ATE524067T1 - Zusammensetzungen und verfahren zur behandlung von zns-schäden - Google Patents

Zusammensetzungen und verfahren zur behandlung von zns-schäden

Info

Publication number
ATE524067T1
ATE524067T1 AT04752310T AT04752310T ATE524067T1 AT E524067 T1 ATE524067 T1 AT E524067T1 AT 04752310 T AT04752310 T AT 04752310T AT 04752310 T AT04752310 T AT 04752310T AT E524067 T1 ATE524067 T1 AT E524067T1
Authority
AT
Austria
Prior art keywords
injury
compositions
methods
functions
nervous system
Prior art date
Application number
AT04752310T
Other languages
English (en)
Inventor
Elliott Gruskin
Anthony Caggiano
Michael Zimber
Andrew Blight
Original Assignee
Acorda Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Acorda Therapeutics Inc filed Critical Acorda Therapeutics Inc
Application granted granted Critical
Publication of ATE524067T1 publication Critical patent/ATE524067T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/51—Lyases (4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A61K9/122—Foams; Dry foams

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Lubricants (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT04752310T 2003-05-16 2004-05-17 Zusammensetzungen und verfahren zur behandlung von zns-schäden ATE524067T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US47123603P 2003-05-16 2003-05-16
PCT/US2004/015253 WO2004103299A2 (en) 2003-05-16 2004-05-17 Compositions and methods for the treatment of cns injuries

Publications (1)

Publication Number Publication Date
ATE524067T1 true ATE524067T1 (de) 2011-09-15

Family

ID=33476545

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04752310T ATE524067T1 (de) 2003-05-16 2004-05-17 Zusammensetzungen und verfahren zur behandlung von zns-schäden

Country Status (10)

Country Link
US (3) US20080025963A1 (de)
EP (2) EP1631234B1 (de)
JP (2) JP4754492B2 (de)
AT (1) ATE524067T1 (de)
AU (1) AU2004241088B2 (de)
CA (1) CA2525804C (de)
ES (2) ES2420510T3 (de)
MX (1) MXPA05012305A (de)
PL (1) PL1631234T3 (de)
WO (1) WO2004103299A2 (de)

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EP3211084B1 (de) 2003-05-16 2019-03-27 Acorda Therapeutics, Inc. Proteoglycan-abbauende mutanten zur behandlung des zns
US7959914B2 (en) 2003-05-16 2011-06-14 Acorda Therapeutics, Inc. Methods of reducing extravasation of inflammatory cells
MXPA06013345A (es) * 2004-05-18 2008-10-31 Acorda Therapeutics Inc Metodos para purificar condrointinasa y sus formulaciones estables.
JP2006232754A (ja) * 2005-02-25 2006-09-07 Gi Biopolis:Kk 消化管粘膜切除後の消化管潰瘍治癒促進用スプレー剤
JP5189985B2 (ja) 2005-09-26 2013-04-24 アコーダ セラピューティクス、インク． コンドロイチナーゼａｂｃｉ変異体を用いた組成物およびその使用方法
CA2663857C (en) 2006-09-20 2017-10-31 The Board Of Regents Of The University Of Texas System Methods for delivering volatile anesthetics for regional anesthesia and/or pain relief
TW200817015A (en) * 2006-10-06 2008-04-16 Hen-Rich Cheng A method for promoting axonal re-growth and behavior recovery in spinal cord injury
AU2016206267B2 (en) * 2006-10-10 2018-07-05 Acorda Therapeutics, Inc. Compositions and methods of using chondroitinase abci mutants
CA3009034C (en) 2006-10-10 2020-08-18 Acorda Therapeutics, Inc. Compositions and methods of using chondroitinase abci mutants
AU2014200000B2 (en) * 2006-10-10 2016-04-21 Acorda Therapeutics, Inc. Compositions and methods of using chondroitinase abci mutants
WO2008149428A1 (ja) * 2007-06-05 2008-12-11 Glycoscience Laboratories, Inc. 自己免疫疾患、炎症及び神経疾患の治療剤及び予防剤
US20110059508A1 (en) 2007-06-29 2011-03-10 National University Corporation Nagoya University Improving agent for dysfunction due to neuropathy and rho kinase activation inhibitor
US8198083B1 (en) 2007-10-31 2012-06-12 William Gunter Loudon Organotypic slices of the central nervous system
PL2244737T3 (pl) 2008-01-22 2020-05-18 The Board Of Regents Of The University Of Texas System Kompozycje lotnego środka znieczulającego zawierające rozpuszczalniki ekstrakcyjne do znieczulania miejscowego i / albo zwalczania bólu
EP2286828B1 (de) * 2008-04-14 2016-05-18 National University Corporation Nagoya University Mittel zur linderung von neurogenen schmerzen
EP2153844A1 (de) * 2008-08-14 2010-02-17 HAUBECK, Hans-Dieter Humane Hyaluronidasen zum erneuten axonalen Wachstum
WO2012136768A1 (en) 2011-04-08 2012-10-11 Hans-Dieter Haubeck Use of mutants of human hyaluronidase ph-20 with increased chondroitinase activity for axonal regrowth
EP3010524B1 (de) 2013-06-18 2019-12-25 University of Helsinki Protamin bei der behandlung von nervenverletzungen
CN108795918A (zh) * 2018-07-18 2018-11-13 北京电子科技职业学院 一种外切型硫酸软骨素酶abc及其制备方法与应用

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US7008783B1 (en) * 1992-09-22 2006-03-07 Maruha Corporation Gene encoding chondroitinase ABC and uses therefor
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EP3211084B1 (de) * 2003-05-16 2019-03-27 Acorda Therapeutics, Inc. Proteoglycan-abbauende mutanten zur behandlung des zns
US7507570B2 (en) * 2004-03-10 2009-03-24 Massachusetts Institute Of Technology Recombinant chondroitinase ABC I and uses thereof
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Also Published As

Publication number Publication date
US20140248253A1 (en) 2014-09-04
AU2004241088A1 (en) 2004-12-02
US20080025963A1 (en) 2008-01-31
JP2007520447A (ja) 2007-07-26
JP4754492B2 (ja) 2011-08-24
CA2525804A1 (en) 2004-12-02
PL1631234T3 (pl) 2012-02-29
WO2004103299A3 (en) 2008-01-24
WO2004103299A2 (en) 2004-12-02
JP5432113B2 (ja) 2014-03-05
ES2420510T3 (es) 2013-08-23
JP2011126880A (ja) 2011-06-30
AU2004241088B2 (en) 2010-08-05
ES2373039T3 (es) 2012-01-30
EP1631234A4 (de) 2008-11-19
EP2353606A2 (de) 2011-08-10
CA2525804C (en) 2017-04-25
EP1631234A2 (de) 2006-03-08
US20200016247A1 (en) 2020-01-16
EP1631234B1 (de) 2011-09-14
MXPA05012305A (es) 2006-04-18
WO2004103299A8 (en) 2005-03-31
EP2353606B1 (de) 2013-04-17
EP2353606A3 (de) 2011-08-31

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