ATE525372T1 - Pyrazinderivate als natriumkanalmodulatoren zur behandlung von schmerzen - Google Patents

Pyrazinderivate als natriumkanalmodulatoren zur behandlung von schmerzen

Info

Publication number
ATE525372T1
ATE525372T1 AT06809149T AT06809149T ATE525372T1 AT E525372 T1 ATE525372 T1 AT E525372T1 AT 06809149 T AT06809149 T AT 06809149T AT 06809149 T AT06809149 T AT 06809149T AT E525372 T1 ATE525372 T1 AT E525372T1
Authority
AT
Austria
Prior art keywords
pain
treatment
sodium channel
channel modulators
pyrazine derivatives
Prior art date
Application number
AT06809149T
Other languages
English (en)
Inventor
Karl Gibson
Cedric Poinsard
Melanie Glossop
Mark KEMP
Stephen Denton
Original Assignee
Pfizer Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Ltd filed Critical Pfizer Ltd
Application granted granted Critical
Publication of ATE525372T1 publication Critical patent/ATE525372T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
AT06809149T 2005-11-04 2006-10-23 Pyrazinderivate als natriumkanalmodulatoren zur behandlung von schmerzen ATE525372T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US73366205P 2005-11-04 2005-11-04
PCT/IB2006/003055 WO2007052123A2 (en) 2005-11-04 2006-10-23 Pyrazine derivatives as sodium channel modulators for the treatment of pain

Publications (1)

Publication Number Publication Date
ATE525372T1 true ATE525372T1 (de) 2011-10-15

Family

ID=37890558

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06809149T ATE525372T1 (de) 2005-11-04 2006-10-23 Pyrazinderivate als natriumkanalmodulatoren zur behandlung von schmerzen

Country Status (27)

Country Link
US (1) US7572797B2 (de)
EP (1) EP1945630B1 (de)
JP (1) JP2009514937A (de)
KR (1) KR20080066073A (de)
CN (1) CN101356169A (de)
AP (1) AP2008004468A0 (de)
AR (1) AR057855A1 (de)
AT (1) ATE525372T1 (de)
AU (1) AU2006310215A1 (de)
BR (1) BRPI0618129A2 (de)
CA (1) CA2624621C (de)
CR (1) CR9954A (de)
DO (1) DOP2006000243A (de)
EA (1) EA200801011A1 (de)
EC (1) ECSP088412A (de)
ES (1) ES2371932T3 (de)
GT (1) GT200600475A (de)
IL (1) IL191059A0 (de)
MA (1) MA29926B1 (de)
NL (1) NL2000284C2 (de)
NO (1) NO20082496L (de)
PE (1) PE20070715A1 (de)
TN (1) TNSN08196A1 (de)
TW (1) TW200804353A (de)
UY (1) UY29893A1 (de)
WO (1) WO2007052123A2 (de)
ZA (1) ZA200803671B (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100491282B1 (ko) 1996-07-24 2005-05-24 워너-램버트 캄파니 엘엘씨 통증 치료용 이소부틸가바 및 그의 유도체
EP1741708A1 (de) * 2005-06-28 2007-01-10 Sanofi-Aventis Deutschland GmbH Heteroaryl substituierte Amide mit ungesättigtem oder zyklischem Linker, und deren Verwendung als Pharmaka
GB2431927B (en) 2005-11-04 2010-03-17 Amira Pharmaceuticals Inc 5-Lipoxygenase-activating protein (FLAP) inhibitors
US7977359B2 (en) 2005-11-04 2011-07-12 Amira Pharmaceuticals, Inc. 5-lipdxygenase-activating protein (FLAP) inhibitors
US8399666B2 (en) 2005-11-04 2013-03-19 Panmira Pharmaceuticals, Llc 5-lipoxygenase-activating protein (FLAP) inhibitors
JP2010526051A (ja) * 2007-05-03 2010-07-29 ファイザー・リミテッド 疼痛を治療するためのｎａｖ１．８チャネルモジュレーターとしてのｎ−［６−アミノ−５−（フェニル）ピラジン−２−イル］−イソオキサゾール−４−カルボキサミド誘導体および関連化合物
WO2008135826A2 (en) 2007-05-03 2008-11-13 Pfizer Limited 2 -pyridine carboxamide derivatives as sodium channel modulators
WO2009026434A1 (en) * 2007-08-21 2009-02-26 Alkermes, Inc. Pulmonary pharmaceutical formulations
EP2231280B1 (de) 2007-12-10 2016-08-10 Novartis AG Amiloride-ähnliche Pyrazine-carboxamide als ENaC Blocker
KR20100124262A (ko) 2008-02-13 2010-11-26 에자이 알앤드디 매니지먼트 가부시키가이샤 비시클로아민 유도체
BRPI0912267A2 (pt) 2008-05-23 2015-10-13 Amira Pharmaceuticals Inc sal farmaceuticamente aceitável, composição farmacêutica, artigo de fabricação, métodos para tratar asma, rinite alérgica, doença, lesões gástricas e dor, métodos para prevenir broncoconstrição e rinite alérgica, uso de um sal farmaceuticamente aceitável, e, processo para a preparação de um sal farmaceuticamente aceitável.
US8546431B2 (en) 2008-10-01 2013-10-01 Panmira Pharmaceuticals, Llc 5-lipoxygenase-activating protein (FLAP) inhibitors
US10703722B2 (en) 2010-04-27 2020-07-07 Calcimedica, Inc. Compounds that modulate intracellular calcium
WO2013059677A1 (en) * 2011-10-19 2013-04-25 Calcimedica, Inc. Compounds that modulate intracellular calcium
WO2013161312A1 (en) * 2012-04-25 2013-10-31 Raqualia Pharma Inc. Pyrrolopyridinone derivatives as ttx-s blockers
TWI644899B (zh) * 2013-02-04 2018-12-21 健生藥品公司 Ｆｌａｐ調節劑
US9079866B2 (en) 2013-02-04 2015-07-14 Janssen Pharmaceutica Nv Flap modulators
CA2960274A1 (en) * 2014-09-10 2016-03-17 Epizyme, Inc. Isoxazole carboxamide compounds
AR103807A1 (es) 2015-02-27 2017-06-07 Calcimedica Inc Tratamiento de la pancreatitis
JP6738575B2 (ja) * 2015-08-07 2020-08-12 カルシメディカ，インク． 脳卒中および外傷性脳損傷の処置のためのｃｒａｃチャネル阻害剤の使用
GB201801128D0 (en) 2018-01-24 2018-03-07 Univ Oxford Innovation Ltd Compounds
EP4121089A4 (de) 2020-03-20 2024-04-10 Calcimedica, Inc. Verfahren und zusammensetzungen zur behandlung von akuter lungenläsion und akutem atemnotsyndrom
US12522589B2 (en) 2020-11-13 2026-01-13 Calcimedica, Inc. Synthesis of CRAC channel inhibitors

