ATE520404T1 - Verfahren zur behandlung einer verletzung des zentralen nervensystems durch ausschleichende verabreichung von progesteron - Google Patents
Verfahren zur behandlung einer verletzung des zentralen nervensystems durch ausschleichende verabreichung von progesteronInfo
- Publication number
- ATE520404T1 ATE520404T1 AT06739662T AT06739662T ATE520404T1 AT E520404 T1 ATE520404 T1 AT E520404T1 AT 06739662 T AT06739662 T AT 06739662T AT 06739662 T AT06739662 T AT 06739662T AT E520404 T1 ATE520404 T1 AT E520404T1
- Authority
- AT
- Austria
- Prior art keywords
- nervous system
- central nervous
- system injury
- progesterone
- teader
- Prior art date
Links
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 5
- 208000001738 Nervous System Trauma Diseases 0.000 title abstract 4
- 210000003169 central nervous system Anatomy 0.000 title abstract 4
- 208000028412 nervous system injury Diseases 0.000 title abstract 4
- 229960003387 progesterone Drugs 0.000 title abstract 2
- 239000000186 progesterone Substances 0.000 title abstract 2
- 206010030113 Oedema Diseases 0.000 abstract 1
- 230000008030 elimination Effects 0.000 abstract 1
- 238000003379 elimination reaction Methods 0.000 abstract 1
- 208000028867 ischemia Diseases 0.000 abstract 1
- 230000004770 neurodegeneration Effects 0.000 abstract 1
- 230000016273 neuron death Effects 0.000 abstract 1
- 239000000583 progesterone congener Substances 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Cardiology (AREA)
- Psychiatry (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Medicinal Preparation (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US66472805P | 2005-03-24 | 2005-03-24 | |
| US72966305P | 2005-10-24 | 2005-10-24 | |
| PCT/US2006/010984 WO2006102644A2 (en) | 2005-03-24 | 2006-03-24 | Methods for the treatment of central nervous system injury via a tapered administration of progesterone |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE520404T1 true ATE520404T1 (de) | 2011-09-15 |
Family
ID=36987966
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06739662T ATE520404T1 (de) | 2005-03-24 | 2006-03-24 | Verfahren zur behandlung einer verletzung des zentralen nervensystems durch ausschleichende verabreichung von progesteron |
| AT08167618T ATE499104T1 (de) | 2005-03-24 | 2006-03-24 | Progesterone dosierungsanweisung in der behandlung einer traumatischen verletzung des gehirns |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT08167618T ATE499104T1 (de) | 2005-03-24 | 2006-03-24 | Progesterone dosierungsanweisung in der behandlung einer traumatischen verletzung des gehirns |
Country Status (15)
| Country | Link |
|---|---|
| US (4) | US20090221544A1 (de) |
| EP (5) | EP2494976A1 (de) |
| JP (5) | JP5394059B2 (de) |
| AT (2) | ATE520404T1 (de) |
| AU (2) | AU2006226774B2 (de) |
| CA (2) | CA2602950C (de) |
| CY (2) | CY1111478T1 (de) |
| DE (1) | DE602006020353D1 (de) |
| DK (2) | DK2030622T3 (de) |
| ES (2) | ES2392454T3 (de) |
| HR (2) | HRP20120688T1 (de) |
| PL (2) | PL1868614T3 (de) |
| PT (2) | PT2030622E (de) |
| RS (1) | RS52471B (de) |
| WO (2) | WO2006102596A2 (de) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7473687B2 (en) * | 2005-03-24 | 2009-01-06 | Emory University | Methods for the treatment of a traumatic central nervous system injury |
