ATE524450T1 - 5-phenyl-isoxazol-3-carboxamid-derivate als trpv1-modulatoren - Google Patents
5-phenyl-isoxazol-3-carboxamid-derivate als trpv1-modulatorenInfo
- Publication number
- ATE524450T1 ATE524450T1 AT08786712T AT08786712T ATE524450T1 AT E524450 T1 ATE524450 T1 AT E524450T1 AT 08786712 T AT08786712 T AT 08786712T AT 08786712 T AT08786712 T AT 08786712T AT E524450 T1 ATE524450 T1 AT E524450T1
- Authority
- AT
- Austria
- Prior art keywords
- isoxazole
- acute
- carboxamide derivatives
- phenyl
- disorders
- Prior art date
Links
- 102000003566 TRPV1 Human genes 0.000 title abstract 2
- 101150016206 Trpv1 gene Proteins 0.000 title abstract 2
- ASVXNFGUPSDDTA-UHFFFAOYSA-N 5-phenyl-1,2-oxazole-3-carboxamide Chemical class O1N=C(C(=O)N)C=C1C1=CC=CC=C1 ASVXNFGUPSDDTA-UHFFFAOYSA-N 0.000 title 1
- 230000001154 acute effect Effects 0.000 abstract 3
- LKYNGTHMKCTTQC-UHFFFAOYSA-N 1,2-oxazole-3-carboxamide Chemical class NC(=O)C=1C=CON=1 LKYNGTHMKCTTQC-UHFFFAOYSA-N 0.000 abstract 2
- 208000002193 Pain Diseases 0.000 abstract 2
- 230000001684 chronic effect Effects 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 208000035475 disorder Diseases 0.000 abstract 2
- 208000000094 Chronic Pain Diseases 0.000 abstract 1
- 206010065390 Inflammatory pain Diseases 0.000 abstract 1
- 208000026723 Urinary tract disease Diseases 0.000 abstract 1
- 208000005298 acute pain Diseases 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 208000004296 neuralgia Diseases 0.000 abstract 1
- 208000021722 neuropathic pain Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 208000023504 respiratory system disease Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 208000014001 urinary system disease Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D261/18—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US95349307P | 2007-08-02 | 2007-08-02 | |
| US1370007P | 2007-12-14 | 2007-12-14 | |
| PCT/EP2008/060090 WO2009016241A1 (en) | 2007-08-02 | 2008-07-31 | 5-phenyl-isoxazole-3-carboxamide derivatives as trpv1 modulators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE524450T1 true ATE524450T1 (de) | 2011-09-15 |
Family
ID=39925074
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT08786712T ATE524450T1 (de) | 2007-08-02 | 2008-07-31 | 5-phenyl-isoxazol-3-carboxamid-derivate als trpv1-modulatoren |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US8211927B2 (de) |
| EP (1) | EP2185530B1 (de) |
| JP (1) | JP2011511756A (de) |
| CN (1) | CN101796036A (de) |
| AT (1) | ATE524450T1 (de) |
| CA (1) | CA2694663A1 (de) |
| MX (1) | MX2010001236A (de) |
| WO (1) | WO2009016241A1 (de) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009151947A1 (en) | 2008-05-27 | 2009-12-17 | Qualcomm Incorporated | Setting up a communication session within a wireless communications system |
| EP3116501A1 (de) | 2014-03-13 | 2017-01-18 | Proteostasis Therapeutics, Inc. | Verbindungen, zusammensetzungen und verfahren zur steigerung der cftr-aktivität |
| EP3116870A1 (de) | 2014-03-13 | 2017-01-18 | Proteostasis Therapeutics, Inc. | Verbindungen, zusammensetzungen und verfahren zur steigerung der cftr-aktivität |
| US9403810B2 (en) | 2014-05-14 | 2016-08-02 | Novartis Ag | Carboxamide derivatives |
| TW201623288A (zh) | 2014-05-14 | 2016-07-01 | 諾華公司 | 甲醯胺衍生物 |
| CA2952862A1 (en) * | 2014-06-19 | 2015-12-23 | Proteostasis Therapeutics, Inc. | Compounds, compositions and methods of increasing cftr activity |
