ATE524431T1 - Verfahren zur stabilisierung von nukeinsäuren in biologischen materialien - Google Patents
Verfahren zur stabilisierung von nukeinsäuren in biologischen materialienInfo
- Publication number
- ATE524431T1 ATE524431T1 AT07010591T AT07010591T ATE524431T1 AT E524431 T1 ATE524431 T1 AT E524431T1 AT 07010591 T AT07010591 T AT 07010591T AT 07010591 T AT07010591 T AT 07010591T AT E524431 T1 ATE524431 T1 AT E524431T1
- Authority
- AT
- Austria
- Prior art keywords
- stabilizing
- nukein
- acids
- biological materials
- composition
- Prior art date
Links
- 230000000087 stabilizing effect Effects 0.000 title abstract 2
- 239000002253 acid Substances 0.000 title 1
- 150000007513 acids Chemical class 0.000 title 1
- 239000012620 biological material Substances 0.000 title 1
- 239000000203 mixture Substances 0.000 abstract 4
- 150000007523 nucleic acids Chemical class 0.000 abstract 3
- 102000039446 nucleic acids Human genes 0.000 abstract 3
- 108020004707 nucleic acids Proteins 0.000 abstract 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 150000001767 cationic compounds Chemical class 0.000 abstract 2
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 abstract 1
- 150000001450 anions Chemical class 0.000 abstract 1
- 239000012472 biological sample Substances 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 150000007524 organic acids Chemical class 0.000 abstract 1
- 229910052698 phosphorus Inorganic materials 0.000 abstract 1
- 239000011574 phosphorus Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1003—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/62—Quaternary ammonium compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/62—Quaternary ammonium compounds
- C07C211/63—Quaternary ammonium compounds having quaternised nitrogen atoms bound to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/62—Quaternary ammonium compounds
- C07C211/64—Quaternary ammonium compounds having quaternised nitrogen atoms bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/54—Quaternary phosphonium compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10031236A DE10031236A1 (de) | 2000-06-27 | 2000-06-27 | Verwendung von Carbonsäuren und anderen Additiven in Kombination mit kationischen Verbindungen zur Stabilisierung von Nukleinsäuren in biologischen Materialien |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE524431T1 true ATE524431T1 (de) | 2011-09-15 |
Family
ID=7646943
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT07010591T ATE524431T1 (de) | 2000-06-27 | 2001-05-22 | Verfahren zur stabilisierung von nukeinsäuren in biologischen materialien |
| AT01947306T ATE374743T1 (de) | 2000-06-27 | 2001-05-22 | Neue kompositionen für die stabilisierung von nukleinsäuren in biologischen materialien |
| AT01953178T ATE394363T1 (de) | 2000-06-27 | 2001-06-26 | Verwendung von kompositionen aus kationischen verbindungen und protonendonoren zur stabilisierung und/oder isolierung von nukleinsäuren in bzw. aus mikroorganismen - wie prokaryonten, pilzen, protozoen oder algen |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01947306T ATE374743T1 (de) | 2000-06-27 | 2001-05-22 | Neue kompositionen für die stabilisierung von nukleinsäuren in biologischen materialien |
