ATE519747T1 - Verfahren zur herstellung von cyclopentaägüchinazolin-derivaten - Google Patents
Verfahren zur herstellung von cyclopentaägüchinazolin-derivatenInfo
- Publication number
- ATE519747T1 ATE519747T1 AT02755271T AT02755271T ATE519747T1 AT E519747 T1 ATE519747 T1 AT E519747T1 AT 02755271 T AT02755271 T AT 02755271T AT 02755271 T AT02755271 T AT 02755271T AT E519747 T1 ATE519747 T1 AT E519747T1
- Authority
- AT
- Austria
- Prior art keywords
- cyclopentaägüquinazoline
- derivatives
- producing
- formula
- aryloxy
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000003277 amino group Chemical group 0.000 abstract 2
- 125000004104 aryloxy group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- BCCZFOXKKDTUTF-UHFFFAOYSA-N 5h-cyclopenta[g]quinazoline Chemical class C1=NC=C2CC3=CC=CC3=CC2=N1 BCCZFOXKKDTUTF-UHFFFAOYSA-N 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
- C07C233/42—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
- C07C233/43—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of a saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C235/16—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
- C07C255/60—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton at least one of the singly-bound nitrogen atoms being acylated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Paints Or Removers (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0121214.1A GB0121214D0 (en) | 2001-08-31 | 2001-08-31 | Synthetic method |
| US34024401P | 2001-12-18 | 2001-12-18 | |
| PCT/GB2002/003967 WO2003020706A1 (en) | 2001-08-31 | 2002-08-30 | PROCESS FOR THE PREPARATION OF CYCLOPENTA[g]QUINAZOLINE DERIVATIVES |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE519747T1 true ATE519747T1 (de) | 2011-08-15 |
Family
ID=9921361
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02755271T ATE519747T1 (de) | 2001-08-31 | 2002-08-30 | Verfahren zur herstellung von cyclopentaägüchinazolin-derivaten |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US7250511B2 (de) |
| EP (2) | EP2213664B1 (de) |
| JP (2) | JP4405798B2 (de) |
| AT (1) | ATE519747T1 (de) |
| CY (1) | CY1112711T1 (de) |
| DK (2) | DK1421069T3 (de) |
| ES (1) | ES2371334T3 (de) |
| GB (1) | GB0121214D0 (de) |
| PT (1) | PT1421069E (de) |
| WO (1) | WO2003020706A1 (de) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4498922B2 (ja) * | 2002-07-09 | 2010-07-07 | アクテリオン ファーマシューティカルズ リミテッド | ７，８，９，１０−テトラヒドロ−６Ｈ−アゼピノ、６，７，８，９−テトラヒドロ−ピリドおよび２，３−ジヒドロ−２Ｈ−ピロロ［２，１−ｂ］−キナゾリノン誘導体 |
| US7799832B2 (en) | 2003-10-23 | 2010-09-21 | Valeant Pharmaceuticals North America | Combinations of retigabine and sodium channel inhibitors or sodium channel-influencing active compounds for treating pains |
| US7960436B2 (en) * | 2006-06-05 | 2011-06-14 | Valeant Pharmaceuticals International | Substituted arylamino-1,2,3,4-tetrahydro naphthalenes and-2,3-dihydro-1H-indenes as potassium channel modulators |
| NZ575652A (en) * | 2006-08-23 | 2011-08-26 | Valeant Pharmaceuticals Int | Derivatives of 4-(n-azacycloalkyl) anilides as potassium channel modulators |
| US8993593B2 (en) | 2006-08-23 | 2015-03-31 | Valeant Pharmaceuticals International | N-(4-(6-fluoro-3,4-dihydroisoquinolin-2(1H)-yl)-2,6-dimethylphenyl)-3,3-dimethylbutanamide as potassium channel modulators |
| US8722929B2 (en) * | 2006-10-10 | 2014-05-13 | Valeant Pharmaceuticals International | N-[2-amino-4-(phenylmethoxy)phenyl] amides and related compounds as potassium channel modulators |
| KR20090083479A (ko) | 2006-11-28 | 2009-08-03 | 밸리언트 파마슈티컬즈 인터내셔널 | 칼륨 채널 조절제로서의 1,4 디아미노 이환 레티가빈 유사체 |
