ATE518496T1 - Verfahren zur gewinnung von lebensfähigen kleinen gewebeteilchen und ihre verwendung für die gewebereparatur - Google Patents

Verfahren zur gewinnung von lebensfähigen kleinen gewebeteilchen und ihre verwendung für die gewebereparatur

Info

Publication number
ATE518496T1
ATE518496T1 AT07862720T AT07862720T ATE518496T1 AT E518496 T1 ATE518496 T1 AT E518496T1 AT 07862720 T AT07862720 T AT 07862720T AT 07862720 T AT07862720 T AT 07862720T AT E518496 T1 ATE518496 T1 AT E518496T1
Authority
AT
Austria
Prior art keywords
tissue
tissue particles
particles
composition
obtaining viable
Prior art date
Application number
AT07862720T
Other languages
English (en)
Inventor
Jian Q Yao
Victor Zaporojan
Original Assignee
Zimmer Orthobiologics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zimmer Orthobiologics Inc filed Critical Zimmer Orthobiologics Inc
Application granted granted Critical
Publication of ATE518496T1 publication Critical patent/ATE518496T1/de

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/32Bones; Osteocytes; Osteoblasts; Tendons; Tenocytes; Teeth; Odontoblasts; Cartilage; Chondrocytes; Synovial membrane
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • A61K38/48Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482Serine endopeptidases (3.4.21)
    • A61K38/4833Thrombin (3.4.21.5)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/04Drugs for skeletal disorders for non-specific disorders of the connective tissue

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Zoology (AREA)
  • Virology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT07862720T 2006-12-20 2007-12-11 Verfahren zur gewinnung von lebensfähigen kleinen gewebeteilchen und ihre verwendung für die gewebereparatur ATE518496T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11/613,250 US8163549B2 (en) 2006-12-20 2006-12-20 Method of obtaining viable small tissue particles and use for tissue repair
PCT/US2007/025252 WO2008079194A1 (en) 2006-12-20 2007-12-11 Method of obtaining viable small tissue particles and use for tissue repair

Publications (1)

Publication Number Publication Date
ATE518496T1 true ATE518496T1 (de) 2011-08-15

Family

ID=39265012

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07862720T ATE518496T1 (de) 2006-12-20 2007-12-11 Verfahren zur gewinnung von lebensfähigen kleinen gewebeteilchen und ihre verwendung für die gewebereparatur

Country Status (8)

Country Link
US (3) US8163549B2 (de)
EP (1) EP2101681B1 (de)
JP (1) JP2010512946A (de)
AT (1) ATE518496T1 (de)
AU (1) AU2007338887A1 (de)
CA (1) CA2673046A1 (de)
ES (1) ES2370668T3 (de)
WO (1) WO2008079194A1 (de)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7067123B2 (en) 2003-04-29 2006-06-27 Musculoskeletal Transplant Foundation Glue for cartilage repair
US7901457B2 (en) 2003-05-16 2011-03-08 Musculoskeletal Transplant Foundation Cartilage allograft plug
ES2404682T3 (es) * 2003-12-11 2013-05-28 Isto Technologies Inc. Sistema de cartílago particulado
US8512730B2 (en) 2004-07-12 2013-08-20 Isto Technologies, Inc. Methods of tissue repair and compositions therefor
US7837740B2 (en) 2007-01-24 2010-11-23 Musculoskeletal Transplant Foundation Two piece cancellous construct for cartilage repair
US20090319045A1 (en) 2004-10-12 2009-12-24 Truncale Katherine G Cancellous constructs, cartilage particles and combinations of cancellous constructs and cartilage particles
US7815926B2 (en) * 2005-07-11 2010-10-19 Musculoskeletal Transplant Foundation Implant for articular cartilage repair
AU2006282754A1 (en) 2005-08-26 2007-03-01 Zimmer, Inc. Implants and methods for repair, replacement and treatment of joint disease
US8921109B2 (en) 2005-09-19 2014-12-30 Histogenics Corporation Cell-support matrix having narrowly defined uniformly vertically and non-randomly organized porosity and pore density and a method for preparation thereof
US8163549B2 (en) 2006-12-20 2012-04-24 Zimmer Orthobiologics, Inc. Method of obtaining viable small tissue particles and use for tissue repair
US8435551B2 (en) 2007-03-06 2013-05-07 Musculoskeletal Transplant Foundation Cancellous construct with support ring for repair of osteochondral defects
AU2008240191B2 (en) 2007-04-12 2013-09-19 Zimmer, Inc. Compositions and methods for tissue repair
US9192695B2 (en) 2008-11-20 2015-11-24 Allosource Allografts combined with tissue derived stem cells for bone healing
US20100274362A1 (en) * 2009-01-15 2010-10-28 Avner Yayon Cartilage particle tissue mixtures optionally combined with a cancellous construct
US20110059178A1 (en) * 2009-09-08 2011-03-10 Musculoskeletal Transplant Foundation Inc. Tissue Engineered Meniscus Repair Composition
WO2011031642A2 (en) * 2009-09-08 2011-03-17 Musculoskeletal Transplant Foundation Inc. Tissue engineered meniscus repair composition
US10130736B1 (en) 2010-05-14 2018-11-20 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
US8883210B1 (en) 2010-05-14 2014-11-11 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
US9352003B1 (en) 2010-05-14 2016-05-31 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
US9115336B2 (en) * 2010-05-25 2015-08-25 Muffin Incorporated Methods, substrates, and systems useful for cell seeding of medical grafts
US8834928B1 (en) 2011-05-16 2014-09-16 Musculoskeletal Transplant Foundation Tissue-derived tissugenic implants, and methods of fabricating and using same
WO2013075091A1 (en) 2011-11-17 2013-05-23 Allosource Multi-piece machine graft systems and methods
US9162011B2 (en) 2011-12-19 2015-10-20 Allosource Flowable matrix compositions and methods
KR102258565B1 (ko) 2012-11-15 2021-05-28 알로소스 세절 연골 시스템 및 방법
US10245306B2 (en) 2012-11-16 2019-04-02 Isto Technologies Ii, Llc Flexible tissue matrix and methods for joint repair
US20140178343A1 (en) 2012-12-21 2014-06-26 Jian Q. Yao Supports and methods for promoting integration of cartilage tissue explants
CA2894750C (en) 2013-02-22 2021-12-14 Allosource Cartilage mosaic compositions and methods
WO2014138612A1 (en) 2013-03-07 2014-09-12 Allosource Consistent calcium content bone allograft systems and methods
WO2014150784A1 (en) 2013-03-15 2014-09-25 Allosource Cell repopulated collagen matrix for soft tissue repair and regeneration
CA2895140C (en) 2013-03-15 2021-07-13 Allosource Perforated osteochondral allograft compositions
JP6229855B2 (ja) * 2014-01-29 2017-11-15 株式会社ジェイ・エム・エス 生体組織切断装置およびその用途
WO2015175983A1 (en) 2014-05-16 2015-11-19 Allosource Composite bone constructs and methods
US10179191B2 (en) 2014-10-09 2019-01-15 Isto Technologies Ii, Llc Flexible tissue matrix and methods for joint repair
US10077420B2 (en) 2014-12-02 2018-09-18 Histogenics Corporation Cell and tissue culture container
US10524774B2 (en) * 2015-04-02 2020-01-07 Arthrex, Inc. Method of repairing cartilage defects
CA3177726A1 (en) 2015-05-21 2016-11-24 Musculoskeletal Transplant Foundation Modified demineralized cortical bone fibers
CA2987045A1 (en) * 2015-05-27 2016-12-01 Cook Regentec Llc Sheet-form cell growth scaffold particles and grafts, and methods for same
US11052175B2 (en) 2015-08-19 2021-07-06 Musculoskeletal Transplant Foundation Cartilage-derived implants and methods of making and using same
US12551509B2 (en) 2015-11-18 2026-02-17 Lucina Patent Holdco, Llc Acellular regenerative products and methods of their manufacture
EP3645066A1 (de) 2017-06-30 2020-05-06 Allosource Zelluläre knochentransplantate, verfahren zur herstellung und verwendung
CN108273135B (zh) * 2018-03-15 2021-03-09 中国人民解放军陆军军医大学第一附属医院 一种骨软骨缺损修复材料及其制备方法
CN109589451B (zh) * 2018-11-19 2022-03-08 浙江星月生物科技股份有限公司 一种一步法软骨再生修复复合物及其制备方法
US12247902B2 (en) 2019-05-06 2025-03-11 Tissuemill Technologies Llc Atraumatically formed tissue compositions, devices and methods of preparation and treatment
US11033295B2 (en) * 2019-05-06 2021-06-15 Tissuemill Technologies Llc Atraumatically formed tissue composition, devices and methods of preparation and treatment
WO2021225763A1 (en) * 2020-05-04 2021-11-11 Tissuemill Technologies Llc Atraumatically formed tissue compositions, devices and methods of preparation and treatment
US11660194B1 (en) 2022-06-20 2023-05-30 University Of Utah Research Foundation Cartilage and bone harvest and delivery system and methods
US11523834B1 (en) 2022-06-20 2022-12-13 University Of Utah Research Foundation Cartilage and bone harvest and delivery system and methods

