BRPI0910592A2 - antagonistas de receptor 2 de somatostatina - Google Patents

antagonistas de receptor 2 de somatostatina

Info

Publication number: BRPI0910592A2
Authority: BR; Brazil
Prior art keywords: antagonists; somatostatin receptor; somatostatin; receptor
Prior art date: 2008-04-16

Application number

BRPI0910592A

Other languages

English (en)

Inventor

Helmut R Maecke

Jean Claude Reubi

Jean E F Rivier

Judit Erchegyi

Original Assignee

Salk Inst For Biological Studi

Universität Bern

Univ Hospital Basel

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-04-16

Filing date

2009-04-15

Publication date

2015-09-22

2009-04-15 Application filed by Salk Inst For Biological Studi, Universität Bern, Univ Hospital Basel filed Critical Salk Inst For Biological Studi

2015-09-22 Publication of BRPI0910592A2 publication Critical patent/BRPI0910592A2/pt

2021-10-19 Publication of BRPI0910592B1 publication Critical patent/BRPI0910592B1/pt

Links

229940122879 Somatostatin receptor 2 antagonist Drugs 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/655—Somatostatins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/575—Hormones
- G01N2333/655—Somatostatins

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Endocrinology (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Diabetes (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Biophysics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Bioinformatics & Cheminformatics (AREA)
Molecular Biology (AREA)
Toxicology (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Biochemistry (AREA)
Genetics & Genomics (AREA)
Emergency Medicine (AREA)
Hematology (AREA)
Obesity (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Investigating Or Analysing Biological Materials (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

BRPI0910592-1A 2008-04-16 2009-04-15 Antagonista de receptor 2 de somatostatina (sstr2), uso de uma composição compreendendo o mesmo, kit e composto para radioimageamento diagnóstico e para tratamento de câncer BRPI0910592B1 (pt)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US12/104,318 US8691761B2 (en)	2006-10-16	2008-04-16	Somatostatin receptor 2 antagonists
US12/104,318		2008-04-16
PCT/US2009/040672 WO2009129311A2 (en)	2008-04-16	2009-04-15	Somatostatin receptor 2 antagonists

Publications (2)

Publication Number	Publication Date
BRPI0910592A2 true BRPI0910592A2 (pt)	2015-09-22
BRPI0910592B1 BRPI0910592B1 (pt)	2021-10-19

Family

ID=41100782

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0910592-1A BRPI0910592B1 (pt)	2008-04-16	2009-04-15	Antagonista de receptor 2 de somatostatina (sstr2), uso de uma composição compreendendo o mesmo, kit e composto para radioimageamento diagnóstico e para tratamento de câncer

Country Status (10)

