ATE52518T1 - Peptid-derivate, pepstatin-analoga, renin- und saeureprotease hemmende mittel. - Google Patents

Peptid-derivate, pepstatin-analoga, renin- und saeureprotease hemmende mittel.

Info

Publication number: ATE52518T1
Authority: AT; Austria
Prior art keywords: pepstatin; renin; analogues; peptide derivatives; protease inhibitors
Prior art date: 1985-02-12

Application number

AT86400272T

Other languages

English (en)

Inventor

Jean Wagnon

Georges Callet

Jean-Pierre Gagnol

Dino Nisato

Catherine Cazaubon

Original Assignee

Sanofi Sa

Inst Nat Sante Rech Med

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-02-12

Filing date

1986-02-10

Publication date

1990-05-15

1985-02-12 Priority claimed from FR8501982A external-priority patent/FR2577226B1/fr

1985-02-12 Priority claimed from FR8501981A external-priority patent/FR2577225B1/fr

1986-02-10 Application filed by Sanofi Sa, Inst Nat Sante Rech Med filed Critical Sanofi Sa

1990-05-15 Application granted granted Critical

1990-05-15 Publication of ATE52518T1 publication Critical patent/ATE52518T1/de

Links

108091005508 Acid proteases Proteins 0.000 title abstract 2
FAXGPCHRFPCXOO-LXTPJMTPSA-N pepstatin A Chemical class OC(=O)C[C@H](O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)C[C@H](O)[C@H](CC(C)C)NC(=O)[C@H](C(C)C)NC(=O)[C@H](C(C)C)NC(=O)CC(C)C FAXGPCHRFPCXOO-LXTPJMTPSA-N 0.000 title abstract 2
108090000765 processed proteins & peptides Proteins 0.000 title abstract 2
229940042399 direct acting antivirals protease inhibitors Drugs 0.000 title 1
239000000137 peptide hydrolase inhibitor Substances 0.000 title 1
108090000783 Renin Proteins 0.000 abstract 1
102100028255 Renin Human genes 0.000 abstract 1
229950000964 pepstatin Drugs 0.000 abstract 1
108010091212 pepstatin Proteins 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0227—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the (partial) peptide sequence -Phe-His-NH-(X)2-C(=0)-, e.g. Renin-inhibitors with n = 2 - 6; for n > 6 see C07K5/06 - C07K5/10
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/02—Linear peptides containing at least one abnormal peptide link
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/86—Renin inhibitors

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Health & Medical Sciences (AREA)
Biochemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Crystallography & Structural Chemistry (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

AT86400272T 1985-02-12 1986-02-10 Peptid-derivate, pepstatin-analoga, renin- und saeureprotease hemmende mittel. ATE52518T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
FR8501982A FR2577226B1 (fr)	1985-02-12	1985-02-12	Analogues de pepstatine inhibiteurs de la renine et des proteases acides
FR8501981A FR2577225B1 (fr)	1985-02-12	1985-02-12	Derives peptidiques inhibiteurs de la renine et des proteases acides
EP86400272A EP0193445B1 (de)	1985-02-12	1986-02-10	Peptid-Derivate, Pepstatin-Analoga, Renin- und Säureprotease hemmende Mittel

Publications (1)

Publication Number	Publication Date
ATE52518T1 true ATE52518T1 (de)	1990-05-15

Family

ID=26224369

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT86400271T ATE71111T1 (de)	1985-02-12	1986-02-10	Peptid-derivate, renin- und saeureprotease hemmende mittel.
AT86400272T ATE52518T1 (de)	1985-02-12	1986-02-10	Peptid-derivate, pepstatin-analoga, renin- und saeureprotease hemmende mittel.

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
AT86400271T ATE71111T1 (de)	1985-02-12	1986-02-10	Peptid-derivate, renin- und saeureprotease hemmende mittel.