Family Cites Families (469)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1347622A (en) 1919-03-29 1920-07-27 Arthur E Deininger Vaccine-injector
US2533004A (en) 1943-10-27 1950-12-05 John D Ferry Fibrin clots and methods for preparing the same
US2621145A (en) 1949-08-17 1952-12-09 Machteld E Sano Bone mat compositions
US3400199A (en) 1965-02-26 1968-09-03 Leslie L. Balassa Wound-healing cartilage powder
USRE28093E (en) 1962-02-28 1974-07-30 Wound-healing cartilage powder
US3476855A (en) 1965-02-26 1969-11-04 Leslie L Balassa Sterilizing and enhancing activity of a finely divided cartilage powder
US3478146A (en) 1965-02-26 1969-11-11 Leslie L Balassa Wound-healing cartilage powder extracting process
US3474146A (en) 1967-01-03 1969-10-21 Stauffer Chemical Co Fluorine-containing ethyl disulfides
US3772432A (en) 1971-01-11 1973-11-13 Lescarden Ltd Cartilage compositions for dental use
US3966908A (en) 1973-11-29 1976-06-29 Lescarden Ltd. Method of treating degenerative joint afflictions
GB2023314B (en) 1978-06-15 1982-10-06 Ibm Digital data processing systems
US4440680A (en) 1980-09-24 1984-04-03 Seton Company Macromolecular biologically active collagen articles
DE3105624A1 (de) 1981-02-16 1982-09-02 Hormon-Chemie München GmbH, 8000 München Material zum abdichten und heilen von wunden
US4466435A (en) 1981-09-04 1984-08-21 Murray William M Bone cement nozzle and method
US4479271A (en) 1981-10-26 1984-10-30 Zimmer, Inc. Prosthetic device adapted to promote bone/tissue ingrowth
US5656587A (en) 1982-09-24 1997-08-12 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Promotion of cell proliferation by use of transforming growth factor beta (TGF-β)
US5002582A (en) 1982-09-29 1991-03-26 Bio-Metric Systems, Inc. Preparation of polymeric surfaces via covalently attaching polymers
DE3247387C2 (de) 1982-12-22 1984-11-22 Rolf Prof. Dr.med. 7400 Tübingen Hettich Verfahren zur Herstellung eines Transplantats und Vorrichtung zur Durchführung des Verfahrens
US4566138A (en) 1983-03-08 1986-01-28 Zimmer, Inc. Prosthetic device with spacers
US4911720A (en) 1983-03-10 1990-03-27 Collier John P Particular surface replacement prosthesis
IL68218A (en) 1983-03-23 1985-12-31 Univ Ramot Compositions for cartilage repair comprising embryonal chondrocytes
US4522096A (en) 1983-06-16 1985-06-11 R. J. Reynolds Tobacco Company Dicing apparatus for sheet material
GB8318483D0 (en) 1983-07-08 1983-08-10 Zimmer Deloro Surgical Ltd Skeletal implants
EP0133934A3 (de) 1983-07-29 1985-09-18 NIKEPHARMA S.r.l. Pharmakologisch aktive 1,3,4-Thiadiazol-(3,2-a)-thieno-(2,3-d)-pyrimidin-5-(H)-onderivate
JPS60109781A (ja) 1983-08-09 1985-06-15 Honda Motor Co Ltd 同期運転制御装置
US4641651A (en) 1983-09-22 1987-02-10 Card George W Cartilage punch and modified prosthesis in tympanoplasty
AT389815B (de) 1984-03-09 1990-02-12 Immuno Ag Verfahren zur inaktivierung von vermehrungsfaehigen filtrierbaren krankheitserregern in blutprodukten
US4609551A (en) 1984-03-20 1986-09-02 Arnold Caplan Process of and material for stimulating growth of cartilage and bony tissue at anatomical sites
US4863475A (en) 1984-08-31 1989-09-05 Zimmer, Inc. Implant and method for production thereof
US4928603A (en) 1984-09-07 1990-05-29 The Trustees Of Columbia University In The City Of New York Method of preparing a cryoprecipitated suspension and use thereof
US4627879A (en) 1984-09-07 1986-12-09 The Trustees Of Columbia University In The City Of New York Fibrin adhesive prepared as a concentrate from single donor fresh frozen plasma
US4678470A (en) 1985-05-29 1987-07-07 American Hospital Supply Corporation Bone-grafting material
US4660755A (en) 1985-09-09 1987-04-28 Zimmer, Inc. Method for constructing a surgical implant
US4656137A (en) 1985-09-12 1987-04-07 Lescarden Inc Method of processing animal cartilage
GB8626226D0 (en) 1985-11-14 1986-12-03 Ici Plc Metal matrix composites
US5032508A (en) 1988-09-08 1991-07-16 Marrow-Tech, Inc. Three-dimensional cell and tissue culture system
US4963489A (en) 1987-04-14 1990-10-16 Marrow-Tech, Inc. Three-dimensional cell and tissue culture system
US5902741A (en) 1986-04-18 1999-05-11 Advanced Tissue Sciences, Inc. Three-dimensional cartilage cultures
US4714457A (en) 1986-09-15 1987-12-22 Robert Alterbaum Method and apparatus for use in preparation of fibrinogen from a patient's blood
US5254471A (en) 1986-10-06 1993-10-19 Toray Industries, Inc. Carrier for cell culture
US5041138A (en) 1986-11-20 1991-08-20 Massachusetts Institute Of Technology Neomorphogenesis of cartilage in vivo from cell culture
GB8708009D0 (en) 1987-04-03 1987-05-07 Clayton Found Res Injectable soft tissue augmentation materials
US4846835A (en) 1987-06-15 1989-07-11 Grande Daniel A Technique for healing lesions in cartilage
US4952403A (en) 1987-06-19 1990-08-28 President And Fellows Of Harvard College Implants for the promotion of healing of meniscal tissue
US5681353A (en) 1987-07-20 1997-10-28 Regen Biologics, Inc. Meniscal augmentation device
US5306311A (en) 1987-07-20 1994-04-26 Regen Corporation Prosthetic articular cartilage
US5018285A (en) 1987-08-24 1991-05-28 Zimmer, Inc. Method of constructing prosthetic implant with wrapped porous surface
US5013324A (en) 1987-08-24 1991-05-07 Zimmer, Inc. Prosthetic implant with wrapped porous surface
US4851354A (en) 1987-12-07 1989-07-25 Trustees Of The University Of Pennsylvania Apparatus for mechanically stimulating cells
US5139527A (en) 1987-12-17 1992-08-18 Immuno Aktiengesellschaft Biologic absorbable implant material for filling and closing soft tissue cavities and method of its preparation
GB8803697D0 (en) 1988-02-17 1988-03-16 Deltanine Research Ltd Clinical developments using amniotic membrane cells
US5219363A (en) 1988-03-22 1993-06-15 Zimmer, Inc. Bone implant
US5053050A (en) 1988-04-29 1991-10-01 Samuel Itay Compositions for repair of cartilage and bone
US4904259A (en) 1988-04-29 1990-02-27 Samuel Itay Compositions and methods for repair of cartilage and bone
EP0341007B1 (de) 1988-05-02 1994-09-14 Project Hear Chirurgisches Klebstoffmaterial
US5290552A (en) 1988-05-02 1994-03-01 Matrix Pharmaceutical, Inc./Project Hear Surgical adhesive material
US5080674A (en) 1988-09-08 1992-01-14 Zimmer, Inc. Attachment mechanism for securing an additional portion to an implant
US5565519A (en) 1988-11-21 1996-10-15 Collagen Corporation Clear, chemically modified collagen-synthetic polymer conjugates for ophthalmic applications
US5475052A (en) 1988-11-21 1995-12-12 Collagen Corporation Collagen-synthetic polymer matrices prepared using a multiple step reaction
DE58905636D1 (de) 1989-03-23 1993-10-21 Straumann Inst Ag Metallisches Implantat.
US5130418A (en) 1989-05-02 1992-07-14 California Biotechnology Inc. Method to stabilize basic fibroblast growth factor
US5226877A (en) 1989-06-23 1993-07-13 Epstein Gordon H Method and apparatus for preparing fibrinogen adhesive from whole blood
CA2020654A1 (en) 1989-07-07 1991-01-08 Yohko Akiyama Stabilized fgf composition and production thereof
EP0493387B1 (de) 1989-08-10 1993-10-20 W.L. Gore & Associates, Inc. Medizinisches spendesystem für gewebeklebstoffkomponenten
US5290558A (en) 1989-09-21 1994-03-01 Osteotech, Inc. Flowable demineralized bone powder composition and its use in bone repair
GB8927546D0 (en) 1989-12-06 1990-02-07 Ciba Geigy Process for the production of biologically active tgf-beta
US4997445A (en) 1989-12-08 1991-03-05 Zimmer, Inc. Metal-backed prosthetic implant with enhanced bonding of polyethylene portion to metal base
US5067964A (en) 1989-12-13 1991-11-26 Stryker Corporation Articular surface repair
US4997444A (en) 1989-12-28 1991-03-05 Zimmer, Inc. Implant having varying modulus of elasticity
US5030215A (en) 1990-01-03 1991-07-09 Cryolife, Inc. Preparation of fibrinogen/factor XIII precipitate
US5514153A (en) 1990-03-02 1996-05-07 General Surgical Innovations, Inc. Method of dissecting tissue layers
US5345927A (en) 1990-03-02 1994-09-13 Bonutti Peter M Arthroscopic retractors
US5217954A (en) 1990-04-04 1993-06-08 Scios Nova Inc. Formulations for stabilizing fibroblast growth factor
US5593425A (en) 1990-06-28 1997-01-14 Peter M. Bonutti Surgical devices assembled using heat bonable materials
US5269785A (en) 1990-06-28 1993-12-14 Bonutti Peter M Apparatus and method for tissue removal
US6464713B2 (en) 1990-06-28 2002-10-15 Peter M. Bonutti Body tissue fastening
US6990982B1 (en) 1990-06-28 2006-01-31 Bonutti Ip, Llc Method for harvesting and processing cells from tissue fragments
US5069881A (en) 1990-07-10 1991-12-03 Mobay Corporation Device and method for applying adhesives
US5067963A (en) 1990-08-21 1991-11-26 Washington University Method of making live autogenous skeletal replacement parts
US5948384A (en) 1990-09-14 1999-09-07 Syngenix Limited Particulate agents
US5410016A (en) 1990-10-15 1995-04-25 Board Of Regents, The University Of Texas System Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
CA2041430C (en) 1990-10-30 2002-11-26 Jack Eldon Parr Orthopaedic implant device
US5811094A (en) 1990-11-16 1998-09-22 Osiris Therapeutics, Inc. Connective tissue regeneration using human mesenchymal stem cell preparations
US5226914A (en) 1990-11-16 1993-07-13 Caplan Arnold I Method for treating connective tissue disorders
US6559119B1 (en) 1990-11-27 2003-05-06 Loyola University Of Chicago Method of preparing a tissue sealant-treated biomedical material
DE69132918T2 (de) 1990-11-27 2002-10-31 American National Red Cross, Washington Gewebeabdeckung und wachstumsfaktor enthaltende verbindungen zur förderung beschleunigter wundheilung
US6054122A (en) 1990-11-27 2000-04-25 The American National Red Cross Supplemented and unsupplemented tissue sealants, methods of their production and use
CA2055966C (en) 1990-12-19 1995-08-01 Oresta Natalia Fedun Cell culture insert
US5198308A (en) 1990-12-21 1993-03-30 Zimmer, Inc. Titanium porous surface bonded to a cobalt-based alloy substrate in an orthopaedic implant device
US5206023A (en) 1991-01-31 1993-04-27 Robert F. Shaw Method and compositions for the treatment and repair of defects or lesions in cartilage
US5853746A (en) 1991-01-31 1998-12-29 Robert Francis Shaw Methods and compositions for the treatment and repair of defects or lesions in cartilage or bone using functional barrier
AT402891B (de) 1991-06-20 1997-09-25 Immuno Ag Verfahren zur herstellung eines inaktivierten blutproduktes
US5356629A (en) 1991-07-12 1994-10-18 United States Surgical Corporation Composition for effecting bone repair
US6773458B1 (en) 1991-07-24 2004-08-10 Baxter International Inc. Angiogenic tissue implant systems and methods
US5092887A (en) 1991-08-12 1992-03-03 El Gendler Artificial ligament produced from demineralized bone for the replacement and augmentation of ligaments, tendons and other fibrous connective tissue
US6503277B2 (en) 1991-08-12 2003-01-07 Peter M. Bonutti Method of transplanting human body tissue
US5329846A (en) 1991-08-12 1994-07-19 Bonutti Peter M Tissue press and system
US5270300A (en) 1991-09-06 1993-12-14 Robert Francis Shaw Methods and compositions for the treatment and repair of defects or lesions in cartilage or bone
US6919067B2 (en) 1991-09-13 2005-07-19 Syngenix Limited Compositions comprising a tissue glue and therapeutic agents
US5281422A (en) 1991-09-24 1994-01-25 Purdue Research Foundation Graft for promoting autogenous tissue growth
JP3524919B2 (ja) 1991-10-30 2004-05-10 マサチューセッツ インスティテュート オブ テクノロジー 臓器移植のための予備血管新生されたポリマー性移植片
US5482929A (en) 1991-12-26 1996-01-09 Kaken Pharmaceutical Co., Ltd. Composition of stabilized fibroblast growth factor
US6818008B1 (en) 1992-01-07 2004-11-16 Cch Associates, Inc. Percutaneous puncture sealing method
US5314476A (en) 1992-02-04 1994-05-24 Osteotech, Inc. Demineralized bone particles and flowable osteogenic composition containing same
US5876452A (en) 1992-02-14 1999-03-02 Board Of Regents, University Of Texas System Biodegradable implant
US5236457A (en) 1992-02-27 1993-08-17 Zimmer, Inc. Method of making an implant having a metallic porous surface
US5282861A (en) 1992-03-11 1994-02-01 Ultramet Open cell tantalum structures for cancellous bone implants and cell and tissue receptors
US5326357A (en) 1992-03-18 1994-07-05 Mount Sinai Hospital Corporation Reconstituted cartridge tissue
DK83092D0 (da) 1992-06-24 1992-06-24 Unes As Fremgangsmaade til udvinding af thrombin
US5312417A (en) 1992-07-29 1994-05-17 Wilk Peter J Laparoscopic cannula assembly and associated method
CN1091315A (zh) 1992-10-08 1994-08-31 E·R·斯奎布父子公司 血纤维蛋白封闭剂组合物及其使用方法
US5275826A (en) 1992-11-13 1994-01-04 Purdue Research Foundation Fluidized intestinal submucosa and its use as an injectable tissue graft
US5387243A (en) 1992-11-23 1995-02-07 Zimmer, Inc. Method for converting a cementable implant to a press fit implant
US5443454A (en) 1992-12-09 1995-08-22 Terumo Kabushiki Kaisha Catheter for embolectomy
US5723011A (en) 1992-12-21 1998-03-03 Zimmer, Inc. Prosthetic implant and method of making same
US5330974A (en) 1993-03-01 1994-07-19 Fibratek, Inc. Therapeutic fibrinogen compositions
US5749968A (en) 1993-03-01 1998-05-12 Focal, Inc. Device for priming for improved adherence of gels to substrates
DE4306661C2 (de) 1993-03-03 1995-04-20 Michael Dipl Biol Sittinger Verfahren zum Herstellen eines Implantates aus Zellkulturen
US5443510A (en) 1993-04-06 1995-08-22 Zimmer, Inc. Porous coated implant and method of making same
US5709854A (en) 1993-04-30 1998-01-20 Massachusetts Institute Of Technology Tissue formation by injecting a cell-polymeric solution that gels in vivo
EP2025353A2 (de) 1993-04-30 2009-02-18 Massachusetts Institute of Technology Injizierbare Polysaccharid-Zell-Zusammensetzungen
US5549904A (en) 1993-06-03 1996-08-27 Orthogene, Inc. Biological adhesive composition and method of promoting adhesion between tissue surfaces
US5795780A (en) 1993-06-23 1998-08-18 Bristol-Myers Squibb Company Method of use of autologous thrombin blood fraction in a cell culture with keratinocytes
US5405742A (en) 1993-07-16 1995-04-11 Cyromedical Sciences, Inc. Solutions for tissue preservation and bloodless surgery and methods using same
EP0641007A3 (de) 1993-08-31 1995-06-21 Samsung Display Devices Co Ltd Direkt beheizte Vorratskathodenstruktur.
US5890898A (en) 1993-11-08 1999-04-06 Wada; Eric Minoru Infection control guard for dental air-water syringes
DE4338129A1 (de) 1993-11-08 1995-05-11 Zimmer Ag Verfahren zur Polymerschmelze-Filtration
US5888491A (en) 1993-12-06 1999-03-30 Minnesota Mining And Manufacturing Company Optionally crosslinkable coatings, compositions and methods of use
US6312668B2 (en) 1993-12-06 2001-11-06 3M Innovative Properties Company Optionally crosslinkable coatings, compositions and methods of use
IL112580A0 (en) 1994-02-24 1995-05-26 Res Dev Foundation Amniotic membrane graft of wrap to prevent adhesions or bleeding of internal organs
JPH09510108A (ja) 1994-03-14 1997-10-14 クリオライフ,インコーポレイティド 移植用処理組織及び調製方法
US5461953A (en) 1994-03-25 1995-10-31 Mccormick; James B. Multi-dimension microtome sectioning device
US5504300A (en) 1994-04-18 1996-04-02 Zimmer, Inc. Orthopaedic implant and method of making same
US6025334A (en) 1994-04-28 2000-02-15 Les Laboratoires Aeterna Inc. Extracts of shark cartilage having anti-collagenolytic, anti-inflammatory, anti-angiogenic and anti-tumoral activities; process of making, methods of using and compositions thereof
US5618925A (en) 1994-04-28 1997-04-08 Les Laboratories Aeterna Inc. Extracts of shark cartilage having an anti-angiogenic activity and an effect on tumor regression; process of making thereof
US5723331A (en) 1994-05-05 1998-03-03 Genzyme Corporation Methods and compositions for the repair of articular cartilage defects in mammals
US5556429A (en) 1994-05-06 1996-09-17 Advanced Bio Surfaces, Inc. Joint resurfacing system
US6140452A (en) 1994-05-06 2000-10-31 Advanced Bio Surfaces, Inc. Biomaterial for in situ tissue repair
US5906827A (en) 1994-06-03 1999-05-25 Creative Biomolecules, Inc. Matrix for the manufacture of autogenous replacement body parts
CA2189646C (en) 1994-06-24 1999-05-25 Francis E. Dwulet A purified mixture of collagenases and two other proteases obtained from clostridium histolyticum
US5516532A (en) 1994-08-05 1996-05-14 Children's Medical Center Corporation Injectable non-immunogenic cartilage and bone preparation
US5769899A (en) 1994-08-12 1998-06-23 Matrix Biotechnologies, Inc. Cartilage repair unit
CH689725A5 (de) 1994-09-08 1999-09-30 Franz Dr Sutter Gelenkkopf-Prothese.
US5496375A (en) 1994-09-14 1996-03-05 Zimmer, Inc. Prosthetic implant with circumferential porous pad having interlocking tabs
US5824093A (en) 1994-10-17 1998-10-20 Raymedica, Inc. Prosthetic spinal disc nucleus
US5654166A (en) 1994-11-09 1997-08-05 Kurth; Gerhard P. Process of preparing hormone-free bovine cartilage for dosage form
US6110212A (en) 1994-11-15 2000-08-29 Kenton W. Gregory Elastin and elastin-based materials
US5585007A (en) 1994-12-07 1996-12-17 Plasmaseal Corporation Plasma concentrate and tissue sealant methods and apparatuses for making concentrated plasma and/or tissue sealant
US5632432A (en) 1994-12-19 1997-05-27 Ethicon Endo-Surgery, Inc. Surgical instrument
DE4445891A1 (de) 1994-12-22 1996-06-27 Boehringer Mannheim Gmbh Rekombinante Proteinase aus Clostridium histolyticum und ihre Verwendung zur Isolierung von Zellen und Zellverbänden
US6965014B1 (en) 1996-01-16 2005-11-15 Baxter International Inc. Fibrin material and method for producing and using the same
US6599515B1 (en) 1995-01-16 2003-07-29 Baxter International Inc. Fibrin porous structure
US5736396A (en) 1995-01-24 1998-04-07 Case Western Reserve University Lineage-directed induction of human mesenchymal stem cell differentiation
DK0805663T3 (da) 1995-01-27 2000-12-18 Coloplast As Bandage
US6080194A (en) 1995-02-10 2000-06-27 The Hospital For Joint Disease Orthopaedic Institute Multi-stage collagen-based template or implant for use in the repair of cartilage lesions
US6485723B1 (en) 1995-02-10 2002-11-26 Purdue Research Foundation Enhanced submucosal tissue graft constructs
US5695998A (en) 1995-02-10 1997-12-09 Purdue Research Foundation Submucosa as a growth substrate for islet cells
US5713374A (en) 1995-02-10 1998-02-03 The Hospital For Joint Diseases Orthopaedic Institute Fixation method for the attachment of wound repair materials to cartilage defects
US5879398A (en) 1995-02-14 1999-03-09 Zimmer, Inc. Acetabular cup
US20050186673A1 (en) 1995-02-22 2005-08-25 Ed. Geistlich Soehne Ag Fuer Chemistrie Industrie Collagen carrier of therapeutic genetic material, and method
US5782835A (en) 1995-03-07 1998-07-21 Innovasive Devices, Inc. Apparatus and methods for articular cartilage defect repair
EP0734736A1 (de) 1995-03-31 1996-10-02 Toyo Boseki Kabushiki Kaisha Medizinische Vorrichtung und Verfahren zu ihrer Herstellung
US5840713A (en) 1995-04-03 1998-11-24 Weisz; Paul B. Therapy for tissue membrane insufficiency
US5643192A (en) 1995-04-06 1997-07-01 Hamilton Civic Hospitals Research Development, Inc. Autologous fibrin glue and methods for its preparation and use
US5554389A (en) 1995-04-07 1996-09-10 Purdue Research Foundation Urinary bladder submucosa derived tissue graft
US5714371A (en) 1995-05-12 1998-02-03 Schering Corporation Method for refolding insoluble aggregates of hepatitis C virus protease
US6129761A (en) 1995-06-07 2000-10-10 Reprogenesis, Inc. Injectable hydrogel compositions
US5674292A (en) 1995-06-07 1997-10-07 Stryker Corporation Terminally sterilized osteogenic devices and preparation thereof
US5655546A (en) 1995-06-07 1997-08-12 Halpern; Alan A. Method for cartilage repair
JP4246795B2 (ja) 1995-07-25 2009-04-02 ノバルティス アクチエンゲゼルシャフト β型トランスフォーミング増殖因子の結晶
US5535810A (en) 1995-07-28 1996-07-16 Zimmer, Inc. Cast orthopaedic implant and method of making same
US5782915A (en) 1995-09-15 1998-07-21 Stone; Kevin R. Articular cartilage heterografts
US5944755A (en) 1995-09-15 1999-08-31 Crosscart, Inc. Articular cartilage xenografts
US6132674A (en) 1995-10-12 2000-10-17 Bristol-Myers Squibb Company Method of making an orthopaedic implant having a porous surface
US5734959A (en) 1995-10-12 1998-03-31 Zimmer, Inc. Method of making an orthopaedic implant having a porous surface using an organic binder
AU1051597A (en) 1995-11-09 1997-05-29 University Of Massachusetts Tissue re-surfacing with hydrogel-cell compositions
DK2111876T3 (da) 1995-12-18 2011-12-12 Angiodevice Internat Gmbh Tværbundne polymerpræparater og fremgangsmåder til anvendelse deraf
US6833408B2 (en) 1995-12-18 2004-12-21 Cohesion Technologies, Inc. Methods for tissue repair using adhesive materials
US5989888A (en) 1996-01-24 1999-11-23 Roche Diagnostics Corporation Purified mixture of collagenase I, collagenase II and two other proteases
US5639280A (en) 1996-02-02 1997-06-17 Zimmer, Inc. Constraining ring for a hip cup
US5842477A (en) 1996-02-21 1998-12-01 Advanced Tissue Sciences, Inc. Method for repairing cartilage
US6087553A (en) 1996-02-26 2000-07-11 Implex Corporation Implantable metallic open-celled lattice/polyethylene composite material and devices
US5755791A (en) 1996-04-05 1998-05-26 Purdue Research Foundation Perforated submucosal tissue graft constructs
DE29723807U1 (de) 1996-04-30 1999-11-04 Medtronic, Inc., Minneapolis, Minn. Autologe Fibrin-Blutstillungsmittel
DE19617369A1 (de) 1996-04-30 1997-11-06 Immuno Ag Lagerstabile Fibrinogen-Präparate
WO2000062828A1 (en) 1996-04-30 2000-10-26 Medtronic, Inc. Autologous fibrin sealant and method for making the same
US6632648B1 (en) 1996-05-14 2003-10-14 Elan Drug Delivery Limited Methods of terminal sterilization of fibrinogen
WO1997045147A1 (en) 1996-05-28 1997-12-04 1218122 Ontario Inc. Resorbable implant biomaterial made of condensed calcium phosphate particles
JP3754708B2 (ja) 1996-06-04 2006-03-15 ツィマー ゲーエム ベーハー 軟骨内及び骨軟骨欠損を修復するための軟骨組織及びインプラントの製造方法並びにその方法を実施するための配置
AU3360197A (en) 1996-07-01 1998-01-21 Universiteit Utrecht Hydrolysable hydrogels for controlled release
WO1998004681A2 (en) 1996-07-25 1998-02-05 Genzyme Corporation Chondrocyte media formulations and culture procedures
US6666892B2 (en) 1996-08-23 2003-12-23 Cook Biotech Incorporated Multi-formed collagenous biomaterial medical device
US5989269A (en) 1996-08-30 1999-11-23 Vts Holdings L.L.C. Method, instruments and kit for autologous transplantation
US6120514A (en) 1996-08-30 2000-09-19 Vts Holdings, Llc Method and kit for autologous transplantation
US5827217A (en) 1996-09-04 1998-10-27 Silver; Frederick H. Process and apparatus for harvesting tissue for processing tissue and process and apparatus for re-injecting processed tissue
US5921987A (en) 1996-09-13 1999-07-13 Depuy Orthopaedic Technology, Inc. Articular cartilage transplant instrument set
US5964805A (en) 1997-02-12 1999-10-12 Stone; Kevin R. Method and paste for articular cartilage transplantation
IT1284550B1 (it) 1996-09-18 1998-05-21 Flavio Tarantino Procedimento per la preparazione di colla di fibrina autologa ad uso chirurgico
NL1004276C2 (nl) 1996-10-15 1998-04-20 Willem Marie Ysebaert Werkwijzen voor het vervaardigen van huideilandjes, voor het verplaatsen van huid of huideilandjes, voor het spreiden van huideilandjes en het aanbrengen hiervan op een brandwond, alsmede een houder, snijraam, snijtafel, contradrager, klemorgaan, membraan, transportorgaan en spreidingsorgaan om te worden toegepast voor dergelijke werkwijzen.
US5919702A (en) 1996-10-23 1999-07-06 Advanced Tissue Science, Inc. Production of cartilage tissue using cells isolated from Wharton's jelly
EP0873145A2 (de) 1996-11-15 1998-10-28 Advanced Bio Surfaces, Inc. Biomaterialsystem für in-situ gewebewiederherstellung
BR9713108A (pt) 1996-11-19 2004-06-22 Roche Diagnostics Gmbh Colagenase recombinante do tipo i de clostridium histolytucum e o uso da mesma para o isolamento de células e de grupos de células
US5928945A (en) 1996-11-20 1999-07-27 Advanced Tissue Sciences, Inc. Application of shear flow stress to chondrocytes or chondrocyte stem cells to produce cartilage
DE19648744A1 (de) 1996-11-25 1998-05-28 Basf Ag Verfahren zur Herstellung einer Polymerdispersion durch radikalische wäßrige Emulsionspolymerisation mit einer kontinuierlich hergestellten wäßrigen Monomerenemulsion
US5830741A (en) 1996-12-06 1998-11-03 Boehringer Mannheim Corporation Composition for tissue dissociation containing collagenase I and II from clostridium histolyticum and a neutral protease
FR2757770B1 (fr) 1996-12-30 1999-02-26 Inoteb Procede de preparation d'une colle biologique capable de coaguler par simple addition d'ions calcium
US8882847B2 (en) 2001-05-25 2014-11-11 Conformis, Inc. Patient selectable knee joint arthroplasty devices
DE19708703C2 (de) 1997-02-24 2002-01-24 Co Don Ag Chirurgisches Besteck
US6152142A (en) 1997-02-28 2000-11-28 Tseng; Scheffer C. G. Grafts made from amniotic membrane; methods of separating, preserving, and using such grafts in surgeries
GB9704749D0 (en) 1997-03-07 1997-04-23 Univ London Tissue Implant
US6733515B1 (en) 1997-03-12 2004-05-11 Neomend, Inc. Universal introducer
US5866415A (en) 1997-03-25 1999-02-02 Villeneuve; Peter E. Materials for healing cartilage and bone defects
DE19713011C2 (de) 1997-03-27 1999-10-21 Friadent Gmbh Folie für die Medizintechnik
EP1018987B1 (de) 1997-04-04 2014-10-29 Barnes-Jewish Hospital Neo-knorpel und seine gebrauchsverfahren
US6224893B1 (en) 1997-04-11 2001-05-01 Massachusetts Institute Of Technology Semi-interpenetrating or interpenetrating polymer networks for drug delivery and tissue engineering
IT1292410B1 (it) 1997-06-24 1999-02-08 Roberto Beretta Contenitore di pronto impiego per ottenere colla di fibrina autologa
US6979307B2 (en) 1997-06-24 2005-12-27 Cascade Medical Enterprises Llc Systems and methods for preparing autologous fibrin glue
US6107085A (en) 1997-07-11 2000-08-22 Corning Incorporated Self contained cell growth system
ZA987019B (en) 1997-08-06 1999-06-04 Focal Inc Hemostatic tissue sealants
US6110209A (en) 1997-08-07 2000-08-29 Stone; Kevin R. Method and paste for articular cartilage transplantation
US6511958B1 (en) 1997-08-14 2003-01-28 Sulzer Biologics, Inc. Compositions for regeneration and repair of cartilage lesions
ATE220564T1 (de) 1997-08-14 2002-08-15 Sulzer Innotec Ag Zusammensetzung und vorrichtung zur reparatur von knorpelgewebe in vivo bestehend aus nanokapseln mit osteoinduktiven und/oder chondroinduktiven faktoren
AU9119798A (en) 1997-08-22 1999-03-16 Direct Therapeutics, Inc. An apparatus for preventing loss of a composition during a medical procedure
JPH1178498A (ja) 1997-09-17 1999-03-23 Toyota Autom Loom Works Ltd クーラント循環方法及びクーラント循環回路
US6041723A (en) 1997-09-26 2000-03-28 Peterson; Graham Portable collapsible self-assembling desk
US20050186283A1 (en) 1997-10-10 2005-08-25 Ed. Geistlich Soehne Ag Fuer Chemistrie Industrie Collagen carrier of therapeutic genetic material, and method
US6458095B1 (en) 1997-10-22 2002-10-01 3M Innovative Properties Company Dispenser for an adhesive tissue sealant having a housing with multiple cavities
US20030099620A1 (en) 1997-10-30 2003-05-29 The General Hospital Corporation Bonding of cartilaginous matrices using isolated chondrocytes
DE69831589T2 (de) 1997-10-30 2006-06-22 The General Hospital Corp., Boston Zusammenfügung von knorpelmatrizen unter verwendung isolierter chondrozyten
US6080579A (en) 1997-11-26 2000-06-27 Charlotte-Mecklenburg Hospital Authority Method for producing human intervertebral disc cells
US6187329B1 (en) 1997-12-23 2001-02-13 Board Of Regents Of The University Of Texas System Variable permeability bone implants, methods for their preparation and use
US5964752A (en) 1998-02-02 1999-10-12 Stone; Kevin R. Articular cartilage surface shaping apparatus and method
US6437018B1 (en) 1998-02-27 2002-08-20 Musculoskeletal Transplant Foundation Malleable paste with high molecular weight buffered carrier for filling bone defects
US6143214A (en) 1998-03-09 2000-11-07 Board Of Regents Of The University Of Texas System Mixing and dispensing system for rapidly polymerizing materials
