ATE517885T1 - Substituierte pyrazolyl-harnstoff-derivate zur behandlung von krebs - Google Patents
Substituierte pyrazolyl-harnstoff-derivate zur behandlung von krebsInfo
- Publication number
- ATE517885T1 ATE517885T1 AT05778149T AT05778149T ATE517885T1 AT E517885 T1 ATE517885 T1 AT E517885T1 AT 05778149 T AT05778149 T AT 05778149T AT 05778149 T AT05778149 T AT 05778149T AT E517885 T1 ATE517885 T1 AT E517885T1
- Authority
- AT
- Austria
- Prior art keywords
- optionally substituted
- cancer
- treatment
- urea derivatives
- substituted pyrazolyl
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 2
- 201000011510 cancer Diseases 0.000 title abstract 2
- XAEGRAIWWBXIRR-UHFFFAOYSA-N 1h-pyrazol-5-ylurea Chemical class NC(=O)NC=1C=CNN=1 XAEGRAIWWBXIRR-UHFFFAOYSA-N 0.000 title 1
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical class 0.000 abstract 3
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000004438 haloalkoxy group Chemical group 0.000 abstract 2
- 125000001188 haloalkyl group Chemical group 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000004957 naphthylene group Chemical group 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US56644504P | 2004-04-30 | 2004-04-30 | |
| PCT/US2005/015106 WO2005110994A2 (en) | 2004-04-30 | 2005-05-02 | Substituted pyrazolyl urea derivatives useful in the treatment of cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE517885T1 true ATE517885T1 (de) | 2011-08-15 |
Family
ID=35064925
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05778149T ATE517885T1 (de) | 2004-04-30 | 2005-05-02 | Substituierte pyrazolyl-harnstoff-derivate zur behandlung von krebs |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US7838524B2 (de) |
| EP (3) | EP2295426A1 (de) |
| JP (1) | JP2007535565A (de) |
| CN (1) | CN101010315A (de) |
| AT (1) | ATE517885T1 (de) |
| CA (1) | CA2564325A1 (de) |
| MX (1) | MXPA06012394A (de) |
| WO (1) | WO2005110994A2 (de) |
Families Citing this family (85)
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| EP1636585B2 (de) | 2003-05-20 | 2012-06-13 | Bayer HealthCare LLC | Diaryl-harnstoffe mit kinasehemmender wirkung |
| PL1663978T3 (pl) | 2003-07-23 | 2008-04-30 | Bayer Healthcare Llc | Fluoropodstawiony omega-karboksyarylodifenylomocznik do leczenia i profilaktyki chorób i stanów |
| US7838524B2 (en) | 2004-04-30 | 2010-11-23 | Bayer Healthcare Llc | Substituted pyrazolyl urea derivatives useful in the treatment of cancer |
| AU2005289100B2 (en) * | 2004-09-29 | 2011-11-03 | Bayer Healthcare Llc | Thermodynamically stable form of bay 43-9006 tosylate |
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| CA2673041A1 (en) * | 2006-12-20 | 2008-07-03 | Bayer Healthcare Llc | 4-{4-[({3-tert-butyl-1-[3-(hydroxymethyl) phenyl]-1h-pyrazol-5-yl } carbamoyl)-amino] -3-fluorophenoxy} -n-methylpyridine-2-carboxamide as well as prodrugs and salts thereof for the treatment of cancer |
| WO2008079972A2 (en) | 2006-12-20 | 2008-07-03 | Bayer Healthcare Llc | 4-{4- [ ({3-tert-butyl-1- [3- (hydroxymethyl) phenyl] - 1h- pyrazol- 5 -yl } carbamoyl) -amin o] -3-chlorophenoxy} -n-methylpyridine-2-carboxamide as an inhibitor of the vegfr kinase for the treatment of cancer |
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-
2005
- 2005-05-02 US US11/579,093 patent/US7838524B2/en not_active Expired - Fee Related
- 2005-05-02 MX MXPA06012394A patent/MXPA06012394A/es active IP Right Grant
- 2005-05-02 EP EP10185804A patent/EP2295426A1/de not_active Withdrawn
- 2005-05-02 EP EP10185914A patent/EP2295427A1/de not_active Withdrawn
- 2005-05-02 CA CA002564325A patent/CA2564325A1/en not_active Abandoned
- 2005-05-02 AT AT05778149T patent/ATE517885T1/de not_active IP Right Cessation
- 2005-05-02 CN CNA2005800222909A patent/CN101010315A/zh active Pending
- 2005-05-02 WO PCT/US2005/015106 patent/WO2005110994A2/en not_active Ceased
- 2005-05-02 EP EP05778149A patent/EP1751139B1/de not_active Expired - Lifetime
- 2005-05-02 JP JP2007511073A patent/JP2007535565A/ja active Pending
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2010
- 2010-11-08 US US12/941,841 patent/US8207166B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP2295427A1 (de) | 2011-03-16 |
| WO2005110994A8 (en) | 2006-12-21 |
| EP1751139A2 (de) | 2007-02-14 |
| EP1751139B1 (de) | 2011-07-27 |
| EP2295426A1 (de) | 2011-03-16 |
| US7838524B2 (en) | 2010-11-23 |
| JP2007535565A (ja) | 2007-12-06 |
| US20080214545A1 (en) | 2008-09-04 |
| WO2005110994A3 (en) | 2006-02-02 |
| MXPA06012394A (es) | 2007-01-31 |
| US20110136809A1 (en) | 2011-06-09 |
| CN101010315A (zh) | 2007-08-01 |
| US8207166B2 (en) | 2012-06-26 |
| CA2564325A1 (en) | 2005-11-24 |
| WO2005110994A2 (en) | 2005-11-24 |
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