MA32956B1 - Derives de 5-amino-2-(1-hydroxyethyl)-tetrahydropyrane - Google Patents

Derives de 5-amino-2-(1-hydroxyethyl)-tetrahydropyrane

Info

Publication number
MA32956B1
MA32956B1 MA34003A MA34003A MA32956B1 MA 32956 B1 MA32956 B1 MA 32956B1 MA 34003 A MA34003 A MA 34003A MA 34003 A MA34003 A MA 34003A MA 32956 B1 MA32956 B1 MA 32956B1
Authority
MA
Morocco
Prior art keywords
hydroxyethyl
amino
tetrahydropyrane
derivatives
tetrahydropyrane derivatives
Prior art date
Application number
MA34003A
Other languages
Arabic (ar)
English (en)
Inventor
Christian Hubschwerlen
Georg Rueedi
Jean-Philippe Surivet
Acklin Cornelia Zumbrunn
Original Assignee
Actelion Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd
Publication of MA32956B1 publication Critical patent/MA32956B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/056—Ortho-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D497/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D497/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D497/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

L'INVENTION PORTE SUR DES COMPOSÉS ANTIBACTÉRIENS DE FORMULE I, DANS LAQUELLE R1 REPRÉSENTE UN GROUPE ALCOXY (NOTAMMENT MÉTHOXY); R2 REPRÉSENTE H OU F; CHACUN DE R3, R4, R5 ET R6 REPRÉSENTE INDÉPENDAMMENT H OU D; V REPRÉSENTE CH ET W REPRÉSENTE CH OU N, OU V REPRÉSENTE N ET W REPRÉSENTE CH; Y REPRÉSENTE CH OU N; Z REPRÉSENTE O, S OU CH2; ET A REPRÉSENTE CH2, CH2CH2 OU CD2CD2; ET SUR DES SELS DE TELS COMPOSÉS.
MA34003A 2008-12-12 2009-12-11 Derives de 5-amino-2-(1-hydroxyethyl)-tetrahydropyrane MA32956B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IB2008055261 2008-12-12
PCT/IB2009/055689 WO2010067332A1 (fr) 2008-12-12 2009-12-11 Dérivés de 5-amino-2-(1-hydroxyéthyl)tétrahydropyrane

Publications (1)

Publication Number Publication Date
MA32956B1 true MA32956B1 (fr) 2012-01-02

Family

ID=41723046

Family Applications (1)

Application Number Title Priority Date Filing Date
MA34003A MA32956B1 (fr) 2008-12-12 2009-12-11 Derives de 5-amino-2-(1-hydroxyethyl)-tetrahydropyrane

Country Status (27)