| AT01953178T ATE394363T1 (de) | 2000-06-27 | 2001-06-26 | Verwendung von kompositionen aus kationischen verbindungen und protonendonoren zur stabilisierung und/oder isolierung von nukleinsäuren in bzw. aus mikroorganismen - wie prokaryonten, pilzen, protozoen oder algen |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | US7270953B2 (fr) |
| EP (3) | EP1820793B1 (fr) |
| JP (5) | JP5795455B2 (fr) |
| CN (1) | CN1250520C (fr) |
| AT (3) | ATE524431T1 (fr) |
| AU (4) | AU2001269031B2 (fr) |
| BR (1) | BR0112002A (fr) |
| CA (2) | CA2412534C (fr) |
| CZ (1) | CZ20024129A3 (fr) |
| DE (3) | DE10031236A1 (fr) |
| DK (2) | DK1294676T3 (fr) |
| ES (2) | ES2295177T3 (fr) |
| HU (1) | HUP0301342A2 (fr) |
| MX (1) | MXPA02012261A (fr) |
| PL (1) | PL360705A1 (fr) |
| SK (1) | SK18022002A3 (fr) |
| WO (2) | WO2002000599A1 (fr) |
Families Citing this family (82)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080064108A1 (en) * | 1997-12-10 | 2008-03-13 | Tony Baker | Urine Preservation System |
| US7569342B2 (en) | 1997-12-10 | 2009-08-04 | Sierra Molecular Corp. | Removal of molecular assay interferences |
| DE10031236A1 (de) * | 2000-06-27 | 2002-01-10 | Qiagen Gmbh | Verwendung von Carbonsäuren und anderen Additiven in Kombination mit kationischen Verbindungen zur Stabilisierung von Nukleinsäuren in biologischen Materialien |
| EP1356302B1 (fr) * | 2000-11-08 | 2008-01-23 | Becton Dickinson and Company | Methode et dispositif de prelevement et de stabilisation d'un echantillon biologique |
| US6602718B1 (en) * | 2000-11-08 | 2003-08-05 | Becton, Dickinson And Company | Method and device for collecting and stabilizing a biological sample |
| DE10147439B4 (de) * | 2001-09-26 | 2014-01-30 | Qiagen Gmbh | Verfahren zur Isolierung von DNA aus biologischen Proben |
| EP1329506A1 (fr) | 2002-01-18 | 2003-07-23 | Cypro S.A. | Procédé de quantification du niveau in vivo d'ARN |
| DE10208005A1 (de) * | 2002-02-26 | 2003-09-04 | Qiagen Gmbh | Verfahren zur Änderung der Transkriptkonzentration in ribonukleinsäurehaltigen biologischen Proben |
| US7482116B2 (en) | 2002-06-07 | 2009-01-27 | Dna Genotek Inc. | Compositions and methods for obtaining nucleic acids from sputum |
| DE10336177B4 (de) * | 2002-08-09 | 2010-02-11 | Alexander Cherkasky | Verwendung von Zellorganellen zur Stabilisierung von Nukleinsäuren und Zellen |
| WO2004020626A1 (fr) * | 2002-08-09 | 2004-03-11 | Alexander Cherkasky | Utilisation d'organites cellulaires pour stabiliser des biomolecules et des cellules |
| JP2006502857A (ja) * | 2002-10-18 | 2006-01-26 | プロメガ コーポレイション | 分子を分離するための方法 |
| JP2006528482A (ja) * | 2003-07-24 | 2006-12-21 | キアゲン ゲゼルシャフト ミット ベシュレンクテル ハフツング | 核酸の逆転写及び/または増幅方法 |
| US20050059024A1 (en) | 2003-07-25 | 2005-03-17 | Ambion, Inc. | Methods and compositions for isolating small RNA molecules |
| GB0327319D0 (en) * | 2003-11-24 | 2003-12-24 | Pfizer Ltd | Novel pharmaceuticals |
| US20070196826A1 (en) * | 2004-03-23 | 2007-08-23 | Hiroyuki Ohno | Solvent For Dissolving Nucleic Acid, Nucleic Acid-Containing Solution And Method Of Preserving Nucleic Acid |
| WO2005113147A2 (fr) | 2004-04-08 | 2005-12-01 | Biomatrica, Inc. | Integration du stockage et de la gestion d'echantillons pour les sciences de la vie |