| PT2030622E (pt) * | 2005-03-24 | 2011-06-02 | Univ Emory | Indicação da dose de progesterona no tratamento de um traumatismo crânio-encefálico |
| EP2052724A1 (de) | 2007-10-26 | 2009-04-29 | sanofi-aventis | Verwendung von Norgestimat als selektivem Hemmer der Ionenkanäle TRPC3, TRPC6 sowie TRPC6 und TRPC7 |
| CA2716095C (en) | 2008-02-26 | 2017-02-07 | Emory University | Steroid analogues for neuroprotection |
| RU2366466C1 (ru) * | 2008-03-25 | 2009-09-10 | Олег Васильевич Онысько | Способ лечения черепно-мозговой травмы |
| KR101769999B1 (ko) | 2008-09-18 | 2017-08-21 | 노오쓰웨스턴 유니버시티 | Nmda 수용체 조절제 및 그의 용도 |
| WO2010088409A2 (en) * | 2009-01-30 | 2010-08-05 | Emory University | Methods of neuroprotection using neuroprotective steroids and a vitamin d |
| US8951968B2 (en) | 2009-10-05 | 2015-02-10 | Northwestern University | Methods of treating depression and other related diseases |
| US20110262502A1 (en) * | 2010-02-08 | 2011-10-27 | Prairie Pharmaceuticals LLC | Pulmonary delivery of 17-hydroxyprogesterone caproate (17-hpc) |
| CN102811730B (zh) | 2010-02-08 | 2014-07-09 | 杜涛 | 孕激素作为糖皮质激素增敏剂的使用 |
| US10993879B2 (en) * | 2010-02-08 | 2021-05-04 | Shenzhen Evergreen Therapeutics Co., Ltd. | Pulmonary delivery of progestogen |
| US10987361B2 (en) | 2010-02-08 | 2021-04-27 | Shenzhen Evergreen Therapeutics Co., Ltd. | Treating auto-immune and auto-inflammatory diseases |
| TW201138782A (en) | 2010-04-26 | 2011-11-16 | Besins Healthcare Lu Sarl | Low-oil pharmaceutical emulsion compositions comprising progestogen |
| SG194230A1 (en) * | 2011-04-27 | 2013-12-30 | Univ Northwestern | Methods of treating alzheimer's disease, huntington's disease, autism, or other disorders |
| WO2013043985A1 (en) | 2011-09-23 | 2013-03-28 | The Regents Of The University Of California | Edible oils to enhance delivery of orally administered steroids |
| WO2013112605A2 (en) * | 2012-01-23 | 2013-08-01 | Sage Therapeutics, Inc. | Neuroactive steroid formulations and methods of treating cns disorders |
| US20130210785A1 (en) | 2012-02-15 | 2013-08-15 | Emory University | Progesterone analogs and uses related thereto |
| MX356427B (es) | 2012-02-29 | 2018-05-29 | Braun Melsungen Ag | Emulsion que contiene hormona. |
| RU2498826C1 (ru) * | 2012-05-14 | 2013-11-20 | Федеральное государственное бюджетное учреждение науки Комплексный научно-исследовательский институт им. Х.И. Ибрагимова Российской академии наук | Способ лечения больных с черепно-мозговой травмой |
| IL275725B (en) | 2012-08-21 | 2022-08-01 | Sage Therapeutics Inc | Treatment methods for epilepsy and status epilepticus |
| EP4335505A3 (de) | 2012-11-30 | 2024-06-05 | The Regents of The University of California | Antikonvulsive aktivität von steroiden |
| MX2015009773A (es) | 2013-01-29 | 2016-08-05 | Aptinyx Inc | Moduladores de receptores nmda de espiro-lactama y sus usos. |
| BR112015018087B1 (pt) | 2013-01-29 | 2022-09-20 | Aptinyx Inc | Compostos moduladores de receptor n-metil-d-aspartato (nmda) de espiro-lactama, composição farmacêutica e uso dos mesmos |
| PE20151436A1 (es) | 2013-01-29 | 2015-10-10 | Naurex Inc | Moduladores de receptores nmda de espiro-lactama y sus usos |