Country Status (11)

Country	Link
US (2)	US4725580A (de)
EP (2)	EP0193445B1 (de)
AT (2)	ATE71111T1 (de)
AU (2)	AU606572B2 (de)
CA (2)	CA1286846C (de)
DE (2)	DE3671021D1 (de)
DK (2)	DK64086A (de)
ES (2)	ES8701782A1 (de)
GR (2)	GR860398B (de)
NZ (2)	NZ215097A (de)
PT (2)	PT81991B (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2585708B1 (fr) *	1985-07-31	1989-07-07	Sanofi Sa	Derives aminoalcools peptidiques inhibiteurs de la resine et des proteases acides, leur procede de preparation et leur application en therapeutique
US4599198A (en) *	1985-08-02	1986-07-08	Pfizer Inc.	Intermediates in polypeptide synthesis
DE3626130A1 (de) *	1986-08-01	1988-02-11	Merck Patent Gmbh	Aminosaeurederivate
DE3640535A1 (de) *	1986-11-27	1988-06-01	Merck Patent Gmbh	Peptide
EP0284510A3 (de) *	1987-03-24	1990-08-22	Asahi Breweries, Ltd.	N-[N-alpha-(1(S)-carboxy-3-cyclohexylpropyl)-L-lysyl]-N-cyclopentylglycin als antihypertensives Mittel
US4874745A (en) *	1987-10-01	1989-10-17	Merck & Co., Inc.	Renin-inhibitory pepstatin phenyl derivatives
US4980283A (en) *	1987-10-01	1990-12-25	Merck & Co., Inc.	Renin-inhibitory pepstatin phenyl derivatives
US5162527A (en) *	1987-10-26	1992-11-10	Warner-Lambert Company	Renin inhibitors, processes for preparing them, methods for using them, and compositions containing them
EP0314060A3 (de) *	1987-10-26	1991-06-19	Warner-Lambert Company	Renin-Hemmer, Verfahren zu ihrer Herstellung, Methoden zu ihrer Verwendung und Zubereitungen, die sie enthalten
US5164388A (en) *	1988-10-19	1992-11-17	Abbott Laboratories	Heterocyclic peptide renin inhibitors
IL92011A0 (en) *	1988-10-19	1990-07-12	Abbott Lab	Heterocyclic peptide renin inhibitors
IE70080B1 (en) *	1989-02-16	1996-10-30	Sankyo Co	Peptides having renin inhibitory activity their preparation and use
FR2646354B1 (fr) *	1989-04-27	1994-06-10	Sanofi Sa	Utilisation de peptides inhibiteurs de proteases acides pour la preparation de medicaments utiles pour le traitement de maladies virales
US5238923A (en) *	1989-05-26	1993-08-24	Warner-Lambert Company	Amino-substituted heterocycles as renin inhibitors
US5149692A (en) *	1989-12-21	1992-09-22	Warner-Lambert Company	Bisalkoxyphosphinyl compounds as renin inhibitors
US5071837A (en) *	1990-11-28	1991-12-10	Warner-Lambert Company	Novel renin inhibiting peptides
US5833946A (en) *	1995-06-06	1998-11-10	Bayer Corporation	Dissemination of fungal infections: animal model and method of prophylaxis
AT407043B (de) *	1998-01-23	2000-11-27	Martin Dr Kratzel	Simplifizierte pepstatin-a-analoga, deren herstellung und verwendung
US7247704B2 (en)	2000-12-18	2007-07-24	Arriva Pharmaceuticals, Inc.	Multifunctional protease inhibitors and their use in treatment of disease
US7929913B2 (en)	2002-12-16	2011-04-19	Intel Corporation	Adaptive receiver architecture
WO2012107153A1 (de)	2011-02-08	2012-08-16	Merck Patent Gmbh	Aminostatin-derivate zur behandlung von arthrose
US9624264B2 (en)	2012-07-24	2017-04-18	Merck Patent Gmbh	Hydroxystatin derivatives for the treatment of arthrosis
WO2014127881A1 (de)	2013-02-25	2014-08-28	Merck Patent Gmbh	2-amino-3,4-dihydrc-chinazolin derivate und ihre verwendung als cathepsin d inhibitoren
CA2920420C (en)	2013-08-06	2021-11-23	Merck Patent Gmbh	Intraarticular administration of pepstatin in the case of arthrosis