| US20080176209A1 (en) * | 2004-04-08 | 2008-07-24 | Biomatrica, Inc. | Integration of sample storage and sample management for life science |
| US20060099567A1 (en) * | 2004-04-08 | 2006-05-11 | Biomatrica, Inc. | Integration of sample storage and sample management for life science |
| DE102004023417A1 (de) * | 2004-05-12 | 2005-12-08 | Clariant Gmbh | Verfahren zur Herstellung von langkettigen quaternären Ammonium-oxalaten und -hydrogenoxalaten |
| JP4810164B2 (ja) * | 2004-09-03 | 2011-11-09 | 富士フイルム株式会社 | 核酸分離精製方法 |
| US20060094023A1 (en) * | 2004-11-02 | 2006-05-04 | Industrial Technology Research Institute | Method for isolating nucleic acid by using amino surfactants |
| TWI294460B (en) * | 2004-12-23 | 2008-03-11 | Ind Tech Res Inst | Method for stabilizing nucleic acids |
| DE102005015005A1 (de) * | 2005-04-01 | 2006-10-05 | Qiagen Gmbh | Verfahren zur Behandlung einer Biomoleküle enthaltenden Probe |
| US20060234251A1 (en) * | 2005-04-19 | 2006-10-19 | Lumigen, Inc. | Methods of enhancing isolation of RNA from biological samples |
| US20070015165A1 (en) * | 2005-07-13 | 2007-01-18 | Sigma-Aldrich Co. | Method for the isolation of RNA from biological sources |
| US20070190526A1 (en) * | 2006-02-16 | 2007-08-16 | Nexgen Diagnostics Llc | Methods of extracting nucleic acids |
| EP2022853A4 (fr) * | 2006-05-17 | 2010-03-10 | Yoshiyuki Koyama | Produit lyophilisé servant à transférer un acide nucléique, un acide oligonucléique ou un dérivé de ceux-ci |
| DE102007016707A1 (de) * | 2007-04-04 | 2008-10-09 | Qiagen Gmbh | Verfahren zur Aufreinigung von Biomolekülen |
| DE102007025277A1 (de) | 2007-05-31 | 2008-12-04 | Qiagen Gmbh | Verfahren zur Stabilisierung einer biologischen Probe |
| DE102007025275A1 (de) | 2007-05-31 | 2008-12-04 | Qiagen Gmbh | Butendisäure oder deren Derivate zur Behandlung einer biologischen Probe |
| DE102007025276A1 (de) | 2007-05-31 | 2008-12-04 | Qiagen Gmbh | Aromatische Alkohole zur Behandlung einer biologischen Probe |
| US20090053704A1 (en) * | 2007-08-24 | 2009-02-26 | Natalia Novoradovskaya | Stabilization of nucleic acids on solid supports |
| US7687027B2 (en) * | 2008-02-27 | 2010-03-30 | Becton, Dickinson And Company | Cleaning compositions, methods and materials for reducing nucleic acid contamination |
| AU2010227509A1 (en) | 2009-03-27 | 2011-09-08 | Universite Libre De Bruxelles | New marker for diagnosis of active multiple sclerosis |
| WO2011051402A1 (fr) | 2009-11-02 | 2011-05-05 | Universite Libre De Bruxelles | Nouveaux biomarqueurs pour déterminer un état d'allergie |
| EP2345719A1 (fr) | 2010-01-18 | 2011-07-20 | Qiagen GmbH | Procédé d'isolation de petit ARN |
| US8932809B2 (en) * | 2010-01-19 | 2015-01-13 | Opgen, Inc. | Methods and kits for isolating nucleic acid from an organism |
| WO2011157678A1 (fr) | 2010-06-14 | 2011-12-22 | Qiagen Gmbh | Procédé de détermination de cellules ou de tissu cibles pour l'extraction de biomolécules à partir d'échantillons biologiques fixés |
| EP2407540A1 (fr) | 2010-07-15 | 2012-01-18 | Qiagen GmbH | Procédé de purification d'un acide nucléique cible |
| US9376709B2 (en) | 2010-07-26 | 2016-06-28 | Biomatrica, Inc. | Compositions for stabilizing DNA and RNA in blood and other biological samples during shipping and storage at ambient temperatures |