Country	Link
US (1)	US8691761B2 (pt)
EP (2)	EP2801582B1 (pt)
JP (2)	JP2011520787A (pt)
CN (1)	CN102089321B (pt)
AU (1)	AU2009236211B2 (pt)
BR (1)	BRPI0910592B1 (pt)
CA (1)	CA2721470C (pt)
ES (1)	ES2646192T3 (pt)
RU (1)	RU2010146497A (pt)
WO (1)	WO2009129311A2 (pt)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US8889632B2 (en)	2007-01-31	2014-11-18	Dana-Farber Cancer Institute, Inc.	Stabilized p53 peptides and uses thereof
EP2508531B1 (en)	2007-03-28	2016-10-19	President and Fellows of Harvard College	Stitched polypeptides
SI2603600T1 (sl)	2010-08-13	2019-04-30	Aileron Therapeutics, Inc.	Peptidomimetični makrocikli
GB201117428D0 (en) *	2011-10-07	2011-11-23	Bicycle Therapeutics Ltd	Structured polypeptides with sarcosine linkers
TW201806968A (zh)	2011-10-18	2018-03-01	艾利倫治療公司	擬肽巨環化合物
HK1205454A1 (en)	2012-02-15	2015-12-18	Aileron Therapeutics, Inc.	Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles
KR102112373B1 (ko)	2012-02-15	2020-05-18	에일러론 테라퓨틱스 인코포레이티드	펩티드모방체 마크로사이클
WO2014071241A1 (en)	2012-11-01	2014-05-08	Aileron Therapeutics, Inc.	Disubstituted amino acids and methods of preparation and use thereof
RU2528414C1 (ru)	2013-01-25	2014-09-20	Закрытое Акционерное Общество "Фарм-Синтез"	Циклический октапептид, радиофармацевтическое средство на его основе и способ применения радиофармацевтического средства для получения лекарственных (фармацевтических) средств для лечения новообразований, экспрессирующих соматостатиновые рецепторы
US10150804B2 (en)	2014-01-03	2018-12-11	British Columbia Cancer Agency Branch	Compositions and methods for imaging cancer
BR112017005598A2 (pt)	2014-09-24	2017-12-12	Aileron Therapeutics Inc	macrociclos peptidomiméticos e usos dos mesmos
WO2016154058A1 (en)	2015-03-20	2016-09-29	Aileron Therapeutics, Inc.	Peptidomimetic macrocycles and uses thereof
AU2017217271C1 (en) *	2016-02-09	2021-08-05	Cdrd Ventures Inc.	Somatostatin receptor antagonist compounds and methods of using the same
RU2019102008A (ru) *	2016-06-28	2020-07-28	Ксенкор, Инк.	Гетеродимерные антитела, которые связывают рецептор соматостатина 2-го типа
US10849955B2 (en)	2016-09-28	2020-12-01	City Of Hope	Methods of treating pancreatic cancer using GPCR antagonists
AU2018261888B2 (en) *	2017-05-05	2022-06-30	Centre For Probe Development And Commercialization	Pharmacokinetic enhancements of bifunctional chelates and uses thereof
WO2018204872A2 (en)	2017-05-05	2018-11-08	Fusion Pharmaceuticals Inc.	Igf-1r monoclonal antibodies and uses thereof
CA3100868A1 (en)	2018-05-23	2019-11-28	Provincial Health Services Authority	Radiolabeled melanocortin 1 receptor-specific alpha-melanocyte-stimulating hormone analogues for imaging or therapy
TW202547563A (zh) *	2018-06-21	2025-12-16	德商愛利穆治療有限公司	用於放射性醫藥之含有體抑素類似物之組成物
TW202015744A (zh) *	2018-06-21	2020-05-01	法商艾普森藥品公司	用於放射性醫藥之含有體抑素類似物之組成物
CA3118223A1 (en)	2018-12-18	2020-06-25	Provincial Health Services Authority	Dual mode 18f-labelled theranostic compounds and uses thereof
US11396535B2 (en)	2019-03-01	2022-07-26	Provincial Health Services Authority	Cyclic peptide analogs of melanocortin and amanitin and methods of making such
CA3136979A1 (en)	2019-04-17	2020-10-22	Provincial Health Services Authority	Radiolabelled compounds for diagnosis or treatment of prostate-spe cific membrane antigen-expressing cancer
WO2020252598A1 (en)	2019-06-21	2020-12-24	Provincial Health Services Authority	Radiolabeled compounds targeting the prostate-specific membrane antigen
WO2022082312A1 (en)	2020-10-21	2022-04-28	Provincial Health Services Authority	Novel cxcr4-targeting compounds
DE102021111452B3 (de)	2021-05-04	2022-07-28	Positron Precision GmbH	Markierungsvorläufer und Radiotracer für neuroendokrine Theranostik
WO2023051941A1 (en) *	2021-09-30	2023-04-06	Universität Basel	[161Tb]-BASED RADIOPEPTIDES
JP2025528439A (ja) *	2022-08-30	2025-08-28	グラフトンセラピューティクスエスアエールエル	複数のソマトスタチン受容体サブタイプ選択性を有するハロゲン化ソマトスタチン類似体
IL319722A (en)	2022-09-23	2025-05-01	Nuclidium Ag	High purity radionuclides and their diagnostic and medical uses
TW202426433A (zh)	2022-09-23	2024-07-01	瑞士商紐利迪姆股份公司	成纖維細胞活化蛋白（ｆａｐ）抑制劑、ｆａｐ結合物及其診斷與治療用途
CN119708199A (zh) *	2023-09-27	2025-03-28	钱杭江医药科技(嘉兴)有限公司	生长抑素肽类类似物、螯合物及其应用