Country Link
US (1) US8211890B2 (fr)
EP (1) EP2376497B1 (fr)
JP (1) JP4955835B2 (fr)
KR (1) KR101297450B1 (fr)
CN (1) CN102232078B (fr)
AR (1) AR074604A1 (fr)
AU (1) AU2009325902B2 (fr)
BR (1) BRPI0924081A2 (fr)
CA (1) CA2744456C (fr)
CL (1) CL2011001413A1 (fr)
CY (1) CY1114869T1 (fr)
DK (1) DK2376497T3 (fr)
ES (1) ES2435596T3 (fr)
HR (1) HRP20140010T1 (fr)
IL (1) IL213432A (fr)
MA (1) MA32956B1 (fr)
MX (1) MX2011005905A (fr)
MY (1) MY159183A (fr)
NZ (1) NZ593891A (fr)
PL (1) PL2376497T3 (fr)
PT (1) PT2376497E (fr)
RU (1) RU2525541C2 (fr)
SG (1) SG172088A1 (fr)
SI (1) SI2376497T1 (fr)
TW (1) TWI426076B (fr)
WO (1) WO2010067332A1 (fr)
ZA (1) ZA201105095B (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR076222A1 (es) 2009-04-09 2011-05-26 Actelion Pharmaceuticals Ltd Derivados 2-hidroxietil-1h-quinolin-ona y sus analogos azaisotericos con actividad antibacteriana y composiciones farmaceuticas que los contienen
AR086604A1 (es) 2011-05-31 2014-01-08 Actelion Pharmaceuticals Ltd Intermediarios sinteticos para preparar antibioticos y metodo para preparar dichos intermediarios
CA2840060A1 (fr) * 2011-06-27 2013-01-03 Kyorin Pharmaceutical Co., Ltd. Composes bicycliques pontes pour le traitement des infections bacteriennes
AR087875A1 (es) 2011-09-16 2014-04-23 Actelion Pharmaceuticals Ltd Proceso para la elaboracion de derivados de piridazina como intermediarios de sintesis de antibioticos
AR089929A1 (es) 2012-02-10 2014-10-01 Actelion Pharmaceuticals Ltd Proceso para manufacturar un derivado de naftiridina
AR090844A1 (es) * 2012-04-27 2014-12-10 Actelion Pharmaceuticals Ltd Proceso para elaborar derivados de naftiridina
TW201722965A (zh) * 2015-08-16 2017-07-01 葛蘭素史密斯克藍智慧財產發展有限公司 用於抗菌應用之化合物
TW201833120A (zh) 2017-02-17 2018-09-16 瑞士商愛杜西亞製藥有限公司 芳基噁唑啶酮抗生素化合物
CN118239937A (zh) 2017-08-09 2024-06-25 戴纳立制药公司 化合物、组合物及方法
DK3676297T3 (da) * 2017-09-01 2023-08-14 Denali Therapeutics Inc Forbindelser, sammensætninger og fremgangsmåder
US12091392B2 (en) 2019-02-13 2024-09-17 Denali Therapeutics Inc. Compounds, compositions and methods
MA54953A (fr) 2019-02-13 2021-12-22 Denali Therapeutics Inc Composés, compositions et procédés