| EP2598661B1 (fr) | 2010-07-26 | 2017-09-27 | Biomatrica, INC. | Compositions de stabilisation d'adn, d'arn, de protéines salivaires et d'autres échantillons biologiques lors du transport et du stockage à températures ambiantes |
| CN102146422B (zh) * | 2011-01-24 | 2013-08-07 | 南京工业大学 | 一种丁二酸的发酵生产工艺 |
| EP3246416B1 (fr) | 2011-04-15 | 2024-06-05 | The Johns Hopkins University | Système de séquençage sûr |
| US9442046B2 (en) | 2011-06-19 | 2016-09-13 | Abogen, Inc. | Device for sample collection |
| JP6096774B2 (ja) | 2011-08-12 | 2017-03-15 | キアゲン ゲゼルシャフト ミット ベシュレンクテル ハフツング | 核酸を単離するための方法 |
| AU2012314514B2 (en) | 2011-09-26 | 2018-03-15 | Qiagen Gmbh | Stabilisation and isolation of extracellular nucleic acids |
| US11021733B2 (en) | 2011-09-26 | 2021-06-01 | Qiagen Gmbh | Stabilization and isolation of extracellular nucleic acids |
| WO2013045458A1 (fr) | 2011-09-26 | 2013-04-04 | Preanalytix Gmbh | Stabilisation et isolement d'acides nucléiques extracellulaires |
| JP6333737B2 (ja) | 2012-02-09 | 2018-05-30 | ライフ テクノロジーズ コーポレーション | コンジュゲートされたポリマー粒子およびその製造方法 |
| ES2567091T3 (es) | 2012-04-05 | 2016-04-19 | F. Hoffmann-La Roche Ag | Compuestos de amina para la preparación selectiva de muestras biológicas |
| US10233508B2 (en) | 2012-08-21 | 2019-03-19 | Qiagen Gmbh | Virus particle stabilisation and method for isolating viral nucleic acids |
| EP2888363B1 (fr) | 2012-08-21 | 2018-06-06 | Qiagen GmbH | Procédé pour isoler des acides nucléiques à partir d'un échantillon stabilisé libérant du formaldéhyde |
| AU2013310861B2 (en) * | 2012-09-03 | 2019-02-14 | Qiagen Gmbh | Method for isolating RNA including small RNA with high yield |
| JP6608280B2 (ja) | 2012-09-25 | 2019-11-20 | キアゲン ゲーエムベーハー | 生物学的試料の安定化 |
| WO2014070462A1 (fr) | 2012-10-29 | 2014-05-08 | The Johns Hopkins University | Test de papanicolaou pour les cancers de l'ovaire et de l'endomètre |
| US9725703B2 (en) | 2012-12-20 | 2017-08-08 | Biomatrica, Inc. | Formulations and methods for stabilizing PCR reagents |
| ES2677723T3 (es) | 2012-12-28 | 2018-08-06 | Cellestis Limited | Un ensayo de la respuesta inmunológica mediada por células |
| GB201303666D0 (en) | 2013-03-01 | 2013-04-17 | Goldsborough Andrew S | Sample fixation and stabilisation |
| EP2976424B1 (fr) | 2013-03-18 | 2018-10-03 | Qiagen GmbH | Stabilisation d'échantillons biologiques |
| US20160281133A1 (en) | 2013-03-18 | 2016-09-29 | Qiagen Gmbh | Stabilization and isolation of extracellular nucleic acids |
| GB201305414D0 (en) | 2013-03-25 | 2013-05-08 | Arcis Biotechnology Holdings Ltd | Method and composition |
| KR102392407B1 (ko) | 2014-03-07 | 2022-04-29 | 디엔에이 제노텍 인코퍼레이티드 | 생물학적 샘플에서 핵산을 안정화하기 위한 조성물 및 방법 |
| CA2940692C (fr) | 2014-03-18 | 2025-07-08 | Qiagen Gmbh | Stabilisation et isolement d’acides nucléiques extracellulaires |
| WO2015191632A1 (fr) | 2014-06-10 | 2015-12-17 | Biomatrica, Inc. | Stabilisation de thrombocytes à des températures ambiantes |
| CN107208032A (zh) | 2014-09-17 | 2017-09-26 | 豪洛捷公司 | 部分裂解和测定的方法 |
| CN107667168A (zh) | 2015-05-27 | 2018-02-06 | 凯杰有限公司 | 用于破碎组织材料的组合物和方法 |
| EP3317426B1 (fr) | 2015-07-02 | 2020-01-15 | Life Technologies Corporation | Conjugaison de billes hydrophiles à fonction carboxyle |
| WO2017007774A1 (fr) | 2015-07-06 | 2017-01-12 | Life Technologies Corporation | Substrats et procédés utiles en séquençage |
| US11286531B2 (en) | 2015-08-11 | 2022-03-29 | The Johns Hopkins University | Assaying ovarian cyst fluid |
| JP7166169B2 (ja) | 2015-11-20 | 2022-11-07 | キアゲン ゲーエムベーハー | 細胞外核酸の滅菌のための滅菌組成物を調製する方法 |
| ES2946184T3 (es) | 2015-12-08 | 2023-07-13 | Biomatrica Inc | Reducción de la velocidad de eritrosedimentación |
| CN110191960A (zh) * | 2016-11-08 | 2019-08-30 | 克维拉公司 | 进行核酸稳定和分离的方法 |
| PT3568475T (pt) | 2017-01-16 | 2023-04-18 | Spectrum Solutions L L C | Solução de preservação de ácido nucleico e métodos de utilização |
| KR20250047324A (ko) | 2017-08-07 | 2025-04-03 | 더 존스 홉킨스 유니버시티 | 암을 평가하고 치료하기 위한 방법 및 재료 |
| CN110012899A (zh) * | 2019-04-12 | 2019-07-16 | 南京科佰生物科技有限公司 | 细胞用rna稳定剂及其使用方法 |
| WO2021163546A1 (fr) | 2020-02-14 | 2021-08-19 | The Johns Hopkins University | Méthodes et matériels d'évaluation d'acides nucléiques |
| CN116529371A (zh) * | 2020-05-29 | 2023-08-01 | 洛克菲勒大学 | 从自收集小体积样品中分离rna的方法和系统 |
| KR20230018435A (ko) * | 2020-05-29 | 2023-02-07 | 더 락커펠러 유니버시티 | 자기-수집된 및 작은 부피 샘플로부터의 rna 단리를 위한 방법 및 시스템 |
| US20250075035A1 (en) | 2021-12-10 | 2025-03-06 | Nitto Boseki Co., Ltd. | Agent for raising melting temperature (tm value) of nucleic acid |
| KR102728359B1 (ko) * | 2021-12-10 | 2024-11-11 | 니토 보세키 가부시기가이샤 | 2 본쇄 핵산의 융해 온도 상승화제 및 그 용도 |
| KR102786563B1 (ko) | 2023-04-27 | 2025-03-26 | 전남대학교산학협력단 | 수송배지로서 혈액 내의 핵산 보존용 조성물 및 이를 이용한 핵산의 보존방법 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2099266A5 (fr) | 1970-06-22 | 1972-03-10 | Shell Int Research | |
| US4900677A (en) * | 1986-09-26 | 1990-02-13 | E. I. Du Pont De Nemours And Company | Process for rapid isolation of high molecular weight DNA |
| US5010183A (en) | 1989-07-07 | 1991-04-23 | Macfarlane Donald E | Process for purifying DNA and RNA using cationic detergents |
| IT1240870B (it) | 1990-02-14 | 1993-12-17 | Talent | Procedimento per l'estrazione e la purificazione di dna genomico umano |
| US5196182A (en) | 1991-05-08 | 1993-03-23 | Streck Laboratories, Inc. | Tissue fixative |
| US5260048A (en) | 1991-05-08 | 1993-11-09 | Streck Laboratories, Inc. | Tissue fixative solution and method |
| US5275708A (en) * | 1992-03-20 | 1994-01-04 | Thomas Jefferson University | Cetyltrimethylammonium bromide gel electrophoresis |
| CA2107939C (fr) * | 1993-01-13 | 2001-01-30 | Stephen B. Kong | Compositions acides de nettoyage en solution aqueuse |
| AU6230594A (en) * | 1993-02-01 | 1994-08-29 | University Of Iowa Research Foundation, The | Quartenary amine surfactants and methods of using same in isolation of rna |
| US5300635A (en) * | 1993-02-01 | 1994-04-05 | University Of Iowa Research Foundation | Quaternary amine surfactants and methods of using same in isolation of nucleic acids |
| US5300645A (en) | 1993-04-14 | 1994-04-05 | Eli Lilly And Company | Tetrahydro-pyrido-indole |
| US5641726A (en) | 1993-06-09 | 1997-06-24 | Lonza, Inc. | Quaternary ammonium carboxylate and borate compositions and preparation thereof |
| ZA943999B (en) * | 1993-06-09 | 1995-02-03 | Lonza Ag | Quaternary ammonium and waterproofing/preservative compositions |