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3773919A (en)	1969-10-23	1973-11-20	Du Pont	Polylactide-drug mixtures
US3904594A (en)	1973-07-02	1975-09-09	Salk Inst For Biological Studi	Somatostatin and acylated des-(ala' 1', gly' 2') derivatives thereof
US4372884A (en)	1975-08-06	1983-02-08	The Salk Institute For Biological Studies	Pharmaceutically active peptides
US4428942A (en)	1982-05-17	1984-01-31	The Salk Institute For Biological Studies	Analogs of somatostatin
US4725577A (en)	1985-04-25	1988-02-16	Administrators Of The Tulane Educational Fund	Biologically active lysine containing octapeptides
US5776894A (en) *	1988-12-05	1998-07-07	Novartis Ag	Chelated somatostatin peptides and complexes thereof, pharmaceutical compositions containing them and their use in treating tumors
US7238340B1 (en) *	1991-11-27	2007-07-03	Cis Bio International	Monoamine, diamide, thiol-containing metal chelating agents
US5590656A (en)	1992-09-15	1997-01-07	The Ohio State University Research Foundation	Application of peptide/cell receptor kinetics utilizing radiolabeled somatostatin congeners in the in situ, in vivo detection and differentiation of neoplastic tissue
US5879657A (en)	1993-03-30	1999-03-09	The Dupont Merck Pharmaceutical Company	Radiolabeled platelet GPIIb/IIIa receptor antagonists as imaging agents for the diagnosis of thromboembolic disorders
EP0752873A4 (en)	1994-02-18	2002-05-15	Mallinckrodt Inc	MARKED PEPTIDE COMPOUNDS
US5663292A (en)	1994-12-12	1997-09-02	The Salk Institute For Biological Studies	Cyclic CRF analogs
US5688489A (en)	1995-09-15	1997-11-18	Resolution Pharmaceuticals, Inc.	Non-receptor mediated imaging agents
US5708135A (en)	1995-09-29	1998-01-13	Biomeasure Incorporated	Cyclic peptide analogs of somatostatin
US5846934A (en) *	1996-02-20	1998-12-08	American Cyanamid Company	Pure somatostatin antagonist and methods of use thereof
PL334089A1 (en)	1996-12-04	2000-01-31	Sod Conseils Rech Applic	Compounds antagonistic in respect to somatostatin
US6262229B1 (en)	1996-12-04	2001-07-17	Biomeasure Incorporated	Somatostatin antagonists
US5925618A (en)	1997-03-06	1999-07-20	American Cyanamid Company	Peptides useful as somatostatin antagonists
CA2246791A1 (en)	1998-09-01	2000-03-01	Alison Buchan	Treatment of endothelium with somatostatin analogues
CN1124281C (zh) *	1999-02-13	2003-10-15	中国人民解放军军事医学科学院基础医学研究所	生长抑素多肽类似物及其应用
US6579967B1 (en)	1999-12-14	2003-06-17	The Salk Institute For Biological Studies	Receptor-selective somatostatin analogs
ATE374786T1 (de)	2000-10-20	2007-10-15	Univ Tulane	Agonisten und antagonisten von urotensin-ii
DK1372688T3 (da)	2001-03-08	2008-08-25	Univ Tulane	Somatostatin-antagonister
US7019109B2 (en)	2001-03-16	2006-03-28	The Salk Institute For Bilogical Studies	SSTR1-selective analogs
EP1283216A1 (en)	2001-08-10	2003-02-12	Mallinckrodt Inc.	Somatostatin analogues binding to all somatostatin receptor subtypes and their use
BR0212897A (pt)	2001-09-21	2004-08-24	Univ Tulane	Conjugados de análogos de somatostatina ou bombesina diagnóstica ou terapêutica e usos dos mesmos
AU2003259172A1 (en)	2002-07-24	2004-02-09	The Salk Institute For Biological Studies	Receptor (sstr4)- selective somatostatin analogs
DK1603598T3 (da)	2003-03-19	2009-01-26	Univ Bern	Radiomærkede konjugater baseret på substans P og anvendelser heraf
ES2410207T3 (es)	2006-10-16	2013-07-01	The Salk Institute For Biological Studies	Antagonistas de la somatostatina selectivos para receptor(SSTR2)

2008
- 2008-04-16 US US12/104,318 patent/US8691761B2/en active Active
2009
- 2009-04-15 CN CN200980122566.9A patent/CN102089321B/zh active Active
- 2009-04-15 BR BRPI0910592-1A patent/BRPI0910592B1/pt active IP Right Grant
- 2009-04-15 EP EP14170052.6A patent/EP2801582B1/en active Active
- 2009-04-15 RU RU2010146497/10A patent/RU2010146497A/ru not_active Application Discontinuation
- 2009-04-15 WO PCT/US2009/040672 patent/WO2009129311A2/en not_active Ceased
- 2009-04-15 CA CA2721470A patent/CA2721470C/en active Active
- 2009-04-15 JP JP2011505166A patent/JP2011520787A/ja active Pending
- 2009-04-15 ES ES14170052.6T patent/ES2646192T3/es active Active
- 2009-04-15 AU AU2009236211A patent/AU2009236211B2/en active Active
- 2009-04-15 EP EP09733164A patent/EP2268667A2/en not_active Withdrawn
2014
- 2014-02-26 JP JP2014035143A patent/JP2014129382A/ja active Pending

