ATE525370T1 - Phthalazin- und pyridoä3,4- düpyridazinverbindungen als h1-rezeptor- antagonisten - Google Patents

Phthalazin- und pyridoä3,4- düpyridazinverbindungen als h1-rezeptor- antagonisten

Info

Publication number: ATE525370T1
Authority: AT; Austria
Prior art keywords: compounds; pyridoä3; düpyridazine; phthalazine; receptor antagonists
Prior art date: 2007-10-11

Application number

AT08805231T

Other languages

English (en)

Inventor

Paul Gore

Brian Looker

Panayiotis Procopiou

Sadie Vile

Original Assignee

Glaxo Group Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-10-11

Filing date

2008-10-10

Publication date

2011-10-15

2008-10-10 Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd

2011-10-15 Application granted granted Critical

2011-10-15 Publication of ATE525370T1 publication Critical patent/ATE525370T1/de

Links

150000001875 compounds Chemical class 0.000 title abstract 2
XSCHRSMBECNVNS-UHFFFAOYSA-N benzopyrazine Natural products N1=CC=NC2=CC=CC=C21 XSCHRSMBECNVNS-UHFFFAOYSA-N 0.000 title 1
LFSXCDWNBUNEEM-UHFFFAOYSA-N phthalazine Chemical compound C1=NN=CC2=CC=CC=C21 LFSXCDWNBUNEEM-UHFFFAOYSA-N 0.000 title 1
239000002464 receptor antagonist Substances 0.000 title 1
229940044551 receptor antagonist Drugs 0.000 title 1
206010039085 Rhinitis allergic Diseases 0.000 abstract 1
201000010105 allergic rhinitis Diseases 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pulmonology (AREA)
Otolaryngology (AREA)
Ophthalmology & Optometry (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Immunology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AT08805231T 2007-10-11 2008-10-10 Phthalazin- und pyridoä3,4- düpyridazinverbindungen als h1-rezeptor- antagonisten ATE525370T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US97910507P	2007-10-11	2007-10-11
PCT/EP2008/063642 WO2009047336A1 (en)	2007-10-11	2008-10-10	Phthalazine and pyrido [3,4-d] pyridaz ine compounds as h1 receptor antagonists

Publications (1)

Publication Number	Publication Date
ATE525370T1 true ATE525370T1 (de)	2011-10-15

Family

ID=40104668

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT08805231T ATE525370T1 (de)	2007-10-11	2008-10-10	Phthalazin- und pyridoä3,4- düpyridazinverbindungen als h1-rezeptor- antagonisten

Country Status (6)

Country	Link
US (1)	US20100216799A1 (de)
EP (1)	EP2215082B1 (de)
JP (1)	JP2011500537A (de)
AT (1)	ATE525370T1 (de)
ES (1)	ES2369320T3 (de)
WO (1)	WO2009047336A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN101163681A (zh) *	2005-04-21	2008-04-16	日本新药株式会社	2,3-二氮杂萘酮衍生物及其医药品
PT2698062E (pt) *	2006-12-28	2015-10-19	Abbvie Inc	Inibidores da poli (adp-ribose) polimerase
WO2008137084A2 (en) *	2007-05-04	2008-11-13	Amgen Inc.	Diazaquinolones that inhibit prolyl hydroxylase activity
KR20220130126A (ko) *	2019-12-20	2022-09-26	미라티 테라퓨틱스, 인크.	Sos1 억제제

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3813384A (en) *	1972-01-17	1974-05-28	Asta Werke Ag Chem Fab	Basically substituted benzyl phthalazone derivatives,acid salts thereof and process for the production thereof
PH23995A (en) *	1984-01-09	1990-02-09	Janssen Pharmaceutica Nv	4((bicycle heterocyclyl)-methyl and hetero)piperidines
EP0174464B1 (de) *	1984-09-14	1990-01-03	ASTA Pharma AG	Substituierte Benzylphthalazinon-Derivate
ES2031813T3 (es) *	1985-11-11	1993-01-01	Asta Pharma Ag	Procedimiento para la preparacion de derivados de 4-bencil-1-(2h)-ftalazinona.
DE3634942A1 (de) *	1985-11-11	1987-05-14	Asta Werke Ag Chem Fab	Neue 4-benzyl-1-(2h)-phthalazinon-derivate
EP0289939A1 (de) *	1987-05-08	1988-11-09	ASTA Pharma AG	Neue 4-Benzyl-1-(2H)-phthalazinon-Derivate mit einem Aminosäurerest
CZ199593A3 (en) *	1992-10-02	1994-04-13	Asta Medica Ag	Phthalazinone derivatives exhibiting anti-arrhythmic and analgesic activity and eliminating resistance to a plurality of medicaments (mdr)
US6180629B1 (en) *	1998-08-14	2001-01-30	Cell Pathways, Inc.	[4,5]-Fused-1,3-disubstituted-1,2-diazine-6-one derivatives with nitrogen containing substitutents in position one for the treatment of neoplasia
DK0997474T3 (da) *	1998-08-14	2004-02-09	Pfizer	Antithrombotiske midler
US20030073692A1 (en) *	2001-08-07	2003-04-17	Pharmacia & Upjohn S.P.A.	Amino-phthalazinone derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions containing them
CN1787818A (zh) *	2003-03-18	2006-06-14	麦克公司	趋化因子受体活性的氨基环丁基酰胺调节剂
CA2529790A1 (en) *	2003-06-27	2005-01-27	Banyu Pharmaceutical Co., Ltd.	Heteroaryloxy nitrogenous saturated heterocyclic derivative
AR064424A1 (es) *	2006-12-20	2009-04-01	Glaxo Group Ltd	Derivados sustituidos de 1-oxo-ftalazinas y 1-oxo-pirido-piridazinas,composiciones farmaceuticas que los contienen y usos para prevenir y/o tratar enfermedades inflamatorias y alergicas del tracto respiratorio.

2008
- 2008-10-10 AT AT08805231T patent/ATE525370T1/de not_active IP Right Cessation
- 2008-10-10 ES ES08805231T patent/ES2369320T3/es active Active
- 2008-10-10 US US12/681,945 patent/US20100216799A1/en not_active Abandoned
- 2008-10-10 WO PCT/EP2008/063642 patent/WO2009047336A1/en not_active Ceased
- 2008-10-10 JP JP2010528414A patent/JP2011500537A/ja not_active Ceased
- 2008-10-10 EP EP08805231A patent/EP2215082B1/de not_active Not-in-force

Also Published As

Publication number	Publication date
WO2009047336A1 (en)	2009-04-16
US20100216799A1 (en)	2010-08-26
JP2011500537A (ja)	2011-01-06
EP2215082B1 (de)	2011-09-21
EP2215082A1 (de)	2010-08-11
ES2369320T3 (es)	2011-11-29

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Legal Events

Date	Code	Title	Description
2012-03-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties