ATE522220T1 - Triterpenzusammensetzungen und deren verwendungsmethoden - Google Patents

Triterpenzusammensetzungen und deren verwendungsmethoden

Info

Publication number: ATE522220T1
Authority: AT; Austria
Prior art keywords: compounds; methods; triterpone; compositions; mixtures
Prior art date: 1998-05-19

Application number

AT99924348T

Other languages

English (en)

Inventor

Charles Arntzen

Mary Blake

Jordan Gutterman

Joseph Hoffmann

David Bailey

Gamini Jayatilake

Original Assignee

Res Dev Foundation

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-05-19

Filing date

1999-05-19

Publication date

2011-09-15

1999-05-19 Application filed by Res Dev Foundation filed Critical Res Dev Foundation

2011-09-15 Application granted granted Critical

2011-09-15 Publication of ATE522220T1 publication Critical patent/ATE522220T1/de

Links

239000000203 mixture Substances 0.000 title abstract 3
150000001875 compounds Chemical class 0.000 abstract 3
MIJYXULNPSFWEK-GTOFXWBISA-N 3beta-hydroxyolean-12-en-28-oic acid Chemical compound C1C[C@H](O)C(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C(O)=O)CCC(C)(C)C[C@H]5C4=CC[C@@H]3[C@]21C MIJYXULNPSFWEK-GTOFXWBISA-N 0.000 abstract 1
241000990235 Acacia victoriae Species 0.000 abstract 1
CFKXWTNHIJAFNL-UHFFFAOYSA-N Acacic acid Natural products CC12CCC(O)C(C)(C)C1CCC1(C)C2CC=C2C3CC(C)(C)C(O)CC3(C(O)=O)C(O)CC21C CFKXWTNHIJAFNL-UHFFFAOYSA-N 0.000 abstract 1
JKLISIRFYWXLQG-UHFFFAOYSA-N Epioleonolsaeure Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C)CCC5(C(O)=O)CCC(C)(C)CC5C4CCC3C21C JKLISIRFYWXLQG-UHFFFAOYSA-N 0.000 abstract 1
YBRJHZPWOMJYKQ-UHFFFAOYSA-N Oleanolic acid Natural products CC1(C)CC2C3=CCC4C5(C)CCC(O)C(C)(C)C5CCC4(C)C3(C)CCC2(C1)C(=O)O YBRJHZPWOMJYKQ-UHFFFAOYSA-N 0.000 abstract 1
MIJYXULNPSFWEK-UHFFFAOYSA-N Oleanolinsaeure Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C)CCC5(C(O)=O)CCC(C)(C)CC5C4=CCC3C21C MIJYXULNPSFWEK-UHFFFAOYSA-N 0.000 abstract 1
CFKXWTNHIJAFNL-OOURDANISA-N acacic acid Chemical compound C([C@@]12C)C[C@H](O)C(C)(C)[C@@H]1CC[C@]1(C)[C@@H]2CC=C2[C@@H]3CC(C)(C)[C@@H](O)C[C@]3(C(O)=O)[C@H](O)C[C@]21C CFKXWTNHIJAFNL-OOURDANISA-N 0.000 abstract 1
230000000259 anti-tumor effect Effects 0.000 abstract 1
210000004027 cell Anatomy 0.000 abstract 1
230000003013 cytotoxicity Effects 0.000 abstract 1
231100000135 cytotoxicity Toxicity 0.000 abstract 1
150000002773 monoterpene derivatives Chemical group 0.000 abstract 1
229940100243 oleanolic acid Drugs 0.000 abstract 1
229920001542 oligosaccharide Polymers 0.000 abstract 1
150000002482 oligosaccharides Chemical class 0.000 abstract 1
230000003389 potentiating effect Effects 0.000 abstract 1
HZLWUYJLOIAQFC-UHFFFAOYSA-N prosapogenin PS-A Natural products C12CC(C)(C)CCC2(C(O)=O)CCC(C2(CCC3C4(C)C)C)(C)C1=CCC2C3(C)CCC4OC1OCC(O)C(O)C1O HZLWUYJLOIAQFC-UHFFFAOYSA-N 0.000 abstract 1
239000001397 quillaja saponaria molina bark Substances 0.000 abstract 1
230000025915 regulation of apoptotic process Effects 0.000 abstract 1
229930182490 saponin Natural products 0.000 abstract 1
150000007949 saponins Chemical class 0.000 abstract 1
150000003648 triterpenes Chemical group 0.000 abstract 1
210000004881 tumor cell Anatomy 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0038—Radiosensitizing, i.e. administration of pharmaceutical agents that enhance the effect of radiotherapy
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01H—NEW PLANTS OR NON-TRANSGENIC PROCESSES FOR OBTAINING THEM; PLANT REPRODUCTION BY TISSUE CULTURE TECHNIQUES
- A01H4/00—Plant reproduction by tissue culture techniques ; Tissue culture techniques therefor
- A01H4/005—Methods for micropropagation; Vegetative plant propagation using cell or tissue culture techniques
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/16—Masculine contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/04—Plant cells or tissues

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Biotechnology (AREA)
Epidemiology (AREA)
Natural Medicines & Medicinal Plants (AREA)
Botany (AREA)
Cell Biology (AREA)
Molecular Biology (AREA)
Developmental Biology & Embryology (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Genetics & Genomics (AREA)
Biomedical Technology (AREA)
Mycology (AREA)
Microbiology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Cardiology (AREA)
Polymers & Plastics (AREA)
Environmental Sciences (AREA)
General Engineering & Computer Science (AREA)
Alternative & Traditional Medicine (AREA)
Medical Informatics (AREA)
Biochemistry (AREA)
Heart & Thoracic Surgery (AREA)
Nutrition Science (AREA)
Food Science & Technology (AREA)

AT99924348T 1998-05-19 1999-05-19 Triterpenzusammensetzungen und deren verwendungsmethoden ATE522220T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US8599798P	1998-05-19	1998-05-19
US9906698P	1998-09-03	1998-09-03
PCT/US1999/011041 WO1999059578A1 (en)	1998-05-19	1999-05-19	Triterpene compositions and methods for use thereof

Publications (1)

Publication Number	Publication Date
ATE522220T1 true ATE522220T1 (de)	2011-09-15

Family

ID=26773317

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99924348T ATE522220T1 (de)	1998-05-19	1999-05-19	Triterpenzusammensetzungen und deren verwendungsmethoden

Country Status (13)

Country	Link
US (8)	US6444233B1 (de)
EP (1)	EP1079824B1 (de)
JP (1)	JP4860039B2 (de)
KR (1)	KR100785718B1 (de)
CN (2)	CN1307473A (de)
AT (1)	ATE522220T1 (de)
AU (1)	AU761879B2 (de)
CA (1)	CA2330916C (de)
DK (1)	DK1079824T3 (de)
IL (2)	IL139307A0 (de)
NZ (2)	NZ507791A (de)
RU (1)	RU2244547C2 (de)
WO (1)	WO1999059578A1 (de)

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AU4087199A (en)	1999-12-06
WO1999059578A1 (en)	1999-11-25
RU2244547C2 (ru)	2005-01-20
US6689398B2 (en)	2004-02-10
CA2330916A1 (en)	1999-11-25
US6746696B2 (en)	2004-06-08
US8324177B2 (en)	2012-12-04
EP1079824B1 (de)	2011-08-31
US20030203049A1 (en)	2003-10-30
US20100189824A1 (en)	2010-07-29
CN1307473A (zh)	2001-08-08
AU761879B2 (en)	2003-06-12
US20110294752A1 (en)	2011-12-01
EP1079824A1 (de)	2001-03-07
IL139307A0 (en)	2001-11-25
KR100785718B1 (ko)	2007-12-18
JP2002515430A (ja)	2002-05-28
US20030039705A1 (en)	2003-02-27
DK1079824T3 (da)	2011-11-21
EP1079824A4 (de)	2008-03-12
US20060073222A1 (en)	2006-04-06
US20030031738A1 (en)	2003-02-13
NZ507791A (en)	2003-12-19
IL139307A (en)	2012-12-31
US7670632B2 (en)	2010-03-02
KR20010034867A (ko)	2001-04-25
CA2330916C (en)	2011-04-05
US7105186B2 (en)	2006-09-12
JP4860039B2 (ja)	2012-01-25
US6444233B1 (en)	2002-09-03
NZ528940A (en)	2005-02-25
US6962720B2 (en)	2005-11-08
CN102274272A (zh)	2011-12-14
US20030054052A1 (en)	2003-03-20
US7985435B2 (en)	2011-07-26

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ATE522220T1 (de)	2011-09-15	Triterpenzusammensetzungen und deren verwendungsmethoden
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AP2004003103A0 (en)	2004-09-30	Controlled synthesis of ziprasidone and compositions thereof
GB0129260D0 (en)	2002-01-23	Pharmaceutical compositions and their uses
PL367682A1 (en)	2005-03-07	Dolastatin 10 derivatives
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