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA1245217A (en) *	1981-12-10	1988-11-22	Joshua S. Boger	Renin inhibitory peptides having phe su13 xx deletion
FR2531951A1 (fr) *	1982-08-17	1984-02-24	Sanofi Sa	Derives peptidiques inhibiteurs de proteases acides, procede pour leur preparation et medicaments qui en contiennent
EP0114993B1 (de) *	1982-12-27	1990-05-16	Merck & Co. Inc.	Reninhemmende Tripeptide

1986
- 1986-02-03 CA CA000500927A patent/CA1286846C/en not_active Expired - Lifetime
- 1986-02-05 US US06/826,349 patent/US4725580A/en not_active Expired - Fee Related
- 1986-02-05 US US06/826,375 patent/US4746648A/en not_active Expired - Fee Related
- 1986-02-05 CA CA000501163A patent/CA1286847C/en not_active Expired - Lifetime
- 1986-02-06 AU AU53273/86A patent/AU606572B2/en not_active Ceased
- 1986-02-06 AU AU53272/86A patent/AU606312B2/en not_active Ceased
- 1986-02-07 PT PT81991A patent/PT81991B/pt not_active IP Right Cessation
- 1986-02-07 PT PT81990A patent/PT81990B/pt not_active IP Right Cessation
- 1986-02-10 DE DE8686400272T patent/DE3671021D1/de not_active Expired - Lifetime
- 1986-02-10 AT AT86400271T patent/ATE71111T1/de not_active IP Right Cessation
- 1986-02-10 AT AT86400272T patent/ATE52518T1/de not_active IP Right Cessation
- 1986-02-10 DK DK64086A patent/DK64086A/da not_active Application Discontinuation
- 1986-02-10 DE DE8686400271T patent/DE3683170D1/de not_active Expired - Lifetime
- 1986-02-10 EP EP86400272A patent/EP0193445B1/de not_active Expired - Lifetime
- 1986-02-10 EP EP86400271A patent/EP0192554B1/de not_active Expired - Lifetime
- 1986-02-10 DK DK64186A patent/DK64186A/da not_active Application Discontinuation
- 1986-02-11 NZ NZ215097A patent/NZ215097A/en unknown
- 1986-02-11 GR GR860398A patent/GR860398B/el unknown
- 1986-02-11 GR GR860399A patent/GR860399B/el unknown
- 1986-02-11 NZ NZ215096A patent/NZ215096A/xx unknown
- 1986-02-11 ES ES551820A patent/ES8701782A1/es not_active Expired
- 1986-02-11 ES ES551821A patent/ES8701783A1/es not_active Expired

Also Published As

Publication number	Publication date
US4746648A (en)	1988-05-24
CA1286847C (en)	1991-07-23
EP0193445A1 (de)	1986-09-03
DK64086D0 (da)	1986-02-10
EP0192554A1 (de)	1986-08-27
DK64186A (da)	1986-08-13
ES8701783A1 (es)	1987-01-01
NZ215096A (en)	1989-10-27
DK64086A (da)	1986-08-13
US4725580A (en)	1988-02-16
ES551821A0 (es)	1987-01-01
NZ215097A (en)	1990-04-26
EP0192554B1 (de)	1992-01-02
ATE71111T1 (de)	1992-01-15
AU5327386A (en)	1986-08-21
GR860398B (en)	1986-06-12
AU606572B2 (en)	1991-02-14
PT81991B (pt)	1988-03-03
AU606312B2 (en)	1991-02-07
ES551820A0 (es)	1986-12-16
DE3671021D1 (de)	1990-06-13
DE3683170D1 (de)	1992-02-13
DK64186D0 (da)	1986-02-10
PT81990A (fr)	1986-03-01
EP0193445B1 (de)	1990-05-09
PT81990B (pt)	1988-03-03
AU5327286A (en)	1986-08-14
ES8701782A1 (es)	1986-12-16
CA1286846C (en)	1991-07-23
PT81991A (fr)	1986-03-01
GR860399B (en)	1986-06-12