| US10865181B2 (en) | 2014-11-05 | 2020-12-15 | University Of Kansas | Small molecule inhibitors of the mitochondrial permeability transition pore (mtPTP) |
| US10738011B2 (en) | 2014-12-23 | 2020-08-11 | Proteostasis Therapeutics, Inc. | Derivatives of 5-(hetero)arylpyrazol-3-carboxylic amide or 1-(hetero)aryltriazol-4-carboxylic amide useful for the treatment of inter alia cystic fibrosis |
| US10344023B2 (en) | 2014-12-23 | 2019-07-09 | Proteostasis Therapeutics, Inc. | Derivatives of 3-heteroarylisoxazol-5-carboxylic amide useful for the treatment of inter alia cystic fibrosis |
| US10392378B2 (en) | 2014-12-23 | 2019-08-27 | Proteostasis Therapeutics, Inc. | Derivatives of 5-phenyl- or 5-heteroarylathiazol-2-carboxylic amide useful for the treatment of inter alia cystic fibrosis |
| MA41253A (fr) | 2014-12-23 | 2017-10-31 | Proteostasis Therapeutics Inc | Composés, compositions et procédés pour augmenter l'activité du cftr |
| US20180147187A1 (en) * | 2015-01-12 | 2018-05-31 | Proteostasis Therapeutics, Inc. | Compounds, compositions, and methods for increasing cftr activity |
| US10548878B2 (en) | 2015-07-24 | 2020-02-04 | Proteostasis Therapeutics, Inc. | Compounds, compositions, and methods of increasing CFTR activity |
| NZ741093A (en) | 2015-10-06 | 2022-12-23 | Proteostasis Therapeutics Inc | Compounds, compositions, and methods for modulating cftr |
| BR112018070747B1 (pt) | 2016-04-07 | 2024-01-09 | Proteostasis Therapeutics, Inc | Átomos de silicone contendo análogos de ivacaftor, composições farmacêuticas e usos terapêuticos |
| EP3472156B1 (de) | 2016-06-21 | 2023-06-07 | Proteostasis Therapeutics, Inc. | Verbindungen, zusammensetzungen und verfahren zur steigerung der cftr-aktivität |
| AU2019280356B2 (en) * | 2018-06-08 | 2022-09-29 | Betta Pharmaceuticals Co., Ltd | ERK inhibitor and use thereof |
| CN111518044A (zh) * | 2019-02-01 | 2020-08-11 | 华东师范大学 | 烷氧基异噁唑类衍生物及其制备方法与应用 |
| WO2021062189A1 (en) * | 2019-09-27 | 2021-04-01 | Collaborations Pharmaceuticals, Inc. | Isoxazole-3-carboxamide derivatives and their use for treatment of diseases caused by virus infection |
| CN115105503B (zh) * | 2022-07-20 | 2023-05-23 | 河南大学 | 一种trpv1拮抗/cox抑制双靶点药物或其药学上可接受的盐、药物制剂和应用 |
| CN118955415A (zh) * | 2024-07-30 | 2024-11-15 | 深圳智微通科技有限公司 | 一种5-(2,4-二氟苯基)异噁唑-3-甲酸乙酯的连续合成方法 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007067710A1 (en) * | 2005-12-08 | 2007-06-14 | Amphora Discovery Corporation | Certain chemical entities, compositions, and methods for modulating trpv1 |
-
2008
- 2008-07-31 US US12/671,113 patent/US8211927B2/en not_active Expired - Fee Related
- 2008-07-31 AT AT08786712T patent/ATE524450T1/de not_active IP Right Cessation
- 2008-07-31 EP EP08786712A patent/EP2185530B1/de not_active Not-in-force
- 2008-07-31 CA CA2694663A patent/CA2694663A1/en not_active Abandoned
- 2008-07-31 MX MX2010001236A patent/MX2010001236A/es not_active Application Discontinuation
- 2008-07-31 JP JP2010518682A patent/JP2011511756A/ja not_active Withdrawn
- 2008-07-31 CN CN200880105334A patent/CN101796036A/zh active Pending
- 2008-07-31 WO PCT/EP2008/060090 patent/WO2009016241A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| JP2011511756A (ja) | 2011-04-14 |
| EP2185530B1 (de) | 2011-09-14 |
| US8211927B2 (en) | 2012-07-03 |
| CN101796036A (zh) | 2010-08-04 |
| CA2694663A1 (en) | 2009-02-05 |
| EP2185530A1 (de) | 2010-05-19 |
| MX2010001236A (es) | 2010-03-04 |
| WO2009016241A1 (en) | 2009-02-05 |
| US20110065764A1 (en) | 2011-03-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |