ATE518967T1 - Verfahren zur verhinderung einer virus-zelle- fusion durch hemmen der funktion des fusionsinitiierungsbereichs in rna-viren mit klasse-i-membranfusogenen hüllproteinen - Google Patents

Verfahren zur verhinderung einer virus-zelle- fusion durch hemmen der funktion des fusionsinitiierungsbereichs in rna-viren mit klasse-i-membranfusogenen hüllproteinen

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Publication number
ATE518967T1
ATE518967T1 AT04810256T AT04810256T ATE518967T1 AT E518967 T1 ATE518967 T1 AT E518967T1 AT 04810256 T AT04810256 T AT 04810256T AT 04810256 T AT04810256 T AT 04810256T AT E518967 T1 ATE518967 T1 AT E518967T1
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AT
Austria
Prior art keywords
fusion
present
viruses
class
membrane
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Application number
AT04810256T
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English (en)
Inventor
Robert Garry
Russell B Wilson
Original Assignee
Univ Tulane
Autoimmune Technologies Llc
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Publication of ATE518967T1 publication Critical patent/ATE518967T1/de

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/162—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/18—Testing for antimicrobial activity of a material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983—Viruses
    • G01N33/56988—HIV or HTLV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/10011—Arenaviridae
    • C12N2760/10022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/14011—Filoviridae
    • C12N2760/14111—Ebolavirus, e.g. Zaire ebolavirus
    • C12N2760/14122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18411—Morbillivirus, e.g. Measles virus, canine distemper
    • C12N2760/18422—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18411—Morbillivirus, e.g. Measles virus, canine distemper
    • C12N2760/18433—Use of viral protein as therapeutic agent other than vaccine, e.g. apoptosis inducing or anti-inflammatory
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/20011—Coronaviridae
    • C12N2770/20022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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  • Gastroenterology & Hepatology (AREA)
  • Wood Science & Technology (AREA)
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  • Veterinary Medicine (AREA)
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  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Analytical Chemistry (AREA)
  • Urology & Nephrology (AREA)
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  • Toxicology (AREA)
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  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
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AT04810256T 2003-11-04 2004-11-03 Verfahren zur verhinderung einer virus-zelle- fusion durch hemmen der funktion des fusionsinitiierungsbereichs in rna-viren mit klasse-i-membranfusogenen hüllproteinen ATE518967T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US51718103P 2003-11-04 2003-11-04
PCT/US2004/036578 WO2005044992A2 (en) 2003-11-04 2004-11-03 Fusion initiation region in rna virus envelope proteins

Publications (1)

Publication Number Publication Date
ATE518967T1 true ATE518967T1 (de) 2011-08-15

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AT04810256T ATE518967T1 (de) 2003-11-04 2004-11-03 Verfahren zur verhinderung einer virus-zelle- fusion durch hemmen der funktion des fusionsinitiierungsbereichs in rna-viren mit klasse-i-membranfusogenen hüllproteinen

Country Status (12)

Country Link
US (5) US7491793B2 (de)
EP (7) EP2261380B1 (de)
JP (1) JP5008398B2 (de)
AT (1) ATE518967T1 (de)
AU (2) AU2004288218B2 (de)
BR (1) BRPI0416187A (de)
CA (1) CA2544848C (de)
DK (7) DK2261380T3 (de)
ES (7) ES2437858T3 (de)
PL (4) PL1692265T3 (de)
PT (4) PT1692265E (de)
WO (1) WO2005044992A2 (de)

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EP2261380A3 (de) 2011-02-23
EP2261375B1 (de) 2013-01-23
PL2261376T3 (pl) 2014-04-30
US20090264362A1 (en) 2009-10-22
PL2261378T3 (pl) 2014-03-31
EP2261375A2 (de) 2010-12-15
US20120289458A1 (en) 2012-11-15
ES2372633T3 (es) 2012-01-25
AU2004288218A1 (en) 2005-05-19
DK2261378T3 (da) 2014-01-20
WO2005044992A3 (en) 2006-12-07
HK1152086A1 (en) 2012-02-17
EP2261378B1 (de) 2013-10-09
PT2261376E (pt) 2013-09-23
DK2261375T3 (da) 2013-04-22
PT2261377E (pt) 2013-11-29
EP2261377B1 (de) 2013-10-02
EP1692265A4 (de) 2007-08-29
JP2007514408A (ja) 2007-06-07
BRPI0416187A (pt) 2007-01-23
EP2261377A3 (de) 2011-05-18
EP2261378A2 (de) 2010-12-15
US7491793B2 (en) 2009-02-17
PT2261378E (pt) 2013-12-09
WO2005044992A2 (en) 2005-05-19
DK2261374T3 (da) 2012-09-10
DK2261376T3 (da) 2013-10-07
AU2010201046B2 (en) 2013-06-27
CA2544848A1 (en) 2005-05-19
EP2261374B1 (de) 2012-06-06
PL1692265T3 (pl) 2011-12-30
DK2261377T3 (da) 2014-01-06
EP2261376A3 (de) 2011-02-23
US9056900B2 (en) 2015-06-16
US20140045743A1 (en) 2014-02-13
EP2261375A3 (de) 2011-06-22
DK2261380T3 (da) 2013-10-07
EP2261374A3 (de) 2011-03-02
EP2261378A3 (de) 2011-06-15
EP2261380B1 (de) 2013-07-17
HK1152084A1 (en) 2012-02-17
EP2261376B1 (de) 2013-07-10
EP1692265A2 (de) 2006-08-23
US20150239940A1 (en) 2015-08-27
ES2427847T3 (es) 2013-11-04
ES2435941T3 (es) 2013-12-26
EP1692265B1 (de) 2011-08-03
EP2261374A2 (de) 2010-12-15
US9725487B2 (en) 2017-08-08
AU2010201046A1 (en) 2010-04-08
US20060280754A1 (en) 2006-12-14
AU2004288218B2 (en) 2009-12-24
ES2437858T3 (es) 2014-01-14
ES2400456T3 (es) 2013-04-10
DK1692265T3 (da) 2011-11-21
ES2392891T3 (es) 2012-12-14
EP2261377A2 (de) 2010-12-15
HK1152082A1 (en) 2012-02-17
US8598116B2 (en) 2013-12-03
PL2261377T3 (pl) 2014-03-31
ES2425600T3 (es) 2013-10-16
HK1152083A1 (en) 2012-02-17
CA2544848C (en) 2015-12-29
HK1152085A1 (en) 2012-02-17
EP2261376A2 (de) 2010-12-15
EP2261380A2 (de) 2010-12-15
PT1692265E (pt) 2011-10-11
HK1152081A1 (en) 2012-02-17
JP5008398B2 (ja) 2012-08-22

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