Legal Events

Date	Code	Title	Description
1990-12-15	UEP	Publication of translation of european patent specification
1994-11-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE71111T1 (de)	1992-01-15	Peptid-derivate, renin- und saeureprotease hemmende mittel.
DE3878991D1 (de)	1993-04-15	Peptide boronsaeure-hemmungsstoffe von trypsintyp-proteasen.
NL300039I2 (nl)	2001-09-03	Sulfonamideremmers van HIV-aspartylprotease.
DK674387D0 (da)	1987-12-21	Proteaseinhibitorer
DE69637307D1 (de)	2007-12-13	Aus d-aminosäuren abgeleitete cystein- und serinproteasehemmer
FI942005A7 (fi)	1994-10-30	Peptidianalogeja irreversiibeleinä interleukiini-1beta-proteaasi-inhibiittoreina
ES2062812T3 (es)	1994-12-16	Composicion detergente enzimatica y metodo para estabilizar enzimas.
NO302883B1 (no)	1998-05-04	N-(alkanoylamino-2-hydroksypropyl)-sulfonamider som er nyttige som retrovirale proteaseinhibitorer, samt preparater inneholdene forbindelsene
ATE148113T1 (de)	1997-02-15	Retrovirale protease inhibitoren, enthaltend cyclische sulfone
FI942625L (fi)	1994-12-05	Peptidisiä fosfinyylioksimetyyliketoneja interleukiini-1beta-muuttuvan entsyymin inhibiittoreina
DK0495918T3 (da)	1996-02-19	Aminosyre-beta-lyaseenzyminhibitorer som deodoranter
EP0975353A4 (de)	2001-11-28	Peptidyl-2-amino-1hydroxyalkansulfonsäuren als cystein-protease-inhibitoren
ES2196436T3 (es)	2003-12-16	Acidos sulfonilalcanoilamino-hidroxietilamino-sulfamicos utiles como inhibidores de proteasas retrovirales.
DK568287D0 (da)	1987-10-30	Relativt lavmolekylaere peptider og deres anvendelse som renininhibitorer
FI865196A7 (fi)	1986-12-18	Halostatiinisubstituoituja reniini-inhibiittoreita.
FI925696A7 (fi)	1992-12-15	Hirudiinin aminohapposekvenssiin perustuvia trombiininestäjiä
DE3667273D1 (de)	1990-01-11	Von hydroxycarbonsaeuren abgeleitete oberflaechenaktive mittel.
ATE90359T1 (de)	1993-06-15	Peptide.
DE59812724D1 (de)	2005-05-12	Serin-proteinase-inhibitoren
DE68904315D1 (de)	1993-02-25	Peptide-hemmer von phospholipase a2.
RU95109909A (ru)	1997-03-27	Способ ингибирования ретровирусной инфекции, ингибитор протеазы, кодирующая его нуклеиновая кислота и способ рекомбинантного продуцирования серинового ингибитора
ATE86628T1 (de)	1993-03-15	Peptide boronsaeure-hemmungsstoffe von trypsintyp- proteasen.
ZA86960B (en)	1986-10-29	Peptide derivatives,analogous to pepstatin,which inhibit renin and acid proteases
DE3684241D1 (de)	1992-04-16	Acetylenische di(t-amylperoxidische) vernetzungs- und treibmittel fuer polyaethylen.
DK658489D0 (da)	1989-12-22	Proteaseinhibitorer