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SU1095611A1 (ru) * 1982-09-10 2007-06-27 Краснодарский ордена Трудового Красного Знамени политехнический институт Хлорид 5-хлорметил-2-этил-8-метил-4Н-м-диоксино-(4,5-с)-пиридиния, обладающий антимикробной активностью
HU225047B1 (en) * 1991-03-28 2006-05-29 Eisai Co Ltd Heterocyclic-piperidin-derivatives, pharmaceutical compositions containing them and process for their production
GB9822450D0 (en) 1998-10-14 1998-12-09 Smithkline Beecham Plc Medicaments
GB0101577D0 (en) 2001-01-22 2001-03-07 Smithkline Beecham Plc Compounds
GB0112834D0 (en) 2001-05-25 2001-07-18 Smithkline Beecham Plc Medicaments
US7312212B2 (en) * 2002-01-29 2007-12-25 Glaxo Group Limited Aminopiperidine derivatives
AR040336A1 (es) * 2002-06-26 2005-03-30 Glaxo Group Ltd Compuesto de piperidina, uso del mismo para la fabricacion de un medicamento, composicion farmaceutica que lo comprende y procedimiento para preparar dicho compuesto
AR042486A1 (es) * 2002-12-18 2005-06-22 Glaxo Group Ltd Compuesto de quinolina y naftiridina halosustituido en la posicion 3, procedimiento para preparar el compuesto, composicion farmaceutica que lo comprende y su uso para preparar dicha composicion .
DE10316081A1 (de) * 2003-04-08 2004-10-21 Morphochem AG Aktiengesellschaft für kombinatorische Chemie Neue Verbindungen mit antibakterieller Aktivität
US7160888B2 (en) 2003-08-22 2007-01-09 Warner Lambert Company Llc [1,8]naphthyridin-2-ones and related compounds for the treatment of schizophrenia
JP2008505920A (ja) 2004-07-08 2008-02-28 グラクソ　グループ　リミテッド 抗菌剤
JP4887297B2 (ja) * 2004-09-24 2012-02-29 アクテリオン ファーマシューティカルズ リミテッド 新規二環式抗生物質
JP5314244B2 (ja) 2004-10-27 2013-10-16 富山化学工業株式会社 新規な含窒素複素環化合物およびその塩
MX2007014507A (es) 2005-05-24 2008-02-07 Astrazeneca Ab Aminopiperidin quinolinas y sus analogos azaisostericos con actividad antibacteriana.
WO2007016610A2 (fr) * 2005-08-02 2007-02-08 Glaxo Group Limited Agents antibactériens
ES2340531T3 (es) 2005-10-21 2010-06-04 Glaxo Group Limited Compuestos triciclos peri-condensados utiles como agentes antibacterianos.
ATE465163T1 (de) 2005-12-22 2010-05-15 Glaxo Group Ltd Heterocyclische verbindungen, ihre herstellung und ihre verwendung als antibakterielle mittel
DE102005062889A1 (de) 2005-12-29 2007-07-05 Robert Bosch Gmbh Elektrische Null-Kraft-Steckvorrichtung
ATE536351T1 (de) * 2006-01-26 2011-12-15 Actelion Pharmaceuticals Ltd Tetrahydropyran-antibiotika
CA2643962A1 (fr) 2006-03-10 2007-09-20 Actelion Pharmaceuticals Ltd Composes antibiotiques
EP2001887B1 (fr) 2006-04-06 2010-09-15 Glaxo Group Limited Derives de pyrrolo-quinoxalinone en tant qu'agents antibacteriens
GB0613208D0 (en) 2006-07-03 2006-08-09 Glaxo Group Ltd Compounds
EP1992628A1 (fr) 2007-05-18 2008-11-19 Glaxo Group Limited Dérivés et analogues de N-éthylquinolones et N-éthylazaquinolones
CL2008001003A1 (es) 2007-04-11 2008-10-17 Actelion Pharmaceuticals Ltd Compuestos derivados de oxazolidinona; composicion farmaceutica que comprende a dichos compuestos; y su uso para preparar un medicamento para tratar una infeccion bacteriana.
ATE520687T1 (de) * 2007-06-15 2011-09-15 Actelion Pharmaceuticals Ltd 3-amino-6-(1-amino-ethyl)-tetrahydropyranderiva e
CN101874032B (zh) 2007-11-26 2013-02-06 富山化学工业株式会社 二氮杂萘衍生物一水合物及其制备方法

Also Published As

Publication number Publication date
CN102232078A (zh) 2011-11-02
BRPI0924081A2 (pt) 2018-03-20
AU2009325902B2 (en) 2015-01-29
US20110245259A1 (en) 2011-10-06
EP2376497A1 (fr) 2011-10-19
SG172088A1 (en) 2011-07-28
AU2009325902A1 (en) 2011-07-21
JP2012511566A (ja) 2012-05-24
CA2744456C (fr) 2017-09-26
IL213432A0 (en) 2011-07-31
CY1114869T1 (el) 2016-12-14
IL213432A (en) 2013-11-28
KR20110086643A (ko) 2011-07-28
MY159183A (en) 2016-12-30
WO2010067332A1 (fr) 2010-06-17
CL2011001413A1 (es) 2011-11-11
HRP20140010T1 (hr) 2014-02-14
PL2376497T3 (pl) 2014-03-31
HK1162478A1 (en) 2012-08-31
MX2011005905A (es) 2011-06-20
ES2435596T3 (es) 2013-12-20
JP4955835B2 (ja) 2012-06-20
EP2376497B1 (fr) 2013-09-18
AR074604A1 (es) 2011-01-26
NZ593891A (en) 2013-05-31
US8211890B2 (en) 2012-07-03
KR101297450B1 (ko) 2013-08-20
TW201026699A (en) 2010-07-16
CA2744456A1 (fr) 2010-06-17
SI2376497T1 (sl) 2014-01-31
RU2525541C2 (ru) 2014-08-20
PT2376497E (pt) 2013-11-21
DK2376497T3 (da) 2013-11-18
RU2011128550A (ru) 2013-01-20
CN102232078B (zh) 2014-07-16
TWI426076B (zh) 2014-02-11
ZA201105095B (en) 2012-12-27

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