.	Substituted aryl hydroxamic acids as metalloproteinase inhibitors
WO1999062880A1 (en) *	1998-06-03	1999-12-09	Gpi Nil Holdings, Inc.	N-linked sulfonamides of n-heterocyclic carboxylic acids or carboxylic acid isosteres
WO1999065867A1 (en) *	1998-06-17	1999-12-23	Du Pont Pharmaceuticals Company	Cyclic hydroxamic acids as metalloproteinase inhibitors
FR2782082B3 (fr) *	1998-08-05	2000-09-22	Sanofi Sa	Formes cristallines de (r)-(+)-n-[[3-[1-benzoyl-3-(3,4- dichlorophenyl)piperidin-3-yl]prop-1-yl]-4-phenylpiperidin-4 -yl]-n-methylacetamide (osanetant) et procede pour la preparation dudit compose
US6339101B1 (en) *	1998-08-14	2002-01-15	Gpi Nil Holdings, Inc.	N-linked sulfonamides of N-heterocyclic carboxylic acids or isosteres for vision and memory disorders
AU764586B2 (en)	1998-10-07	2003-08-21	Yazaki Corporation	Sol-gel process using porous mold
DK1004578T3 (da) *	1998-11-05	2004-06-28	Pfizer Prod Inc	5-oxo-pyrrolidin-2-carboxylsyrehydroxamidderivater
US6340691B1 (en) *	1999-01-27	2002-01-22	American Cyanamid Company	Alkynyl containing hydroxamic acid compounds as matrix metalloproteinase and tace inhibitors
HK1039492A1 (en)	1999-01-28	2002-04-26	Chugai Seiyaku Kabushiki Kaisha	Substitute phenethylamine derivatives
US20020006920A1 (en) *	1999-07-22	2002-01-17	Robinson Ralph Pelton	Arylsulfonylamino hydroxamic acid derivatives
DK1078923T3 (da) *	1999-08-02	2006-07-10	Hoffmann La Roche	Fremgangsmåde til fremstilling af benzothiophenderivater
WO2001012189A1 (en) *	1999-08-12	2001-02-22	Pharmacia Italia S.P.A.	3(5)-amino-pyrazole derivatives, process for their preparation and their use as antitumor agents
US6525202B2 (en) *	2000-07-17	2003-02-25	Wyeth	Cyclic amine phenyl beta-3 adrenergic receptor agonists
US20020065219A1 (en) *	2000-08-15	2002-05-30	Naidu B. Narasimhulu	Water soluble thiazolyl peptide derivatives
US20020091107A1 (en) *	2000-09-08	2002-07-11	Madar David J.	Oxazolidinone antibacterial agents
EP1191024A1 (de)	2000-09-22	2002-03-27	Harald Tschesche	Thiadiazine und ihre Verwendung als Metallproteinaseinhibotoren
SE0100902D0 (sv) *	2001-03-15	2001-03-15	Astrazeneca Ab	Compounds
SE0100903D0 (sv) *	2001-03-15	2001-03-15	Astrazeneca Ab	Compounds
JP2004527511A (ja) *	2001-03-15	2004-09-09	アストラゼネカ・アクチエボラーグ	メタロプロテイナーゼ阻害剤
JP2004535411A (ja) *	2001-05-25	2004-11-25	ブリストルーマイヤーズスクイブカンパニー	マトリックスメタロプロテナーゼ及び／またはＴＮＦ−α転換酵素（ＴＡＣＥ）の阻害剤としてのヒダントイン及び関連複素環化合物
GB0114004D0 (en) *	2001-06-08	2001-08-01	Glaxo Group Ltd	Chemical compounds
SE0103710D0 (sv) *	2001-11-07	2001-11-07	Astrazeneca Ab	Compounds
JP4485941B2 (ja)	2002-06-05	2010-06-23	株式会社カネカ	光学活性α−メチルシステイン誘導体の製造方法
SE0202539D0 (sv) *	2002-08-27	2002-08-27	Astrazeneca Ab	Compounds
GB0221246D0 (en) *	2002-09-13	2002-10-23	Astrazeneca Ab	Compounds
GB0221250D0 (en) *	2002-09-13	2002-10-23	Astrazeneca Ab	Compounds
US20040266832A1 (en) *	2003-06-26	2004-12-30	Li Zheng J.	Crystal forms of 2-(3-difluoromethyl-5-phenyl-pyrazol-1-yl)-5-methanesulfonyl pyridine
TWI220073B (en) *	2003-07-24	2004-08-01	Au Optronics Corp	Method for manufacturing polysilicon film
SE0400284D0 (sv) *	2004-02-10	2004-02-10	Astrazeneca Ab	Novel compounds
SE0401763D0 (sv) *	2004-07-05	2004-07-05	Astrazeneca Ab	Compounds
SE0401762D0 (sv) *	2004-07-05	2004-07-05	Astrazeneca Ab	Novel compounds
US7648992B2 (en) *	2004-07-05	2010-01-19	Astrazeneca Ab	Hydantoin derivatives for the treatment of obstructive airway diseases
SE0403085D0 (sv) *	2004-12-17	2004-12-17	Astrazeneca Ab	Novel componds
SE0403086D0 (sv) *	2004-12-17	2004-12-17	Astrazeneca Ab	Compounds
TW200740769A (en) *	2006-03-16	2007-11-01	Astrazeneca Ab	Novel process
TW200800954A (en) *	2006-03-16	2008-01-01	Astrazeneca Ab	Novel crystal modifications
TW200831488A (en)	2006-11-29	2008-08-01	Astrazeneca Ab	Novel compounds