| CA2899010A1 (en) | 2013-01-29 | 2014-08-07 | Naurex, Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
| JP6531042B2 (ja) | 2013-01-29 | 2019-06-12 | アプティニックス インコーポレイテッド | スピロラクタム系nmda受容体モジュレーターおよびその使用 |
| EP3033350B1 (de) | 2013-08-12 | 2021-07-28 | Emory University | Progesteronphosphatanaloga und damit einhergehende verwendungen |
| JOP20200195A1 (ar) | 2014-09-08 | 2017-06-16 | Sage Therapeutics Inc | سترويدات وتركيبات نشطة عصبياً، واستخداماتها |
| US10231979B2 (en) * | 2015-08-07 | 2019-03-19 | Indiana University Research And Technology Corporation | Modulation of inflammation using progesterone metabolites |
| SG11201807785VA (en) | 2016-03-08 | 2018-10-30 | Sage Therapeutics Inc | Neuroactive steroids, compositions, and uses thereof |
| PE20190174A1 (es) | 2016-05-19 | 2019-02-01 | Aptinyx Inc | Moduladores del receptor espiro-lactama n-metil-d-aspartato y usos de los mismos |
| WO2017201285A1 (en) | 2016-05-19 | 2017-11-23 | Aptinyx Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
| AU2017306152A1 (en) | 2016-08-01 | 2019-01-31 | Aptinyx Inc. | Spiro-lactam NMDA receptor modulators and uses thereof |
| US10918637B2 (en) | 2016-08-01 | 2021-02-16 | Aptinyx Inc. | Spiro-lactam NMDA receptor modulators and uses thereof |
| CN109661398B (zh) | 2016-08-01 | 2022-07-05 | 阿普廷伊克斯股份有限公司 | 螺-内酰胺和二-螺-内酰胺nmda受体调节剂及其用途 |
| SG11201900554YA (en) | 2016-08-01 | 2019-02-27 | Aptinyx Inc | Spiro-lactam nmda modulators and methods of using same |
| BR112019001921A2 (pt) | 2016-08-01 | 2019-05-14 | Aptinyx Inc. | moduladores do receptor nmda de espiro-lactama e seus usos |
| US11578072B2 (en) | 2018-01-31 | 2023-02-14 | Aptinyx Inc. | Spiro-lactam NMDA receptor modulators and uses thereof |
| CN113366318A (zh) * | 2019-01-31 | 2021-09-07 | 日内瓦大学 | 创伤性脑损伤(tbi)的前瞻性标志物 |
| US11216742B2 (en) | 2019-03-04 | 2022-01-04 | Iocurrents, Inc. | Data compression and communication using machine learning |
| US12012413B2 (en) | 2019-11-11 | 2024-06-18 | Tenacia Biotechnology (Hong Kong) Co., Limited | Methods of treating painful diabetic peripheral neuropathy |
| JP2024542727A (ja) * | 2021-12-02 | 2024-11-15 | マーベルバイオーム・インコーポレイテッド | 迷走神経関連疾患、障害、及び状態を治療するための方法、及び微生物叢組成物、成分、または代謝産物の使用 |
| US20230293722A1 (en) * | 2022-01-05 | 2023-09-21 | Metaqor Llc | Compositions and Methods for Treating Neurological-associated Disorders |
| WO2024059056A1 (en) * | 2022-09-12 | 2024-03-21 | Emory University | Methods of managing traumatic brain injury |
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| JPS5217085A (en) | 1975-07-30 | 1977-02-08 | Ono Pharmaceut Co Ltd | Method of quantitative determination of free fatty acids in serum usin g fatty acid activating enzymes |
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| US5232917A (en) | 1987-08-25 | 1993-08-03 | University Of Southern California | Methods, compositions, and compounds for allosteric modulation of the GABA receptor by members of the androstane and pregnane series |
| US5120723A (en) * | 1987-08-25 | 1992-06-09 | University Of Southern California | Method, compositions, and compounds for modulating brain excitability |
| USRE35517E (en) * | 1987-08-25 | 1997-05-20 | University Of Southern California | Method, compositions, and compounds for modulating brain excitability |