Also Published As

Publication number	Publication date
WO2009129311A2 (en)	2009-10-22
RU2010146497A (ru)	2012-05-27
AU2009236211B2 (en)	2013-12-19
EP2268667A2 (en)	2011-01-05
CA2721470C (en)	2017-03-07
BRPI0910592B1 (pt)	2021-10-19
EP2801582B1 (en)	2017-09-06
JP2011520787A (ja)	2011-07-21
US20080299040A1 (en)	2008-12-04
CA2721470A1 (en)	2009-10-22
WO2009129311A3 (en)	2010-07-22
AU2009236211A1 (en)	2009-10-22
CN102089321A (zh)	2011-06-08
ES2646192T3 (es)	2017-12-12
EP2801582A1 (en)	2014-11-12
JP2014129382A (ja)	2014-07-10
US8691761B2 (en)	2014-04-08
CN102089321B (zh)	2017-03-22

Legal Events

Date	Code	Title	Description
2018-04-17	B06F	Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
2018-10-02	B07D	Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]	Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001
2020-05-05	B07E	Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
2020-09-01	B06U	Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
2021-09-08	B09A	Decision: intention to grant [chapter 9.1 patent gazette]
2021-10-19	B16A	Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]	Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 15/04/2009, OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF, QUE DETERMINA A ALTERACAO DO PRAZO DE CONCESSAO.

Publication	Publication Date	Title
FR22C1020I1 (fr)	2022-07-15	Antagonistes de c5ar
BRPI0910118A2 (pt)	2015-12-29	antagonistas de receptores do glucagon
EP1981902A4 (en)	2009-12-23	NOGO RECEPTOR ANTAGONISTS
DK2089382T3 (da)	2013-02-04	Substituerede diazepan-forbindelser som orexin-receptor-antagonister
EP2150115A4 (en)	2011-08-03	CYCLOPROPYLPYRROLIDINOREXIN Receptor Antagonists
BRPI0923512A2 (pt)	2016-01-26	antagonistas de receptores de ácido lisofosfatídico
EP2350060A4 (en)	2012-07-25	Melanocortin receptor AGONISTS
ATE505467T1 (de)	2011-04-15	2-aza-bicycloä3.1.0ühexanderivate als orexin- rezeptorantagonisten
BRPI0921696A2 (pt)	2015-08-18	Antagonistas do receptor do tipo toll 3
DK2094709T3 (da)	2010-12-06	Thiazol-pyrazolopyrimidiner som CRF1-receptorantagonister
BRPI0913930A2 (pt)	2015-10-20	antagonistas de receptores de prostaglandinas d2
DK2081951T3 (da)	2010-08-09	Progesteron-receptorantagonister
DK2009992T3 (da)	2012-08-13	Il-8 receptor-antagonister
BRPI0717937A2 (pt)	2013-12-03	Compostos de pirazona como antagonistas do receptor mineralocorticóide
BR112012003701A2 (pt)	2019-09-24	"novos antagonistas de quinolina-hepcidina"
BRPI0810926A2 (pt)	2014-11-04	Antagonista de crig
BRPI0918004A2 (pt)	2015-11-17	antagonistas de glucagon
EP2170064A4 (en)	2010-08-04	6,5-pyrrolopiperidine tachykinin receptor antagonists
EP2254413A4 (en)	2011-10-26	IMIDAZOBENZAZEPIN-CGRP receptor antagonists
IL209264A0 (en)	2011-01-31	Heteroaromatic monoamides as orexinin receptor antagonists
DK2121630T3 (da)	2012-11-12	Hurtigt dissocierende dopamin-2-receptor-antagonister
BRPI0720078A2 (pt)	2013-12-24	2-aminoquinolinas como antagonistas de receptores de 5-ht(5a)
DK1973886T3 (da)	2013-03-18	Prokineticin-1-receptor-antagonister
BRPI0820633A2 (pt)	2019-09-24	antagonistas de receptores de il-4 muteína modificada
ATE547407T1 (de)	2012-03-15	Alkylthiopyrimidine als crth2-antagonisten