| EP0743950B1 (fr) | 1994-02-11 | 2001-12-12 | QIAGEN GmbH | Procede de separation de structures d'acides nucleiques a deux brins et a un brin |
| JP2001526051A (ja) | 1997-12-10 | 2001-12-18 | シエラ ダイアグノスティクス,インク. | 体液中のdnaを保存するための方法及び試薬 |
| EP1041996A4 (fr) * | 1997-12-22 | 2003-05-14 | Human Genome Sciences Inc | Formulations du facteur-2 de croissance des keratinocytes |
| US6204375B1 (en) * | 1998-07-31 | 2001-03-20 | Ambion, Inc. | Methods and reagents for preserving RNA in cell and tissue samples |
| US7683035B1 (en) * | 1999-02-23 | 2010-03-23 | Qiagen, Gmbh | Method of stabilizing and/or isolating nucleic acids |
| DE10031236A1 (de) * | 2000-06-27 | 2002-01-10 | Qiagen Gmbh | Verwendung von Carbonsäuren und anderen Additiven in Kombination mit kationischen Verbindungen zur Stabilisierung von Nukleinsäuren in biologischen Materialien |
-
2000
- 2000-06-27 DE DE10031236A patent/DE10031236A1/de not_active Ceased
-
2001
- 2001-05-22 AT AT07010591T patent/ATE524431T1/de active
- 2001-05-22 AU AU2001269031A patent/AU2001269031B2/en not_active Expired
- 2001-05-22 WO PCT/EP2001/005888 patent/WO2002000599A1/fr not_active Ceased
- 2001-05-22 DK DK01947306T patent/DK1294676T3/da active
- 2001-05-22 US US10/312,745 patent/US7270953B2/en not_active Expired - Lifetime
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- 2001-05-22 AU AU6903101A patent/AU6903101A/xx active Pending
- 2001-05-22 JP JP2002505349A patent/JP5795455B2/ja not_active Expired - Lifetime
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- 2001-05-22 DE DE50113086T patent/DE50113086D1/de not_active Expired - Lifetime
- 2001-05-22 DK DK07010591.1T patent/DK1820793T3/da active
- 2001-05-22 CA CA2412534A patent/CA2412534C/fr not_active Expired - Lifetime
- 2001-05-22 EP EP01947306A patent/EP1294676B1/fr not_active Expired - Lifetime
- 2001-05-22 AT AT01947306T patent/ATE374743T1/de active
- 2001-06-26 AU AU75685/01A patent/AU783922B2/en not_active Expired
- 2001-06-26 EP EP01953178A patent/EP1296932B1/fr not_active Expired - Lifetime
- 2001-06-26 BR BR0112002-6A patent/BR0112002A/pt not_active IP Right Cessation
- 2001-06-26 CN CNB01811945XA patent/CN1250520C/zh not_active Expired - Lifetime
- 2001-06-26 CA CA2410388A patent/CA2410388C/fr not_active Expired - Lifetime
- 2001-06-26 JP JP2002505350A patent/JP5657847B2/ja not_active Expired - Lifetime
- 2001-06-26 HU HU0301342A patent/HUP0301342A2/hu unknown
- 2001-06-26 WO PCT/EP2001/007281 patent/WO2002000600A1/fr not_active Ceased
- 2001-06-26 SK SK1802-2002A patent/SK18022002A3/sk unknown
- 2001-06-26 US US10/312,432 patent/US6861213B2/en not_active Expired - Lifetime
- 2001-06-26 MX MXPA02012261A patent/MXPA02012261A/es not_active Application Discontinuation
- 2001-06-26 DE DE50113941T patent/DE50113941D1/de not_active Expired - Lifetime
- 2001-06-26 AT AT01953178T patent/ATE394363T1/de not_active IP Right Cessation
- 2001-06-26 CZ CZ20024129A patent/CZ20024129A3/cs unknown
- 2001-06-26 PL PL01360705A patent/PL360705A1/xx not_active Application Discontinuation
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2007
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2012
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2014
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2015
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