US6471958B2 (en) 1998-03-24 2002-10-29 University Of North Texas Health Science Center Non-contracting tissue equivalent
US6637437B1 (en) 1998-04-08 2003-10-28 Johns Hopkins University Cell-culture and polymer constructs
US6378527B1 (en) 1998-04-08 2002-04-30 Chondros, Inc. Cell-culture and polymer constructs
US20040044408A1 (en) 1998-04-08 2004-03-04 Hungerford David S. Cell-culture and polymer constructs
US6886568B2 (en) 1998-04-08 2005-05-03 The Johns Hopkins University Method for fabricating cell-containing implants
US6514522B2 (en) 1998-04-08 2003-02-04 Chondros, Inc. Polymer constructs
EP1084454B1 (de) 1998-04-21 2016-03-09 University of Connecticut Freie strukturierung im nanometerbereich mit multiphotonanregung
US6171610B1 (en) 1998-04-24 2001-01-09 University Of Massachusetts Guided development and support of hydrogel-cell compositions
WO1999057817A2 (en) 1998-04-30 1999-11-11 Koninklijke Philips Electronics N.V. Code division multiple access transmitter and receiver
US6132465A (en) 1998-06-04 2000-10-17 Raymedica, Inc. Tapered prosthetic spinal disc nucleus
US6083383A (en) 1998-06-25 2000-07-04 Huang; Xun Yang Apparatus for production of fibrin ogen or fibrin glue
US6086593A (en) 1998-06-30 2000-07-11 Bonutti; Peter M. Method and apparatus for use in operating on a bone
US6045990A (en) 1998-07-09 2000-04-04 Baust; John M. Inclusion of apoptotic regulators in solutions for cell storage at low temperature
US6274090B1 (en) 1998-08-05 2001-08-14 Thermogenesis Corp. Apparatus and method of preparation of stable, long term thrombin from plasma and thrombin formed thereby
WO2000009732A1 (en) 1998-08-13 2000-02-24 Warner-Lambert Company Electroporation buffer with cryprotective capabilities
US6551355B1 (en) 1998-08-14 2003-04-22 Cambridge Scientific, Inc. Tissue transplant coated with biocompatible biodegradable polymer
US6099531A (en) 1998-08-20 2000-08-08 Bonutti; Peter M. Changing relationship between bones
CA2344399A1 (en) 1998-09-18 2000-03-30 Massachusetts Institute Of Technology Use of growth factors and hormones for expansion of mammalian cells and tissue engineering
US6140123A (en) 1998-10-07 2000-10-31 Cedars-Sinai Medical Center Method for conditioning and cryopreserving cells
US6022361A (en) 1998-10-09 2000-02-08 Biointerventional Corporation Device for introducing and polymerizing polymeric biomaterials in the human body and method
US20030114936A1 (en) 1998-10-12 2003-06-19 Therics, Inc. Complex three-dimensional composite scaffold resistant to delimination
US7276235B2 (en) 1998-11-18 2007-10-02 Zlb Behring Gmbh Tissue glue with improved antiadhesive properties
US6200330B1 (en) 1998-11-23 2001-03-13 Theodore V. Benderev Systems for securing sutures, grafts and soft tissue to bone and periosteum
DE19855890A1 (de) 1998-12-03 2000-06-08 Nerlich Michael Poröse Kompositmatrix, deren Herstellung und Verwendung
US6264659B1 (en) 1999-02-22 2001-07-24 Anthony C. Ross Method of treating an intervertebral disk
US6436143B1 (en) 1999-02-22 2002-08-20 Anthony C. Ross Method and apparatus for treating intervertebral disks
DE19908628A1 (de) 1999-02-27 2000-08-31 Lurgi Zimmer Ag Katalysator, Verfahren zu dessen Herstellung und Verwendung des Katalysators
US6395327B1 (en) 1999-03-12 2002-05-28 Zimmer, Inc. Enhanced fatigue strength orthopaedic implant with porous coating and method of making same
JP2002539172A (ja) 1999-03-17 2002-11-19 ノバルティス アクチエンゲゼルシャフト Tgf−ベータを含む医薬組成物
US6662805B2 (en) 1999-03-24 2003-12-16 The Johns Hopkins University Method for composite cell-based implants
US6110210A (en) 1999-04-08 2000-08-29 Raymedica, Inc. Prosthetic spinal disc nucleus having selectively coupled bodies
US6428576B1 (en) 1999-04-16 2002-08-06 Endospine, Ltd. System for repairing inter-vertebral discs
US6370920B1 (en) 1999-04-28 2002-04-16 Alcatel Apparatus to improve degree of cure for ultraviolet curable optical fiber coating by actively removing heat from the coating during irradiation
US6287340B1 (en) 1999-05-14 2001-09-11 Trustees Of Tufts College Bioengineered anterior cruciate ligament
US6645947B1 (en) 1999-05-20 2003-11-11 Chitogenics, Inc. Adhesive N, O-carboxymethylchitosan coatings which inhibit attachment of substrate-dependent cells and proteins
WO2000073536A1 (de) 1999-05-28 2000-12-07 Henkel Kommanditgesellschaft Auf Aktien Nachpassivierung einer phosphatierten metalloberfläche
US6472162B1 (en) 1999-06-04 2002-10-29 Thermogenesis Corp. Method for preparing thrombin for use in a biological glue
US20040059416A1 (en) 1999-06-22 2004-03-25 Murray Martha M. Biologic replacement for fibrin clot
US6333029B1 (en) 1999-06-30 2001-12-25 Ethicon, Inc. Porous tissue scaffoldings for the repair of regeneration of tissue
US6652872B2 (en) 1999-07-06 2003-11-25 Ramat At Tel Aviv University Ltd. Scaffold formed of tissue treated to eliminate cellular and cytosolic elements
WO2001005443A1 (fr) 1999-07-21 2001-01-25 Imedex Biomateriaux Mousse proteique adhesive a usage chirurgical et/ou therapeutique
ES2239608T3 (es) 1999-07-28 2005-10-01 Interface Biotech A/S Reparacion in vitro de defectos de hueso y/o cartilago.
US6425919B1 (en) 1999-08-18 2002-07-30 Intrinsic Orthopedics, Inc. Devices and methods of vertebral disc augmentation
US6280993B1 (en) 1999-08-24 2001-08-28 Ichiro Yamato Gene encoding class I collagenase
US6620169B1 (en) 1999-08-26 2003-09-16 Spineology Group, Llc. Tools and method for processing and injecting bone graft
US6322563B1 (en) 1999-09-17 2001-11-27 Genzyme Corporation Small tissue and membrane fixation apparatus and methods for use thereof
US6528052B1 (en) 2000-09-29 2003-03-04 The Board Of Trustees Of The Leland Stanford Junior University Method for in vivo ex vivo and in vitro repair and regeneration of cartilage and collagen and bone remodeling
US6576265B1 (en) 1999-12-22 2003-06-10 Acell, Inc. Tissue regenerative composition, method of making, and method of use thereof
US6579538B1 (en) 1999-12-22 2003-06-17 Acell, Inc. Tissue regenerative compositions for cardiac applications, method of making, and method of use thereof
US6425704B2 (en) 2000-01-07 2002-07-30 Closure Medical Corporation Adhesive applicators with improved applicator tips
US6626859B2 (en) 2000-01-18 2003-09-30 Coraflo Ltd. High performance cannulas
US6447514B1 (en) 2000-03-07 2002-09-10 Zimmer Polymer filled hip fracture fixation device
US6336930B1 (en) 2000-03-07 2002-01-08 Zimmer, Inc. Polymer filled bone plate
US6652883B2 (en) 2000-03-13 2003-11-25 Biocure, Inc. Tissue bulking and coating compositions
WO2001068720A1 (en) 2000-03-13 2001-09-20 Biocure, Inc. Embolic compositions
DE10013223C2 (de) 2000-03-13 2002-07-18 Co Don Ag Verfahren zur in vitro-Herstellung von dreidimensionalem, vitalem Knorpel- oder Knochengewebe und dessen Verwendung als Transplantationsmaterial
US6626945B2 (en) 2000-03-14 2003-09-30 Chondrosite, Llc Cartilage repair plug
US6632246B1 (en) 2000-03-14 2003-10-14 Chondrosite, Llc Cartilage repair plug
DE10026789B4 (de) 2000-05-31 2004-09-02 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Knorpelersatz und Verfahren zu dessen Herstellung
US6533817B1 (en) 2000-06-05 2003-03-18 Raymedica, Inc. Packaged, partially hydrated prosthetic disc nucleus
US6991652B2 (en) 2000-06-13 2006-01-31 Burg Karen J L Tissue engineering composite
AU7362301A (en) 2000-06-22 2002-01-02 Sam L Austin Bioadhesive compositions and methods of preparation and use
US6921532B1 (en) 2000-06-22 2005-07-26 Spinal Restoration, Inc. Biological Bioadhesive composition and methods of preparation and use
US9387094B2 (en) 2000-07-19 2016-07-12 Warsaw Orthopedic, Inc. Osteoimplant and method of making same
ES2341641T3 (es) 2000-07-21 2010-06-24 The Spineology Group, Llc Un dispositivo de bolsa de malla porosa expansible y su uso para cirugia osea.
US6653062B1 (en) 2000-07-26 2003-11-25 Wisconsin Alumni Research Foundation Preservation and storage medium for biological materials
CA2417688A1 (en) 2000-07-29 2002-02-07 Smith & Nephew Plc Tissue implant for cartilage repair
MY130475A (en) 2000-08-25 2007-06-29 Contura As Polyacrylamide hydrogel and its use as an endoprosthesis
US7186419B2 (en) 2000-08-25 2007-03-06 Contura Sa Polyacrylamide hydrogel for arthritis
EP1315470B1 (de) 2000-08-28 2009-07-15 Disc Dynamics, Inc. System zur wiederherstellung von gelenkoberflächen von säugetieren
US6620196B1 (en) 2000-08-30 2003-09-16 Sdgi Holdings, Inc. Intervertebral disc nucleus implants and methods
US6610033B1 (en) 2000-10-13 2003-08-26 Incept, Llc Dual component medicinal polymer delivery system and methods of use
JP2004535836A (ja) 2000-11-14 2004-12-02 エヌ.ブイ.アール. ラブズ インコーポレイテッド 架橋ヒアルロン酸−ラミニンゲル並びに細胞培養及び医療用移植組織におけるその使用
JP2002233567A (ja) 2000-12-06 2002-08-20 Mitsuo Ochi 移植用組織等価物及びその製造方法
DE10061195B4 (de) 2000-12-08 2004-12-02 3M Espe Ag Verwendung von Abformmassen zur Herstellung von Behandlungsvorrichtungen
US6852330B2 (en) 2000-12-21 2005-02-08 Depuy Mitek, Inc. Reinforced foam implants with enhanced integrity for soft tissue repair and regeneration
CA2365376C (en) 2000-12-21 2006-03-28 Ethicon, Inc. Use of reinforced foam implants with enhanced integrity for soft tissue repair and regeneration
US6890295B2 (en) 2002-10-31 2005-05-10 Medtronic, Inc. Anatomical space access tools and methods
US6697143B2 (en) 2001-02-12 2004-02-24 Viztec, Inc. Electrooptical displays constructed with polymerization initiating and enhancing elements positioned between substrates
US7666192B2 (en) 2001-02-16 2010-02-23 Kci Licensing, Inc. Skin grafting devices and methods
US7651507B2 (en) * 2003-03-03 2010-01-26 Kci Licensing, Inc. Tissue processing system
US7544196B2 (en) 2001-02-20 2009-06-09 Orthovita, Inc. System and kit for delivery of restorative materials
US20020151974A1 (en) 2001-02-23 2002-10-17 Bonassar Lawrence J. Tympanic membrane patch
WO2002067856A2 (en) 2001-02-23 2002-09-06 University Of Massachusetts Injection molding of living tissues
US6743232B2 (en) 2001-02-26 2004-06-01 David W. Overaker Tissue scaffold anchor for cartilage repair
IL142118A0 (en) 2001-03-20 2002-03-10 Prochon Biotech Ltd Method and composition for treatment of skeletal dysplasias
US20040151705A1 (en) 2002-03-22 2004-08-05 Shuichi Mizuno Neo-cartilage constructs and a method for preparation thereof
US6949252B2 (en) 2001-03-23 2005-09-27 Histogenics, Corp. Method for preparing an implantable multilayer tissue construct
EP1420833B1 (de) 2001-04-09 2010-06-09 Arteriocyte Medical Systems, Inc. System zur Herstellung eines Gels aus autologen Blutplättchen
US6942880B1 (en) 2001-04-09 2005-09-13 Medtronic, Inc. Autologous platelet gel having beneficial geometric shapes and methods of making the same
US7615593B2 (en) 2001-04-23 2009-11-10 Wisconsin Alumni Research Foundation Bifunctional-modified hydrogels
DE60121826T2 (de) 2001-05-09 2007-02-22 Baxter International Inc., Deerfield Fibrinmaterial und verfahren zu seiner herstellung und verwendung
KR20020088848A (ko) 2001-05-21 2002-11-29 (주)코아바이오텍 세포배양관 및 이를 이용한 대량 세포배양기
JP2004535425A (ja) 2001-06-13 2004-11-25 マサチューセッツ インスティチュート オブ テクノロジー invivoバイオリアクタ
KR20020095842A (ko) 2001-06-16 2002-12-28 삼성전자 주식회사 반도체 에싱장치
US6626950B2 (en) 2001-06-28 2003-09-30 Ethicon, Inc. Composite scaffold with post anchor for the repair and regeneration of tissue
EP1402008B1 (de) 2001-07-02 2005-08-24 Nordmark Arzneimittel GmbH & Co.KG Verfahren zur aufreinigung eines enzyms und hiernach hergestelltes, aufgereinigtes enzym sowie verwendung des enzyms
FR2827290B1 (fr) 2001-07-13 2004-07-09 Pierre Jouan Biotechnologies Sa Procede d'obtention d'une fraction proteique enrichie en tgf-beta sous forme activee, fraction proteique et applications therapeutiques
IL144446A0 (en) 2001-07-19 2002-05-23 Prochon Biotech Ltd Plasma protein matrices and methods for their preparation
AU2002300450B2 (en) 2001-08-10 2007-04-05 Ed. Geistlich Soehne Ag Fuer Chemische Industrie Collagen Carrier of Therapeutic Genetic Material, and Method
JP4015618B2 (ja) 2001-08-25 2007-11-28 コンチュラ ソシエテ アノニム 補綴に使用されるポリマーヒドロゲル、ポリマーヒドロゲルの補綴具の作製のための使用及び粉末ポリアクリルアミドヒドロゲル
ES2672815T3 (es) 2001-10-18 2018-06-18 Lifecell Corporation Remodelación de tejidos y órganos
US20030134032A1 (en) 2001-11-16 2003-07-17 Hassan Chaouk Methods for initiating in situ formation of hydrogels
JP4223961B2 (ja) 2002-01-31 2009-02-12 Agcテクノグラス株式会社 霊長類胚性幹細胞の凍結保存方法
US20020106625A1 (en) 2002-02-07 2002-08-08 Hung Clark T. Bioreactor for generating functional cartilaginous tissue
US7042803B2 (en) 2002-02-08 2006-05-09 Input/Output Inc. Marine seismic source towing apparatus and method
US7504115B2 (en) 2002-02-15 2009-03-17 Ocean Nutrition Canada Limited Shark cartilage extracts and use thereof for immunomodulation
US6740186B2 (en) 2002-02-20 2004-05-25 Zimmer Technology, Inc. Method of making an orthopeadic implant having a porous metal surface
TWI290055B (en) 2002-03-14 2007-11-21 Tissuetech Inc Amniotic membrane covering for a tissue surface and devices facilitating fastening of membranes
US7537780B2 (en) 2002-03-22 2009-05-26 Histogenics Corporation Method for preparing and implanting a cartilage construct to treat cartilage lesions
US7468192B2 (en) 2002-03-22 2008-12-23 Histogenics Corporation Method for repair of cartilage lesions
US20030187515A1 (en) 2002-03-26 2003-10-02 Hariri Robert J. Collagen biofabric and methods of preparing and using the collagen biofabric
GB0211963D0 (en) 2002-05-24 2002-07-03 British American Tobacco Co An exposure device
US7299805B2 (en) 2002-06-07 2007-11-27 Marctec, Llc Scaffold and method for implanting cells
US7166133B2 (en) 2002-06-13 2007-01-23 Kensey Nash Corporation Devices and methods for treating defects in the tissue of a living being
US6797006B2 (en) 2002-06-18 2004-09-28 Zimmer Technology, Inc. Porous unicondylar knee
DE10261126A1 (de) 2002-08-13 2004-03-04 Aventis Behring Gmbh Lagerungsstabile, flüssige Fibrinogen-Formulierung
US7494460B2 (en) 2002-08-21 2009-02-24 Medtronic, Inc. Methods and apparatus providing suction-assisted tissue engagement through a minimally invasive incision
JPWO2004018615A1 (ja) 2002-08-23 2005-12-08 旭化成メディカル株式会社 フィブリン含有組成物
US20040126881A1 (en) 2002-09-06 2004-07-01 Vincent Ronfard Fibrin cell supports and methods of use thereof
US7744651B2 (en) 2002-09-18 2010-06-29 Warsaw Orthopedic, Inc Compositions and methods for treating intervertebral discs with collagen-based materials
US20040054414A1 (en) 2002-09-18 2004-03-18 Trieu Hai H. Collagen-based materials and methods for augmenting intervertebral discs
US6840960B2 (en) 2002-09-27 2005-01-11 Stephen K. Bubb Porous implant system and treatment method
US7666134B2 (en) 2002-09-28 2010-02-23 Kci Licensing, Inc. System and method for transplantation of dermal tissue
AU2003265103A1 (en) 2002-09-30 2004-04-19 Bioland Ltd. Dermal substitute consisting of amnion and biodegradable polymer, the preparation method and the use thereof
US6800663B2 (en) 2002-10-18 2004-10-05 Alkermes Controlled Therapeutics Inc. Ii, Crosslinked hydrogel copolymers
US7824701B2 (en) 2002-10-18 2010-11-02 Ethicon, Inc. Biocompatible scaffold for ligament or tendon repair
US20040078090A1 (en) 2002-10-18 2004-04-22 Francois Binette Biocompatible scaffolds with tissue fragments
IL153699A (en) 2002-12-26 2008-11-26 Prochon Biotech Ltd The composition for transplantation basically
US7115100B2 (en) 2002-11-15 2006-10-03 Ethicon, Inc. Tissue biopsy and processing device
US6921633B2 (en) 2002-11-18 2005-07-26 Biolife Solutions Incorporated Methods and compositions for the preservation of cells, tissues or organs in the vitreous state
US20040230309A1 (en) 2003-02-14 2004-11-18 Depuy Spine, Inc. In-situ formed intervertebral fusion device and method
US20040191819A1 (en) 2003-02-28 2004-09-30 Bayer Pharmaceuticals Corporation Expression profiles for breast cancer and methods of use
GB0304799D0 (en) 2003-03-03 2003-04-09 Glaxosmithkline Biolog Sa Novel method
US20040175690A1 (en) 2003-03-03 2004-09-09 Kci Licensing, Inc. Tissue harvesting device and method
US7067123B2 (en) 2003-04-29 2006-06-27 Musculoskeletal Transplant Foundation Glue for cartilage repair
US20050222687A1 (en) 2004-04-02 2005-10-06 Gordana Vunjak-Novakovic Cartilage implant assembly and method for implantation
US20050064042A1 (en) 2003-04-29 2005-03-24 Musculoskeletal Transplant Foundation Cartilage implant plug with fibrin glue and method for implantation
US20050123520A1 (en) 2003-05-05 2005-06-09 Eavey Roland D. Generation of living tissue in vivo using a mold
US7901457B2 (en) 2003-05-16 2011-03-08 Musculoskeletal Transplant Foundation Cartilage allograft plug
US20090291112A1 (en) 2003-05-16 2009-11-26 Truncale Katherine G Allograft osteochondral plug combined with cartilage particle mixture
US7488348B2 (en) 2003-05-16 2009-02-10 Musculoskeletal Transplant Foundation Cartilage allograft plug
KR20060031808A (ko) 2003-06-11 2006-04-13 오스테오테크, 인코포레이티드 뼈 임플란트 및 그의 제조 방법
AU2004246749A1 (en) 2003-06-12 2004-12-23 Interface Biotech A/S A method for cell implantation
US20050124038A1 (en) 2003-07-14 2005-06-09 Pharmacia Corporation Transfection of cartilage and matrices thereof in vitro
US20080039939A1 (en) 2003-07-31 2008-02-14 Yukihide Iwamoto Method of Constructing Artificial Joint
GB0318125D0 (en) 2003-08-01 2003-09-03 Inst Of Cancer Res The Apparatus and methods for tissue preparation
WO2005016123A2 (en) 2003-08-11 2005-02-24 Chudik Steven C M D Devices and methods used for shoulder replacement
US10583220B2 (en) 2003-08-11 2020-03-10 DePuy Synthes Products, Inc. Method and apparatus for resurfacing an articular surface
US7217294B2 (en) 2003-08-20 2007-05-15 Histogenics Corp. Acellular matrix implants for treatment of articular cartilage, bone or osteochondral defects and injuries and method for use thereof
CA2536104A1 (en) 2003-08-20 2005-03-03 Histogenics Corporation Acellular matrix implanted into an articular cartilage or osteochondral lesion protected with a biodegradable polymer modified to have extended polymerization time and methods forpreparation and use thereof
US8043614B2 (en) 2004-03-09 2011-10-25 Ahlfors Jan-Eric W Autogenic living scaffolds and living tissue matrices: methods and uses thereof
US7897384B2 (en) 2003-09-08 2011-03-01 Ethicon, Inc. Chondrocyte therapeutic delivery system
US20060281173A1 (en) 2003-09-19 2006-12-14 Keiichi Fukuda Composition for coating support for preparation of cell sheet support for preparation of cell sheet and process for producing cell sheet
US7375077B2 (en) 2003-09-19 2008-05-20 The Board Of Trustees Of The University Of Illinois In vivo synthesis of connective tissues
EP1529543A1 (de) 2003-11-04 2005-05-11 Institut National De La Sante Et De La Recherche Medicale (Inserm) Verwendung eines hydrogels zur Chondrozyten-Kultur
