PT81991B - Processo para a preparacao de derivados peptidicos, analogos a pepestatina, inibidores darenina e das proteases acidas - Google Patents

Processo para a preparacao de derivados peptidicos, analogos a pepestatina, inibidores darenina e das proteases acidas

Info

Publication number: PT81991B
Authority: PT; Portugal
Prior art keywords: pepestatin; darenine; analogs; inhibitors; preparation
Prior art date: 1985-02-12

Application number

PT81991A

Other languages

English (en)

Other versions

PT81991A (fr

Inventor

Dino Nisato

Jean Wagnon

Georges Callet

Jean-Pierre Gagnol

Catherine Cazaubon

Original Assignee

Sanofi Sa

Inst Nat Sante Rech Med

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-02-12

Filing date

1986-02-07

Publication date

1988-03-03

1985-02-12 Priority claimed from FR8501981A external-priority patent/FR2577225B1/fr

1985-02-12 Priority claimed from FR8501982A external-priority patent/FR2577226B1/fr

1986-02-07 Application filed by Sanofi Sa, Inst Nat Sante Rech Med filed Critical Sanofi Sa

1986-03-01 Publication of PT81991A publication Critical patent/PT81991A/pt

1988-03-03 Publication of PT81991B publication Critical patent/PT81991B/pt

Links

108091005508 Acid proteases Proteins 0.000 title abstract 2
239000003112 inhibitor Substances 0.000 title 1
108090000783 Renin Proteins 0.000 abstract 1
102100028255 Renin Human genes 0.000 abstract 1
229950000964 pepstatin Drugs 0.000 abstract 1
108010091212 pepstatin Proteins 0.000 abstract 1
FAXGPCHRFPCXOO-LXTPJMTPSA-N pepstatin A Chemical compound OC(=O)C[C@H](O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)C[C@H](O)[C@H](CC(C)C)NC(=O)[C@H](C(C)C)NC(=O)[C@H](C(C)C)NC(=O)CC(C)C FAXGPCHRFPCXOO-LXTPJMTPSA-N 0.000 abstract 1
108090000765 processed proteins & peptides Proteins 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0227—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the (partial) peptide sequence -Phe-His-NH-(X)2-C(=0)-, e.g. Renin-inhibitors with n = 2 - 6; for n > 6 see C07K5/06 - C07K5/10
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/02—Linear peptides containing at least one abnormal peptide link
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/86—Renin inhibitors

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Health & Medical Sciences (AREA)
Biochemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Crystallography & Structural Chemistry (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

PT81991A 1985-02-12 1986-02-07 Processo para a preparacao de derivados peptidicos, analogos a pepestatina, inibidores darenina e das proteases acidas PT81991B (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR8501981A FR2577225B1 (fr)	1985-02-12	1985-02-12	Derives peptidiques inhibiteurs de la renine et des proteases acides
FR8501982A FR2577226B1 (fr)	1985-02-12	1985-02-12	Analogues de pepstatine inhibiteurs de la renine et des proteases acides

Publications (2)

Publication Number	Publication Date
PT81991A PT81991A (fr)	1986-03-01
PT81991B true PT81991B (pt)	1988-03-03

Family

ID=26224369

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
PT81990A PT81990B (pt)	1985-02-12	1986-02-07	Processo para a preparacao de derivados peptidicos inibidores da renina e das proteases acidas
PT81991A PT81991B (pt)	1985-02-12	1986-02-07	Processo para a preparacao de derivados peptidicos, analogos a pepestatina, inibidores darenina e das proteases acidas

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
PT81990A PT81990B (pt)	1985-02-12	1986-02-07	Processo para a preparacao de derivados peptidicos inibidores da renina e das proteases acidas

Country Status (11)

Country	Link
US (2)	US4725580A (pt)
EP (2)	EP0193445B1 (pt)
AT (2)	ATE52518T1 (pt)
AU (2)	AU606312B2 (pt)
CA (2)	CA1286846C (pt)
DE (2)	DE3683170D1 (pt)
DK (2)	DK64186A (pt)
ES (2)	ES8701782A1 (pt)
GR (2)	GR860399B (pt)
NZ (2)	NZ215097A (pt)
PT (2)	PT81990B (pt)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2585708B1 (fr) *	1985-07-31	1989-07-07	Sanofi Sa	Derives aminoalcools peptidiques inhibiteurs de la resine et des proteases acides, leur procede de preparation et leur application en therapeutique
US4599198A (en) *	1985-08-02	1986-07-08	Pfizer Inc.	Intermediates in polypeptide synthesis
DE3626130A1 (de) *	1986-08-01	1988-02-11	Merck Patent Gmbh	Aminosaeurederivate
DE3640535A1 (de) *	1986-11-27	1988-06-01	Merck Patent Gmbh	Peptide
EP0284510A3 (en) *	1987-03-24	1990-08-22	Asahi Breweries, Ltd.	N-[N alpha-(1(S)-carboxy-3-cyclohexyl-propyl)-1-lysyl] N-cyclopentylglycine as antihypertensives
US4874745A (en) *	1987-10-01	1989-10-17	Merck & Co., Inc.	Renin-inhibitory pepstatin phenyl derivatives
US4980283A (en) *	1987-10-01	1990-12-25	Merck & Co., Inc.	Renin-inhibitory pepstatin phenyl derivatives
US5162527A (en) *	1987-10-26	1992-11-10	Warner-Lambert Company	Renin inhibitors, processes for preparing them, methods for using them, and compositions containing them
JPH03500880A (ja) *	1987-10-26	1991-02-28	ワーナー‐ランバート・コンパニー	レニン阻害剤、その製造方法、その使用のための方法およびそれを含有する組成物
IL92011A0 (en) *	1988-10-19	1990-07-12	Abbott Lab	Heterocyclic peptide renin inhibitors
US5164388A (en) *	1988-10-19	1992-11-17	Abbott Laboratories	Heterocyclic peptide renin inhibitors
DE69020752T2 (de) *	1989-02-16	1996-03-28	Sankyo Co	Peptide, die eine reninhemmende Aktivität besitzen, deren Herstellung und Verwendung.
FR2646354B1 (fr) *	1989-04-27	1994-06-10	Sanofi Sa	Utilisation de peptides inhibiteurs de proteases acides pour la preparation de medicaments utiles pour le traitement de maladies virales
US5238923A (en) *	1989-05-26	1993-08-24	Warner-Lambert Company	Amino-substituted heterocycles as renin inhibitors
US5149692A (en) *	1989-12-21	1992-09-22	Warner-Lambert Company	Bisalkoxyphosphinyl compounds as renin inhibitors
US5071837A (en) *	1990-11-28	1991-12-10	Warner-Lambert Company	Novel renin inhibiting peptides
US5833946A (en) *	1995-06-06	1998-11-10	Bayer Corporation	Dissemination of fungal infections: animal model and method of prophylaxis
AT407043B (de) *	1998-01-23	2000-11-27	Martin Dr Kratzel	Simplifizierte pepstatin-a-analoga, deren herstellung und verwendung
US7247704B2 (en) *	2000-12-18	2007-07-24	Arriva Pharmaceuticals, Inc.	Multifunctional protease inhibitors and their use in treatment of disease
US7929913B2 (en)	2002-12-16	2011-04-19	Intel Corporation	Adaptive receiver architecture
SG192592A1 (en)	2011-02-08	2013-09-30	Merck Patent Gmbh	Amino statin derivatives for the treatment of arthrosis
CN104507957B (zh)	2012-07-24	2018-12-25	默克专利股份有限公司	用于治疗关节病的羟基他汀衍生物
US9663475B2 (en)	2013-02-25	2017-05-30	Merck Patent Gmbh	2 amino-3,4-dihydrcquinazoline derivatives and the use thereof as cathepsin D inhibitors
ES2759060T3 (es)	2013-08-06	2020-05-07	Merck Patent Gmbh	Administración intraarticular de pepstatina para la artrosis

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA1245217A (en) *	1981-12-10	1988-11-22	Joshua S. Boger	Renin inhibitory peptides having phe su13 xx deletion
FR2531951A1 (fr) *	1982-08-17	1984-02-24	Sanofi Sa	Derives peptidiques inhibiteurs de proteases acides, procede pour leur preparation et medicaments qui en contiennent
DE3381565D1 (de) *	1982-12-27	1990-06-21	Merck & Co Inc	Reninhemmende tripeptide.

1986
- 1986-02-03 CA CA000500927A patent/CA1286846C/en not_active Expired - Lifetime
- 1986-02-05 CA CA000501163A patent/CA1286847C/en not_active Expired - Lifetime
- 1986-02-05 US US06/826,349 patent/US4725580A/en not_active Expired - Fee Related
- 1986-02-05 US US06/826,375 patent/US4746648A/en not_active Expired - Fee Related
- 1986-02-06 AU AU53272/86A patent/AU606312B2/en not_active Ceased
- 1986-02-06 AU AU53273/86A patent/AU606572B2/en not_active Ceased
- 1986-02-07 PT PT81990A patent/PT81990B/pt not_active IP Right Cessation
- 1986-02-07 PT PT81991A patent/PT81991B/pt not_active IP Right Cessation
- 1986-02-10 DE DE8686400271T patent/DE3683170D1/de not_active Expired - Lifetime
- 1986-02-10 EP EP86400272A patent/EP0193445B1/fr not_active Expired - Lifetime
- 1986-02-10 EP EP86400271A patent/EP0192554B1/fr not_active Expired - Lifetime
- 1986-02-10 AT AT86400272T patent/ATE52518T1/de not_active IP Right Cessation
- 1986-02-10 DE DE8686400272T patent/DE3671021D1/de not_active Expired - Lifetime
- 1986-02-10 AT AT86400271T patent/ATE71111T1/de not_active IP Right Cessation
- 1986-02-10 DK DK64186A patent/DK64186A/da not_active Application Discontinuation
- 1986-02-10 DK DK64086A patent/DK64086A/da not_active Application Discontinuation
- 1986-02-11 GR GR860399A patent/GR860399B/el unknown
- 1986-02-11 ES ES551820A patent/ES8701782A1/es not_active Expired
- 1986-02-11 NZ NZ215097A patent/NZ215097A/en unknown
- 1986-02-11 NZ NZ215096A patent/NZ215096A/xx unknown
- 1986-02-11 ES ES551821A patent/ES8701783A1/es not_active Expired
- 1986-02-11 GR GR860398A patent/GR860398B/el unknown