| US8367684B2 (en) | 2007-06-13 | 2013-02-05 | Valeant Pharmaceuticals International | Derivatives of 4-(N-azacycloalkyl) anilides as potassium channel modulators |
| US8563566B2 (en) | 2007-08-01 | 2013-10-22 | Valeant Pharmaceuticals International | Naphthyridine derivatives as potassium channel modulators |
| US7786146B2 (en) * | 2007-08-13 | 2010-08-31 | Valeant Pharmaceuticals International | Derivatives of 5-amino-4,6-disubstituted indole and 5-amino-4,6-disubstituted indoline as potassium channel modulators |
| US8809526B2 (en) * | 2010-07-19 | 2014-08-19 | Onyx Pharmaceuticals, Inc. | Synthesis of cyclopentaquinazolines |
| CA2819510A1 (en) * | 2010-12-22 | 2012-06-28 | Onyx Pharmaceuticals, Inc. | Efficient peptide couplings and their use in the synthesis and isolation of a cyclopenta(g)quinazoline trisodium salt |
| US9717797B2 (en) | 2013-12-05 | 2017-08-01 | International Business Machines Corporation | Polycarbonates bearing aromatic N-heterocycles for drug delivery |
| GB201707864D0 (en) | 2017-05-16 | 2017-06-28 | Inst Of Cancer Research: Royal Cancer Hospital | Platinum-reistant cancer treatment |
| TWI886158B (zh) | 2019-10-10 | 2025-06-11 | 加拿大商再諾製藥公司 | 選擇性鉀通道調節劑之固態晶型 |
| CA3155812A1 (en) | 2019-11-08 | 2021-05-14 | Cynthia Louise HARDEN | Methods of treating depressive disorders |
| TW202245744A (zh) | 2021-02-09 | 2022-12-01 | 加拿大商再諾製藥公司 | 治療失樂症之方法及用途 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9223352D0 (en) | 1992-11-06 | 1992-12-23 | Ici Plc | Tricyclic compounds |
| GB9408936D0 (en) * | 1994-05-05 | 1994-06-22 | Cancer Res Inst | Anti-cancer compounds |
| GB9904275D0 (en) | 1999-02-24 | 1999-04-21 | Cancer Res Campaign Tech | Anti-cancer compounds |
| GB9913083D0 (en) * | 1999-06-04 | 1999-08-04 | Novartis Ag | Organic compounds |
| JP3897594B2 (ja) * | 2000-01-18 | 2007-03-28 | ノバルティス アクチエンゲゼルシャフト | ミクロソームトリグリセリド輸送タンパク質およびアポリポタンパク質分泌の阻害剤として有用なカルボキサミド |
-
2001
- 2001-08-31 GB GBGB0121214.1A patent/GB0121214D0/en not_active Ceased
-
2002
- 2002-08-30 PT PT02755271T patent/PT1421069E/pt unknown
- 2002-08-30 DK DK02755271.0T patent/DK1421069T3/da active
- 2002-08-30 WO PCT/GB2002/003967 patent/WO2003020706A1/en not_active Ceased
- 2002-08-30 EP EP10003257.2A patent/EP2213664B1/de not_active Expired - Lifetime
- 2002-08-30 EP EP02755271A patent/EP1421069B1/de not_active Expired - Lifetime
- 2002-08-30 DK DK10003257.2T patent/DK2213664T3/da active
- 2002-08-30 ES ES02755271T patent/ES2371334T3/es not_active Expired - Lifetime
- 2002-08-30 US US10/487,863 patent/US7250511B2/en not_active Expired - Lifetime
- 2002-08-30 AT AT02755271T patent/ATE519747T1/de active
- 2002-08-30 JP JP2003524977A patent/JP4405798B2/ja not_active Expired - Lifetime
-
2009
- 2009-08-21 JP JP2009192490A patent/JP5275945B2/ja not_active Expired - Lifetime
-
2011
- 2011-11-07 CY CY20111101068T patent/CY1112711T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| GB0121214D0 (en) | 2001-10-24 |
| WO2003020706A1 (en) | 2003-03-13 |
| DK1421069T3 (da) | 2011-11-21 |
| EP1421069A1 (de) | 2004-05-26 |
| JP2009280609A (ja) | 2009-12-03 |
| PT1421069E (pt) | 2011-11-21 |
| US7250511B2 (en) | 2007-07-31 |
| EP1421069B1 (de) | 2011-08-10 |
| US20040266798A1 (en) | 2004-12-30 |
| DK2213664T3 (da) | 2014-07-21 |
| CY1112711T1 (el) | 2016-02-10 |
| JP4405798B2 (ja) | 2010-01-27 |
| JP2005507384A (ja) | 2005-03-17 |
| ES2371334T3 (es) | 2011-12-29 |
| JP5275945B2 (ja) | 2013-08-28 |
| EP2213664B1 (de) | 2014-04-30 |
| EP2213664A1 (de) | 2010-08-04 |
| HK1145321A1 (en) | 2011-04-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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