2007
- 2007-11-26 TW TW096144755A patent/TW200831488A/zh unknown
- 2007-11-28 RU RU2009119290/04A patent/RU2463301C2/ru not_active IP Right Cessation
- 2007-11-28 EP EP07824738A patent/EP2097406B1/de active Active
- 2007-11-28 CN CN2007800442217A patent/CN101541789B/zh not_active Expired - Fee Related
- 2007-11-28 CA CA002670166A patent/CA2670166A1/en not_active Abandoned
- 2007-11-28 AT AT07824738T patent/ATE517101T1/de not_active IP Right Cessation
- 2007-11-28 WO PCT/GB2007/004556 patent/WO2008065393A1/en not_active Ceased
- 2007-11-28 JP JP2009538778A patent/JP5097212B2/ja not_active Expired - Fee Related
- 2007-11-28 CL CL200703423A patent/CL2007003423A1/es unknown
- 2007-11-28 AU AU2007327105A patent/AU2007327105B2/en not_active Ceased
- 2007-11-28 NZ NZ576821A patent/NZ576821A/en not_active IP Right Cessation
- 2007-11-28 US US11/946,517 patent/US8183251B2/en not_active Expired - Fee Related
- 2007-11-28 KR KR1020097010942A patent/KR20090083416A/ko not_active Ceased
- 2007-11-28 ES ES07824738T patent/ES2368013T3/es active Active
- 2007-11-28 UA UAA200904629A patent/UA93425C2/ru unknown
- 2007-11-28 PE PE2007001670A patent/PE20081120A1/es not_active Application Discontinuation
- 2007-11-28 MX MX2009005357A patent/MX2009005357A/es active IP Right Grant
- 2007-11-28 BR BRPI0719389-0A2A patent/BRPI0719389A2/pt not_active IP Right Cessation
- 2007-11-28 SA SA07280646A patent/SA07280646B1/ar unknown
- 2007-11-29 UY UY30748A patent/UY30748A1/es not_active Application Discontinuation
- 2007-11-29 AR ARP070105317A patent/AR064041A1/es not_active Application Discontinuation
2009
- 2009-05-07 CO CO09046407A patent/CO6210692A2/es not_active Application Discontinuation
- 2009-05-07 IL IL198640A patent/IL198640A0/en unknown
- 2009-05-12 ZA ZA200903286A patent/ZA200903286B/xx unknown
- 2009-05-29 EC EC2009009370A patent/ECSP099370A/es unknown
- 2009-06-24 NO NO20092412A patent/NO20092412L/no not_active Application Discontinuation
2012
- 2012-03-09 US US13/416,510 patent/US20120232101A1/en not_active Abandoned