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MA26473A1 (fr) * 1997-03-01 2004-12-20 Glaxo Group Ltd Composes pharmacologiquement actifs.
AU2002343557A1 (en) * 2001-11-21 2003-06-10 Pharmacia And Upjohn Company Substituted aryl 1,4-pyrazine derivatives
US20030187026A1 (en) 2001-12-13 2003-10-02 Qun Li Kinase inhibitors
EP1678160A1 (de) * 2003-10-27 2006-07-12 Astellas Pharma Inc. Pyrazinderivate und deren pharmazeutische verwendung
DE602005015742D1 (de) * 2004-10-22 2009-09-10 Janssen Pharmaceutica Nv Aromatische amide als hemmer der c-fms-kinase

Also Published As

Publication number Publication date
EA200801011A1 (ru) 2009-02-27
EP1945630A2 (de) 2008-07-23
ECSP088412A (es) 2008-05-30
NL2000284C2 (nl) 2007-09-28
DOP2006000243A (es) 2007-05-31
US20070105872A1 (en) 2007-05-10
NL2000284A1 (nl) 2007-05-07
TNSN08196A1 (fr) 2009-10-30
AR057855A1 (es) 2007-12-19
AU2006310215A1 (en) 2007-05-10
CR9954A (es) 2008-05-28
ZA200803671B (en) 2009-03-25
CN101356169A (zh) 2009-01-28
ES2371932T3 (es) 2012-01-11
CA2624621C (en) 2010-11-30
US7572797B2 (en) 2009-08-11
CA2624621A1 (en) 2007-05-10
GT200600475A (es) 2007-07-06
AP2008004468A0 (en) 2008-06-30
MA29926B1 (fr) 2008-11-03
JP2009514937A (ja) 2009-04-09
NO20082496L (no) 2008-07-24
EP1945630B1 (de) 2011-09-21
WO2007052123A3 (en) 2007-07-12
KR20080066073A (ko) 2008-07-15
PE20070715A1 (es) 2007-08-11
IL191059A0 (en) 2008-12-29
BRPI0618129A2 (pt) 2011-08-16
WO2007052123A2 (en) 2007-05-10
UY29893A1 (es) 2007-06-29
TW200804353A (en) 2008-01-16

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