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| US20020072509A1 (en) * | 2000-10-11 | 2002-06-13 | Stein Donald Gerald | Methods for the treatment of a traumatic central nervous system injury |
| US7473687B2 (en) * | 2005-03-24 | 2009-01-06 | Emory University | Methods for the treatment of a traumatic central nervous system injury |
| PT2030622E (pt) * | 2005-03-24 | 2011-06-02 | Univ Emory | Indicação da dose de progesterona no tratamento de um traumatismo crânio-encefálico |
-
2006
- 2006-03-24 PT PT08167618T patent/PT2030622E/pt unknown
- 2006-03-24 AT AT06739662T patent/ATE520404T1/de not_active IP Right Cessation
- 2006-03-24 DK DK08167618.1T patent/DK2030622T3/da active
- 2006-03-24 EP EP12163432A patent/EP2494976A1/de not_active Withdrawn
- 2006-03-24 RS RS20120433A patent/RS52471B/sr unknown
- 2006-03-24 AU AU2006226774A patent/AU2006226774B2/en not_active Ceased
- 2006-03-24 DK DK06748657.1T patent/DK1868614T3/da active
- 2006-03-24 EP EP11177154.9A patent/EP2431042B1/de not_active Expired - Lifetime
- 2006-03-24 PL PL06748657T patent/PL1868614T3/pl unknown
- 2006-03-24 EP EP08167618A patent/EP2030622B1/de not_active Expired - Lifetime
- 2006-03-24 JP JP2008503262A patent/JP5394059B2/ja not_active Expired - Fee Related
- 2006-03-24 ES ES06748657T patent/ES2392454T3/es not_active Expired - Lifetime
- 2006-03-24 AT AT08167618T patent/ATE499104T1/de active
- 2006-03-24 ES ES11177154T patent/ES2428313T3/es not_active Expired - Lifetime
- 2006-03-24 WO PCT/US2006/010797 patent/WO2006102596A2/en not_active Ceased
- 2006-03-24 US US11/909,276 patent/US20090221544A1/en not_active Abandoned
- 2006-03-24 PL PL08167618T patent/PL2030622T3/pl unknown
- 2006-03-24 US US11/909,278 patent/US20090325920A1/en not_active Abandoned
- 2006-03-24 PT PT06748657T patent/PT1868614E/pt unknown
- 2006-03-24 HR HRP20120688TT patent/HRP20120688T1/hr unknown
- 2006-03-24 CA CA2602950A patent/CA2602950C/en not_active Expired - Fee Related
- 2006-03-24 JP JP2008503227A patent/JP5295755B2/ja not_active Expired - Fee Related
- 2006-03-24 EP EP06748657A patent/EP1868614B1/de not_active Expired - Lifetime
- 2006-03-24 AU AU2006226811A patent/AU2006226811B2/en not_active Ceased
- 2006-03-24 CA CA2601715A patent/CA2601715C/en not_active Expired - Fee Related
- 2006-03-24 WO PCT/US2006/010984 patent/WO2006102644A2/en not_active Ceased
- 2006-03-24 DE DE602006020353T patent/DE602006020353D1/de not_active Expired - Lifetime
- 2006-03-24 EP EP06739662A patent/EP1871382B1/de not_active Expired - Lifetime
-
2011
- 2011-03-17 HR HR20110198T patent/HRP20110198T1/hr unknown
- 2011-05-20 CY CY20111100496T patent/CY1111478T1/el unknown
- 2011-08-17 JP JP2011178655A patent/JP2011225629A/ja not_active Withdrawn
-
2012
- 2012-04-24 US US13/454,503 patent/US20120245133A1/en not_active Abandoned
- 2012-07-16 US US13/550,148 patent/US8614203B2/en not_active Expired - Fee Related
- 2012-10-25 CY CY20121101012T patent/CY1113253T1/el unknown
-
2013
- 2013-07-12 JP JP2013146680A patent/JP2013234191A/ja not_active Withdrawn
- 2013-12-20 JP JP2013263682A patent/JP5496407B2/ja not_active Expired - Fee Related
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