Also Published As

Publication number	Publication date
CN101541789A (zh)	2009-09-23
UA93425C2 (ru)	2011-02-10
NZ576821A (en)	2011-05-27
AU2007327105A1 (en)	2008-06-05
HK1133650A1 (en)	2010-04-01
RU2463301C2 (ru)	2012-10-10
JP2010511027A (ja)	2010-04-08
SA07280646B1 (ar)	2010-10-05
US20080221139A1 (en)	2008-09-11
CO6210692A2 (es)	2010-10-20
CL2007003423A1 (es)	2008-07-18
EP2097406B1 (de)	2011-07-20
NO20092412L (no)	2009-08-19
RU2009119290A (ru)	2011-01-10
CA2670166A1 (en)	2008-06-05
ES2368013T3 (es)	2011-11-11
EP2097406A1 (de)	2009-09-09
AU2007327105B2 (en)	2011-05-26
IL198640A0 (en)	2010-02-17
AR064041A1 (es)	2009-03-11
ECSP099370A (es)	2009-06-30
KR20090083416A (ko)	2009-08-03
MX2009005357A (es)	2009-06-05
TW200831488A (en)	2008-08-01
US8183251B2 (en)	2012-05-22
WO2008065393A1 (en)	2008-06-05
UY30748A1 (es)	2008-07-03
JP5097212B2 (ja)	2012-12-12
US20120232101A1 (en)	2012-09-13
ZA200903286B (en)	2010-10-27
CN101541789B (zh)	2013-02-20
PE20081120A1 (es)	2008-10-11
BRPI0719389A2 (pt)	2014-10-07

Legal Events

Date	Code	Title	Description
2012-01-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
BRPI0719389A2 (pt)	2014-10-07	Derivados de hidantoína utilizados como inibidores de mmp
ATE510825T1 (de)	2011-06-15	Acylaminopyrazole als fgfr-inhibitoren
ATE478064T1 (de)	2010-09-15	Als pi-3-kinaseinhibitoren verwendete pyrimidinderivate
DK2041138T3 (da)	2014-08-11	Pyrroltriazinkinase-inhibitorer
CR10831A (es)	2009-06-18	INHIBIDORES ESPIRO CETONA DE ACETIL-CoA CARBOXILASA
DK2024375T3 (da)	2011-06-27	Cyclopropyl-kondenserede indolobenzazepin-HCV-NS5B-hæmmere
ATE485268T1 (de)	2010-11-15	Pyrrolidin-derivate als erk-hemmer
DE602007008837D1 (de)	2010-10-14	Als protein-kinase-inhibitoren nutzbare dyhydrodiazepine
DE602006011363D1 (de)	2010-02-04	Heteroaryl-substituierte piperidin-derivate als l-cpt1-hemmer
ATE543816T1 (de)	2012-02-15	Azacycloalkanderivate als inhibitoren von stearoyl-coenzym-a-delta-9-desaturase
ATE549340T1 (de)	2012-03-15	Spiroindolinon-derivate als mdm2-p53 inhibitoren
BRPI0717460A2 (pt)	2013-12-24	Composições de inibidores de chk1
ATE400271T1 (de)	2008-07-15	Aryl-pyridinderivate als 11-beta-hsd1-hemmer
DK1940839T3 (da)	2013-10-14	Pyridopyrimidione Inhibitors of P13Ka
BRPI0719204A2 (pt)	2014-03-04	Inibidores de hdac
DK2086939T3 (da)	2010-10-11	Pyridiacarboxamid som II-beta-HSDI-inhibitorer
ATE467623T1 (de)	2010-05-15	Diazepan-acetamidderivate als selektive 11-hsd1- hemmer
DOP2007000084A (es)	2007-12-31	Derivados de dihidropirazolopirimidinona
DK1989206T3 (da)	2012-10-08	E1-aktiveringsenzymhæmmere
ATE420076T1 (de)	2009-01-15	Indozolonderivate als 11b-hsd1-inhibitoren
NO20085127L (no)	2009-01-08	Leptomycinderivater
BRPI0720547A2 (pt)	2014-05-06	Inibidores de metaloprotease derivada de heterocíclico
ATE506358T1 (de)	2011-05-15	2-benzylpyridazinonderivate als met-kinasehemmer
CR10562A (es)	2009-03-20	Nuevos derivados de piridazina
CR10809A (es)	2009-06-25	Derivados de heteroaril-pirrolidinil-y-piperidinil-cetona