ATE519738T1 - Pyrrolidinarylether als nk3-rezeptorantagonisten - Google Patents
Pyrrolidinarylether als nk3-rezeptorantagonistenInfo
- Publication number
- ATE519738T1 ATE519738T1 AT08787130T AT08787130T ATE519738T1 AT E519738 T1 ATE519738 T1 AT E519738T1 AT 08787130 T AT08787130 T AT 08787130T AT 08787130 T AT08787130 T AT 08787130T AT E519738 T1 ATE519738 T1 AT E519738T1
- Authority
- AT
- Austria
- Prior art keywords
- pyrrolidinaryl
- ether
- receptor antagonists
- antagonists
- receptor
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Rheumatology (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07114790 | 2007-08-22 | ||
| PCT/EP2008/060566 WO2009024502A1 (en) | 2007-08-22 | 2008-08-12 | Pyrrolidine aryl-ether as nk3 receptor antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE519738T1 true ATE519738T1 (de) | 2011-08-15 |
Family
ID=39870345
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT08787130T ATE519738T1 (de) | 2007-08-22 | 2008-08-12 | Pyrrolidinarylether als nk3-rezeptorantagonisten |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US7812021B2 (de) |
| EP (1) | EP2190815B1 (de) |
| JP (1) | JP2010536818A (de) |
| KR (1) | KR101194467B1 (de) |
| CN (1) | CN101861302A (de) |
| AR (1) | AR067991A1 (de) |
| AT (1) | ATE519738T1 (de) |
| AU (1) | AU2008290634B2 (de) |
| BR (1) | BRPI0815674A2 (de) |
| CA (1) | CA2697325A1 (de) |
| CL (1) | CL2008002450A1 (de) |
| ES (1) | ES2369955T3 (de) |
| MX (1) | MX2010001774A (de) |
| PE (1) | PE20090621A1 (de) |
| RU (1) | RU2010108687A (de) |
| TW (1) | TW200916462A (de) |
| WO (1) | WO2009024502A1 (de) |
| ZA (1) | ZA201001125B (de) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8063075B2 (en) * | 2008-06-10 | 2011-11-22 | Hoffmann-La Roche Inc. | Pyrrolidine ether derivatives as NK3 receptor antagonists |
| EP2331500A1 (de) * | 2008-10-09 | 2011-06-15 | F. Hoffmann-La Roche AG | Pyrrolidin-n-benzylderivate |
| CA2747961C (en) | 2009-01-30 | 2016-11-08 | F. Hoffmann-La Roche Ag | Piperidine derivatives as nk3 receptor antagonists |
| US8318759B2 (en) * | 2009-02-18 | 2012-11-27 | Hoffmann-La Roche Inc. | Pyrrolidine derivatives as NK3 receptor antagonists |
| SA110310332B1 (ar) | 2009-05-01 | 2013-12-10 | Astrazeneca Ab | مركبات ميثانون (3 استبدال -ازيتيدين -1-يل )(5- فينيل -1، 3، 4- أوكساديازول -2-يل ) |
| US8394834B2 (en) | 2009-08-25 | 2013-03-12 | Hoffman-La Roche Inc. | Pyrrolidines as NK3 receptor antagonists |
| US20110144081A1 (en) | 2009-12-15 | 2011-06-16 | Henner Knust | Pyrrolidine derivatives |
| US20110152233A1 (en) * | 2009-12-18 | 2011-06-23 | Henner Knust | Pyrrolidine compounds |
| SA111320581B1 (ar) | 2010-07-06 | 2014-06-17 | استرازينيكا ايه بي | مركبات (3-(4-(أمينو ميثيل ) فينوكسي أو فينيل ثيو) أزيتيدين -1- يل) (5- فينيل -1، 3، 4- أوكسا ديازول -2- يل) ميثانون |
| US8507535B2 (en) * | 2010-07-07 | 2013-08-13 | Hoffmann-La Roche Inc. | Methyl-pyrrolidine ether derivatives |
| US8618303B2 (en) * | 2011-01-07 | 2013-12-31 | Hoffmann-La Roche Inc. | Pyrrolidine derivatives |
| UY34194A (es) | 2011-07-15 | 2013-02-28 | Astrazeneca Ab | ?(3-(4-(espiroheterocíclico)metil)fenoxi)azetidin-1-il)(5-(fenil)-1,3,4-oxadiazol-2-il)metanona en el tratamiento de la obesidad? |
| BR112019016827A2 (pt) | 2017-02-17 | 2020-04-07 | Trevena Inc | compostos moduladores de receptor delta-opioide contendo aza-heterocíclico com 5 membros, métodos de uso e produção dos mesmos |