Also Published As

Publication number	Publication date
EP0193445B1 (fr)	1990-05-09
NZ215097A (en)	1990-04-26
PT81991A (fr)	1986-03-01
PT81990A (fr)	1986-03-01
EP0192554B1 (fr)	1992-01-02
US4725580A (en)	1988-02-16
AU606572B2 (en)	1991-02-14
GR860399B (en)	1986-06-12
DK64186A (da)	1986-08-13
ES8701783A1 (es)	1987-01-01
NZ215096A (en)	1989-10-27
PT81990B (pt)	1988-03-03
ATE71111T1 (de)	1992-01-15
ES551821A0 (es)	1987-01-01
DE3671021D1 (de)	1990-06-13
DK64086A (da)	1986-08-13
AU5327386A (en)	1986-08-21
DK64186D0 (da)	1986-02-10
CA1286846C (en)	1991-07-23
EP0193445A1 (fr)	1986-09-03
ATE52518T1 (de)	1990-05-15
DK64086D0 (da)	1986-02-10
DE3683170D1 (de)	1992-02-13
CA1286847C (en)	1991-07-23
AU5327286A (en)	1986-08-14
EP0192554A1 (fr)	1986-08-27
GR860398B (en)	1986-06-12
ES8701782A1 (es)	1986-12-16
US4746648A (en)	1988-05-24
ES551820A0 (es)	1986-12-16
AU606312B2 (en)	1991-02-07

Legal Events

Date

Code

Title

Description

1994-07-29

MM3A

Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 19940331

Publication	Publication Date	Title
PT81990B (pt)	1988-03-03	Processo para a preparacao de derivados peptidicos inibidores da renina e das proteases acidas
FI864427A7 (fi)	1986-10-30	Menetelmä polypeptidin valmistamiseksi, joka on komplementaarinen ainakin osalle alkuperäistä peptidiä tai proteiinia, ja komplementaarisen polypeptidin käyttö
ES552093A0 (es)	1987-09-01	Un procedimiento para sintetizar una secuencia de aminoacidos que contienen la totalidad o parte de la secuencia de aminoacidos de la preprorrelaxina -h2 humana.
DK565987D0 (da)	1987-10-28	Substituerede aminosyrer
DK0495918T3 (da)	1996-02-19	Aminosyre-beta-lyaseenzyminhibitorer som deodoranter
PT83673B (pt)	1988-08-17	Processo para a producao de analogos de peptideos atriais natriureticos
DE3787657D1 (de)	1993-11-11	Aminosäure-Derivate.
NO884434L (no)	1989-04-07	Aminosyrederivater.
DK482185D0 (da)	1985-10-21	Peptider, deres fremstilling og anvendelse som laegemidler
PT83045B (pt)	1988-07-01	Processo para a obtencao de derivados aminoalcoois peptidicos contendo um atomo de carbono tetrasubstituido inibidores da renina e das proteases acidas
MX167236B (es)	1993-03-11	Peptidos sinteticos de timosina -1 y metodo para su obtencion
PT90504A (pt)	1989-11-30	Processo para a preparacao de alcoois peptidicos com actividade anticoagulante
ES557727A0 (es)	1988-03-16	Procedimiento para la obtencion de acidos 4-quinolon-3-carboxilicos 1,8-puenteados
FI890699L (fi)	1989-08-17	Renin inhiberande aminosyraderivat.
ES553691A0 (es)	1987-08-01	Procedimiento para la obtencion de un peptido.
NO892266D0 (no)	1989-06-02	Amblyommin, et nytt virkemiddel for antikoagulasjonsterapien.
IT8619557A0 (it)	1986-02-27	Analoghi di ammino prostaglandine tiabicicloeptano-sostituite.
IT8224380A0 (it)	1982-11-23	Amminoacidi fosfinilalcanoici utili come agenti ipotensivi.
IT1188557B (it)	1988-01-20	Acidi 8-osso-2-ossa-1-azabiciclo (4.2.0)ottano-3-carbossilici
JPS5775960A (en)	1982-05-12	Purified polypeptide
PT83116B (pt)	1988-07-01	Processo para a preparacao de acidos 5-cloro-s-triazolo{4,3-a}-piridino-7-carboxilicos
ZA86960B (en)	1986-10-29	Peptide derivatives,analogous to pepstatin,which inhibit renin and acid proteases
NO870781D0 (no)	1987-02-25	Aminosyrederivater.
ATE86628T1 (de)	1993-03-15	Peptide boronsaeure-hemmungsstoffe von trypsintyp- proteasen.
FI931988L (fi)	1993-05-03	Menetelmä terapeuttisesti aktiivisten fosfopeptidien valmistamiseksi