CA2536041A1 (en) 2003-11-10 2005-05-26 Angiotech International Ag Medical implants and fibrosis-inducing agents
US8673021B2 (en) 2003-11-26 2014-03-18 Depuy Mitek, Llc Arthroscopic tissue scaffold delivery device
US7316822B2 (en) 2003-11-26 2008-01-08 Ethicon, Inc. Conformable tissue repair implant capable of injection delivery
US7901461B2 (en) 2003-12-05 2011-03-08 Ethicon, Inc. Viable tissue repair implants and methods of use
KR20060130580A (ko) 2003-12-10 2006-12-19 셀룰라 바이오엔지니어링 인코포레이티드 연조직 형태 복원을 위한 조성물 및 방법
ES2404682T3 (es) 2003-12-11 2013-05-28 Isto Technologies Inc. Sistema de cartílago particulado
DK1722834T3 (da) 2003-12-22 2012-10-22 Regentis Biomaterials Ltd Matrix, som omfatter naturligt forekommende tværbundet proteinskelet
US20050137600A1 (en) 2003-12-23 2005-06-23 Jacobs Andrew M. Articular cartilage repair implant delivery device and method of use
KR100531922B1 (ko) 2003-12-23 2005-11-29 주식회사 셀론텍 연골치료제 조성물 및 그 사용방법
US6997381B2 (en) 2003-12-24 2006-02-14 Michael Arnouse Dual-sided smart card reader
US7500947B2 (en) 2004-01-29 2009-03-10 Cannonflow, Inc. Atraumatic arthroscopic instrument sheath
US7445596B2 (en) 2004-01-29 2008-11-04 Cannuflow, Inc. Atraumatic arthroscopic instrument sheath
US7413542B2 (en) 2004-01-29 2008-08-19 Cannuflow, Inc. Atraumatic arthroscopic instrument sheath
US7435214B2 (en) 2004-01-29 2008-10-14 Cannuflow, Inc. Atraumatic arthroscopic instrument sheath
US11395865B2 (en) 2004-02-09 2022-07-26 DePuy Synthes Products, Inc. Scaffolds with viable tissue
US20060275273A1 (en) 2004-02-20 2006-12-07 Seyedin Mitchell S Intervertebral Disc Repair, Methods and Devices Therefor
EP1753860B1 (de) 2004-02-20 2012-04-11 Isto Technologies Inc. Bandscheibenreparatur und verfahren dafür
CA2556902A1 (en) 2004-03-03 2005-10-06 Schwartz Biomedical, Llc Articular cartilage fixation device and method
US20050196460A1 (en) 2004-03-08 2005-09-08 Malinin Theodore I. Particulate cartilage compositions, processes for their preparation and methods for regenerating cartilage
EP1731177A4 (de) 2004-03-11 2009-07-22 Arblast Co Ltd Biologische gewebefläche, verfahren zu ihrer herstellung und transplantationsverfahren unter verwendung dieser fläche
US20050209602A1 (en) 2004-03-22 2005-09-22 Disc Dynamics, Inc. Multi-stage biomaterial injection system for spinal implants
US20070292945A1 (en) 2004-03-25 2007-12-20 Lin Wenglong R Cell Culture Apparatus and Methods
US20060041270A1 (en) 2004-05-07 2006-02-23 Jay Lenker Medical access sheath
US20050265980A1 (en) 2004-05-14 2005-12-01 Becton, Dickinson And Company Cell culture environments for the serum-free expansion of mesenchymal stem cells
US20050288796A1 (en) 2004-06-23 2005-12-29 Hani Awad Native soft tissue matrix for therapeutic applications
US20050287223A1 (en) 2004-06-23 2005-12-29 Peyman Gholam A Use of amniotic membrane as biocompatible devices
AU2005260646A1 (en) 2004-06-29 2006-01-12 Bruktawit T. Asfaw Biomaterial
US7789913B2 (en) 2004-06-29 2010-09-07 Spine Wave, Inc. Methods for injecting a curable biomaterial into an intervertebral space
ATE500318T1 (de) 2004-07-09 2011-03-15 Univ Rice William M Gerüstlose konstrukte für die erzeugung von gelenkknorpel aus gewebe
US8512730B2 (en) 2004-07-12 2013-08-20 Isto Technologies, Inc. Methods of tissue repair and compositions therefor
CA2570521C (en) 2004-07-12 2013-06-25 Isto Technologies, Inc. Tissue matrix system
US20070213660A1 (en) 2004-10-29 2007-09-13 Mark Richards Fibrin sealant delivery device including pressure monitoring, and method and kits thereof
US20090181892A1 (en) 2004-07-16 2009-07-16 Spinal Restoration, Inc. Methods and kits for treating joints and soft tissues
US8419722B2 (en) 2004-10-29 2013-04-16 Spinal Restoration, Inc. Apparatus and method for injection of fibrin sealant in spinal applications
US20090181092A1 (en) 2004-07-16 2009-07-16 Spinal Restoration, Inc. Methods for Treating Joints and Discs with a Carrier Matrix and Cells
US20090181093A1 (en) 2004-07-16 2009-07-16 Spinal Restoration, Inc. Methods for treating soft tissue damage associated with a surgical procedure
US8357147B2 (en) 2005-08-17 2013-01-22 Spinal Restoration, Inc. Method for repairing intervertebral discs
US7335508B2 (en) 2004-07-22 2008-02-26 Prochon Biotech Ltd. Porous plasma protein matrices and methods for preparation thereof
GB0421298D0 (en) 2004-09-24 2004-10-27 Univ Bristol Cellular bandage
US8017394B2 (en) 2004-10-01 2011-09-13 Isto Technologies, Inc. Method for chondrocyte expansion with phenotype retention
US7273756B2 (en) 2004-10-01 2007-09-25 Isto Technologies, Inc. Method for chondrocyte expansion with phenotype retention
US20090319045A1 (en) 2004-10-12 2009-12-24 Truncale Katherine G Cancellous constructs, cartilage particles and combinations of cancellous constructs and cartilage particles
US7837740B2 (en) 2007-01-24 2010-11-23 Musculoskeletal Transplant Foundation Two piece cancellous construct for cartilage repair
US20060078872A1 (en) 2004-10-12 2006-04-13 Atsushi Taguchi Cell-preservation liquid
JP4783373B2 (ja) 2004-10-18 2011-09-28 タイコ ヘルスケア グループ エルピー 組織穿通針を使用して創傷治療物質を適用するための装置
WO2006050213A2 (en) 2004-10-29 2006-05-11 Michalow Alexander E Methods of promoting healing of cartilage defects and method of causing stem cells to differentiate by the articular chondrocyte pathway
US9981063B2 (en) 2004-11-24 2018-05-29 Mayo Foundation For Medical Education And Research Biosynthetic composite for osteochondral defect repair
WO2006061824A2 (en) 2004-12-06 2006-06-15 Prochon Biotech Limited Chondrocyte-based implant for the delivery of therapeutic agents
WO2006101548A2 (en) 2004-12-21 2006-09-28 Ethicon, Inc. Postpartum cells derived from umbilical cord tissue, and methods of making, culturing, and using the same
US20060153815A1 (en) 2004-12-21 2006-07-13 Agnieszka Seyda Tissue engineering devices for the repair and regeneration of tissue
WO2006075602A1 (ja) 2005-01-14 2006-07-20 Arblast Co., Ltd. 羊膜を用いたシート状組成物及びその作製方法
EP1850661A2 (de) * 2005-02-22 2007-11-07 Interface Multigrad Technology (IMT) Ltd. Konservierter lebensfähiger knorpel, verfahren zu seiner konservierung, sowie hierfür verwendete(s) system und geräte
JP2006230749A (ja) 2005-02-25 2006-09-07 Kaneka Corp 軟骨組織に補綴材を固定するための材料
WO2006113642A1 (en) 2005-04-18 2006-10-26 Duke University Three-dimensional fiber scaffolds for tissue engineering
US20060251631A1 (en) 2005-05-05 2006-11-09 Isto Technologies, Inc. Treatment of joint disease, methods and apparatuses therefor
US20060264966A1 (en) 2005-05-12 2006-11-23 Med Institute, Inc. Vertebroplasty leak prevention sleeve and method
US20070038299A1 (en) 2005-08-12 2007-02-15 Arthrotek, Inc Multilayer microperforated implant
AU2006282754A1 (en) 2005-08-26 2007-03-01 Zimmer, Inc. Implants and methods for repair, replacement and treatment of joint disease
WO2007028169A2 (en) 2005-09-02 2007-03-08 Interface Biotech A/S A method for cell implantation
US8158141B2 (en) 2005-11-09 2012-04-17 Paul Hong-Dze Chen Cell transplant device for treatment of corneal wound
WO2007054939A2 (en) 2005-11-10 2007-05-18 Carticure Ltd. New Generation Technology Technical Incubator Method for non-autologous cartilage regeneration
ES2528272T3 (es) 2005-12-07 2015-02-06 Isto Technologies Inc. Métodos de reparación de cartílago
EP2492285A1 (de) 2006-03-07 2012-08-29 ProChon Biotech Ltd. Hydrazidderivate von Hyaluronsäure
AU2007234365A1 (en) 2006-04-05 2007-10-11 William Marsh Rice University A shape-based approach for scaffoldless tissue engineering
US20070250164A1 (en) 2006-04-21 2007-10-25 Biomet Manufacturing Corp. Method for grafting whole superficial articular cartilage
US20070299517A1 (en) 2006-06-21 2007-12-27 Howmedica Osteonics Corp. Articular cartilage implant
US20080033333A1 (en) 2006-08-04 2008-02-07 Macphee Martin Solid dressing for treating wounded tissue
WO2008021127A2 (en) 2006-08-08 2008-02-21 Howmedica Osteonics Corp. Expandable cartilage implant
US8449622B2 (en) 2006-09-11 2013-05-28 Warsaw Orthopedic, Inc. Multi-phase osteochondral implantable device
US8163549B2 (en) 2006-12-20 2012-04-24 Zimmer Orthobiologics, Inc. Method of obtaining viable small tissue particles and use for tissue repair
US7720533B2 (en) 2006-12-20 2010-05-18 Zimmer Orthobiologicals, Inc. Apparatus and method for delivering a biocompatible material to a surgical site
US20080154233A1 (en) 2006-12-20 2008-06-26 Zimmer Orthobiologics, Inc. Apparatus for delivering a biocompatible material to a surgical site and method of using same
US20100136082A1 (en) 2006-12-22 2010-06-03 Laboratoire Medidom S.A. In situ system for intra-articular chondral and osseous tissue repair
EP2106263B1 (de) 2007-01-04 2016-12-21 Hepacore Ltd. Wasserlösliche und reaktive derivate von carboxy-polysacchariden und fibrinogen-konjugate daraus
US8435551B2 (en) 2007-03-06 2013-05-07 Musculoskeletal Transplant Foundation Cancellous construct with support ring for repair of osteochondral defects
AU2008240191B2 (en) 2007-04-12 2013-09-19 Zimmer, Inc. Compositions and methods for tissue repair
CA2708147A1 (en) 2007-12-05 2009-06-18 Musculoskeletal Transplant Foundation Cancellous bone implant for cartilage repair
US20100168856A1 (en) 2008-12-31 2010-07-01 Howmedica Osteonics Corp. Multiple piece tissue void filler
US20100274362A1 (en) 2009-01-15 2010-10-28 Avner Yayon Cartilage particle tissue mixtures optionally combined with a cancellous construct