| US11225487B2 (en) | 2017-02-17 | 2022-01-18 | Trevena, Inc. | 7-membered aza-heterocyclic containing δ-opioid receptor modulating compounds, methods of using and making the same |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IN148482B (de) | 1977-06-03 | 1981-03-07 | Pfizer | |
| GB9321557D0 (en) | 1992-11-03 | 1993-12-08 | Zeneca Ltd | Carboxamide derivatives |
| EP0714891A1 (de) * | 1994-11-22 | 1996-06-05 | Eli Lilly And Company | Heterozyklische Tachykinin-Rezeptorantagonisten |
| IL130223A (en) | 1996-12-19 | 2005-09-25 | Aventis Pharma Inc | Heterocyclic substituted pyrrolidine amide derivatives, process for their preparation and pharmaceutical compositions containing them |
| US7468437B2 (en) * | 2003-09-30 | 2008-12-23 | Merck & Co., Inc. | Phenyl pyrrolidine ether tachykinin receptor antagonists |
| US7138423B2 (en) * | 2004-07-20 | 2006-11-21 | Bristol-Myers Squibb Company | Arylpyrrolidine derivatives as NK-1 /SSRI antagonists |
| WO2006073589A2 (en) * | 2004-11-22 | 2006-07-13 | Merck & Co., Inc. | Cycloalkyl keto piperidine tachykinin receptor antagonists |
| AU2005309826A1 (en) * | 2004-11-22 | 2006-06-01 | Merck & Co., Inc. | Piperidinyl piperidine tachykinin receptor antagonists |
| BRPI0815658A2 (pt) * | 2007-08-07 | 2015-02-18 | Hoffmann La Roche | Aril-éter pirrolidina como antagonistas do receptor nk3 |
-
2008
- 2008-08-12 CN CN200880103704A patent/CN101861302A/zh active Pending
- 2008-08-12 EP EP08787130A patent/EP2190815B1/de not_active Not-in-force
- 2008-08-12 JP JP2010521396A patent/JP2010536818A/ja active Pending
- 2008-08-12 AT AT08787130T patent/ATE519738T1/de active
- 2008-08-12 CA CA2697325A patent/CA2697325A1/en not_active Abandoned
- 2008-08-12 MX MX2010001774A patent/MX2010001774A/es active IP Right Grant
- 2008-08-12 RU RU2010108687/04A patent/RU2010108687A/ru not_active Application Discontinuation
- 2008-08-12 KR KR1020107006058A patent/KR101194467B1/ko not_active Expired - Fee Related
- 2008-08-12 BR BRPI0815674-3A2A patent/BRPI0815674A2/pt not_active IP Right Cessation
- 2008-08-12 WO PCT/EP2008/060566 patent/WO2009024502A1/en not_active Ceased
- 2008-08-12 AU AU2008290634A patent/AU2008290634B2/en not_active Expired - Fee Related
- 2008-08-12 ES ES08787130T patent/ES2369955T3/es active Active
- 2008-08-20 CL CL2008002450A patent/CL2008002450A1/es unknown
- 2008-08-21 TW TW097131984A patent/TW200916462A/zh unknown
- 2008-08-21 AR ARP080103635A patent/AR067991A1/es unknown
- 2008-08-21 US US12/195,545 patent/US7812021B2/en not_active Expired - Fee Related
- 2008-08-21 PE PE2008001420A patent/PE20090621A1/es not_active Application Discontinuation
-
2010
- 2010-02-16 ZA ZA201001125A patent/ZA201001125B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AR067991A1 (es) | 2009-10-28 |
| WO2009024502A1 (en) | 2009-02-26 |
| ZA201001125B (en) | 2010-10-27 |
| EP2190815B1 (de) | 2011-08-10 |
| ES2369955T3 (es) | 2011-12-09 |
| AU2008290634A1 (en) | 2009-02-26 |
| BRPI0815674A2 (pt) | 2015-02-18 |
| CL2008002450A1 (es) | 2009-07-31 |
| US20090054644A1 (en) | 2009-02-26 |
| CN101861302A (zh) | 2010-10-13 |
| PE20090621A1 (es) | 2009-05-16 |
| KR20100043105A (ko) | 2010-04-27 |
| CA2697325A1 (en) | 2009-02-26 |
| US7812021B2 (en) | 2010-10-12 |
| AU2008290634B2 (en) | 2012-12-06 |
| KR101194467B1 (ko) | 2012-10-24 |
| MX2010001774A (es) | 2010-03-10 |
| RU2010108687A (ru) | 2011-09-27 |
| EP2190815A1 (de) | 2010-06-02 |
| JP2010536818A (ja) | 2010-12-02 |
| TW200916462A (en) | 2009-04-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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