Also Published As

Publication number Publication date
ES2370668T3 (es) 2011-12-21
US20130330415A1 (en) 2013-12-12
WO2008079194A1 (en) 2008-07-03
AU2007338887A1 (en) 2008-07-03
JP2010512946A (ja) 2010-04-30
CA2673046A1 (en) 2008-07-03
EP2101681A1 (de) 2009-09-23
US20080153157A1 (en) 2008-06-26
US20120183586A1 (en) 2012-07-19
US8497121B2 (en) 2013-07-30
EP2101681B1 (de) 2011-08-03
US8163549B2 (en) 2012-04-24

Similar Documents

Publication Publication Date Title
ATE518496T1 (de) Verfahren zur gewinnung von lebensfähigen kleinen gewebeteilchen und ihre verwendung für die gewebereparatur
ATE522233T1 (de) Vorbereitung von gewebe für die meniskus- implantation
ATE538816T1 (de) Verfahren zur herstellung eines bioaktiven implantats
ATE510005T1 (de) Verfahren zur isolierung von zellen aus der nabelschnur
MX354253B (es) Composiciones de colageno placentario (telopeptido), natural.
DE602007003331D1 (de) Verfahren zur bestimmung der kopienummer
EP2134297A4 (de) Zusammensetzungen und verfahren zur gewebereparatur
EP2061527B8 (de) Reparatur von knorpelgewebe
DE60232234D1 (de) Verfahren zur kultivierung von circovirus
ATE453634T1 (de) Regioselektives verfahren zur zubereitung von benzimidazol-thiophenen
EP4406915A4 (de) Verfahren zur herstellung von kohlenstoffbeschichtetem natriumeisenfluorphosphat aus lithiumeisenphosphatabfall und verwendung davon
ATE542803T1 (de) Verfahren zur herstellung von dihydrochinazolinen
DE602006016735D1 (de) Verfahren zur proliferation von stammzellen
EP2350013A4 (de) Zusammensetzungen zur markierung und identifizierung von autophagosomen sowie verfahren zu ihrer herstellung und verwendung
BRPI0912164A2 (pt) processo para a degradação de lignina.
EP2014783A4 (de) Verfahren zur herstellung von feuerverzinktem stahlblech und feuerverzinktes stahlblech
WO2008133536A3 (en) New stem cell lines, their application and culture methods
ATE544462T1 (de) Verwendung des epidermalen wachstumsfaktors zur morphofunktionellen wiederherstellung von peripheren nerven bei diabetischer neuropathie
ATE495286T1 (de) Verfahren zur hydrolyse von polyphosphorsäure in polyareneazolfasern
DE602005007476D1 (de) Verfahren zur reinigung von oozysten mittels enzymatischer verdauung von faeces
DE602005026690D1 (de) Gerüstlose konstrukte für die erzeugung von gelenkknorpel aus gewebe
ATE480265T1 (de) Verwendung von zahnfleischfibroblasten zur behandlung von vaskulären zellen
EP2421467A4 (de) Verfahren zur herstellung und verwendung von dreidimensionalen extrazellulären matrizen
TW200738752A (en) Modulation of MDL-1 activity for treatment of inflammatory disease
EP1730199A4 (de) Zusammensetzung auf basis von nativen zellwänden und verfahren zur verwendung

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties